iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-009103

Ensembl Protein ID

CADAFUAP00006994

UniProt Accession

Q4WTF3; RSP5_ASPFU

Genbank Protein ID

EAL90279.1

Protein Name

Probable E3 ubiquitin-protein ligase hulA; HECT ubiquitin ligase A; HECT-type E3 ubiquitin transferase hulA

Genbank Nucleotide ID

AAHF01000004

Gene Name

AFUA_1G09500; hulA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00006994	CADAFUAT00006994	CADAFUAP00006994

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-126	420.5	505	836

Active Site

Position(s)	Description	Evidence
781	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsk 94
           +sdlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld ++  
   Q: 505  ASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGV-NPEHLNYFKFIGRVVGLAIFHRRFLDSFFIG 596
           689*********************************************************9.89***************************** PP
   S: 95   sfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegik 187
           +fyk++l+kk+sl+d+e vd++l+++l++ ++n   die   l+ltfsv++e++ge+++ +LkpgG++ipVtneNk eYv+lv+e+++ ++++
   Q: 597  AFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLDN---DIEGV-LELTFSVDDEKFGERRTIDLKPGGRDIPVTNENKAEYVELVTEWKIVKRVE 685
           *******************************99...9***8.*************************************************** PP
   S: 188  eqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfa 280
           eq++af +Gfne+ip +l+++F+e+elelli G ++idv+d+kk+t y+g y+e++++iq+Fw++++++++e+++++LqF+Tg+sr+P++Gf+
   Q: 686  EQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRG-YQESDEVIQNFWKIVRSWDAEQKSRLLQFTTGTSRIPVNGFK 777
           ************************************************76.****************************************** PP
   S: 281  elk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +l+    pr+f+i+k+++++ lP+s+TCfn+L+LP+Y+s+e+l++k+ +A+eet gF++
   Q: 778  DLQgsdgPRRFTIEKSGDPAALPKSHTCFNRLDLPPYKSYETLEHKMSIAVEETLGFGQ 836
           *********************************************************86 PP

Organism

Aspergillus fumigatus

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.

Protein Sequence
(Fasta)

MGSNLPAQPN LRLTTDGLYK RDVFRFPDPF AVATVGGEQT HTTSVIKKTL NPYWNEMFDL 60
RVNEDSILAI QIFDQKKFKK KDQGFLGVIN VRIGDVIDLQ MGGDGESLPI RHSCDVSRLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTTCCA ATCTGCCAGC GTAAGTTTCG CCGCTCCCTA CCTGGACTGG CACTCAGGAG 60
CGGGATCTGT CTGCATTGAG TGATTTTGAG GACGAAAAAG CTAACGAGTA AATGCAATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0016567--P:protein ubiquitination

