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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105237
UUCD1 version UUC-RaN-01082
Ensembl Protein ID ENSRNOP00000002173.5
UniProt Accession Q2KJ09; UBP16_RAT
Genbank Protein ID EDM10641.1; AAI12387.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID CH473989; BC112386
Gene Name Usp16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000001598.6 ENSRNOT00000002173.6 ENSRNOP00000002173.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 8.50e-90 301.7 194 823
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.............kkkeklneenp.........kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e                                  ep g+l+ ++ ++++e++++kk+ 
   Q: 194  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppD---------LalteplevnLEPPGPLTLAMSQFLNEMQENKKRI 273
           5******************************86666666654441.........04444455558899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a +f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk  +s+++++F+g+l+
   Q: 274  VTPKELFSQVCKKATRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEEvknkvKDYEKKKAIPSFVDRIFGGELT 362
           ************************************************************99999999999999999************ PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c +c++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 363  STIMCDDCRTVSLVHESFLDLSLPVLDDQSGKKNindknvkktmeeedkdseeekddsymktrsdvpsgtskhtqkkakkqakkqaknq 451
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 452  rrqqkiqerflhfneicttnytedndheaetalpgegevdtefnrgsqeeltqtelcanqkdvngqeemiesaaderkcpehpevksvs 540
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 541  tesdlgsltsapecprdlngafleertsgelditnglknltlnaavdpdeisieilndshspalkvyevmnedpetafctlanreafst 629
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 630  decSIQHCLYQFTRNEKLQDANKLLCEVCTRRQCngpkanikgerkhvytnAKKQMLVSLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 716
           ******************************888899999999999999999*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k+                        +kg+W++++D++V++
   Q: 717  FPEILDLAPFCTLKCKNVAEestRVLYSLYGVVEHSGTMRSGHYTAYAKErtaschlsnlvlhgdipqdcemesTKGQWFHISDTHVQA 805
           *************9999888888999************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 806  VPITKVLN---SQAYLLFYER 823
           ********...********98 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRTKGKS VPEKASSEST EPMCRHLRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEEAEDPSV WLCLKCGHQG CGRDSQEQHA LKHYTTPRSE PHYLVLSLDN WSVWCYKCDE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105237|DUB,USP|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGGTTCCACC GCGTCGCTCT CTATTCGTCA CCTGGAGGAA GCGGAGCTGG CGGCCGGCTC 60
CGGGCCCGTC GCGGGAGGCA GTTATGGGCG CCGTCTCACC GGGTGAGTAC CGGTCGCGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105237|DUB,USP|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016578--P:histone deubiquitination
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG rno:288306
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 27.99 4.00e-28 120.00
IUUC-Aml-001931 Ailuropoda melanoleuca 82.37 0.00e+00 1268.00
IUUC-Atr-003015 Amborella trichopoda 30.51 4.00e-35 144.00
IUUC-Apl-004145 Anas platyrhynchos 59.98 0.00e+00 877.00
IUUC-Aca-004314 Anolis carolinensis 58.02 0.00e+00 859.00
IUUC-Aly-006422 Arabidopsis lyrata 28.62 9.00e-30 125.00
IUUC-Ath-006732 Arabidopsis thaliana 30.39 2.00e-33 137.00
IUUC-Ame-011659 Astyanax mexicanus 47.95 7.00e-110 391.00
IUUC-Bta-013362 Bos taurus 81.76 0.00e+00 1255.00
IUUC-Bdi-014465 Brachypodium distachyon 29.66 9.00e-28 119.00
IUUC-Bol-015941 Brassica oleracea 29.76 4.00e-33 137.00
IUUC-Bra-016751 Brassica rapa 29.29 7.00e-31 129.00
IUUC-Cja-019177 Callithrix jacchus 83.59 0.00e+00 1308.00
IUUC-Cfa-020051 Canis familiaris 83.21 0.00e+00 1286.00
IUUC-Cpo-021886 Cavia porcellus 74.13 0.00e+00 1184.00
IUUC-Csa-024103 Chlorocebus sabaeus 84.08 0.00e+00 1321.00
IUUC-Cho-024315 Choloepus hoffmanni 70.38 2.00e-116 413.00
IUUC-Cin-025775 Ciona intestinalis 49.65 5.00e-39 152.00
IUUC-Csv-026075 Ciona savignyi 50.95 5.00e-58 218.00
IUUC-Cme-027348 Cyanidioschyzon merolae 37.84 7.00e-20 92.40
IUUC-Dre-028388 Danio rerio 51.33 1.00e-114 407.00
IUUC-Dno-029409 Dasypus novemcinctus 80.43 0.00e+00 1260.00
IUUC-Dor-030443 Dipodomys ordii 73.54 9.00e-171 593.00
IUUC-Ete-032807 Echinops telfairi 76.74 0.00e+00 630.00
IUUC-Eca-033479 Equus caballus 83.09 0.00e+00 1299.00
IUUC-Eeu-034835 Erinaceus europaeus 73.85 3.00e-170 592.00
IUUC-Fca-036320 Felis catus 83.21 0.00e+00 1316.00
IUUC-Fal-037029 Ficedula albicollis 58.21 0.00e+00 810.00
IUUC-Gmo-039480 Gadus morhua 51.48 4.00e-111 395.00
IUUC-Gga-040527 Gallus gallus 60.94 0.00e+00 873.00
IUUC-Gac-042343 Gasterosteus aculeatus 49.41 2.00e-110 393.00
IUUC-Gma-044402 Glycine max 29.52 2.00e-33 137.00
IUUC-Ggo-045598 Gorilla gorilla 83.47 0.00e+00 1308.00
IUUC-Hsa-046598 Homo sapiens 83.21 0.00e+00 1301.00
IUUC-Hvu-047146 Hordeum vulgare 27.95 2.00e-27 117.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 82.51 0.00e+00 1289.00
IUUC-Lch-050536 Latimeria chalumnae 55.10 3.00e-122 432.00
IUUC-Lpe-050703 Leersia perrieri 28.48 7.00e-29 123.00
IUUC-Loc-051814 Lepisosteus oculatus 54.43 3.00e-122 432.00
IUUC-Laf-053732 Loxodonta africana 78.37 0.00e+00 1256.00
IUUC-Mcc-054661 Macaca mulatta 84.32 0.00e+00 1323.00
IUUC-Meu-055967 Macropus eugenii 69.86 3.00e-144 505.00
IUUC-Mtr-057945 Medicago truncatula 31.21 3.00e-34 140.00
IUUC-Mga-059551 Meleagris gallopavo 60.91 0.00e+00 881.00
IUUC-Mvi-060391 Microbotryum violaceum 32.65 6.00e-20 93.20
IUUC-Mmr-061747 Microcebus murinus 84.20 0.00e+00 1290.00
IUUC-Mdo-062220 Monodelphis domestica 66.26 0.00e+00 1009.00
IUUC-Mmu-063582 Mus musculus 91.65 0.00e+00 1421.00
IUUC-Mac-064941 Musa acuminata 33.13 7.00e-38 152.00
IUUC-Mpu-066339 Mustela putorius furo 82.85 0.00e+00 1296.00
IUUC-Mlu-067511 Myotis lucifugus 79.18 0.00e+00 1212.00
IUUC-Nle-069252 Nomascus leucogenys 84.20 0.00e+00 1322.00
IUUC-Opr-070969 Ochotona princeps 80.42 0.00e+00 1217.00
IUUC-Ont-071786 Oreochromis niloticus 49.88 5.00e-112 399.00
IUUC-Ocu-074704 Oryctolagus cuniculus 82.98 0.00e+00 1277.00
IUUC-Oba-075094 Oryza barthii 29.05 5.00e-30 126.00
IUUC-Obr-076743 Oryza brachyantha 30.34 3.00e-31 130.00
IUUC-Ogl-077739 Oryza glaberrima 29.05 4.00e-30 127.00
IUUC-Ogu-078851 Oryza glumaepatula 29.05 6.00e-30 126.00
IUUC-Oin-079402 Oryza indica 29.05 6.00e-30 126.00
IUUC-Olo-080431 Oryza longistaminata 29.05 5.00e-30 126.00
IUUC-Ome-081580 Oryza meridionalis 29.05 8.00e-30 126.00
IUUC-Oni-082644 Oryza nivara 29.05 6.00e-30 126.00
IUUC-Opu-083452 Oryza punctata 28.17 1.00e-29 125.00
IUUC-Oru-084546 Oryza rufipogon 29.05 6.00e-30 126.00
IUUC-Osa-085858 Oryza sativa 29.05 5.00e-30 126.00
IUUC-Oga-088713 Otolemur garnettii 82.75 0.00e+00 1291.00
IUUC-Oar-089887 Ovis aries 82.39 0.00e+00 1263.00
IUUC-Ptr-091670 Pan troglodytes 83.23 0.00e+00 1305.00
IUUC-Pan-092293 Papio anubis 84.32 0.00e+00 1323.00
IUUC-Psi-093101 Pelodiscus sinensis 64.92 0.00e+00 897.00
IUUC-Ppa-095622 Physcomitrella patens 30.52 7.00e-36 146.00
IUUC-Pfo-097202 Poecilia formosa 51.18 5.00e-111 395.00
IUUC-Pab-098773 Pongo abelii 83.13 0.00e+00 1032.00
IUUC-Pop-099136 Populus trichocarpa 29.61 3.00e-39 157.00
IUUC-Pca-101069 Procavia capensis 65.91 0.00e+00 790.00
IUUC-Ppe-101794 Prunus persica 31.66 1.00e-36 148.00
IUUC-Pva-103092 Pteropus vampyrus 75.33 1.00e-168 587.00
IUUC-Sha-106889 Sarcophilus harrisii 69.89 0.00e+00 1068.00
IUUC-Sit-110283 Setaria italica 30.52 6.00e-28 120.00
IUUC-Sly-111491 Solanum lycopersicum 28.33 8.00e-36 145.00
IUUC-Stu-112820 Solanum tuberosum 29.41 1.00e-38 155.00
IUUC-Sar-113530 Sorex araneus 76.99 0.00e+00 1186.00
IUUC-Sbi-113785 Sorghum bicolor 38.06 2.00e-24 108.00
IUUC-Ssc-116091 Sus scrofa 80.79 0.00e+00 1252.00
IUUC-Tgu-117478 Taeniopygia guttata 58.47 0.00e+00 826.00
IUUC-Tru-118640 Takifugu rubripes 52.43 3.00e-115 409.00
IUUC-Tsy-119042 Tarsius syrichta 70.69 0.00e+00 806.00
IUUC-Tca-121701 Theobroma cacao 29.22 3.00e-38 154.00
IUUC-Tae-125785 Triticum aestivum 28.17 3.00e-26 114.00
IUUC-Tur-126788 Triticum urartu 27.86 5.00e-26 113.00
IUUC-Tbe-127309 Tupaia belangeri 69.80 0.00e+00 981.00
IUUC-Ttr-128271 Tursiops truncatus 80.31 0.00e+00 1268.00
IUUC-Vpa-130674 Vicugna pacos 79.97 0.00e+00 1160.00
IUUC-Xtr-131869 Xenopus tropicalis 49.43 0.00e+00 706.00
IUUC-Xma-134195 Xiphophorus maculatus 51.42 5.00e-113 402.00
IUUC-Zma-135157 Zea mays 29.72 5.00e-27 117.00
Created Date 25-Jun-2017

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