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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045780
UUCD1 version UUC-HoS-00467
Ensembl Protein ID ENSP00000463650.1
UniProt Accession Q9Y4L5; A8K3Y4; Q5T2V9; Q7Z2J2; RN115_HUMAN
Genbank Protein ID AAQ09535.1; AAP97292.1; BAF83438.1; CAI13717.1; CAI13717.1; EAW71437.1; AAH54049.1; AAH64903.1; CAB45280.1
Protein Name E3 ubiquitin-protein ligase RNF115; RING finger protein 115; RING-type E3 ubiquitin transferase RNF115; Rabring 7; Zinc finger protein 364
Genbank Nucleotide ID AF542552; AF419857; AK290749; AL390725; AL160282; CH471244; BC054049; BC064903; AL079314
Gene Name RNF115; ZNF364
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000265491.4 ENST00000582693.4 ENSP00000463650.1
Annotation
Cancer Mutation
TCGACOSMICCGAPIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOTCGAICGCCOSMIC
THPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17462600; 18819927; 21179390
UBD/ZnF/Other UBD/ZnF/Other 23418353
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.70e-09 37.8 228 269
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+ed+  +++++ lpC+H+fh +C+  w         +++CP+Cr
   Q: 228  CPVCKEDYtvEEEVRQLPCNHFFHSSCIVPW------LELHDTCPVCR 269
           ********99777******************......**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
 E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
Protein Sequence
(Fasta)
MAEASAAGAD SGAAVAAHRF FCHFCKGEVS PKLPEYICPR CESGFIEEVT DDSSFLGGGG 60
SRIDNTTTTH FAELWGHLDH TMFFQDFRPF LSSSPLDQDN RANERGHQTH TDFWGARPPR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045780|E3,RING;UBD,UBD/ZnF/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCTTTGGTGC TGGGAGGCGG GCCGCAGGGT AGCTGTTGGC GCCGCCGCGT TTCTGGGCCT 60
GGCCAACTCA CGTGACCGAC GCGGGCTCTG AAGCGGTGGG CCGCACCGAG GCGGCGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045780|E3,RING;UBD,UBD/ZnF/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG hsa:27246
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000079 Aegilops tauschii 30.32 3.00e-24 105.00
IUUC-Aml-002035 Ailuropoda melanoleuca 93.75 2.00e-148 518.00
IUUC-Apl-003694 Anas platyrhynchos 89.16 1.00e-79 289.00
IUUC-Aca-004365 Anolis carolinensis 77.98 9.00e-44 168.00
IUUC-Acl-008247 Aspergillus clavatus 37.33 3.00e-19 89.70
IUUC-Ate-010398 Aspergillus terreus 38.66 1.00e-18 87.80
IUUC-Ame-011898 Astyanax mexicanus 53.52 1.00e-71 263.00
IUUC-Bta-013190 Bos taurus 81.94 3.00e-122 431.00
IUUC-Bci-013958 Botrytis cinerea 37.14 2.00e-17 84.30
IUUC-Bol-016085 Brassica oleracea 41.18 5.00e-28 119.00
IUUC-Bra-016939 Brassica rapa 31.79 3.00e-28 119.00
IUUC-Cja-020001 Callithrix jacchus 95.47 2.00e-151 528.00
IUUC-Cfa-020882 Canis familiaris 93.73 8.00e-148 516.00
IUUC-Cpo-021690 Cavia porcellus 80.22 3.00e-114 404.00
IUUC-Csa-024004 Chlorocebus sabaeus 98.61 9.00e-154 536.00
IUUC-Cho-024643 Choloepus hoffmanni 92.55 3.00e-80 291.00
IUUC-Cin-025452 Ciona intestinalis 39.50 7.00e-19 86.30
IUUC-Csv-025892 Ciona savignyi 36.51 7.00e-21 92.80
IUUC-Dre-027515 Danio rerio 58.68 3.00e-81 295.00
IUUC-Dno-029010 Dasypus novemcinctus 93.40 7.00e-148 516.00
IUUC-Dor-030147 Dipodomys ordii 84.13 1.00e-127 448.00
IUUC-Dse-031376 Dothistroma septosporum 33.57 1.00e-17 84.30
IUUC-Dme-031601 Drosophila melanogaster 54.55 9.00e-35 140.00
IUUC-Ete-032392 Echinops telfairi 90.06 1.00e-78 286.00
IUUC-Eca-033803 Equus caballus 92.62 2.00e-135 475.00
IUUC-Eeu-034831 Erinaceus europaeus 74.74 1.00e-95 343.00
IUUC-Fca-036192 Felis catus 93.40 4.00e-156 543.00
IUUC-Gmo-039513 Gadus morhua 59.56 4.00e-88 317.00
IUUC-Gga-040282 Gallus gallus 79.41 3.00e-76 277.00
IUUC-Ggo-044873 Gorilla gorilla 99.30 2.00e-154 538.00
IUUC-Itr-048142 Ictidomys tridecemlineatus 91.88 2.00e-138 484.00
IUUC-Lch-050673 Latimeria chalumnae 75.78 1.00e-121 429.00
IUUC-Laf-054384 Loxodonta africana 87.50 6.00e-137 479.00
IUUC-Mcc-055137 Macaca mulatta 98.61 9.00e-154 536.00
IUUC-Meu-056635 Macropus eugenii 85.98 4.00e-113 400.00
IUUC-Mtr-058295 Medicago truncatula 30.34 3.00e-24 106.00
IUUC-Mla-058832 Melampsora laricipopulina 46.84 1.00e-14 72.80
IUUC-Mmr-060631 Microcebus murinus 94.79 9.00e-159 552.00
IUUC-Mdo-062489 Monodelphis domestica 87.85 1.00e-127 448.00
IUUC-Mmu-064196 Mus musculus 93.06 6.00e-156 543.00
IUUC-Mac-065133 Musa acuminata 44.25 2.00e-26 112.00
IUUC-Mpu-066575 Mustela putorius furo 93.75 2.00e-156 545.00
IUUC-Mlu-067024 Myotis lucifugus 87.08 2.00e-136 478.00
IUUC-Nle-069348 Nomascus leucogenys 97.56 5.00e-150 523.00
IUUC-Opr-070812 Ochotona princeps 86.46 1.00e-141 495.00
IUUC-Ont-072238 Oreochromis niloticus 46.84 2.00e-61 228.00
IUUC-Ocu-074691 Oryctolagus cuniculus 94.79 2.00e-145 508.00
IUUC-Oin-079595 Oryza indica 50.00 3.00e-21 97.40
IUUC-Ola-087047 Oryzias latipes 61.72 1.00e-90 325.00
IUUC-Oga-089111 Otolemur garnettii 92.73 6.00e-140 489.00
IUUC-Oar-089999 Ovis aries 81.94 1.00e-122 433.00
IUUC-Ptr-091473 Pan troglodytes 98.95 7.00e-154 536.00
IUUC-Pan-092618 Papio anubis 85.37 2.00e-124 438.00
IUUC-Psi-093930 Pelodiscus sinensis 81.38 7.00e-114 403.00
IUUC-Pma-094530 Petromyzon marinus 47.19 3.00e-59 221.00
IUUC-Pno-094903 Phaeosphaeria nodorum 41.88 6.00e-18 85.50
IUUC-Pfo-096461 Poecilia formosa 69.09 2.00e-64 239.00
IUUC-Pab-098466 Pongo abelii 99.30 9.00e-155 539.00
IUUC-Pca-100550 Procavia capensis 73.61 1.00e-106 379.00
IUUC-Pva-102881 Pteropus vampyrus 89.58 3.00e-142 497.00
IUUC-Rno-104914 Rattus norvegicus 93.40 2.00e-156 544.00
IUUC-Sha-107616 Sarcophilus harrisii 87.45 3.00e-115 407.00
IUUC-Sja-107922 Schizosaccharomyces japonicus 41.04 7.00e-24 105.00
IUUC-Spo-108354 Schizosaccharomyces pombe 36.08 3.00e-26 113.00
IUUC-Smo-109522 Selaginella moellendorffii 51.43 5.00e-20 88.60
IUUC-Sar-113319 Sorex araneus 70.37 3.00e-61 228.00
IUUC-Sre-115230 Sporisorium reilianum 38.79 1.00e-17 85.10
IUUC-Ssc-115917 Sus scrofa 83.33 1.00e-127 449.00
IUUC-Tgu-117105 Taeniopygia guttata 90.55 4.00e-67 246.00
IUUC-Tru-118087 Takifugu rubripes 48.71 1.00e-60 226.00
IUUC-Tsy-119630 Tarsius syrichta 84.56 5.00e-133 466.00
IUUC-Tni-120265 Tetraodon nigroviridis 63.79 2.00e-94 338.00
IUUC-Tae-124758 Triticum aestivum 49.50 9.00e-22 97.80
IUUC-Tur-126410 Triticum urartu 42.31 8.00e-15 73.90
IUUC-Tme-127143 Tuber melanosporum 47.75 5.00e-28 118.00
IUUC-Tbe-127794 Tupaia belangeri 71.31 4.00e-94 337.00
IUUC-Ttr-129117 Tursiops truncatus 81.25 1.00e-116 412.00
IUUC-Uma-129414 Ustilago maydis 36.67 1.00e-17 85.10
IUUC-Vpa-130755 Vicugna pacos 80.81 3.00e-110 390.00
IUUC-Xtr-132520 Xenopus tropicalis 72.99 7.00e-97 346.00
IUUC-Xma-133074 Xiphophorus maculatus 68.48 4.00e-64 238.00
Created Date 25-Jun-2017

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