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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106294
UUCD1 version UUC-SaC-00047
Ensembl Protein ID YML088W
UniProt Accession Q04511; D6W0J5; UFO1_YEAST
Genbank Protein ID CAA86650.1; DAA09809.1
Protein Name Ubiquitin ligase complex F-box protein UFO1
Genbank Nucleotide ID Z46660; BK006946
Gene Name UFO1; YML088W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YML088W YML088W YML088W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 16671359; 17198712
UBD/Alpha-Helix/UIM UIM 11406394
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00021 19.8 8 51
UBD/Alpha-Helix/UIM 3.60e-05 21.9 653 666
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           l++lp eil++i+++ld+++l ++++ + ++++l+++++lwk++
   Q: 8    LQDLPPEILINIFSHLDEKDLFTLQELSTHFRNLIHDEELWKNL 51
           679*****************************99999****997 PP
   

   UBD/Alpha-Helix/UIM
   S: 3    deeLqlAlalSlqE 16
           de+LqlA+alSl+E
   Q: 653  DEDLQLAIALSLSE 666
           9************9 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).
Protein Sequence
(Fasta)
MERPGLVLQD LPPEILINIF SHLDEKDLFT LQELSTHFRN LIHDEELWKN LFKSRVHTTH 60
FPTFSQSSKF SVEYIERTRG LHHWQHNKAI RTKYTIIPTR NWDQPSIERI VFDYPRVAAY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106294|E3,F-box;UBD,UIM|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGCGGC CTGGCTTGGT ATTGCAGGAC CTTCCACCCG AAATCCTGAT AAACATCTTT 60
TCTCACTTAG ACGAAAAGGA CTTGTTCACG TTGCAAGAAC TTTCTACGCA TTTCCGGAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106294|E3,F-box;UBD,UIM|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR003903--UIM_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS50330--UIM
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
SM00726--UIM
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030674--F:protein binding, bridging
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071406--P:cellular response to methylmercury
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG sce:YML088W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003755 Anas platyrhynchos 35.42 7.00e-06 43.90
IUUC-Aca-005125 Anolis carolinensis 33.33 5.00e-05 40.40
IUUC-Aly-005661 Arabidopsis lyrata 35.71 7.00e-04 36.20
IUUC-Ath-007384 Arabidopsis thaliana 32.08 5.50e-01 25.80
IUUC-Ago-007783 Ashbya gossypii 40.53 4.00e-117 413.00
IUUC-Bci-013711 Botrytis cinerea 41.67 3.00e-06 44.70
IUUC-Bdi-015059 Brachypodium distachyon 35.56 4.10e-02 30.00
IUUC-Bol-015838 Brassica oleracea 32.43 2.40e-02 30.40
IUUC-Bra-017713 Brassica rapa 40.00 2.00e-04 37.70
IUUC-Cel-018135 Caenorhabditis elegans 29.25 9.00e-05 40.80
IUUC-Cpo-022420 Cavia porcellus 39.13 2.00e-06 45.10
IUUC-Cgl-026674 Colletotrichum gloeosporioides 39.22 2.00e-04 38.90
IUUC-Dme-031852 Drosophila melanogaster 33.05 1.00e-06 47.40
IUUC-Fal-037500 Ficedula albicollis 30.91 3.00e-06 44.30
IUUC-Ggr-039812 Gaeumannomyces graminis 39.22 1.00e-04 39.70
IUUC-Gga-040271 Gallus gallus 35.42 8.00e-06 43.90
IUUC-Gac-041561 Gasterosteus aculeatus 40.91 7.00e-07 46.60
IUUC-Hvu-047576 Hordeum vulgare 35.56 4.00e-05 40.00
IUUC-Kpa-049204 Komagataella pastoris 23.55 3.00e-23 101.00
IUUC-Lch-049972 Latimeria chalumnae 32.69 1.00e-05 42.70
IUUC-Mcc-054623 Macaca mulatta 38.57 9.00e-05 39.70
IUUC-Mpo-057335 Magnaporthe poae 40.91 4.00e-05 41.20
IUUC-Mla-059163 Melampsora laricipopulina 32.61 2.00e-03 34.30
IUUC-Mga-059675 Meleagris gallopavo 35.42 8.00e-06 43.50
IUUC-Mlu-067776 Myotis lucifugus 40.82 9.00e-08 49.70
IUUC-Ncr-068772 Neurospora crassa 50.00 3.00e-04 37.40
IUUC-Oan-072870 Ornithorhynchus anatinus 38.10 7.00e-05 40.00
IUUC-Oba-075381 Oryza barthii 34.00 4.00e-04 37.00
IUUC-Obr-076074 Oryza brachyantha 38.00 4.00e-05 40.40
IUUC-Olo-080372 Oryza longistaminata 34.00 4.00e-04 37.00
IUUC-Oni-082278 Oryza nivara 34.04 1.00e-04 38.10
IUUC-Opu-083767 Oryza punctata 33.33 8.00e-04 35.80
IUUC-Psi-093154 Pelodiscus sinensis 35.71 1.00e-05 42.70
IUUC-Pfo-097267 Poecilia formosa 34.29 1.00e-05 42.70
IUUC-Pop-099426 Populus trichocarpa 35.59 3.00e-05 40.80
IUUC-Ssl-108666 Sclerotinia sclerotiorum 40.48 8.00e-05 40.40
IUUC-Sre-115181 Sporisorium reilianum 45.24 2.00e-05 42.40
IUUC-Tgu-117170 Taeniopygia guttata 40.43 3.00e-06 44.30
IUUC-Tru-117759 Takifugu rubripes 32.08 5.50e-01 26.90
IUUC-Tni-120176 Tetraodon nigroviridis 39.22 4.00e-04 37.40
IUUC-Tre-122121 Trichoderma reesei 26.42 1.00e-04 40.80
IUUC-Tae-123934 Triticum aestivum 33.33 1.20e-01 28.50
IUUC-Tur-126782 Triticum urartu 28.57 6.00e-04 36.20
IUUC-Uma-129621 Ustilago maydis 46.15 8.00e-05 40.40
IUUC-Xtr-132725 Xenopus tropicalis 37.21 1.00e-05 43.10
Created Date 25-Jun-2017

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