iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115821

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine signaling 4

Genbank Nucleotide ID

CU855754

Gene Name

SOCS4; socs4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000005053.2	ENSSSCT00000005570.2	ENSSSCP00000005432.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	5.70e-17	61.6	379	426

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l+r+ p+SLqh+CR +I++c++++++   d+LP+P+s+k YL++++y+
   Q: 379  STPLIRTFPFSLQHICRTVICNCTTYDGI---DALPIPSSMKLYLKEYHYK 426
           678899***********************...****************985 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MAENSENNSK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESCSDAE TVNAIEKTEV 60
PLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCGCGCC GGCCGCCTGG GAAAAAGCCG GTTGCTGGGG GAGTGAGGAA GAAAGGGAGG 60
GAGCCGAATA CGGAAGTGGT GGCATCGCTG GGAGAGCGGG TGGAGGCAGT GACGGCGATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	94.99	0.00e+00	798.00
IUUC-Apl-003839	Anas platyrhynchos	80.00	0.00e+00	646.00
IUUC-Aca-004840	Anolis carolinensis	76.82	0.00e+00	692.00
IUUC-Ame-010732	Astyanax mexicanus	79.65	1.00e-85	310.00
IUUC-Bta-012503	Bos taurus	96.37	0.00e+00	811.00
IUUC-Bol-016597	Brassica oleracea	29.11	1.60e-01	30.80
IUUC-Cja-019284	Callithrix jacchus	93.42	0.00e+00	786.00
IUUC-Cfa-020890	Canis familiaris	94.56	0.00e+00	798.00
IUUC-Cpo-022081	Cavia porcellus	79.64	0.00e+00	687.00
IUUC-Csa-023076	Chlorocebus sabaeus	93.42	0.00e+00	790.00
IUUC-Cho-024700	Choloepus hoffmanni	93.65	0.00e+00	834.00
IUUC-Dno-029961	Dasypus novemcinctus	94.56	0.00e+00	835.00
IUUC-Dor-030273	Dipodomys ordii	93.65	0.00e+00	801.00
IUUC-Ete-032972	Echinops telfairi	93.29	3.00e-170	590.00
IUUC-Eca-034289	Equus caballus	95.01	0.00e+00	803.00
IUUC-Eeu-035208	Erinaceus europaeus	91.49	0.00e+00	759.00
IUUC-Fal-036829	Ficedula albicollis	80.23	0.00e+00	644.00
IUUC-Gga-040725	Gallus gallus	79.09	0.00e+00	665.00
IUUC-Ggo-044886	Gorilla gorilla	93.42	0.00e+00	790.00
IUUC-Hsa-046322	Homo sapiens	93.20	0.00e+00	788.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	94.72	0.00e+00	791.00
IUUC-Lch-049459	Latimeria chalumnae	58.31	2.00e-140	491.00
IUUC-Laf-053484	Loxodonta africana	95.40	0.00e+00	800.00
IUUC-Mcc-054890	Macaca mulatta	93.20	0.00e+00	788.00
IUUC-Meu-056532	Macropus eugenii	84.14	0.00e+00	648.00
IUUC-Mtr-057670	Medicago truncatula	36.67	1.80e+00	26.60
IUUC-Mvi-060418	Microbotryum violaceum	32.10	1.10e-02	33.10
IUUC-Mmr-061714	Microcebus murinus	94.78	0.00e+00	798.00
IUUC-Mmu-063161	Mus musculus	88.30	0.00e+00	742.00
IUUC-Mac-064598	Musa acuminata	33.33	2.40e-01	28.50
IUUC-Mpu-066499	Mustela putorius furo	95.00	0.00e+00	828.00
IUUC-Mlu-066945	Myotis lucifugus	93.65	0.00e+00	790.00
IUUC-Nle-069976	Nomascus leucogenys	93.20	0.00e+00	787.00
IUUC-Opr-070255	Ochotona princeps	88.44	0.00e+00	757.00
IUUC-Ocu-074764	Oryctolagus cuniculus	94.10	0.00e+00	800.00
IUUC-Oga-088910	Otolemur garnettii	87.33	0.00e+00	769.00
IUUC-Oar-090330	Ovis aries	96.15	0.00e+00	808.00
IUUC-Ptr-090709	Pan troglodytes	93.42	0.00e+00	790.00
IUUC-Pan-092540	Papio anubis	93.42	0.00e+00	790.00
IUUC-Psi-093678	Pelodiscus sinensis	81.36	0.00e+00	720.00
IUUC-Pfo-097139	Poecilia formosa	80.81	3.00e-87	315.00
IUUC-Pab-097970	Pongo abelii	91.44	0.00e+00	645.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.20e-01	30.80
IUUC-Pca-100211	Procavia capensis	83.22	0.00e+00	677.00
IUUC-Rno-106014	Rattus norvegicus	85.55	0.00e+00	727.00
IUUC-Sha-106822	Sarcophilus harrisii	84.83	0.00e+00	727.00
IUUC-Tgu-117117	Taeniopygia guttata	80.68	0.00e+00	647.00
IUUC-Tsy-118979	Tarsius syrichta	96.17	6.00e-126	442.00
IUUC-Tca-121131	Theobroma cacao	30.77	2.00e-03	36.20
IUUC-Vpa-130626	Vicugna pacos	95.69	0.00e+00	817.00
IUUC-Vvi-131327	Vitis vinifera	43.24	8.50e-02	31.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence