iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062014

UUCD1 version

UUC-MoD-00522

Ensembl Protein ID

ENSMODP00000023757.3

UniProt Accession

F7BKV5; F7BKV5_MONDO

Protein Name

Uncharacterized protein

Gene Name

UBR2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000019037.3	ENSMODT00000024180.3	ENSMODP00000023757.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/N-recognin/N-domain	1.10e-39	134.6	227	302
E3 activity/RING/RING	1.90e-09	38.1	1108	1213
E3 activity/N-recognin/UBR-box	1.10e-30	106.1	97	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v++Gd+++ce+ak++i++n++++++ pLkV+v
   Q: 227  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRNTSRQTK-PLKVQV 302
           9*********************************************************************.****98 PP

E3 activity/RING/RING

   S: 1    CaiC......................................ledf........kdgplvlpCgHvfhadClqkw............ 29
           C++C                                      +           ++g+++++CgH++ha+C+q++            
   Q: 1108 CILCqeeqevkvdnkamvlaafvqrstvlsknrnkfiqdpekY--DplfmhpdlSCGTHTGSCGHIMHAHCWQRYfdavqakeqrrq 1192
           8888444333333333333333333333333333333333321..02344444455899**************************** PP
   S: 30   .....pglknssskefrCPlC 45
                + +++++++ef+CPlC
   Q: 1193 qrlrvHTSYDVENGEFLCPLC 1213
           ********************* PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkl 70
           +lCgrvfkvge +y+Cr+C+vd+t+vlC+eCf  ++H++H+y++++sggggfCdCGdteAw++g++C k+
   Q: 97   HLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHREHRYRMTTSGGGGFCDCGDTEAWKEGPYCTKH 166
           68*****************************************************************998 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MASELEPEVQ AIDRSLLECS AEETAGKWLQ ATDLTREVYQ HLAHYVPKIY CRGPNPAPQR 60
EDMLAQHVLL GPMEWYLCGE DPAFGFPKLE QANKPSHLCG RVFKVGEPTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCCATCTA TAAGTATTTA TTAAACGTCT ATTATTGCTC GACATTGATG ATTCAAAGAC 60
AAAAAAAGAA ACAGTTTCTG GTCTTTTGGG TGGAAACACT CGTACACATA TGAATAAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0007141--P:male meiosis I
GO:0032007--P:negative regulation of TOR signaling
GO:0007283--P:spermatogenesis
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	26.48	3.00e-21	98.20
IUUC-Aml-001876	Ailuropoda melanoleuca	80.62	0.00e+00	2592.00
IUUC-Atr-002501	Amborella trichopoda	29.37	3.00e-28	121.00
IUUC-Apl-003828	Anas platyrhynchos	89.28	0.00e+00	3127.00
IUUC-Aca-005189	Anolis carolinensis	88.43	0.00e+00	3121.00
IUUC-Aly-005901	Arabidopsis lyrata	31.46	2.00e-25	112.00
IUUC-Ath-007148	Arabidopsis thaliana	30.05	4.00e-24	108.00
IUUC-Ago-007946	Ashbya gossypii	22.30	1.00e-24	109.00
IUUC-Afl-008479	Aspergillus flavus	24.12	7.00e-48	187.00
IUUC-Afu-008929	Aspergillus fumigatus	24.77	1.00e-56	216.00
IUUC-Ang-009550	Aspergillus niger	24.29	2.00e-48	189.00
IUUC-Aor-010124	Aspergillus oryzae	24.12	8.00e-48	187.00
IUUC-Ame-011917	Astyanax mexicanus	74.47	0.00e+00	2512.00
IUUC-Bta-012768	Bos taurus	88.33	0.00e+00	3103.00
IUUC-Bdi-014635	Brachypodium distachyon	25.43	5.00e-31	130.00
IUUC-Bol-015669	Brassica oleracea	30.39	1.00e-29	126.00
IUUC-Bra-017776	Brassica rapa	30.39	3.00e-30	128.00
IUUC-Cel-018476	Caenorhabditis elegans	30.70	5.00e-81	297.00
IUUC-Cja-019797	Callithrix jacchus	90.32	0.00e+00	2475.00
IUUC-Cfa-020950	Canis familiaris	92.14	0.00e+00	3220.00
IUUC-Cpo-022385	Cavia porcellus	88.89	0.00e+00	3145.00
IUUC-Csa-024082	Chlorocebus sabaeus	91.79	0.00e+00	3209.00
IUUC-Cho-025029	Choloepus hoffmanni	84.07	0.00e+00	2114.00
IUUC-Cin-025148	Ciona intestinalis	35.88	4.00e-137	482.00
IUUC-Dre-028343	Danio rerio	73.49	0.00e+00	2522.00
IUUC-Dno-030002	Dasypus novemcinctus	88.56	0.00e+00	1882.00
IUUC-Dor-030207	Dipodomys ordii	76.98	0.00e+00	1538.00
IUUC-Dse-031531	Dothistroma septosporum	24.37	6.00e-56	214.00
IUUC-Dme-031910	Drosophila melanogaster	33.63	0.00e+00	679.00
IUUC-Ete-033162	Echinops telfairi	82.66	0.00e+00	1353.00
IUUC-Eca-033454	Equus caballus	90.09	0.00e+00	3154.00
IUUC-Eeu-034783	Erinaceus europaeus	74.39	0.00e+00	1455.00
IUUC-Fca-036588	Felis catus	91.52	0.00e+00	3194.00
IUUC-Fal-036919	Ficedula albicollis	89.40	0.00e+00	3066.00
IUUC-Fox-037984	Fusarium oxysporum	24.89	9.00e-40	160.00
IUUC-Fso-038463	Fusarium solani	24.67	1.00e-43	173.00
IUUC-Gmo-039698	Gadus morhua	70.43	0.00e+00	1632.00
IUUC-Ggr-040070	Gaeumannomyces graminis	24.33	2.00e-46	182.00
IUUC-Gga-041123	Gallus gallus	90.43	0.00e+00	3186.00
IUUC-Gac-042622	Gasterosteus aculeatus	66.93	0.00e+00	2215.00
IUUC-Gma-043622	Glycine max	29.68	4.00e-25	111.00
IUUC-Ggo-045583	Gorilla gorilla	90.31	0.00e+00	3175.00
IUUC-Hsa-046343	Homo sapiens	90.83	0.00e+00	3173.00
IUUC-Hvu-047707	Hordeum vulgare	28.37	2.00e-21	99.00
IUUC-Kpa-049088	Komagataella pastoris	23.00	3.00e-45	177.00
IUUC-Lch-049649	Latimeria chalumnae	76.23	0.00e+00	2625.00
IUUC-Lpe-051516	Leersia perrieri	26.09	3.00e-31	131.00
IUUC-Loc-052818	Lepisosteus oculatus	76.37	0.00e+00	2667.00
IUUC-Lma-053059	Leptosphaeria maculans	23.47	3.00e-50	194.00
IUUC-Laf-054142	Loxodonta africana	89.70	0.00e+00	3162.00
IUUC-Mcc-055677	Macaca mulatta	91.45	0.00e+00	3190.00
IUUC-Meu-056204	Macropus eugenii	71.68	0.00e+00	776.00
IUUC-Mor-057051	Magnaporthe oryzae	23.23	7.00e-49	190.00
IUUC-Mpo-057372	Magnaporthe poae	26.16	2.00e-48	188.00
IUUC-Mtr-058538	Medicago truncatula	29.68	7.00e-27	117.00
IUUC-Mla-058963	Melampsora laricipopulina	25.00	9.00e-55	209.00
IUUC-Mga-059698	Meleagris gallopavo	90.81	0.00e+00	3159.00
IUUC-Mvi-060535	Microbotryum violaceum	25.46	9.00e-49	189.00
IUUC-Mmr-060901	Microcebus murinus	88.89	0.00e+00	3096.00
IUUC-Mmu-063699	Mus musculus	86.61	0.00e+00	3042.00
IUUC-Mpu-066153	Mustela putorius furo	91.91	0.00e+00	3214.00
IUUC-Mlu-068151	Myotis lucifugus	89.12	0.00e+00	3105.00
IUUC-Nfi-068403	Neosartorya fischeri	24.39	2.00e-55	212.00
IUUC-Ncr-068864	Neurospora crassa	23.61	1.00e-43	172.00
IUUC-Nle-069529	Nomascus leucogenys	91.74	0.00e+00	3211.00
IUUC-Opr-071107	Ochotona princeps	83.97	0.00e+00	1286.00
IUUC-Ont-072189	Oreochromis niloticus	66.12	0.00e+00	2190.00
IUUC-Oan-072893	Ornithorhynchus anatinus	91.91	0.00e+00	3218.00
IUUC-Ocu-074082	Oryctolagus cuniculus	88.86	0.00e+00	3117.00
IUUC-Obr-076117	Oryza brachyantha	25.41	1.00e-26	117.00
IUUC-Ome-081738	Oryza meridionalis	22.20	3.00e-14	75.50
IUUC-Opu-083202	Oryza punctata	26.26	4.00e-27	117.00
IUUC-Ola-087460	Oryzias latipes	65.28	0.00e+00	2164.00
IUUC-Oga-088432	Otolemur garnettii	89.18	0.00e+00	3147.00
IUUC-Oar-090206	Ovis aries	88.72	0.00e+00	3131.00
IUUC-Ptr-091180	Pan troglodytes	90.66	0.00e+00	3175.00
IUUC-Pan-092375	Papio anubis	91.51	0.00e+00	3204.00
IUUC-Psi-093049	Pelodiscus sinensis	90.10	0.00e+00	3133.00
IUUC-Pno-094877	Phaeosphaeria nodorum	22.62	1.00e-41	166.00
IUUC-Pfo-096524	Poecilia formosa	64.09	0.00e+00	2050.00
IUUC-Pab-097989	Pongo abelii	89.97	0.00e+00	3124.00
IUUC-Pca-100207	Procavia capensis	75.96	0.00e+00	1192.00
IUUC-Ppe-101802	Prunus persica	28.52	2.00e-25	112.00
IUUC-Pva-102538	Pteropus vampyrus	87.48	0.00e+00	1144.00
IUUC-Pgr-103372	Puccinia graminis	24.68	4.00e-51	197.00
IUUC-Ptt-103878	Puccinia triticina	24.65	5.00e-48	187.00
IUUC-Rno-105567	Rattus norvegicus	86.62	0.00e+00	2997.00
IUUC-Sce-106272	Saccharomyces cerevisiae	20.96	5.00e-25	111.00
IUUC-Sha-106980	Sarcophilus harrisii	97.58	0.00e+00	3297.00
IUUC-Sja-107980	Schizosaccharomyces japonicus	23.56	5.00e-48	187.00
IUUC-Spo-108183	Schizosaccharomyces pombe	25.26	7.00e-53	203.00
IUUC-Smo-108719	Selaginella moellendorffii	32.26	6.00e-30	127.00
IUUC-Sit-110716	Setaria italica	25.50	5.00e-31	131.00
IUUC-Sly-111701	Solanum lycopersicum	29.37	1.00e-25	113.00
IUUC-Sar-113332	Sorex araneus	84.05	0.00e+00	2113.00
IUUC-Sbi-114577	Sorghum bicolor	28.17	5.00e-30	127.00
IUUC-Sre-115045	Sporisorium reilianum	26.35	3.00e-46	181.00
IUUC-Ssc-115525	Sus scrofa	91.58	0.00e+00	2479.00
IUUC-Tgu-116943	Taeniopygia guttata	90.38	0.00e+00	3173.00
IUUC-Tru-117673	Takifugu rubripes	66.29	0.00e+00	2202.00
IUUC-Tsy-119032	Tarsius syrichta	90.13	0.00e+00	1790.00
IUUC-Tni-119987	Tetraodon nigroviridis	65.66	0.00e+00	2149.00
IUUC-Tca-121077	Theobroma cacao	32.70	3.00e-26	115.00
IUUC-Tvi-122272	Trichoderma virens	23.66	1.00e-56	216.00
IUUC-Tur-126562	Triticum urartu	28.21	1.00e-27	119.00
IUUC-Tme-127156	Tuber melanosporum	23.98	2.00e-52	202.00
IUUC-Tbe-128103	Tupaia belangeri	83.42	0.00e+00	1193.00
IUUC-Ttr-128253	Tursiops truncatus	92.02	0.00e+00	2111.00
IUUC-Uma-129344	Ustilago maydis	26.39	9.00e-52	200.00
IUUC-Vda-129778	Verticillium dahliae	22.73	6.00e-55	210.00
IUUC-Vpa-130540	Vicugna pacos	86.52	0.00e+00	2826.00
IUUC-Vvi-131290	Vitis vinifera	32.08	6.00e-27	117.00
IUUC-Xtr-132690	Xenopus tropicalis	82.24	0.00e+00	2904.00
IUUC-Xma-133748	Xiphophorus maculatus	64.77	0.00e+00	2032.00
IUUC-Yli-134662	Yarrowia lipolytica	24.30	1.00e-29	126.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence