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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064152
Ensembl Protein ID ENSMUSP00000034428.7
UniProt Accession P60521; O08765; Q9DCP8; Q9UQF7; GBRL2_MOUSE
Genbank Protein ID AAK16238.1; BAB22217.1; BAC33933.1; AAH26798.1; AAH81436.1
Protein Name Gamma-aminobutyric acid receptor-associated protein-like 2; GABA(A) receptor-associated protein-like 2; Golgi-associated ATPase enhancer of 16 kDa
Genbank Nucleotide ID AF190644; AK002596; AK049819; BC026798; BC081436
Gene Name Gabarapl2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031950.7 ENSMUST00000034428.7 ENSMUSP00000034428.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG8 56.03 1.00e-35 142.00 IUUC-Sce-106150
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
 Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Protein Sequence
(Fasta)
MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF 60
MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF 117
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Protein Fasta Sequence


>IUUC-Mmu-064152|ULD,ATG8|Mus musculus
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Nucleotide Sequence
(Fasta)
AGCCGGAAGT CCCGCCTGTG GAGTAGTCGT CGCTGCCGCC GCCGCCTCCG TTGTTGTTGT 60
GGTCGCTTCG CCGAAGTCCG CGGCTCGAAG AGCCGGCTCC GTCGCTTCCC GTCGCCATGA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064152|ULD,ATG8|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-0449--Lipoprotein
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom
Pfam

PF02991--Atg8
Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0031625--F:ubiquitin protein ligase binding
GO:0006914--P:autophagy
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0015031--P:protein transport
KEGG mmu:93739
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000059 Aegilops tauschii 60.00 5.00e-39 152.00
IUUC-Aml-001629 Ailuropoda melanoleuca 100.00 1.00e-65 241.00
IUUC-Atr-002842 Amborella trichopoda 62.50 6.00e-35 139.00
IUUC-Aca-005288 Anolis carolinensis 99.14 3.00e-65 239.00
IUUC-Aly-005554 Arabidopsis lyrata 62.07 3.00e-35 139.00
IUUC-Ath-006958 Arabidopsis thaliana 62.07 3.00e-35 139.00
IUUC-Ani-009196 Aspergillus nidulans 59.48 5.00e-39 152.00
IUUC-Ame-010751 Astyanax mexicanus 98.29 5.00e-65 238.00
IUUC-Bta-012520 Bos taurus 99.15 1.00e-65 240.00
IUUC-Bdi-014390 Brachypodium distachyon 61.06 1.00e-39 154.00
IUUC-Bol-016488 Brassica oleracea 62.93 6.00e-41 159.00
IUUC-Bra-017452 Brassica rapa 61.21 1.00e-40 157.00
IUUC-Cja-019273 Callithrix jacchus 99.15 8.00e-66 241.00
IUUC-Cfa-020373 Canis familiaris 100.00 4.00e-66 242.00
IUUC-Cpo-021831 Cavia porcellus 100.00 4.00e-66 242.00
IUUC-Cre-022866 Chlamydomonas reinhardtii 62.50 3.00e-35 140.00
IUUC-Csa-024201 Chlorocebus sabaeus 100.00 4.00e-66 242.00
IUUC-Dre-028371 Danio rerio 96.58 5.00e-64 235.00
IUUC-Dno-029331 Dasypus novemcinctus 100.00 1.00e-65 240.00
IUUC-Dor-030453 Dipodomys ordii 100.00 4.00e-66 242.00
IUUC-Eca-034113 Equus caballus 100.00 5.00e-66 242.00
IUUC-Fca-036385 Felis catus 100.00 4.00e-66 242.00
IUUC-Fal-036896 Ficedula albicollis 99.15 7.00e-66 241.00
IUUC-Gmo-039289 Gadus morhua 98.29 4.00e-65 239.00
IUUC-Ggr-039770 Gaeumannomyces graminis 58.62 1.00e-37 148.00
IUUC-Gac-041604 Gasterosteus aculeatus 98.29 7.00e-65 238.00
IUUC-Gma-043572 Glycine max 62.50 2.00e-34 137.00
IUUC-Ggo-044429 Gorilla gorilla 100.00 4.00e-66 242.00
IUUC-Hsa-046764 Homo sapiens 100.00 4.00e-66 242.00
IUUC-Hvu-047062 Hordeum vulgare 60.00 5.00e-39 152.00
IUUC-Kpa-049124 Komagataella pastoris 58.62 1.00e-38 151.00
IUUC-Lch-049542 Latimeria chalumnae 97.44 3.00e-64 236.00
IUUC-Lpe-051450 Leersia perrieri 60.34 3.00e-39 153.00
IUUC-Meu-056515 Macropus eugenii 100.00 4.00e-66 242.00
IUUC-Mor-057276 Magnaporthe oryzae 58.62 1.00e-37 148.00
IUUC-Mpo-057469 Magnaporthe poae 58.62 9.00e-38 148.00
IUUC-Mtr-058417 Medicago truncatula 61.74 1.00e-34 137.00
IUUC-Mdo-061915 Monodelphis domestica 100.00 2.00e-66 244.00
IUUC-Mac-065529 Musa acuminata 61.74 1.00e-35 140.00
IUUC-Mpu-066760 Mustela putorius furo 100.00 2.00e-66 243.00
IUUC-Mlu-068211 Myotis lucifugus 100.00 4.00e-66 242.00
IUUC-Nle-069755 Nomascus leucogenys 100.00 4.00e-66 242.00
IUUC-Ont-072343 Oreochromis niloticus 97.44 4.00e-65 239.00
IUUC-Oan-073485 Ornithorhynchus anatinus 99.06 4.00e-58 215.00
IUUC-Ocu-073861 Oryctolagus cuniculus 100.00 4.00e-66 242.00
IUUC-Oba-075722 Oryza barthii 60.34 8.00e-40 155.00
IUUC-Obr-076374 Oryza brachyantha 61.06 2.00e-39 154.00
IUUC-Ogl-077551 Oryza glaberrima 60.34 8.00e-40 155.00
IUUC-Ogu-078499 Oryza glumaepatula 60.34 8.00e-40 155.00
IUUC-Oin-079771 Oryza indica 61.06 2.00e-39 154.00
IUUC-Olo-080412 Oryza longistaminata 61.06 2.00e-39 154.00
IUUC-Ome-081791 Oryza meridionalis 61.06 2.00e-39 154.00
IUUC-Oni-082774 Oryza nivara 61.06 2.00e-39 154.00
IUUC-Opu-083486 Oryza punctata 61.06 7.00e-39 154.00
IUUC-Oru-084425 Oryza rufipogon 60.34 3.00e-39 152.00
IUUC-Osa-085439 Oryza sativa 61.06 2.00e-39 154.00
IUUC-Ola-086310 Oryzias latipes 94.02 3.00e-63 232.00
IUUC-Oga-088483 Otolemur garnettii 100.00 4.00e-66 242.00
IUUC-Ptr-091560 Pan troglodytes 100.00 4.00e-66 242.00
IUUC-Pan-092269 Papio anubis 100.00 4.00e-66 242.00
IUUC-Pma-094337 Petromyzon marinus 85.34 9.00e-57 211.00
IUUC-Pfo-096380 Poecilia formosa 98.28 2.00e-64 236.00
IUUC-Pab-098563 Pongo abelii 100.00 4.00e-66 242.00
IUUC-Pop-099701 Populus trichocarpa 62.61 2.00e-35 140.00
IUUC-Ppe-101863 Prunus persica 62.07 1.00e-35 140.00
IUUC-Rno-105111 Rattus norvegicus 100.00 4.00e-66 242.00
IUUC-Sce-106150 Saccharomyces cerevisiae 56.03 5.00e-36 142.00
IUUC-Sja-107857 Schizosaccharomyces japonicus 57.76 3.00e-38 150.00
IUUC-Spo-108156 Schizosaccharomyces pombe 60.34 2.00e-33 134.00
IUUC-Smo-109082 Selaginella moellendorffii 59.48 3.00e-39 153.00
IUUC-Sly-110959 Solanum lycopersicum 60.34 6.00e-35 139.00
IUUC-Stu-112323 Solanum tuberosum 60.34 6.00e-35 139.00
IUUC-Sbi-114346 Sorghum bicolor 61.06 2.00e-39 153.00
IUUC-Sre-114964 Sporisorium reilianum 59.83 1.00e-39 154.00
IUUC-Ssc-115828 Sus scrofa 100.00 4.00e-66 242.00
IUUC-Tgu-117195 Taeniopygia guttata 99.15 7.00e-66 241.00
IUUC-Tni-120706 Tetraodon nigroviridis 96.58 6.00e-64 235.00
IUUC-Tca-121217 Theobroma cacao 61.74 5.00e-35 139.00
IUUC-Tae-122697 Triticum aestivum 60.00 2.00e-38 152.00
IUUC-Tur-126158 Triticum urartu 59.13 4.00e-38 149.00
IUUC-Tme-126955 Tuber melanosporum 58.97 5.00e-39 153.00
IUUC-Tbe-127765 Tupaia belangeri 100.00 9.00e-47 177.00
IUUC-Ttr-128205 Tursiops truncatus 100.00 4.00e-66 242.00
IUUC-Uma-129435 Ustilago maydis 60.34 1.00e-39 154.00
IUUC-Vpa-130804 Vicugna pacos 97.44 3.00e-64 236.00
IUUC-Vvi-131085 Vitis vinifera 61.95 7.00e-40 155.00
IUUC-Xtr-132685 Xenopus tropicalis 100.00 9.00e-66 241.00
IUUC-Xma-133675 Xiphophorus maculatus 98.28 2.00e-64 236.00
IUUC-Yli-134327 Yarrowia lipolytica 60.34 3.00e-33 133.00
Created Date 25-Jun-2017

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