iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Dme-032000

Ensembl Protein ID

FBpp0305644

UniProt Accession

P55035; Q86R87; Q9V473; PSMD4_DROME

Genbank Protein ID

AAB35145.1; AAF51741.1; AAL90071.2

Protein Name

26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; 54 kDa subunit of mu particle; Multiubiquitin chain-binding protein; p54

Genbank Nucleotide ID

S79502; AE014296; AY089333

Gene Name

Rpn10; PROS-54; Pros54; CG7619

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0015283	FBtr0333453	FBpp0305644

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	11406394

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	6.60e-10	37.9	212	231
UBD/Alpha-Helix/UIM	3e-06	16.3	303	319

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeees 20
           +Ed+eL+lAl++S++E++++
   Q: 212  NEDPELALALRVSMEEQRQR 231
           59***************985 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEe 17
           +E+e+++ A+++S+q++
   Q: 303  TEEEQIAFAMQMSMQDA 319
           59*************98 PP

Organism

Drosophila melanogaster

Functional Description
(View)

The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity). Interacts with Ubc4.

Protein Sequence
(Fasta)

MVLESTMICF DNSDFQRNGD YFPTRLIVQR DGINLVCLTK LRSNPENNVG LMTLSNTVEV 60
LATLTSDAGR IFSKMHLVQP KGEINLLTGI RIAHLVLKHR QGKNHKMRIV VFVGSPINHE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACAACGGT CATACAAATC CGATATTTTA ATGCCGATAG TTCAGGCAGC ACAGCACCTG 60
GCAACCCTGG GGAATTACAG TTCAGTGGCA AAGTGACAAG CAAAAATACG AAAATGGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR027040--Proteasome_su_Rpn10
IPR003903--UIM_dom
IPR002035--VWF_A

PROSITE

PS50330--UIM

Pfam

PF02809--UIM
PF13519--VWA_2

SMART

SM00726--UIM
SM00327--VWA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0005838--C:proteasome regulatory particle
GO:0008540--C:proteasome regulatory particle, base subcomplex
GO:0031593--F:polyubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000070--P:mitotic sister chromatid segregation
GO:0043248--P:proteasome assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG7619

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001241	Ailuropoda melanoleuca	56.88	4.00e-106	377.00
IUUC-Atr-002938	Amborella trichopoda	41.28	2.00e-65	242.00
IUUC-Apl-003881	Anas platyrhynchos	66.51	3.00e-77	280.00
IUUC-Aca-004397	Anolis carolinensis	68.44	1.00e-86	311.00
IUUC-Aly-005564	Arabidopsis lyrata	41.43	4.00e-55	207.00
IUUC-Ath-007436	Arabidopsis thaliana	40.92	4.00e-54	204.00
IUUC-Ago-007858	Ashbya gossypii	43.48	2.00e-46	177.00
IUUC-Acl-008094	Aspergillus clavatus	41.99	5.00e-33	133.00
IUUC-Afl-008689	Aspergillus flavus	41.99	6.00e-33	133.00
IUUC-Afu-008959	Aspergillus fumigatus	43.23	1.00e-32	132.00
IUUC-Ani-009344	Aspergillus nidulans	39.69	3.00e-20	91.30
IUUC-Ang-009602	Aspergillus niger	39.83	8.00e-32	129.00
IUUC-Aor-009906	Aspergillus oryzae	40.84	2.00e-21	95.10
IUUC-Ate-010267	Aspergillus terreus	40.87	1.00e-24	105.00
IUUC-Ame-011018	Astyanax mexicanus	56.36	8.00e-108	382.00
IUUC-Bgr-012200	Blumeria graminis	45.97	8.00e-46	176.00
IUUC-Bta-013066	Bos taurus	56.84	5.00e-106	376.00
IUUC-Bci-013904	Botrytis cinerea	46.59	2.00e-45	175.00
IUUC-Bdi-014537	Brachypodium distachyon	47.88	2.00e-48	185.00
IUUC-Bol-015474	Brassica oleracea	51.69	1.00e-51	196.00
IUUC-Bra-018039	Brassica rapa	51.69	6.00e-52	197.00
IUUC-Cel-018187	Caenorhabditis elegans	51.93	3.00e-59	221.00
IUUC-Cja-019738	Callithrix jacchus	57.40	4.00e-106	377.00
IUUC-Cfa-020362	Canis familiaris	56.88	3.00e-106	377.00
IUUC-Cpo-021297	Cavia porcellus	55.95	2.00e-99	356.00
IUUC-Cre-022783	Chlamydomonas reinhardtii	50.20	4.00e-46	176.00
IUUC-Cho-024800	Choloepus hoffmanni	59.74	1.00e-23	102.00
IUUC-Cin-025469	Ciona intestinalis	49.60	2.00e-80	291.00
IUUC-Csv-026297	Ciona savignyi	50.40	2.00e-88	318.00
IUUC-Cgl-026657	Colletotrichum gloeosporioides	45.57	3.00e-34	137.00
IUUC-Cne-027027	Cryptococcus neoformans	45.71	7.00e-48	183.00
IUUC-Cme-027212	Cyanidioschyzon merolae	37.14	9.00e-41	160.00
IUUC-Dre-027759	Danio rerio	54.08	5.00e-108	383.00
IUUC-Dno-029528	Dasypus novemcinctus	57.66	4.00e-106	377.00
IUUC-Dor-030255	Dipodomys ordii	57.60	3.00e-100	357.00
IUUC-Dse-031464	Dothistroma septosporum	47.26	2.00e-45	175.00
IUUC-Ete-032762	Echinops telfairi	57.40	2.00e-105	374.00
IUUC-Eca-034399	Equus caballus	56.53	2.00e-100	359.00
IUUC-Eeu-035072	Erinaceus europaeus	55.11	1.00e-81	295.00
IUUC-Fca-035993	Felis catus	57.49	3.00e-100	357.00
IUUC-Fal-037623	Ficedula albicollis	55.98	5.00e-55	207.00
IUUC-Fox-037746	Fusarium oxysporum	43.22	7.00e-41	159.00
IUUC-Fso-038431	Fusarium solani	46.19	2.00e-41	161.00
IUUC-Gmo-038712	Gadus morhua	55.41	5.00e-97	348.00
IUUC-Ggr-039821	Gaeumannomyces graminis	43.52	2.00e-35	141.00
IUUC-Gga-040288	Gallus gallus	56.69	6.00e-105	373.00
IUUC-Gac-041309	Gasterosteus aculeatus	55.11	1.00e-96	347.00
IUUC-Gma-044042	Glycine max	41.84	6.00e-56	210.00
IUUC-Ggo-044628	Gorilla gorilla	57.40	4.00e-106	377.00
IUUC-Hsa-045850	Homo sapiens	57.14	2.00e-106	378.00
IUUC-Hvu-047715	Hordeum vulgare	47.83	2.00e-52	198.00
IUUC-Itr-048388	Ictidomys tridecemlineatus	57.26	7.00e-103	366.00
IUUC-Kpa-049158	Komagataella pastoris	46.33	3.00e-42	164.00
IUUC-Lch-050472	Latimeria chalumnae	56.80	1.00e-101	363.00
IUUC-Lpe-051233	Leersia perrieri	47.46	2.00e-43	170.00
IUUC-Loc-052437	Lepisosteus oculatus	58.08	5.00e-59	221.00
IUUC-Lma-053295	Leptosphaeria maculans	43.75	1.00e-40	159.00
IUUC-Laf-053504	Loxodonta africana	57.92	2.00e-106	378.00
IUUC-Mcc-054877	Macaca mulatta	57.40	6.00e-106	376.00
IUUC-Meu-056114	Macropus eugenii	56.62	5.00e-106	376.00
IUUC-Mor-057212	Magnaporthe oryzae	42.31	9.00e-36	142.00
IUUC-Mpo-057587	Magnaporthe poae	44.56	3.00e-36	144.00
IUUC-Mtr-058520	Medicago truncatula	40.20	3.00e-55	208.00
IUUC-Mla-059105	Melampsora laricipopulina	39.16	4.00e-15	74.70
IUUC-Mga-059537	Meleagris gallopavo	57.66	7.00e-106	376.00
IUUC-Mvi-060277	Microbotryum violaceum	36.63	3.00e-37	148.00
IUUC-Mmr-061736	Microcebus murinus	56.84	2.00e-105	374.00
IUUC-Mdo-062403	Monodelphis domestica	53.16	6.00e-100	358.00
IUUC-Mmu-063937	Mus musculus	56.05	4.00e-105	374.00
IUUC-Mac-065367	Musa acuminata	48.54	6.00e-52	197.00
IUUC-Mpu-065901	Mustela putorius furo	56.88	4.00e-106	377.00
IUUC-Mlu-067994	Myotis lucifugus	57.40	7.00e-107	379.00
IUUC-Nfi-068540	Neosartorya fischeri	43.23	2.00e-32	132.00
IUUC-Ncr-068760	Neurospora crassa	46.64	4.00e-46	177.00
IUUC-Nle-069463	Nomascus leucogenys	57.66	7.00e-106	376.00
IUUC-Opr-070298	Ochotona princeps	57.92	2.00e-106	377.00
IUUC-Ont-072615	Oreochromis niloticus	56.70	4.00e-108	383.00
IUUC-Ocu-074141	Oryctolagus cuniculus	57.92	3.00e-106	377.00
IUUC-Oba-075955	Oryza barthii	47.46	2.00e-44	172.00
IUUC-Obr-076545	Oryza brachyantha	47.46	9.00e-44	170.00
IUUC-Ogl-077252	Oryza glaberrima	47.03	5.00e-42	164.00
IUUC-Ogu-078986	Oryza glumaepatula	47.46	3.00e-44	171.00
IUUC-Oin-080166	Oryza indica	46.35	1.00e-42	166.00
IUUC-Olo-080390	Oryza longistaminata	46.75	5.00e-41	162.00
IUUC-Ome-082015	Oryza meridionalis	47.46	2.00e-44	172.00
IUUC-Oni-082397	Oryza nivara	47.46	2.00e-44	172.00
IUUC-Opu-083674	Oryza punctata	47.46	2.00e-44	172.00
IUUC-Oru-085199	Oryza rufipogon	47.46	2.00e-44	172.00
IUUC-Osa-085911	Oryza sativa	47.46	2.00e-44	172.00
IUUC-Ola-087383	Oryzias latipes	56.61	2.00e-102	365.00
IUUC-Olu-087857	Ostreococcus lucimarinus	41.53	5.00e-40	156.00
IUUC-Oga-088882	Otolemur garnettii	56.27	2.00e-99	355.00
IUUC-Oar-089311	Ovis aries	56.58	1.00e-105	375.00
IUUC-Ptr-090931	Pan troglodytes	57.14	2.00e-106	378.00
IUUC-Pan-092286	Papio anubis	57.92	2.00e-106	378.00
IUUC-Psi-093908	Pelodiscus sinensis	67.27	5.00e-83	300.00
IUUC-Pma-094737	Petromyzon marinus	55.96	1.00e-97	348.00
IUUC-Pno-094807	Phaeosphaeria nodorum	45.20	1.00e-49	189.00
IUUC-Ppa-095749	Physcomitrella patens	47.10	3.00e-50	191.00
IUUC-Pfo-097212	Poecilia formosa	57.99	9.00e-109	385.00
IUUC-Pab-097708	Pongo abelii	56.53	6.00e-101	359.00
IUUC-Pop-099138	Populus trichocarpa	39.80	9.00e-64	236.00
IUUC-Pca-100722	Procavia capensis	68.70	5.00e-45	174.00
IUUC-Ppe-101377	Prunus persica	40.35	7.00e-58	217.00
IUUC-Pva-103185	Pteropus vampyrus	57.66	2.00e-105	375.00
IUUC-Pgr-103361	Puccinia graminis	35.68	2.00e-28	119.00
IUUC-Ptt-103848	Puccinia triticina	34.34	8.00e-15	73.20
IUUC-Pte-104114	Pyrenophora teres	43.97	6.00e-41	160.00
IUUC-Pyt-104662	Pyrenophora triticirepentis	45.19	2.00e-44	172.00
IUUC-Rno-104906	Rattus norvegicus	57.40	6.00e-108	383.00
IUUC-Sce-106427	Saccharomyces cerevisiae	42.37	4.00e-44	170.00
IUUC-Sha-106574	Sarcophilus harrisii	56.33	3.00e-103	367.00
IUUC-Sja-107706	Schizosaccharomyces japonicus	47.97	3.00e-45	174.00
IUUC-Spo-108378	Schizosaccharomyces pombe	45.83	6.00e-45	172.00
IUUC-Smo-109639	Selaginella moellendorffii	39.21	5.00e-59	220.00
IUUC-Sit-110284	Setaria italica	48.62	2.00e-49	188.00
IUUC-Sly-111246	Solanum lycopersicum	38.81	3.00e-59	221.00
IUUC-Stu-112695	Solanum tuberosum	38.81	6.00e-60	223.00
IUUC-Sar-113015	Sorex araneus	69.88	2.00e-68	251.00
IUUC-Sbi-114495	Sorghum bicolor	48.80	2.00e-49	189.00
IUUC-Sre-114891	Sporisorium reilianum	52.16	8.00e-53	199.00
IUUC-Ssc-116142	Sus scrofa	57.66	4.00e-107	380.00
IUUC-Tgu-116946	Taeniopygia guttata	68.45	1.00e-60	225.00
IUUC-Tru-118224	Takifugu rubripes	54.19	1.00e-100	358.00
IUUC-Tsy-119004	Tarsius syrichta	52.13	2.00e-82	298.00
IUUC-Tni-120074	Tetraodon nigroviridis	57.22	1.00e-107	382.00
IUUC-Tca-121251	Theobroma cacao	42.04	5.00e-54	204.00
IUUC-Tre-122168	Trichoderma reesei	45.99	2.00e-47	181.00
IUUC-Tvi-122655	Trichoderma virens	45.49	1.00e-40	159.00
IUUC-Tae-124568	Triticum aestivum	47.83	2.00e-52	199.00
IUUC-Tur-126420	Triticum urartu	47.83	2.00e-52	198.00
IUUC-Tme-126937	Tuber melanosporum	47.33	2.00e-48	184.00
IUUC-Tbe-128080	Tupaia belangeri	57.40	5.00e-104	370.00
IUUC-Ttr-128811	Tursiops truncatus	57.40	4.00e-106	377.00
IUUC-Uma-129436	Ustilago maydis	52.16	4.00e-54	204.00
IUUC-Vda-129920	Verticillium dahliae	46.28	2.00e-38	151.00
IUUC-Vpa-130762	Vicugna pacos	70.00	2.00e-46	178.00
IUUC-Vvi-130840	Vitis vinifera	39.55	3.00e-57	214.00
IUUC-Xtr-131967	Xenopus tropicalis	53.95	3.00e-65	241.00
IUUC-Xma-134224	Xiphophorus maculatus	56.96	3.00e-109	387.00
IUUC-Yli-134643	Yarrowia lipolytica	47.58	3.00e-49	187.00
IUUC-Zma-135870	Zea mays	38.90	3.00e-55	208.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence