iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013533

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

DAAA02063512

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000003967.3	ENSBTAT00000005174.3	ENSBTAP00000005174.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.70e-51	173.7	81	271

Active Site

Position(s)	Description	Evidence
88	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
91	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
265		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 81   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekrtpvadLLASFNDQSTSD 169
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 170  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHVFPEGS-E 254
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 255  PKVYLLYRPGHYDILYK 271
           ***************96 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE 60
YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCGGCGC TGTTTAAAGA TGGCGGCGGA GGAACCTCAG CAGCAGAAGC AGGAGCCGCT 60
TGGCAGCGAC TCCGAAGGTA CCGACCAGGG GAGAGCCGCC CGGCCTGGGC TAGCGGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

KEGG

bta:540984

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	97.07	1.00e-154	538.00
IUUC-Apl-003233	Anas platyrhynchos	61.54	2.00e-20	89.70
IUUC-Aca-004648	Anolis carolinensis	85.40	9.00e-137	479.00
IUUC-Aly-005710	Arabidopsis lyrata	41.76	3.00e-51	195.00
IUUC-Ath-007112	Arabidopsis thaliana	41.61	3.00e-50	191.00
IUUC-Afl-008439	Aspergillus flavus	34.18	2.00e-08	52.40
IUUC-Ame-010662	Astyanax mexicanus	82.89	2.00e-129	454.00
IUUC-Bol-016100	Brassica oleracea	41.67	9.00e-50	190.00
IUUC-Bra-017705	Brassica rapa	38.79	2.00e-44	172.00
IUUC-Cel-018295	Caenorhabditis elegans	34.42	9.00e-42	163.00
IUUC-Cja-019190	Callithrix jacchus	98.89	6.00e-153	533.00
IUUC-Cfa-020430	Canis familiaris	98.81	2.00e-148	517.00
IUUC-Cpo-022355	Cavia porcellus	99.26	4.00e-153	533.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	38.80	1.00e-46	179.00
IUUC-Csa-023286	Chlorocebus sabaeus	95.71	2.00e-150	524.00
IUUC-Cin-025507	Ciona intestinalis	43.33	2.00e-44	171.00
IUUC-Csv-026273	Ciona savignyi	49.80	5.00e-69	253.00
IUUC-Dre-027843	Danio rerio	78.20	1.00e-125	442.00
IUUC-Dno-029165	Dasypus novemcinctus	97.50	1.00e-116	411.00
IUUC-Dor-030943	Dipodomys ordii	99.26	4.00e-153	533.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	6.00e-78	283.00
IUUC-Ete-032296	Echinops telfairi	95.60	2.00e-88	318.00
IUUC-Eca-033695	Equus caballus	98.41	4.00e-148	516.00
IUUC-Fca-036441	Felis catus	98.81	4.00e-148	516.00
IUUC-Gmo-038908	Gadus morhua	80.30	4.00e-126	443.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.41	3.00e-32	133.00
IUUC-Gga-040460	Gallus gallus	82.29	1.00e-134	471.00
IUUC-Gac-042417	Gasterosteus aculeatus	80.80	1.00e-121	429.00
IUUC-Gma-043712	Glycine max	40.78	8.00e-51	193.00
IUUC-Ggo-044552	Gorilla gorilla	98.11	4.00e-91	327.00
IUUC-Hsa-046766	Homo sapiens	98.89	5.00e-153	533.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	99.26	4.00e-153	533.00
IUUC-Lch-050602	Latimeria chalumnae	80.16	6.00e-118	416.00
IUUC-Laf-053705	Loxodonta africana	99.26	4.00e-153	533.00
IUUC-Mcc-055745	Macaca mulatta	92.73	3.00e-149	520.00
IUUC-Meu-056569	Macropus eugenii	85.24	2.00e-134	471.00
IUUC-Mtr-057712	Medicago truncatula	42.75	8.00e-46	177.00
IUUC-Mvi-060358	Microbotryum violaceum	34.55	2.00e-15	76.60
IUUC-Mmr-061123	Microcebus murinus	98.71	9.00e-127	446.00
IUUC-Mdo-062613	Monodelphis domestica	86.72	1.00e-122	432.00
IUUC-Mmu-063658	Mus musculus	99.26	4.00e-153	533.00
IUUC-Mac-065274	Musa acuminata	38.00	1.00e-39	156.00
IUUC-Mpu-066172	Mustela putorius furo	98.89	5.00e-153	533.00
IUUC-Mlu-066966	Myotis lucifugus	98.15	4.00e-152	530.00
IUUC-Nle-069519	Nomascus leucogenys	86.56	9.00e-92	329.00
IUUC-Ont-071901	Oreochromis niloticus	82.47	2.00e-124	438.00
IUUC-Ola-087331	Oryzias latipes	80.34	4.00e-85	306.00
IUUC-Oga-088064	Otolemur garnettii	98.89	5.00e-153	533.00
IUUC-Oar-089251	Ovis aries	99.21	3.00e-149	520.00
IUUC-Ptr-091430	Pan troglodytes	98.89	1.00e-152	531.00
IUUC-Psi-093823	Pelodiscus sinensis	87.74	3.00e-133	467.00
IUUC-Pma-094366	Petromyzon marinus	71.27	3.00e-102	364.00
IUUC-Pfo-096734	Poecilia formosa	80.48	1.00e-113	402.00
IUUC-Pab-097919	Pongo abelii	99.14	3.00e-126	444.00
IUUC-Pop-099401	Populus trichocarpa	40.88	8.00e-48	183.00
IUUC-Ppe-101977	Prunus persica	42.01	8.00e-51	194.00
IUUC-Pva-102499	Pteropus vampyrus	98.80	5.00e-148	516.00
IUUC-Rno-105233	Rattus norvegicus	99.26	4.00e-153	533.00
IUUC-Sha-107081	Sarcophilus harrisii	96.90	1.00e-148	518.00
IUUC-Sly-111640	Solanum lycopersicum	41.64	1.00e-48	186.00
IUUC-Ssc-116202	Sus scrofa	98.89	5.00e-153	533.00
IUUC-Tru-117664	Takifugu rubripes	77.32	4.00e-122	430.00
IUUC-Tca-121467	Theobroma cacao	41.18	9.00e-50	190.00
IUUC-Tbe-128116	Tupaia belangeri	96.89	4.00e-92	331.00
IUUC-Ttr-128622	Tursiops truncatus	98.15	2.00e-150	524.00
IUUC-Vvi-131389	Vitis vinifera	43.38	4.00e-52	198.00
IUUC-Xma-134191	Xiphophorus maculatus	80.88	2.00e-114	405.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence