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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046128
UUCD1 version UUC-HoS-00395
Ensembl Protein ID ENSP00000413572.3
UniProt Accession Q9NVX2; O60868; Q59GJ8; Q9BU54; NLE1_HUMAN
Genbank Protein ID BAA91621.1; BAD92348.1; AAH02884.2; AAH12075.1; CAA06444.1
Protein Name Notchless protein homolog 1
Genbank Nucleotide ID AK001320; AB209111; AC022916; BC012075; AJ005257
Gene Name NLE1; HUSSY-07
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000073536.17 ENST00000442241.8 ENSP00000413572.3
ENSG00000073536.17 ENST00000360831.9 ENSP00000354075.5
ENSG00000073536.17 ENST00000588019.1 ENSP00000466764.1
ENSG00000073536.17 ENST00000588642.1 ENSP00000465420.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-66 218.8 197 240
UBD/Beta-Prp 2.70e-79 268.1 106 299
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg++++WD++ g++++
   Q: 197  GHSKWITGLSWeplhanPEcRYVASSSKDGSVRIWDTTAGRCER 240
           8***************9889**********************86 PP
   

   UBD/Beta-Prp
   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsg 135
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+s+sp+g kl+sG +   i +wd +tg+ +  tl+g
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAG 197
           5899**************************************************************************************** PP
   S: 136  hdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght 222
           h+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   rtl+gh 
   Q: 198  HSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
           *******9873332257889**************************9.************98.***************************** PP
   S: 223  dnvksvrfspnde 235
            +v+ +++s  d 
   Q: 288  HWVNTMALS-TDY 299
           *******99.333 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).
 Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).
Protein Sequence
(Fasta)
MAAAVPDEAV ARDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDRLQLVCNA LLAQEDPLPL 60
AFFVHDAEIV SSLGKTLESQ AVETEKVLDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046128|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGTCTGCCG GGCTCTTTCT CCTCCACGTG GGGACGCAGG ATGGCGGCAG CAGTGCCGGT 60
GGGTGTGCGT GGATGGGGGC GGGGGGCGTC GCCGCGGGGC GCTAGGGCCC GGGTCCCTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046128|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08154--NLE
PF00400--WD40
PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005840--C:ribosome
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0000027--P:ribosomal large subunit assembly
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis
KEGG hsa:54475
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000437 Aegilops tauschii 58.15 8.00e-169 586.00
IUUC-Aml-001793 Ailuropoda melanoleuca 96.83 0.00e+00 946.00
IUUC-Atr-002507 Amborella trichopoda 57.59 7.00e-168 583.00
IUUC-Apl-003964 Anas platyrhynchos 85.02 0.00e+00 818.00
IUUC-Aly-006396 Arabidopsis lyrata 54.68 1.00e-161 563.00
IUUC-Ath-007278 Arabidopsis thaliana 54.89 1.00e-161 562.00
IUUC-Ago-007951 Ashbya gossypii 47.58 1.00e-129 456.00
IUUC-Acl-008298 Aspergillus clavatus 46.44 5.00e-121 428.00
IUUC-Afl-008581 Aspergillus flavus 52.79 4.00e-109 387.00
IUUC-Afu-008906 Aspergillus fumigatus 45.73 2.00e-120 426.00
IUUC-Ani-009189 Aspergillus nidulans 44.58 3.00e-116 412.00
IUUC-Ang-009630 Aspergillus niger 50.12 3.00e-122 432.00
IUUC-Aor-010038 Aspergillus oryzae 46.95 2.00e-127 449.00
IUUC-Ate-010278 Aspergillus terreus 46.34 2.00e-122 432.00
IUUC-Ame-011890 Astyanax mexicanus 80.76 0.00e+00 823.00
IUUC-Bgr-012011 Blumeria graminis 48.24 7.00e-131 461.00
IUUC-Bta-012964 Bos taurus 95.99 0.00e+00 943.00
IUUC-Bci-013592 Botrytis cinerea 44.56 2.00e-120 426.00
IUUC-Bdi-015035 Brachypodium distachyon 58.24 2.00e-170 591.00
IUUC-Bol-015501 Brassica oleracea 55.77 5.00e-162 564.00
IUUC-Bra-017642 Brassica rapa 55.56 3.00e-161 561.00
IUUC-Cel-018430 Caenorhabditis elegans 59.10 3.00e-169 588.00
IUUC-Cja-019125 Callithrix jacchus 98.31 0.00e+00 958.00
IUUC-Cfa-021013 Canis familiaris 95.61 0.00e+00 859.00
IUUC-Cpo-021743 Cavia porcellus 95.98 0.00e+00 942.00
IUUC-Cre-022973 Chlamydomonas reinhardtii 46.71 2.00e-121 429.00
IUUC-Csa-024270 Chlorocebus sabaeus 98.75 0.00e+00 970.00
IUUC-Cin-025795 Ciona intestinalis 64.89 0.00e+00 688.00
IUUC-Csv-025953 Ciona savignyi 66.95 0.00e+00 682.00
IUUC-Cgl-026517 Colletotrichum gloeosporioides 51.19 5.00e-108 384.00
IUUC-Cne-026901 Cryptococcus neoformans 48.72 2.00e-138 485.00
IUUC-Cme-027281 Cyanidioschyzon merolae 47.89 2.00e-114 406.00
IUUC-Dre-028515 Danio rerio 77.52 0.00e+00 805.00
IUUC-Dno-029596 Dasypus novemcinctus 95.46 0.00e+00 954.00
IUUC-Dor-030494 Dipodomys ordii 96.19 0.00e+00 937.00
IUUC-Dse-031538 Dothistroma septosporum 47.28 7.00e-130 457.00
IUUC-Dme-031974 Drosophila melanogaster 58.40 3.00e-169 588.00
IUUC-Ete-032948 Echinops telfairi 96.65 4.00e-117 415.00
IUUC-Eca-033399 Equus caballus 97.88 0.00e+00 951.00
IUUC-Eeu-035013 Erinaceus europaeus 94.26 1.00e-115 409.00
IUUC-Fca-035860 Felis catus 96.62 0.00e+00 944.00
IUUC-Fal-037069 Ficedula albicollis 88.00 5.00e-133 466.00
IUUC-Fox-038059 Fusarium oxysporum 46.14 2.00e-124 439.00
IUUC-Fso-038445 Fusarium solani 47.39 3.00e-125 442.00
IUUC-Gmo-039319 Gadus morhua 75.53 0.00e+00 734.00
IUUC-Ggr-040095 Gaeumannomyces graminis 47.17 7.00e-122 431.00
IUUC-Gga-040303 Gallus gallus 86.00 3.00e-131 461.00
IUUC-Gac-042267 Gasterosteus aculeatus 78.15 0.00e+00 768.00
IUUC-Gma-043974 Glycine max 57.66 1.00e-170 592.00
IUUC-Ggo-044637 Gorilla gorilla 99.15 0.00e+00 955.00
IUUC-Hvu-047373 Hordeum vulgare 57.60 3.00e-168 584.00
IUUC-Itr-048070 Ictidomys tridecemlineatus 95.92 0.00e+00 960.00
IUUC-Kpa-049274 Komagataella pastoris 43.82 4.00e-127 448.00
IUUC-Lch-049907 Latimeria chalumnae 81.07 0.00e+00 824.00
IUUC-Lpe-050778 Leersia perrieri 53.25 4.00e-152 531.00
IUUC-Loc-051889 Lepisosteus oculatus 80.29 0.00e+00 829.00
IUUC-Lma-053041 Leptosphaeria maculans 50.12 7.00e-118 417.00
IUUC-Laf-053598 Loxodonta africana 96.06 0.00e+00 956.00
IUUC-Mcc-055660 Macaca mulatta 98.54 0.00e+00 968.00
IUUC-Meu-056197 Macropus eugenii 79.50 0.00e+00 785.00
IUUC-Mor-056949 Magnaporthe oryzae 46.17 4.00e-119 422.00
IUUC-Mpo-057571 Magnaporthe poae 44.41 7.00e-63 234.00
IUUC-Mtr-058530 Medicago truncatula 57.59 2.00e-166 578.00
IUUC-Mla-059133 Melampsora laricipopulina 46.68 2.00e-125 442.00
IUUC-Mga-059252 Meleagris gallopavo 84.66 0.00e+00 664.00
IUUC-Mvi-060522 Microbotryum violaceum 49.49 2.00e-135 475.00
IUUC-Mmr-061117 Microcebus murinus 96.04 0.00e+00 944.00
IUUC-Mdo-062892 Monodelphis domestica 88.25 0.00e+00 897.00
IUUC-Mmu-064108 Mus musculus 95.98 0.00e+00 914.00
IUUC-Mac-064430 Musa acuminata 59.10 1.00e-172 599.00
IUUC-Mpu-065882 Mustela putorius furo 96.19 0.00e+00 936.00
IUUC-Mlu-068123 Myotis lucifugus 96.62 0.00e+00 952.00
IUUC-Nfi-068484 Neosartorya fischeri 46.12 2.00e-120 426.00
IUUC-Ncr-068649 Neurospora crassa 43.38 7.00e-116 410.00
IUUC-Nle-069140 Nomascus leucogenys 99.15 0.00e+00 958.00
IUUC-Opr-070220 Ochotona princeps 88.87 0.00e+00 825.00
IUUC-Ont-072643 Oreochromis niloticus 80.46 0.00e+00 824.00
IUUC-Ocu-074007 Oryctolagus cuniculus 96.41 0.00e+00 914.00
IUUC-Oba-075904 Oryza barthii 58.89 9.00e-172 596.00
IUUC-Obr-076280 Oryza brachyantha 58.46 8.00e-171 593.00
IUUC-Ogl-077425 Oryza glaberrima 58.89 8.00e-172 596.00
IUUC-Ogu-078586 Oryza glumaepatula 58.89 1.00e-171 596.00
IUUC-Oin-079489 Oryza indica 56.75 8.00e-163 566.00
IUUC-Olo-080766 Oryza longistaminata 58.76 1.00e-171 596.00
IUUC-Ome-081905 Oryza meridionalis 58.89 8.00e-172 596.00
IUUC-Oni-083022 Oryza nivara 58.89 5.00e-172 597.00
IUUC-Opu-083615 Oryza punctata 58.89 5.00e-172 597.00
IUUC-Oru-085076 Oryza rufipogon 58.89 5.00e-172 597.00
IUUC-Osa-085744 Oryza sativa 59.10 3.00e-172 597.00
IUUC-Ola-087290 Oryzias latipes 77.66 0.00e+00 806.00
IUUC-Olu-087898 Ostreococcus lucimarinus 52.93 4.00e-144 504.00
IUUC-Oga-088980 Otolemur garnettii 95.97 0.00e+00 935.00
IUUC-Oar-089580 Ovis aries 96.10 0.00e+00 820.00
IUUC-Ptr-090845 Pan troglodytes 98.73 0.00e+00 951.00
IUUC-Pan-092836 Papio anubis 98.14 0.00e+00 976.00
IUUC-Psi-093965 Pelodiscus sinensis 82.46 6.00e-56 208.00
IUUC-Pno-095052 Phaeosphaeria nodorum 47.23 1.00e-122 433.00
IUUC-Ppa-095432 Physcomitrella patens 58.02 4.00e-170 591.00
IUUC-Pfo-096963 Poecilia formosa 72.06 0.00e+00 709.00
IUUC-Pab-097716 Pongo abelii 95.33 0.00e+00 910.00
IUUC-Pop-099224 Populus trichocarpa 58.94 7.00e-172 597.00
IUUC-Pca-100682 Procavia capensis 92.68 0.00e+00 681.00
IUUC-Ppe-101819 Prunus persica 58.23 8.00e-170 590.00
IUUC-Pva-102338 Pteropus vampyrus 95.89 0.00e+00 726.00
IUUC-Pgr-103583 Puccinia graminis 55.23 3.00e-132 465.00
IUUC-Ptt-103737 Puccinia triticina 45.03 2.00e-100 359.00
IUUC-Pte-104150 Pyrenophora teres 50.34 6.00e-122 431.00
IUUC-Pyt-104606 Pyrenophora triticirepentis 50.34 8.00e-122 430.00
IUUC-Rno-105987 Rattus norvegicus 95.76 0.00e+00 937.00
IUUC-Sce-106315 Saccharomyces cerevisiae 46.81 7.00e-130 457.00
IUUC-Sha-107273 Sarcophilus harrisii 89.28 0.00e+00 912.00
IUUC-Sja-107677 Schizosaccharomyces japonicus 46.09 7.00e-119 421.00
IUUC-Spo-108092 Schizosaccharomyces pombe 49.20 4.00e-124 438.00
IUUC-Ssl-108442 Sclerotinia sclerotiorum 43.33 2.00e-114 405.00
IUUC-Smo-108855 Selaginella moellendorffii 56.06 1.00e-164 572.00
IUUC-Sit-110329 Setaria italica 59.10 1.00e-171 596.00
IUUC-Sly-111830 Solanum lycopersicum 59.74 2.00e-174 605.00
IUUC-Stu-112603 Solanum tuberosum 59.74 2.00e-174 605.00
IUUC-Sar-113504 Sorex araneus 89.12 6.00e-74 271.00
IUUC-Sbi-114560 Sorghum bicolor 58.24 4.00e-169 587.00
IUUC-Sre-115133 Sporisorium reilianum 41.79 1.00e-124 440.00
IUUC-Ssc-115903 Sus scrofa 96.62 0.00e+00 945.00
IUUC-Tgu-116798 Taeniopygia guttata 85.41 0.00e+00 860.00
IUUC-Tru-118361 Takifugu rubripes 77.99 0.00e+00 807.00
IUUC-Tsy-118849 Tarsius syrichta 97.26 0.00e+00 951.00
IUUC-Tni-120094 Tetraodon nigroviridis 78.90 0.00e+00 806.00
IUUC-Tca-121634 Theobroma cacao 58.09 4.00e-168 584.00
IUUC-Tre-122051 Trichoderma reesei 45.62 1.00e-118 420.00
IUUC-Tvi-122322 Trichoderma virens 46.67 3.00e-122 432.00
IUUC-Tae-125822 Triticum aestivum 58.03 5.00e-169 587.00
IUUC-Tur-126766 Triticum urartu 51.81 1.00e-160 559.00
IUUC-Tme-127175 Tuber melanosporum 49.80 1.00e-131 463.00
IUUC-Tbe-127779 Tupaia belangeri 95.78 0.00e+00 836.00
IUUC-Ttr-128224 Tursiops truncatus 91.59 0.00e+00 811.00
IUUC-Uma-129537 Ustilago maydis 41.82 2.00e-124 439.00
IUUC-Vda-129927 Verticillium dahliae 44.98 2.00e-110 393.00
IUUC-Vpa-130658 Vicugna pacos 84.03 0.00e+00 803.00
IUUC-Vvi-131659 Vitis vinifera 58.64 3.00e-171 595.00
IUUC-Xtr-132918 Xenopus tropicalis 76.81 0.00e+00 795.00
IUUC-Xma-133700 Xiphophorus maculatus 80.25 0.00e+00 820.00
IUUC-Yli-134478 Yarrowia lipolytica 49.70 4.00e-139 488.00
IUUC-Zma-135835 Zea mays 55.78 4.00e-166 577.00
Created Date 25-Jun-2017

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