iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091742

Ensembl Protein ID

ENSPANP00000002208.1

UniProt Accession

A0A096MR14; A0A096MR14_PAPAN

Genbank Protein ID

ENSPANP00000002208

Protein Name

Presenilin

Genbank Nucleotide ID

AHZZ01076344

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000015683.1	ENSPANT00000024828.1	ENSPANP00000002208.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.30e-08	33.5	278	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP

Organism

Papio anubis

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPTPRS CQEGRQGPED GENIAQWRSQ ENEEDGEEDP 60
DRYVCSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGAACC TGAGAGCATC CCAAAGAGAC GATTGCAGAC TAAACTCTAT GGAGTAACTT 60
GATTAGGACC GACCCCATCT TCCAGTAAGG AGGCCCCTGA TGCCTCTGTA GCCAATTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	56.79	3.00e-15	77.40
IUUC-Aml-002356	Ailuropoda melanoleuca	89.06	0.00e+00	631.00
IUUC-Apl-003959	Anas platyrhynchos	77.02	2.00e-163	568.00
IUUC-Aca-005160	Anolis carolinensis	75.85	1.00e-160	559.00
IUUC-Ang-009768	Aspergillus niger	48.15	3.80e-01	30.00
IUUC-Ame-010686	Astyanax mexicanus	79.43	3.00e-147	514.00
IUUC-Bta-013097	Bos taurus	96.66	0.00e+00	728.00
IUUC-Bdi-014196	Brachypodium distachyon	38.92	7.00e-19	88.60
IUUC-Bra-017580	Brassica rapa	57.47	3.00e-17	82.80
IUUC-Cel-018553	Caenorhabditis elegans	48.69	1.00e-92	333.00
IUUC-Cja-018824	Callithrix jacchus	97.54	0.00e+00	749.00
IUUC-Cfa-020253	Canis familiaris	95.98	0.00e+00	743.00
IUUC-Cpo-021401	Cavia porcellus	95.54	0.00e+00	739.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	5.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	99.55	0.00e+00	775.00
IUUC-Cin-025780	Ciona intestinalis	60.90	2.00e-116	412.00
IUUC-Csv-025967	Ciona savignyi	59.91	2.00e-117	415.00
IUUC-Dre-028526	Danio rerio	70.29	2.00e-144	505.00
IUUC-Dor-031127	Dipodomys ordii	91.74	0.00e+00	687.00
IUUC-Ete-033081	Echinops telfairi	84.04	5.00e-94	338.00
IUUC-Eca-034387	Equus caballus	96.21	0.00e+00	705.00
IUUC-Eeu-034846	Erinaceus europaeus	82.06	9.00e-152	530.00
IUUC-Fca-035396	Felis catus	94.85	0.00e+00	751.00
IUUC-Fal-037457	Ficedula albicollis	76.52	3.00e-161	561.00
IUUC-Gga-040706	Gallus gallus	76.92	3.00e-157	548.00
IUUC-Gac-042511	Gasterosteus aculeatus	65.41	1.00e-129	456.00
IUUC-Ggo-045338	Gorilla gorilla	99.78	0.00e+00	775.00
IUUC-Hsa-046455	Homo sapiens	99.78	0.00e+00	775.00
IUUC-Hvu-047141	Hordeum vulgare	58.02	5.00e-16	79.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	97.10	0.00e+00	754.00
IUUC-Lch-049638	Latimeria chalumnae	69.11	3.00e-147	514.00
IUUC-Lpe-051132	Leersia perrieri	37.68	2.00e-17	84.00
IUUC-Loc-052427	Lepisosteus oculatus	75.39	5.00e-158	550.00
IUUC-Laf-053758	Loxodonta africana	88.98	0.00e+00	736.00
IUUC-Mcc-054755	Macaca mulatta	100.00	0.00e+00	776.00
IUUC-Mtr-058392	Medicago truncatula	33.25	8.00e-30	124.00
IUUC-Mmr-060890	Microcebus murinus	96.21	0.00e+00	748.00
IUUC-Mdo-062197	Monodelphis domestica	81.22	2.00e-178	618.00
IUUC-Mmu-063823	Mus musculus	95.76	0.00e+00	748.00
IUUC-Mac-064858	Musa acuminata	43.27	8.00e-22	97.40
IUUC-Mpu-066181	Mustela putorius furo	95.54	0.00e+00	740.00
IUUC-Nle-069596	Nomascus leucogenys	99.75	0.00e+00	724.00
IUUC-Opr-070344	Ochotona princeps	95.54	0.00e+00	753.00
IUUC-Ont-071867	Oreochromis niloticus	70.56	7.00e-133	467.00
IUUC-Oan-073378	Ornithorhynchus anatinus	75.61	4.00e-157	547.00
IUUC-Ocu-074652	Oryctolagus cuniculus	95.09	0.00e+00	711.00
IUUC-Oba-075256	Oryza barthii	60.49	3.00e-16	79.70
IUUC-Obr-076302	Oryza brachyantha	37.68	2.00e-17	84.00
IUUC-Ogl-077097	Oryza glaberrima	37.68	4.00e-17	82.40
IUUC-Ogu-078570	Oryza glumaepatula	37.68	4.00e-17	82.40
IUUC-Oin-079244	Oryza indica	38.41	3.00e-17	83.20
IUUC-Olo-080484	Oryza longistaminata	60.49	1.00e-16	80.10
IUUC-Ome-081814	Oryza meridionalis	36.87	1.00e-17	84.30
IUUC-Oni-082057	Oryza nivara	38.41	2.00e-17	83.20
IUUC-Opu-084176	Oryza punctata	38.41	5.00e-17	82.40
IUUC-Oru-084618	Oryza rufipogon	38.41	2.00e-17	83.20
IUUC-Osa-085602	Oryza sativa	37.43	1.00e-17	84.30
IUUC-Ola-086707	Oryzias latipes	70.16	2.00e-106	378.00
IUUC-Olu-087811	Ostreococcus lucimarinus	38.44	1.00e-46	180.00
IUUC-Oga-088560	Otolemur garnettii	96.67	0.00e+00	716.00
IUUC-Oar-089200	Ovis aries	96.21	0.00e+00	705.00
IUUC-Ptr-090569	Pan troglodytes	99.55	0.00e+00	773.00
IUUC-Psi-093297	Pelodiscus sinensis	77.10	3.00e-133	468.00
IUUC-Pma-094612	Petromyzon marinus	77.75	2.00e-128	452.00
IUUC-Ppa-095431	Physcomitrella patens	31.78	6.00e-28	118.00
IUUC-Pab-098531	Pongo abelii	99.55	0.00e+00	775.00
IUUC-Pca-101120	Procavia capensis	93.97	0.00e+00	728.00
IUUC-Pva-102934	Pteropus vampyrus	86.61	0.00e+00	695.00
IUUC-Rno-106052	Rattus norvegicus	95.09	0.00e+00	761.00
IUUC-Sha-106876	Sarcophilus harrisii	79.74	2.00e-174	605.00
IUUC-Sit-110624	Setaria italica	58.02	9.00e-16	78.20
IUUC-Sbi-114305	Sorghum bicolor	47.83	4.00e-16	79.30
IUUC-Ssc-115380	Sus scrofa	97.99	0.00e+00	781.00
IUUC-Tgu-117280	Taeniopygia guttata	77.17	6.00e-162	563.00
IUUC-Tae-125925	Triticum aestivum	58.02	5.00e-16	79.00
IUUC-Tur-126237	Triticum urartu	58.02	5.00e-16	78.60
IUUC-Tbe-127632	Tupaia belangeri	97.94	0.00e+00	639.00
IUUC-Ttr-129008	Tursiops truncatus	95.76	0.00e+00	737.00
IUUC-Xtr-132756	Xenopus tropicalis	71.86	2.00e-162	565.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence