iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134503

Ensembl Protein ID

CAG80377

UniProt Accession

Q6C3J2; IPL1_YARLI

Genbank Protein ID

CAG80377.1

Protein Name

Spindle assembly checkpoint kinase; Aurora kinase

Genbank Nucleotide ID

CR382131

Gene Name

IPL1; YALI0E34375g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_E34375g	CAG80377	CAG80377

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	53.85	1.00e-84	310.00	IUUC-Hsa-046968

Active Site

Position(s)	Description	Evidence
222	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10027}

Organism

Yarrowia lipolytica

Functional Description
(View)

Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension (By similarity).

Protein Sequence
(Fasta)

MSMKQLETSM SSVSLQEKKP TRIKIALHPQ SKSEQNETDR ASKIPTGRIS TTQPQTYYRP 60
TNLTKTPASQ VSRRSSYTTD PPSPLTGITG FRNYSLDDFE IGKALGKGKF GKVYLVKDKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTATGA AGCAATTGGA GACTTCAATG TCGAGTGTCT CCCTGCAAGA GAAGAAGCCC 60
ACTCGAATAA AGATTGCTCT GCATCCTCAG TCCAAGAGCG AACAAAATGA GACTGATCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0995--Kinetochore
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR030616--Aur
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0032133--C:chromosome passenger complex
GO:0000939--C:condensed chromosome inner kinetochore
GO:0000778--C:condensed nuclear chromosome kinetochore
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005737--C:cytoplasm
GO:0005828--C:kinetochore microtubule
GO:1990385--C:meiotic spindle midzone
GO:1990023--C:mitotic spindle midzone
GO:0005876--C:spindle microtubule
GO:0051233--C:spindle midzone
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0051316--P:attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation
GO:0090699--P:correction of merotelic kinetochore attachment, meiosis I
GO:0098783--P:correction of merotelic kinetochore attachment, mitotic
GO:2000775--P:histone H3-S10 phosphorylation involved in chromosome condensation
GO:0045144--P:meiotic sister chromatid segregation
GO:0033316--P:meiotic spindle assembly checkpoint
GO:0007076--P:mitotic chromosome condensation
GO:0000281--P:mitotic cytokinesis
GO:0044774--P:mitotic DNA integrity checkpoint
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0051228--P:mitotic spindle disassembly
GO:0007052--P:mitotic spindle organization
GO:1901925--P:negative regulation of protein import into nucleus during spindle assembly checkpoint
GO:0034501--P:protein localization to kinetochore
GO:0034503--P:protein localization to nucleolar rDNA repeats
GO:0000320--P:re-entry into mitotic cell cycle
GO:0032465--P:regulation of cytokinesis
GO:0090266--P:regulation of mitotic cell cycle spindle assembly checkpoint
GO:1901673--P:regulation of mitotic spindle assembly

KEGG

yli:YALI0E34375g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000930	Aegilops tauschii	55.13	5.00e-85	305.00
IUUC-Aml-001426	Ailuropoda melanoleuca	54.23	1.00e-86	311.00
IUUC-Atr-002453	Amborella trichopoda	55.13	2.00e-85	306.00
IUUC-Apl-003626	Anas platyrhynchos	57.14	8.00e-91	325.00
IUUC-Aca-004602	Anolis carolinensis	47.09	3.00e-89	320.00
IUUC-Aly-005878	Arabidopsis lyrata	53.61	1.00e-83	300.00
IUUC-Ath-007117	Arabidopsis thaliana	54.37	1.00e-84	303.00
IUUC-Acl-008199	Aspergillus clavatus	59.39	3.00e-88	316.00
IUUC-Afl-008419	Aspergillus flavus	55.99	6.00e-88	315.00
IUUC-Afu-008751	Aspergillus fumigatus	57.66	4.00e-89	319.00
IUUC-Ani-009181	Aspergillus nidulans	53.07	6.00e-95	338.00
IUUC-Ang-009787	Aspergillus niger	57.45	4.00e-89	319.00
IUUC-Aor-009980	Aspergillus oryzae	55.99	6.00e-88	315.00
IUUC-Ate-010286	Aspergillus terreus	59.39	4.00e-88	316.00
IUUC-Ame-010849	Astyanax mexicanus	52.33	2.00e-82	297.00
IUUC-Bgr-012110	Blumeria graminis	49.40	2.00e-91	327.00
IUUC-Bta-013474	Bos taurus	47.65	4.00e-87	312.00
IUUC-Bci-013756	Botrytis cinerea	52.96	2.00e-95	340.00
IUUC-Bdi-014257	Brachypodium distachyon	55.89	6.00e-86	308.00
IUUC-Bol-016310	Brassica oleracea	56.32	8.00e-86	307.00
IUUC-Bra-017438	Brassica rapa	55.89	4.00e-86	308.00
IUUC-Cel-018157	Caenorhabditis elegans	48.20	8.00e-78	281.00
IUUC-Cja-019282	Callithrix jacchus	48.86	1.00e-86	311.00
IUUC-Cfa-020162	Canis familiaris	54.23	3.00e-87	313.00
IUUC-Cpo-021764	Cavia porcellus	52.69	6.00e-85	305.00
IUUC-Cre-022827	Chlamydomonas reinhardtii	55.17	7.00e-87	311.00
IUUC-Csa-023694	Chlorocebus sabaeus	53.85	3.00e-86	310.00
IUUC-Cho-024350	Choloepus hoffmanni	53.33	3.00e-61	225.00
IUUC-Cin-025542	Ciona intestinalis	54.38	3.00e-90	322.00
IUUC-Csv-025873	Ciona savignyi	54.58	3.00e-88	316.00
IUUC-Cgl-026632	Colletotrichum gloeosporioides	46.15	7.00e-84	301.00
IUUC-Cne-026928	Cryptococcus neoformans	57.59	6.00e-92	328.00
IUUC-Cme-027336	Cyanidioschyzon merolae	52.44	3.00e-92	329.00
IUUC-Dre-028198	Danio rerio	53.10	3.00e-85	306.00
IUUC-Dno-029928	Dasypus novemcinctus	54.23	2.00e-86	310.00
IUUC-Dor-030238	Dipodomys ordii	48.08	2.00e-72	264.00
IUUC-Dse-031266	Dothistroma septosporum	48.60	4.00e-93	332.00
IUUC-Dme-032007	Drosophila melanogaster	51.54	6.00e-81	292.00
IUUC-Ete-032911	Echinops telfairi	39.52	1.00e-50	191.00
IUUC-Eca-033749	Equus caballus	54.23	1.00e-86	311.00
IUUC-Eeu-035170	Erinaceus europaeus	52.49	1.00e-81	294.00
IUUC-Fca-035498	Felis catus	53.85	5.00e-87	312.00
IUUC-Fal-037397	Ficedula albicollis	56.76	5.00e-90	322.00
IUUC-Fox-037747	Fusarium oxysporum	50.15	2.00e-94	337.00
IUUC-Fso-038429	Fusarium solani	52.60	5.00e-89	318.00
IUUC-Gmo-039378	Gadus morhua	53.46	8.00e-84	301.00
IUUC-Ggr-039939	Gaeumannomyces graminis	58.11	7.00e-94	335.00
IUUC-Gga-040187	Gallus gallus	56.37	7.00e-89	318.00
IUUC-Gac-042223	Gasterosteus aculeatus	49.66	1.00e-84	304.00
IUUC-Gma-042870	Glycine max	53.99	5.00e-79	285.00
IUUC-Ggo-045617	Gorilla gorilla	53.85	1.00e-86	311.00
IUUC-Hsa-046968	Homo sapiens	53.85	2.00e-86	310.00
IUUC-Hvu-047072	Hordeum vulgare	53.44	3.00e-71	259.00
IUUC-Itr-048233	Ictidomys tridecemlineatus	43.63	9.00e-61	225.00
IUUC-Kpa-049093	Komagataella pastoris	60.98	1.00e-88	317.00
IUUC-Lch-050346	Latimeria chalumnae	55.77	4.00e-90	322.00
IUUC-Lpe-051466	Leersia perrieri	55.51	8.00e-85	304.00
IUUC-Lma-053006	Leptosphaeria maculans	48.72	6.00e-89	318.00
IUUC-Laf-053422	Loxodonta africana	54.23	1.00e-85	308.00
IUUC-Mcc-055245	Macaca mulatta	53.85	4.00e-86	309.00
IUUC-Mor-056952	Magnaporthe oryzae	56.60	1.00e-91	327.00
IUUC-Mpo-057605	Magnaporthe poae	57.74	1.00e-93	334.00
IUUC-Mtr-057726	Medicago truncatula	54.37	9.00e-84	301.00
IUUC-Mla-059174	Melampsora laricipopulina	56.92	9.00e-94	335.00
IUUC-Mga-059562	Meleagris gallopavo	54.37	2.00e-66	243.00
IUUC-Mvi-060305	Microbotryum violaceum	53.03	3.00e-86	310.00
IUUC-Mmr-061588	Microcebus murinus	53.85	3.00e-86	310.00
IUUC-Mdo-061914	Monodelphis domestica	55.38	2.00e-89	320.00
IUUC-Mmu-063288	Mus musculus	53.67	2.00e-86	310.00
IUUC-Mac-064969	Musa acuminata	52.46	1.00e-85	307.00
IUUC-Mpu-066855	Mustela putorius furo	49.18	3.00e-87	313.00
IUUC-Mlu-068046	Myotis lucifugus	54.62	4.00e-87	312.00
IUUC-Nfi-068527	Neosartorya fischeri	57.66	2.00e-88	317.00
IUUC-Ncr-068678	Neurospora crassa	57.14	1.00e-90	324.00
IUUC-Nle-069848	Nomascus leucogenys	53.85	5.00e-86	309.00
IUUC-Opr-070589	Ochotona princeps	53.85	5.00e-85	305.00
IUUC-Ont-071733	Oreochromis niloticus	51.99	1.00e-81	294.00
IUUC-Oan-073399	Ornithorhynchus anatinus	55.00	1.00e-87	313.00
IUUC-Ocu-074063	Oryctolagus cuniculus	46.69	1.00e-86	311.00
IUUC-Oba-075264	Oryza barthii	55.51	4.00e-85	305.00
IUUC-Obr-076048	Oryza brachyantha	55.89	4.00e-86	308.00
IUUC-Ogl-077637	Oryza glaberrima	55.51	1.00e-84	303.00
IUUC-Ogu-078830	Oryza glumaepatula	55.51	6.00e-85	305.00
IUUC-Oin-079150	Oryza indica	55.51	5.00e-85	305.00
IUUC-Olo-080398	Oryza longistaminata	55.27	3.00e-74	269.00
IUUC-Ome-081544	Oryza meridionalis	54.96	2.00e-82	296.00
IUUC-Oni-082250	Oryza nivara	55.51	5.00e-85	305.00
IUUC-Opu-083638	Oryza punctata	55.51	9.00e-85	304.00
IUUC-Oru-084981	Oryza rufipogon	55.51	4.00e-85	305.00
IUUC-Osa-085961	Oryza sativa	55.51	4.00e-85	305.00
IUUC-Olu-087880	Ostreococcus lucimarinus	55.98	3.00e-90	322.00
IUUC-Oga-088891	Otolemur garnettii	54.44	1.00e-87	314.00
IUUC-Oar-090021	Ovis aries	54.62	2.00e-86	310.00
IUUC-Ptr-091458	Pan troglodytes	53.85	2.00e-86	310.00
IUUC-Pan-092546	Papio anubis	54.23	1.00e-86	310.00
IUUC-Psi-093280	Pelodiscus sinensis	48.05	2.00e-88	317.00
IUUC-Pma-094298	Petromyzon marinus	56.37	9.00e-85	304.00
IUUC-Pno-094847	Phaeosphaeria nodorum	46.63	6.00e-89	318.00
IUUC-Ppa-095855	Physcomitrella patens	55.34	2.00e-84	303.00
IUUC-Pfo-096428	Poecilia formosa	44.41	2.00e-84	304.00
IUUC-Pab-098696	Pongo abelii	53.46	2.00e-85	307.00
IUUC-Pop-099405	Populus trichocarpa	55.13	1.00e-85	307.00
IUUC-Pca-100740	Procavia capensis	54.05	1.00e-86	311.00
IUUC-Ppe-101854	Prunus persica	53.62	3.00e-86	309.00
IUUC-Pva-103212	Pteropus vampyrus	54.62	1.00e-86	311.00
IUUC-Pgr-103474	Puccinia graminis	56.46	5.00e-93	332.00
IUUC-Ptt-103933	Puccinia triticina	43.40	6.00e-59	218.00
IUUC-Pte-104089	Pyrenophora teres	47.80	3.00e-88	316.00
IUUC-Pyt-104555	Pyrenophora triticirepentis	47.80	4.00e-88	316.00
IUUC-Rno-105057	Rattus norvegicus	54.05	4.00e-86	309.00
IUUC-Sha-107137	Sarcophilus harrisii	51.67	1.00e-90	324.00
IUUC-Sja-107767	Schizosaccharomyces japonicus	62.17	2.00e-105	373.00
IUUC-Spo-108078	Schizosaccharomyces pombe	58.89	1.00e-105	374.00
IUUC-Smo-109288	Selaginella moellendorffii	54.79	1.00e-84	303.00
IUUC-Sit-110246	Setaria italica	55.51	7.00e-85	304.00
IUUC-Sly-111379	Solanum lycopersicum	54.75	5.00e-84	301.00
IUUC-Stu-112777	Solanum tuberosum	55.51	3.00e-86	309.00
IUUC-Sar-113569	Sorex araneus	29.59	6.00e-29	121.00
IUUC-Sbi-114325	Sorghum bicolor	56.27	2.00e-85	306.00
IUUC-Sre-115203	Sporisorium reilianum	54.24	1.00e-83	301.00
IUUC-Ssc-115361	Sus scrofa	54.23	2.00e-86	310.00
IUUC-Tgu-116967	Taeniopygia guttata	56.59	4.00e-89	319.00
IUUC-Tru-117570	Takifugu rubripes	51.06	6.00e-84	302.00
IUUC-Tsy-119280	Tarsius syrichta	53.57	2.00e-63	234.00
IUUC-Tni-120721	Tetraodon nigroviridis	49.16	4.00e-83	299.00
IUUC-Tca-121494	Theobroma cacao	53.99	2.00e-84	303.00
IUUC-Tre-121869	Trichoderma reesei	45.65	5.00e-93	332.00
IUUC-Tvi-122510	Trichoderma virens	55.28	2.00e-92	330.00
IUUC-Tae-123071	Triticum aestivum	55.13	5.00e-85	305.00
IUUC-Tur-126240	Triticum urartu	55.13	2.00e-84	303.00
IUUC-Tme-126921	Tuber melanosporum	56.99	2.00e-96	343.00
IUUC-Tbe-127872	Tupaia belangeri	48.85	4.00e-75	272.00
IUUC-Ttr-129134	Tursiops truncatus	54.23	8.00e-87	311.00
IUUC-Uma-129412	Ustilago maydis	56.30	2.00e-79	287.00
IUUC-Vda-130003	Verticillium dahliae	56.98	4.00e-93	332.00
IUUC-Vvi-131272	Vitis vinifera	54.75	2.00e-85	306.00
IUUC-Xtr-132019	Xenopus tropicalis	56.54	2.00e-90	323.00
IUUC-Xma-134203	Xiphophorus maculatus	46.02	4.00e-87	312.00
IUUC-Zma-135232	Zea mays	55.89	6.00e-85	305.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence