iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049704

Ensembl Protein ID

ENSLACP00000020625.1

UniProt Accession

H3BFF4; H3BFF4_LATCH

Genbank Protein ID

ENSLACP00000020625

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AFYH01011913

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000018124.1	ENSLACT00000020765.1	ENSLACP00000020625.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.70e-26	90.7	1328	1381

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1328 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1381
           58********************************.*****99999*******876 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

DDQFLGFGSD DEIKRVRSPP RPLAVRSHQR KSRGRPRASS AQKANVPPDS SSEPSPPSQP 60
EAKIVEKEKK SEAKSGEKRR GRPPLHGSLK LQAPQEKETV DAQKEKEERQ KVKKVKKTPP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGACCAGT TTTTGGGTTT TGGCTCTGAT GATGAGATCA AGAGAGTCCG CAGTCCCCCA 60
AGACCCCTTG CAGGTACTGT TTCTCTAATG TTTCATTGAC AGCAGTTCAG GCAGCACTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR017956--AT_hook_DNA-bd_motif
IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00384--AT_hook
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0021782--P:glial cell development
GO:0048823--P:nucleate erythrocyte development
GO:0048339--P:paraxial mesoderm development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	33.68	1.00e-12	68.60
IUUC-Aml-002274	Ailuropoda melanoleuca	66.55	0.00e+00	2915.00
IUUC-Atr-002455	Amborella trichopoda	47.47	2.00e-38	154.00
IUUC-Apl-003478	Anas platyrhynchos	62.85	0.00e+00	1691.00
IUUC-Aca-005086	Anolis carolinensis	76.08	0.00e+00	1373.00
IUUC-Aly-006448	Arabidopsis lyrata	47.47	6.00e-39	156.00
IUUC-Ath-006690	Arabidopsis thaliana	46.10	1.00e-36	148.00
IUUC-Ame-011195	Astyanax mexicanus	45.11	0.00e+00	855.00
IUUC-Bta-012974	Bos taurus	66.29	0.00e+00	2892.00
IUUC-Bdi-014882	Brachypodium distachyon	31.66	7.00e-25	108.00
IUUC-Bol-016540	Brassica oleracea	46.75	2.00e-37	150.00
IUUC-Cja-019226	Callithrix jacchus	65.51	0.00e+00	2924.00
IUUC-Cfa-021049	Canis familiaris	66.46	0.00e+00	2947.00
IUUC-Cpo-021459	Cavia porcellus	65.66	0.00e+00	2882.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.00	2.00e-38	155.00
IUUC-Csa-023434	Chlorocebus sabaeus	65.82	0.00e+00	2901.00
IUUC-Cho-024652	Choloepus hoffmanni	62.67	0.00e+00	2523.00
IUUC-Cin-025724	Ciona intestinalis	54.06	7.00e-98	352.00
IUUC-Csv-026268	Ciona savignyi	37.25	4.00e-126	446.00
IUUC-Cme-027224	Cyanidioschyzon merolae	35.80	1.00e-13	71.60
IUUC-Dre-028180	Danio rerio	63.83	0.00e+00	1078.00
IUUC-Dno-029068	Dasypus novemcinctus	62.49	0.00e+00	2685.00
IUUC-Dor-030550	Dipodomys ordii	61.67	0.00e+00	2576.00
IUUC-Dme-032023	Drosophila melanogaster	46.82	2.00e-91	332.00
IUUC-Ete-032834	Echinops telfairi	56.42	0.00e+00	1661.00
IUUC-Eca-033615	Equus caballus	66.12	0.00e+00	2856.00
IUUC-Eeu-035136	Erinaceus europaeus	66.79	0.00e+00	905.00
IUUC-Fca-036453	Felis catus	55.86	0.00e+00	1375.00
IUUC-Fal-037256	Ficedula albicollis	65.55	0.00e+00	4027.00
IUUC-Gmo-038641	Gadus morhua	65.84	0.00e+00	1042.00
IUUC-Gga-040828	Gallus gallus	65.75	0.00e+00	3934.00
IUUC-Gac-041452	Gasterosteus aculeatus	68.30	0.00e+00	1094.00
IUUC-Gma-043554	Glycine max	49.02	1.00e-38	155.00
IUUC-Ggo-045124	Gorilla gorilla	64.43	0.00e+00	2654.00
IUUC-Hsa-046143	Homo sapiens	65.93	0.00e+00	2871.00
IUUC-Hvu-047762	Hordeum vulgare	33.59	2.00e-18	87.40
IUUC-Itr-049024	Ictidomys tridecemlineatus	60.87	0.00e+00	3181.00
IUUC-Lpe-051476	Leersia perrieri	30.41	4.00e-22	99.80
IUUC-Loc-052181	Lepisosteus oculatus	76.76	0.00e+00	1244.00
IUUC-Laf-053946	Loxodonta africana	64.61	0.00e+00	3739.00
IUUC-Mcc-055508	Macaca mulatta	65.90	0.00e+00	2886.00
IUUC-Meu-056485	Macropus eugenii	60.27	0.00e+00	1660.00
IUUC-Mtr-058327	Medicago truncatula	41.23	4.00e-39	156.00
IUUC-Mga-059943	Meleagris gallopavo	64.67	0.00e+00	3677.00
IUUC-Mmr-061178	Microcebus murinus	66.55	0.00e+00	2940.00
IUUC-Mdo-063031	Monodelphis domestica	67.62	0.00e+00	2977.00
IUUC-Mmu-063650	Mus musculus	64.53	0.00e+00	2784.00
IUUC-Mpu-066495	Mustela putorius furo	63.54	0.00e+00	1832.00
IUUC-Mlu-068045	Myotis lucifugus	64.39	0.00e+00	2836.00
IUUC-Nle-069064	Nomascus leucogenys	65.86	0.00e+00	2902.00
IUUC-Opr-071043	Ochotona princeps	74.89	0.00e+00	1205.00
IUUC-Ont-072556	Oreochromis niloticus	68.05	0.00e+00	1071.00
IUUC-Oan-073324	Ornithorhynchus anatinus	64.89	0.00e+00	1746.00
IUUC-Ocu-074190	Oryctolagus cuniculus	65.42	0.00e+00	2868.00
IUUC-Oba-075647	Oryza barthii	48.72	7.00e-38	152.00
IUUC-Obr-076458	Oryza brachyantha	32.99	3.00e-25	110.00
IUUC-Ogl-077851	Oryza glaberrima	32.49	8.00e-25	108.00
IUUC-Ogu-078706	Oryza glumaepatula	31.68	5.00e-25	109.00
IUUC-Oin-079802	Oryza indica	28.44	7.00e-20	92.00
IUUC-Olo-080577	Oryza longistaminata	47.71	5.00e-36	146.00
IUUC-Ome-081214	Oryza meridionalis	48.72	7.00e-38	152.00
IUUC-Oni-083000	Oryza nivara	48.72	7.00e-38	152.00
IUUC-Opu-083842	Oryza punctata	48.72	7.00e-38	152.00
IUUC-Oru-084361	Oryza rufipogon	48.72	8.00e-38	152.00
IUUC-Osa-085421	Oryza sativa	32.49	1.00e-24	108.00
IUUC-Ola-087176	Oryzias latipes	63.13	0.00e+00	1076.00
IUUC-Oga-088208	Otolemur garnettii	66.44	0.00e+00	2922.00
IUUC-Oar-090152	Ovis aries	66.54	0.00e+00	2915.00
IUUC-Ptr-091127	Pan troglodytes	65.78	0.00e+00	2866.00
IUUC-Pan-092679	Papio anubis	65.86	0.00e+00	2880.00
IUUC-Psi-094059	Pelodiscus sinensis	71.69	0.00e+00	2358.00
IUUC-Pma-094258	Petromyzon marinus	58.81	0.00e+00	629.00
IUUC-Pfo-096536	Poecilia formosa	65.56	0.00e+00	1060.00
IUUC-Pab-098262	Pongo abelii	65.63	0.00e+00	2890.00
IUUC-Pca-100358	Procavia capensis	63.65	0.00e+00	2665.00
IUUC-Pva-102522	Pteropus vampyrus	59.30	0.00e+00	1402.00
IUUC-Rno-105200	Rattus norvegicus	64.57	0.00e+00	2747.00
IUUC-Sha-107174	Sarcophilus harrisii	65.02	0.00e+00	3892.00
IUUC-Smo-109164	Selaginella moellendorffii	51.30	1.00e-40	162.00
IUUC-Sit-110552	Setaria italica	31.50	2.00e-25	110.00
IUUC-Sly-111158	Solanum lycopersicum	39.29	5.00e-37	149.00
IUUC-Stu-112529	Solanum tuberosum	48.37	1.00e-38	154.00
IUUC-Sar-113503	Sorex araneus	59.51	0.00e+00	1360.00
IUUC-Sbi-114254	Sorghum bicolor	26.28	6.00e-10	59.30
IUUC-Ssc-115509	Sus scrofa	51.01	0.00e+00	731.00
IUUC-Tgu-117047	Taeniopygia guttata	66.08	0.00e+00	3975.00
IUUC-Tru-118328	Takifugu rubripes	64.19	0.00e+00	1088.00
IUUC-Tsy-118953	Tarsius syrichta	57.75	0.00e+00	1800.00
IUUC-Tni-120837	Tetraodon nigroviridis	63.60	0.00e+00	1078.00
IUUC-Tae-124647	Triticum aestivum	33.59	2.00e-18	87.40
IUUC-Tbe-127950	Tupaia belangeri	58.25	0.00e+00	1684.00
IUUC-Ttr-128643	Tursiops truncatus	62.35	0.00e+00	2210.00
IUUC-Vpa-130660	Vicugna pacos	59.32	0.00e+00	1108.00
IUUC-Vvi-131476	Vitis vinifera	46.15	4.00e-39	156.00
IUUC-Xtr-132869	Xenopus tropicalis	60.51	0.00e+00	2011.00
IUUC-Xma-133393	Xiphophorus maculatus	63.30	0.00e+00	1016.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence