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Tag Content
UUCD2 ID IUUC-Tgu-117112
UUCD1 version UUC-TaG-00259
Ensembl Protein ID ENSTGUP00000004726.1
UniProt Accession H0Z2D5; H0Z2D5_TAEGU
Genbank Protein ID ENSTGUP00000004726
Protein Name Uncharacterized protein
Genbank Nucleotide ID ABQF01037353
Gene Name SMURF2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSTGUG00000004569.1 ENSTGUT00000004775.1 ENSTGUP00000004726.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 6.10e-129 430.0 420 752
Active Site
Position(s) Description Evidence
721 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 420  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 507
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 508  GFTLPFYKQLLGKPITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 592
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 593  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKTNTRLKH-CTPDSNIVKWFWKAVELFDEERRARLLQFV 680
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++  Y+s+e+l+ekLl+Aieet gF +
   Q: 681  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDISAYESYEKLYEKLLTAIEETCGFAV 752
           **********************************************************************76 PP
   
Organism Taeniopygia guttata
Protein Sequence
(Fasta)
MSNPGARRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYIG KSDSITISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Tgu-117112|E3,HECT|Taeniopygia guttata
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGGAGGGAG AGGAGAGGAG CCGAGCCCGC CGCCAGCCCG TCCGTCCGTC CGTCCGTCCG 60
TGCGGCTCCG ACCCGCTTTG TTGTGCTCGG GCCCGGGGGC GGGGAAGCGG AGGGAAGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Tgu-117112|E3,HECT|Taeniopygia guttata
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
KEGG tgu:100230714
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001305 Ailuropoda melanoleuca 96.76 0.00e+00 1469.00
IUUC-Apl-003513 Anas platyrhynchos 97.42 0.00e+00 1496.00
IUUC-Aca-005358 Anolis carolinensis 98.14 0.00e+00 1515.00
IUUC-Ame-011320 Astyanax mexicanus 87.47 0.00e+00 1404.00
IUUC-Bta-013399 Bos taurus 96.88 0.00e+00 1464.00
IUUC-Cja-019355 Callithrix jacchus 96.76 0.00e+00 1467.00
IUUC-Cpo-022200 Cavia porcellus 97.15 0.00e+00 1471.00
IUUC-Cho-024804 Choloepus hoffmanni 97.73 0.00e+00 633.00
IUUC-Cin-025126 Ciona intestinalis 65.25 0.00e+00 973.00
IUUC-Csv-026339 Ciona savignyi 64.84 0.00e+00 1007.00
IUUC-Dre-027650 Danio rerio 90.90 0.00e+00 1449.00
IUUC-Dno-029534 Dasypus novemcinctus 96.95 0.00e+00 1498.00
IUUC-Ete-032715 Echinops telfairi 92.11 0.00e+00 1375.00
IUUC-Eca-033580 Equus caballus 97.15 0.00e+00 1470.00
IUUC-Eeu-034945 Erinaceus europaeus 95.16 0.00e+00 1364.00
IUUC-Fal-037275 Ficedula albicollis 98.52 0.00e+00 1506.00
IUUC-Gga-041060 Gallus gallus 95.09 0.00e+00 1444.00
IUUC-Gac-041295 Gasterosteus aculeatus 91.43 0.00e+00 1419.00
IUUC-Hsa-046726 Homo sapiens 97.08 0.00e+00 1498.00
IUUC-Lch-050026 Latimeria chalumnae 95.89 0.00e+00 1472.00
IUUC-Loc-051760 Lepisosteus oculatus 89.06 0.00e+00 1399.00
IUUC-Laf-053753 Loxodonta africana 97.01 0.00e+00 1468.00
IUUC-Mcc-054815 Macaca mulatta 96.81 0.00e+00 1495.00
IUUC-Meu-056436 Macropus eugenii 75.30 0.00e+00 1098.00
IUUC-Mmr-060806 Microcebus murinus 96.88 0.00e+00 1467.00
IUUC-Mdo-062805 Monodelphis domestica 95.88 0.00e+00 1477.00
IUUC-Mmu-064034 Mus musculus 96.68 0.00e+00 1492.00
IUUC-Mpu-066762 Mustela putorius furo 96.76 0.00e+00 1468.00
IUUC-Mlu-066981 Myotis lucifugus 97.01 0.00e+00 1466.00
IUUC-Nle-069804 Nomascus leucogenys 97.07 0.00e+00 1491.00
IUUC-Opr-070591 Ochotona princeps 91.56 0.00e+00 1366.00
IUUC-Ont-072243 Oreochromis niloticus 90.08 0.00e+00 1426.00
IUUC-Oan-072699 Ornithorhynchus anatinus 94.17 0.00e+00 1490.00
IUUC-Ocu-074913 Oryctolagus cuniculus 97.08 0.00e+00 1498.00
IUUC-Ola-086597 Oryzias latipes 85.42 0.00e+00 1304.00
IUUC-Oga-089116 Otolemur garnettii 93.62 0.00e+00 1406.00
IUUC-Oar-089366 Ovis aries 96.61 0.00e+00 1465.00
IUUC-Ptr-091382 Pan troglodytes 97.08 0.00e+00 1498.00
IUUC-Psi-093298 Pelodiscus sinensis 96.74 0.00e+00 1456.00
IUUC-Pma-094354 Petromyzon marinus 73.48 0.00e+00 1136.00
IUUC-Pfo-096071 Poecilia formosa 90.44 0.00e+00 1441.00
IUUC-Pab-098682 Pongo abelii 97.08 0.00e+00 1497.00
IUUC-Pca-100516 Procavia capensis 88.95 0.00e+00 627.00
IUUC-Pva-102754 Pteropus vampyrus 95.92 0.00e+00 1431.00
IUUC-Rno-105600 Rattus norvegicus 96.88 0.00e+00 1268.00
IUUC-Sha-107144 Sarcophilus harrisii 96.06 0.00e+00 1341.00
IUUC-Spo-108171 Schizosaccharomyces pombe 40.24 2.00e-162 566.00
IUUC-Sar-113122 Sorex araneus 85.85 0.00e+00 1251.00
IUUC-Tru-118497 Takifugu rubripes 89.87 0.00e+00 1379.00
IUUC-Tni-120781 Tetraodon nigroviridis 89.92 0.00e+00 1185.00
IUUC-Tme-126897 Tuber melanosporum 39.33 6.00e-152 530.00
IUUC-Tbe-127371 Tupaia belangeri 87.63 0.00e+00 1205.00
IUUC-Ttr-129305 Tursiops truncatus 90.03 0.00e+00 1263.00
IUUC-Vpa-130591 Vicugna pacos 86.67 0.00e+00 1269.00
IUUC-Xtr-132979 Xenopus tropicalis 77.51 0.00e+00 1104.00
Created Date 25-Jun-2017

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