iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-072783

Ensembl Protein ID

ENSOANP00000001680.2

UniProt Accession

F6PHW7; F6PHW7_ORNAN

Protein Name

Presenilin

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000001055.3	ENSOANT00000001681.3	ENSOANP00000001680.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.30e-08	34.9	146	183

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnL 39
           +eta+e+++++FP+l+ys+++v+L++++  +++a+ + 
   Q: 146  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRKV 183
           89***************************999998775 PP

Organism

Ornithorhynchus anatinus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

SVQRLAHGKR LTDTVIVFII LLLWASVSSS ATWRVIHGWL IISSLLLLFV FSFIYLGEVF 60
KTYNVAMDYI TLALMIWNFG VVGMICIHWK GPLRLQQAYL IMISALMALV FIKYLPEWTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGTACAGC GCCTGGCACA TGGGAAGCGC TTAACAGATA CCGTCATCGT CTTCATCATC 60
CTTCTTCTCT GGGCCTCAGT TTCCTCATCT GCAACATGGA GAGTCAGCAG ATACCCCTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	36.39	2.00e-25	110.00
IUUC-Aml-001648	Ailuropoda melanoleuca	85.62	2.00e-134	471.00
IUUC-Atr-003039	Amborella trichopoda	33.63	2.00e-30	125.00
IUUC-Apl-003727	Anas platyrhynchos	89.03	4.00e-137	480.00
IUUC-Aca-004582	Anolis carolinensis	86.41	2.00e-137	481.00
IUUC-Aly-005455	Arabidopsis lyrata	58.82	3.00e-17	82.00
IUUC-Ath-006730	Arabidopsis thaliana	60.00	4.00e-18	85.50
IUUC-Ame-011500	Astyanax mexicanus	78.53	8.00e-113	399.00
IUUC-Bta-013026	Bos taurus	85.27	4.00e-136	477.00
IUUC-Bdi-014196	Brachypodium distachyon	34.23	6.00e-28	118.00
IUUC-Bol-015841	Brassica oleracea	34.84	2.00e-30	125.00
IUUC-Bra-017580	Brassica rapa	53.92	2.00e-17	83.20
IUUC-Cja-019994	Callithrix jacchus	87.38	5.00e-134	470.00
IUUC-Cfa-020074	Canis familiaris	88.35	3.00e-136	478.00
IUUC-Cpo-022237	Cavia porcellus	87.06	1.00e-134	471.00
IUUC-Csa-023537	Chlorocebus sabaeus	87.38	1.00e-135	475.00
IUUC-Cho-024735	Choloepus hoffmanni	84.15	7.00e-124	436.00
IUUC-Csv-025967	Ciona savignyi	58.17	1.00e-89	322.00
IUUC-Dre-028689	Danio rerio	75.79	6.00e-110	390.00
IUUC-Dno-029758	Dasypus novemcinctus	87.06	9.00e-136	476.00
IUUC-Dor-030609	Dipodomys ordii	70.68	1.00e-108	386.00
IUUC-Dme-031929	Drosophila melanogaster	53.31	2.00e-82	299.00
IUUC-Ete-032487	Echinops telfairi	76.67	7.00e-75	273.00
IUUC-Eca-033391	Equus caballus	67.85	6.00e-108	383.00
IUUC-Eeu-035134	Erinaceus europaeus	86.32	7.00e-132	462.00
IUUC-Fca-036243	Felis catus	88.67	4.00e-137	480.00
IUUC-Fal-036600	Ficedula albicollis	88.67	1.00e-137	482.00
IUUC-Gmo-039665	Gadus morhua	72.35	4.00e-99	354.00
IUUC-Gga-040993	Gallus gallus	89.00	9.00e-139	486.00
IUUC-Gma-043822	Glycine max	38.72	3.00e-23	102.00
IUUC-Ggo-044859	Gorilla gorilla	83.03	8.00e-97	346.00
IUUC-Hsa-046822	Homo sapiens	87.38	1.00e-135	475.00
IUUC-Hvu-047141	Hordeum vulgare	36.27	4.00e-27	115.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	86.73	3.00e-134	470.00
IUUC-Lch-049946	Latimeria chalumnae	71.29	1.00e-98	352.00
IUUC-Lpe-051132	Leersia perrieri	33.63	2.00e-27	115.00
IUUC-Laf-053979	Loxodonta africana	84.52	7.00e-124	436.00
IUUC-Mcc-055682	Macaca mulatta	87.38	1.00e-135	475.00
IUUC-Meu-056004	Macropus eugenii	75.35	1.00e-108	385.00
IUUC-Mtr-058392	Medicago truncatula	39.13	2.00e-22	99.80
IUUC-Mga-059466	Meleagris gallopavo	88.67	3.00e-138	484.00
IUUC-Mdo-062122	Monodelphis domestica	88.39	2.00e-138	485.00
IUUC-Mmu-063176	Mus musculus	85.76	1.00e-126	445.00
IUUC-Mac-064858	Musa acuminata	37.95	1.00e-20	93.20
IUUC-Mpu-065927	Mustela putorius furo	87.38	5.00e-135	473.00
IUUC-Mlu-067079	Myotis lucifugus	82.52	6.00e-135	473.00
IUUC-Nle-070180	Nomascus leucogenys	87.38	1.00e-135	475.00
IUUC-Opr-070847	Ochotona princeps	80.00	1.00e-118	419.00
IUUC-Ont-071846	Oreochromis niloticus	75.24	2.00e-114	405.00
IUUC-Ocu-074527	Oryctolagus cuniculus	87.42	3.00e-135	474.00
IUUC-Oba-075256	Oryza barthii	32.33	4.00e-24	105.00
IUUC-Obr-076302	Oryza brachyantha	50.89	5.00e-16	78.60
IUUC-Ogl-077097	Oryza glaberrima	32.33	8.00e-24	104.00
IUUC-Ogu-078570	Oryza glumaepatula	32.33	7.00e-24	104.00
IUUC-Oin-079244	Oryza indica	61.73	5.00e-16	78.60
IUUC-Olo-080484	Oryza longistaminata	61.73	2.00e-16	79.00
IUUC-Ome-081814	Oryza meridionalis	33.33	1.00e-26	113.00
IUUC-Oni-082057	Oryza nivara	61.73	5.00e-16	78.20
IUUC-Opu-084176	Oryza punctata	61.73	4.00e-16	78.60
IUUC-Oru-084618	Oryza rufipogon	32.33	9.00e-24	103.00
IUUC-Osa-085602	Oryza sativa	32.33	7.00e-24	104.00
IUUC-Olu-087811	Ostreococcus lucimarinus	36.30	4.00e-36	144.00
IUUC-Oar-090348	Ovis aries	87.06	3.00e-136	478.00
IUUC-Ptr-091060	Pan troglodytes	87.38	1.00e-135	475.00
IUUC-Pan-091855	Papio anubis	77.67	6.00e-111	393.00
IUUC-Psi-093505	Pelodiscus sinensis	89.64	6.00e-139	486.00
IUUC-Pfo-097396	Poecilia formosa	75.47	7.00e-121	426.00
IUUC-Pab-098591	Pongo abelii	87.38	1.00e-135	475.00
IUUC-Pop-099661	Populus trichocarpa	37.72	1.00e-26	113.00
IUUC-Pca-101029	Procavia capensis	85.26	1.00e-131	462.00
IUUC-Ppe-101495	Prunus persica	34.14	5.00e-24	105.00
IUUC-Pva-102244	Pteropus vampyrus	73.75	1.00e-116	412.00
IUUC-Ptt-103917	Puccinia triticina	55.56	1.60e-01	26.60
IUUC-Rno-105861	Rattus norvegicus	85.16	6.00e-124	436.00
IUUC-Sha-107045	Sarcophilus harrisii	88.06	1.00e-137	482.00
IUUC-Smo-109325	Selaginella moellendorffii	38.38	6.00e-36	144.00
IUUC-Sit-110624	Setaria italica	34.27	2.00e-25	110.00
IUUC-Sly-110865	Solanum lycopersicum	55.56	2.00e-07	47.00
IUUC-Stu-112433	Solanum tuberosum	35.62	3.00e-28	118.00
IUUC-Sar-113169	Sorex araneus	81.16	2.00e-122	431.00
IUUC-Sbi-114305	Sorghum bicolor	32.59	2.00e-24	105.00
IUUC-Ssc-115766	Sus scrofa	87.38	2.00e-134	471.00
IUUC-Tgu-116469	Taeniopygia guttata	89.00	1.00e-137	481.00
IUUC-Tru-117732	Takifugu rubripes	75.86	8.00e-116	409.00
IUUC-Tsy-119624	Tarsius syrichta	81.82	3.00e-114	404.00
IUUC-Tni-119852	Tetraodon nigroviridis	71.38	1.00e-108	385.00
IUUC-Tca-121865	Theobroma cacao	35.83	3.00e-31	128.00
IUUC-Tae-123984	Triticum aestivum	36.30	1.00e-26	113.00
IUUC-Tur-126237	Triticum urartu	36.72	9.00e-27	114.00
IUUC-Tbe-128148	Tupaia belangeri	82.90	2.00e-92	332.00
IUUC-Ttr-128793	Tursiops truncatus	87.70	2.00e-134	471.00
IUUC-Vpa-130625	Vicugna pacos	78.83	2.00e-114	405.00
IUUC-Vvi-131312	Vitis vinifera	36.31	2.00e-30	126.00
IUUC-Xtr-131790	Xenopus tropicalis	83.23	7.00e-118	416.00
IUUC-Xma-133377	Xiphophorus maculatus	76.77	2.00e-118	418.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence