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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045733
UUCD1 version UUC-HoS-00281
Ensembl Protein ID ENSP00000232744.8
UniProt Accession Q969K4; D3DNB0; Q6ZNU9; Q71MF1; Q96S62; Q96S63; ABTB1_HUMAN
Genbank Protein ID BAB55648.1; BAB55649.1; BAB55650.1; AAQ04661.1; BAC85392.1; EAW79333.1; EAW79334.1; AAH11858.1; AAK57478.1
Protein Name Ankyrin repeat and BTB/POZ domain-containing protein 1; Elongation factor 1A-binding protein
Genbank Nucleotide ID AB053324; AB053325; AB053326; AF447886; AK130594; CH471052; CH471052; BC011858; AF297986
Gene Name ABTB1; BPOZ; PP2259
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000114626.17 ENST00000483857.5 ENSP00000420748.1
ENSG00000114626.17 ENST00000232744.12 ENSP00000232744.8
ENSG00000114626.17 ENST00000497162.1 ENSP00000418439.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other BTB_Other 18429817; 18459963
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 4.60e-30 105.4 115 180
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd..vqpevfrallkFlYtgklde 67
           +Dv++vv g+ f++h++vL a+S +F ++++++++    k+ v+++   + p +f all++lYtg+ld+
   Q: 115  SDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKG---KSVVVLRHplINPVAFGALLQYLYTGRLDI 180
           6*****************************999985...4699999889******************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes.
 May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes.
Protein Sequence
(Fasta)
MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE LVLYLLANGA 60
RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY YDDFLQRLLE QGIHSDVVFV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045733|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGGGCGGGG CGGGGCTGAG CGTGTTTACA TCCGCCGGGT GCGCGGCTTC GCCGCCCGAG 60
GTCGTTCGGC TCGGGTACCA TCCTCCGCGC CATGGACACC AGCGACCTGT TCGCCAGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045733|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0251--Elongation factor
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB
Pfam

PF12796--Ank_2
PF00651--BTB
SMART

SM00248--ANK
SM00225--BTB
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0003746--F:translation elongation factor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
KEGG hsa:80325
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000443 Aegilops tauschii 24.07 2.00e-18 87.00
IUUC-Aml-001651 Ailuropoda melanoleuca 96.03 0.00e+00 891.00
IUUC-Atr-002929 Amborella trichopoda 24.92 1.00e-24 107.00
IUUC-Apl-003737 Anas platyrhynchos 76.74 0.00e+00 677.00
IUUC-Aca-005362 Anolis carolinensis 76.15 0.00e+00 705.00
IUUC-Aly-005560 Arabidopsis lyrata 30.42 1.00e-50 194.00
IUUC-Ath-007684 Arabidopsis thaliana 30.62 5.00e-51 195.00
IUUC-Acl-008196 Aspergillus clavatus 37.63 2.00e-23 103.00
IUUC-Afl-008477 Aspergillus flavus 29.34 1.00e-36 148.00
IUUC-Afu-009053 Aspergillus fumigatus 39.44 3.00e-23 103.00
IUUC-Ang-009825 Aspergillus niger 40.57 3.00e-24 107.00
IUUC-Aor-010132 Aspergillus oryzae 29.34 1.00e-36 148.00
IUUC-Ate-010330 Aspergillus terreus 27.54 8.00e-33 135.00
IUUC-Ame-010691 Astyanax mexicanus 65.32 5.00e-163 567.00
IUUC-Bgr-012002 Blumeria graminis 26.87 7.00e-31 129.00
IUUC-Bta-012987 Bos taurus 82.85 0.00e+00 734.00
IUUC-Bci-013710 Botrytis cinerea 34.68 4.00e-24 106.00
IUUC-Bdi-014977 Brachypodium distachyon 49.43 1.00e-17 85.10
IUUC-Bol-016212 Brassica oleracea 31.87 5.00e-51 195.00
IUUC-Bra-016855 Brassica rapa 31.51 6.00e-49 188.00
IUUC-Cja-019303 Callithrix jacchus 96.65 0.00e+00 916.00
IUUC-Cfa-020840 Canis familiaris 95.61 0.00e+00 909.00
IUUC-Cpo-021992 Cavia porcellus 93.31 0.00e+00 868.00
IUUC-Csa-023233 Chlorocebus sabaeus 98.54 0.00e+00 907.00
IUUC-Cin-025170 Ciona intestinalis 44.63 1.00e-94 339.00
IUUC-Csv-026159 Ciona savignyi 45.74 2.00e-114 406.00
IUUC-Cgl-026440 Colletotrichum gloeosporioides 27.59 2.00e-34 140.00
IUUC-Cme-027271 Cyanidioschyzon merolae 29.89 8.00e-24 105.00
IUUC-Dre-027436 Danio rerio 69.25 0.00e+00 687.00
IUUC-Dno-029837 Dasypus novemcinctus 93.10 0.00e+00 714.00
IUUC-Dse-031307 Dothistroma septosporum 25.20 2.00e-22 100.00
IUUC-Ete-032833 Echinops telfairi 88.28 0.00e+00 835.00
IUUC-Eca-034247 Equus caballus 95.82 0.00e+00 905.00
IUUC-Fca-035764 Felis catus 95.22 0.00e+00 870.00
IUUC-Fal-036709 Ficedula albicollis 76.63 0.00e+00 706.00
IUUC-Fox-037679 Fusarium oxysporum 26.09 1.00e-29 124.00
IUUC-Fso-038182 Fusarium solani 28.02 3.00e-32 133.00
IUUC-Gmo-038709 Gadus morhua 61.47 2.00e-171 595.00
IUUC-Ggr-039933 Gaeumannomyces graminis 25.69 3.00e-23 103.00
IUUC-Gga-040642 Gallus gallus 76.78 0.00e+00 718.00
IUUC-Gac-041542 Gasterosteus aculeatus 63.56 0.00e+00 631.00
IUUC-Gma-044195 Glycine max 30.97 4.00e-48 186.00
IUUC-Ggo-045298 Gorilla gorilla 98.91 0.00e+00 900.00
IUUC-Hvu-047766 Hordeum vulgare 24.04 3.00e-14 73.20
IUUC-Itr-048809 Ictidomys tridecemlineatus 86.13 0.00e+00 672.00
IUUC-Kpa-049236 Komagataella pastoris 25.31 2.00e-25 110.00
IUUC-Lch-050088 Latimeria chalumnae 70.80 0.00e+00 627.00
IUUC-Lpe-051044 Leersia perrieri 23.78 1.00e-19 91.70
IUUC-Loc-052787 Lepisosteus oculatus 70.56 0.00e+00 699.00
IUUC-Lma-053329 Leptosphaeria maculans 36.65 7.00e-23 102.00
IUUC-Laf-054099 Loxodonta africana 93.10 0.00e+00 844.00
IUUC-Mcc-055242 Macaca mulatta 97.02 0.00e+00 874.00
IUUC-Meu-056512 Macropus eugenii 78.66 0.00e+00 686.00
IUUC-Mor-057053 Magnaporthe oryzae 34.21 1.00e-18 88.20
IUUC-Mpo-057397 Magnaporthe poae 33.87 8.00e-19 89.00
IUUC-Mtr-058594 Medicago truncatula 28.88 1.00e-44 174.00
IUUC-Mga-059397 Meleagris gallopavo 76.52 0.00e+00 685.00
IUUC-Mmr-061427 Microcebus murinus 78.35 1.00e-105 376.00
IUUC-Mdo-061956 Monodelphis domestica 78.12 0.00e+00 676.00
IUUC-Mmu-063506 Mus musculus 94.14 0.00e+00 872.00
IUUC-Mac-065218 Musa acuminata 28.23 3.00e-42 166.00
IUUC-Mpu-066102 Mustela putorius furo 95.61 0.00e+00 904.00
IUUC-Mlu-067293 Myotis lucifugus 84.94 0.00e+00 769.00
IUUC-Nfi-068356 Neosartorya fischeri 30.88 6.00e-37 149.00
IUUC-Ncr-068884 Neurospora crassa 32.97 9.00e-19 89.00
IUUC-Nle-069809 Nomascus leucogenys 99.16 0.00e+00 938.00
IUUC-Opr-070691 Ochotona princeps 94.56 0.00e+00 832.00
IUUC-Ont-072314 Oreochromis niloticus 65.27 0.00e+00 649.00
IUUC-Oan-073035 Ornithorhynchus anatinus 74.29 1.00e-168 585.00
IUUC-Ocu-073868 Oryctolagus cuniculus 94.57 0.00e+00 804.00
IUUC-Oba-075254 Oryza barthii 23.97 7.00e-21 95.50
IUUC-Obr-076877 Oryza brachyantha 24.84 1.00e-22 101.00
IUUC-Ogu-078108 Oryza glumaepatula 23.97 5.00e-21 96.30
IUUC-Olo-081059 Oryza longistaminata 23.97 4.00e-21 95.90
IUUC-Oni-082081 Oryza nivara 23.97 2.00e-20 94.40
IUUC-Opu-083551 Oryza punctata 23.20 5.00e-19 89.40
IUUC-Oru-085228 Oryza rufipogon 23.97 1.00e-20 95.10
IUUC-Osa-085844 Oryza sativa 23.97 1.00e-20 95.10
IUUC-Ola-086680 Oryzias latipes 65.06 0.00e+00 646.00
IUUC-Oga-088474 Otolemur garnettii 94.98 0.00e+00 888.00
IUUC-Oar-090327 Ovis aries 82.21 6.00e-147 513.00
IUUC-Ptr-090511 Pan troglodytes 98.69 5.00e-168 583.00
IUUC-Pan-092758 Papio anubis 98.33 0.00e+00 907.00
IUUC-Psi-093772 Pelodiscus sinensis 74.35 2.00e-153 535.00
IUUC-Pma-094548 Petromyzon marinus 64.52 1.00e-155 543.00
IUUC-Pno-094959 Phaeosphaeria nodorum 30.49 2.00e-17 84.70
IUUC-Ppa-095931 Physcomitrella patens 34.16 1.00e-33 138.00
IUUC-Pfo-096211 Poecilia formosa 65.14 0.00e+00 651.00
IUUC-Pab-098352 Pongo abelii 90.17 0.00e+00 828.00
IUUC-Pop-099552 Populus trichocarpa 30.62 2.00e-46 180.00
IUUC-Pca-100943 Procavia capensis 89.29 1.00e-108 387.00
IUUC-Ppe-101944 Prunus persica 30.02 8.00e-47 181.00
IUUC-Pva-102566 Pteropus vampyrus 86.61 0.00e+00 781.00
IUUC-Pte-104208 Pyrenophora teres 34.60 1.00e-25 111.00
IUUC-Pyt-104617 Pyrenophora triticirepentis 34.08 8.00e-26 112.00
IUUC-Rno-104967 Rattus norvegicus 94.56 0.00e+00 877.00
IUUC-Sce-106261 Saccharomyces cerevisiae 27.78 6.00e-30 125.00
IUUC-Sha-107095 Sarcophilus harrisii 81.63 0.00e+00 736.00
IUUC-Sja-107811 Schizosaccharomyces japonicus 28.09 1.00e-37 151.00
IUUC-Spo-108277 Schizosaccharomyces pombe 29.72 2.00e-40 160.00
IUUC-Ssl-108583 Sclerotinia sclerotiorum 28.89 6.00e-30 125.00
IUUC-Smo-108744 Selaginella moellendorffii 29.34 7.00e-30 125.00
IUUC-Sit-110191 Setaria italica 28.67 1.00e-36 148.00
IUUC-Sly-110836 Solanum lycopersicum 28.82 6.00e-44 172.00
IUUC-Stu-112766 Solanum tuberosum 28.60 5.00e-43 169.00
IUUC-Sbi-114848 Sorghum bicolor 28.67 2.00e-37 150.00
IUUC-Ssc-115778 Sus scrofa 86.67 0.00e+00 778.00
IUUC-Tgu-117174 Taeniopygia guttata 76.78 0.00e+00 712.00
IUUC-Tru-117645 Takifugu rubripes 60.79 1.00e-171 595.00
IUUC-Tsy-119394 Tarsius syrichta 93.71 2.00e-158 551.00
IUUC-Tni-120500 Tetraodon nigroviridis 58.80 3.00e-163 568.00
IUUC-Tca-121738 Theobroma cacao 31.58 1.00e-45 177.00
IUUC-Tre-121929 Trichoderma reesei 27.92 4.00e-28 119.00
IUUC-Tvi-122627 Trichoderma virens 26.91 6.00e-33 135.00
IUUC-Tae-125436 Triticum aestivum 26.37 2.00e-35 143.00
IUUC-Tme-126911 Tuber melanosporum 25.65 5.00e-21 95.90
IUUC-Ttr-128844 Tursiops truncatus 84.10 0.00e+00 701.00
IUUC-Vda-129922 Verticillium dahliae 27.01 2.00e-31 130.00
IUUC-Vvi-131681 Vitis vinifera 27.06 8.00e-43 168.00
IUUC-Xtr-132110 Xenopus tropicalis 71.27 0.00e+00 681.00
IUUC-Xma-132990 Xiphophorus maculatus 65.90 0.00e+00 659.00
IUUC-Yli-134395 Yarrowia lipolytica 28.70 3.00e-31 129.00
IUUC-Zma-135189 Zea mays 28.30 6.00e-35 142.00
Created Date 25-Jun-2017

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