KEGG

afm:AFUA_1G09500

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	49.16	9.00e-158	549.00
IUUC-Apl-003893	Anas platyrhynchos	48.66	1.00e-155	542.00
IUUC-Aca-005338	Anolis carolinensis	47.98	1.00e-156	545.00
IUUC-Ago-007742	Ashbya gossypii	64.95	0.00e+00	999.00
IUUC-Acl-008273	Aspergillus clavatus	91.36	0.00e+00	1429.00
IUUC-Afl-008713	Aspergillus flavus	90.29	0.00e+00	1407.00
IUUC-Ani-009259	Aspergillus nidulans	86.41	0.00e+00	1403.00
IUUC-Ang-009738	Aspergillus niger	89.72	0.00e+00	1431.00
IUUC-Aor-010053	Aspergillus oryzae	96.32	1.00e-176	610.00
IUUC-Ate-010529	Aspergillus terreus	91.07	0.00e+00	1452.00
IUUC-Ame-010810	Astyanax mexicanus	52.47	4.00e-146	510.00
IUUC-Bgr-012148	Blumeria graminis	72.09	0.00e+00	1091.00
IUUC-Bta-012679	Bos taurus	49.16	4.00e-158	550.00
IUUC-Bci-013785	Botrytis cinerea	71.98	0.00e+00	1154.00
IUUC-Cel-018299	Caenorhabditis elegans	45.71	8.00e-151	525.00
IUUC-Cja-018732	Callithrix jacchus	48.66	3.00e-158	550.00
IUUC-Cfa-021226	Canis familiaris	49.16	8.00e-158	549.00
IUUC-Cpo-021671	Cavia porcellus	48.42	6.00e-158	549.00
IUUC-Csa-023344	Chlorocebus sabaeus	46.86	4.00e-154	537.00
IUUC-Cho-024695	Choloepus hoffmanni	48.48	1.00e-158	552.00
IUUC-Cin-025212	Ciona intestinalis	49.69	3.00e-143	500.00
IUUC-Csv-026256	Ciona savignyi	49.39	7.00e-142	495.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	71.17	0.00e+00	1092.00
IUUC-Cne-026849	Cryptococcus neoformans	71.90	0.00e+00	872.00
IUUC-Dre-027770	Danio rerio	52.47	5.00e-147	513.00
IUUC-Dno-029466	Dasypus novemcinctus	49.16	7.00e-158	549.00
IUUC-Dor-030138	Dipodomys ordii	47.99	4.00e-153	533.00
IUUC-Dse-031241	Dothistroma septosporum	72.21	0.00e+00	1174.00
IUUC-Dme-032041	Drosophila melanogaster	46.50	3.00e-146	511.00
IUUC-Ete-033145	Echinops telfairi	45.82	4.00e-145	507.00
IUUC-Eca-033445	Equus caballus	49.16	1.00e-157	548.00
IUUC-Eeu-035247	Erinaceus europaeus	48.49	3.00e-157	547.00
IUUC-Fca-036384	Felis catus	48.57	4.00e-159	554.00
IUUC-Fal-037604	Ficedula albicollis	46.84	9.00e-152	529.00
IUUC-Fox-037774	Fusarium oxysporum	70.49	0.00e+00	1105.00
IUUC-Fso-038393	Fusarium solani	70.33	0.00e+00	1087.00
IUUC-Gmo-039674	Gadus morhua	52.26	5.00e-146	510.00
IUUC-Ggr-040107	Gaeumannomyces graminis	70.62	0.00e+00	1123.00
IUUC-Gga-040703	Gallus gallus	48.16	5.00e-155	540.00
IUUC-Gac-042020	Gasterosteus aculeatus	49.08	7.00e-157	546.00
IUUC-Ggo-045332	Gorilla gorilla	48.42	8.00e-158	549.00
IUUC-Hsa-045968	Homo sapiens	48.42	4.00e-158	550.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	48.32	2.00e-158	551.00
IUUC-Kpa-049273	Komagataella pastoris	66.22	0.00e+00	1026.00
IUUC-Lch-050443	Latimeria chalumnae	48.67	9.00e-157	545.00
IUUC-Loc-052662	Lepisosteus oculatus	52.47	5.00e-143	500.00
IUUC-Lma-052980	Leptosphaeria maculans	72.89	0.00e+00	682.00
IUUC-Laf-053850	Loxodonta africana	49.16	1.00e-157	548.00
IUUC-Mcc-055821	Macaca mulatta	48.42	5.00e-158	550.00
IUUC-Meu-055953	Macropus eugenii	40.37	8.00e-119	419.00
IUUC-Mor-057097	Magnaporthe oryzae	71.53	0.00e+00	1137.00
IUUC-Mpo-057442	Magnaporthe poae	67.57	0.00e+00	1011.00
IUUC-Mla-058996	Melampsora laricipopulina	60.23	0.00e+00	946.00
IUUC-Mga-059362	Meleagris gallopavo	47.24	2.00e-153	534.00
IUUC-Mvi-060395	Microbotryum violaceum	79.42	0.00e+00	823.00
IUUC-Mmr-061061	Microcebus murinus	47.79	5.00e-160	557.00
IUUC-Mdo-062173	Monodelphis domestica	46.54	2.00e-153	534.00
IUUC-Mmu-064136	Mus musculus	49.16	5.00e-158	550.00
IUUC-Mpu-066765	Mustela putorius furo	49.16	6.00e-158	549.00
IUUC-Mlu-067565	Myotis lucifugus	49.16	2.00e-157	547.00
IUUC-Nfi-068427	Neosartorya fischeri	96.19	0.00e+00	1475.00
IUUC-Ncr-068918	Neurospora crassa	70.77	0.00e+00	1083.00
IUUC-Nle-069225	Nomascus leucogenys	47.96	6.00e-159	553.00
IUUC-Opr-071044	Ochotona princeps	48.49	6.00e-157	546.00
IUUC-Ont-071664	Oreochromis niloticus	47.00	2.00e-146	511.00
IUUC-Oan-073019	Ornithorhynchus anatinus	46.43	2.00e-150	524.00
IUUC-Ocu-074160	Oryctolagus cuniculus	48.01	5.00e-157	546.00
IUUC-Ola-087467	Oryzias latipes	48.00	2.00e-155	541.00
IUUC-Oga-088460	Otolemur garnettii	48.42	6.00e-158	549.00
IUUC-Oar-090198	Ovis aries	47.93	4.00e-158	550.00
IUUC-Ptr-090939	Pan troglodytes	48.42	4.00e-158	550.00
IUUC-Pan-092284	Papio anubis	48.42	5.00e-158	550.00
IUUC-Psi-093645	Pelodiscus sinensis	48.49	4.00e-157	546.00
IUUC-Pma-094364	Petromyzon marinus	52.05	3.00e-143	499.00
IUUC-Pno-095118	Phaeosphaeria nodorum	71.87	0.00e+00	1160.00
IUUC-Pfo-097145	Poecilia formosa	47.37	7.00e-152	529.00
IUUC-Pab-098088	Pongo abelii	48.42	4.00e-158	550.00
IUUC-Pca-100568	Procavia capensis	45.42	8.00e-138	483.00
IUUC-Pva-102354	Pteropus vampyrus	49.16	2.00e-157	547.00
IUUC-Pgr-103620	Puccinia graminis	77.96	0.00e+00	803.00
IUUC-Ptt-103806	Puccinia triticina	78.78	0.00e+00	690.00
IUUC-Pte-104016	Pyrenophora teres	74.02	0.00e+00	1159.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	74.02	0.00e+00	1159.00
IUUC-Rno-105318	Rattus norvegicus	49.16	4.00e-158	550.00
IUUC-Sce-106289	Saccharomyces cerevisiae	75.38	0.00e+00	926.00
IUUC-Sha-107482	Sarcophilus harrisii	47.75	2.00e-153	534.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	63.49	0.00e+00	996.00
IUUC-Spo-108171	Schizosaccharomyces pombe	65.25	0.00e+00	1008.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	73.05	0.00e+00	1144.00
IUUC-Sar-113761	Sorex araneus	48.15	1.00e-157	548.00
IUUC-Sre-114929	Sporisorium reilianum	71.45	0.00e+00	879.00
IUUC-Ssc-115368	Sus scrofa	44.29	2.00e-148	518.00
IUUC-Tgu-117130	Taeniopygia guttata	48.49	1.00e-155	541.00
IUUC-Tru-118610	Takifugu rubripes	54.53	4.00e-154	536.00
IUUC-Tsy-119492	Tarsius syrichta	48.17	3.00e-156	544.00
IUUC-Tni-119993	Tetraodon nigroviridis	46.99	1.00e-150	525.00
IUUC-Tre-122203	Trichoderma reesei	70.05	0.00e+00	1088.00
IUUC-Tvi-122595	Trichoderma virens	69.85	0.00e+00	1103.00
IUUC-Tme-126897	Tuber melanosporum	78.19	0.00e+00	920.00
IUUC-Tbe-127793	Tupaia belangeri	47.63	5.00e-132	463.00
IUUC-Ttr-128235	Tursiops truncatus	53.09	3.00e-148	517.00
IUUC-Uma-129332	Ustilago maydis	71.62	0.00e+00	843.00
IUUC-Vda-129753	Verticillium dahliae	68.65	0.00e+00	1058.00
IUUC-Vpa-130503	Vicugna pacos	50.73	3.00e-139	488.00
IUUC-Xtr-132859	Xenopus tropicalis	48.66	3.00e-158	550.00
IUUC-Xma-133797	Xiphophorus maculatus	48.35	2.00e-158	551.00
IUUC-Yli-134668	Yarrowia lipolytica	74.76	0.00e+00	945.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence