iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.90e-08	34.2	350	385

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedek...slveCekCrewfHpaClkls 35
            C vC++g+ +++   ++ +C++C + +H +Cl ++
   Q: 350  KCSVCENGEVKTDsnlQFAVCRRCPKSYHRKCLPRE 385
           6******9988877899***************9766 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Together with SUVH4, monitors repressive epigenetic marks H3K27me1, H3K9me2, and prevents DNA-methylation at CHG sites, affecting especially the expression of transposons and developmentally important genes (PubMed:21830950, PubMed:23609044, PubMed:24248388). Regulates alternative RNA processing such as distal 3' polyadenylation by intronic heterochromatin (PubMed:24248388). Transcription factor that binds DNA and contributes to transcriptional transposable element (TE) silencing by modulating levels of the repressive post-translational histone modifications (PHM) H3K9me2 (PubMed:23609044). In cv. Columbia, required for RPP7-dependent disease resistance against the Hyaloperonospora arabidopsidis isolate Hiks1, by promoting levels of RPP7 via alternative polyadenylation (APA), resulting from cooption of epigenetic information at the TE insertion locus COPIA-R7 (PubMed:23940361, PubMed:17253987, PubMed:20149132). Regulates development processes such as the formation of leaf pavement cells, leaf expansion, fertility and flowering (PubMed:20840782, PubMed:20149132, PubMed:23609044). Prevents FLC accumulation to control flowering (PubMed:23976921).

Protein Sequence
(Fasta)

MTFVDDDEEE DFSVPQSASN YYFEDDDKEP VSFARLPIQW SVEEKVDGSG LGFYLRGRSD 60
NGLLPLHKLV KAWRYDLSNF QPEISVLTKD NIWIKLEEPR KSYGELIRTV LVTLHSIQFL 120

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Nucleotide Sequence
(Fasta)

CGATTCTTAC TCTTTTTTTT TCCTCAATTC TTACTCTCTT TTGATTCAAT TGCGTCATAG 60
TATAATCTCC ATCAACACAC AGAGACGATA ATTCTCATAG GTTTTTATCA CTTCTCTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR029063--SAM-dependent_MTases
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

SMART

SM00249--PHD

Gene Ontology

GO:0005634--C:nucleus
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0050832--P:defense response to fungus
GO:0070829--P:heterochromatin maintenance
GO:0090436--P:leaf pavement cell development
GO:0031937--P:positive regulation of chromatin silencing
GO:0009911--P:positive regulation of flower development
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:1900111--P:positive regulation of histone H3-K9 dimethylation
GO:0044030--P:regulation of DNA methylation
GO:2000024--P:regulation of leaf development
GO:1900363--P:regulation of mRNA polyadenylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007165--P:signal transduction
GO:0006351--P:transcription, DNA-templated
GO:0010228--P:vegetative to reproductive phase transition of meristem

KEGG

ath:AT5G55390

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000732	Aegilops tauschii	28.09	1.00e-24	106.00
IUUC-Atr-002482	Amborella trichopoda	50.00	0.00e+00	691.00
IUUC-Aly-006105	Arabidopsis lyrata	92.52	0.00e+00	2341.00
IUUC-Bdi-014781	Brachypodium distachyon	36.95	1.00e-58	220.00
IUUC-Bol-016001	Brassica oleracea	73.07	0.00e+00	1819.00
IUUC-Bra-017864	Brassica rapa	73.10	0.00e+00	1795.00
IUUC-Cho-024405	Choloepus hoffmanni	29.01	1.00e-09	58.20
IUUC-Csv-026298	Ciona savignyi	26.90	5.00e-10	58.50
IUUC-Dre-028152	Danio rerio	29.70	3.00e-14	74.30
IUUC-Dno-030020	Dasypus novemcinctus	30.38	1.00e-12	68.90
IUUC-Gma-044054	Glycine max	48.44	0.00e+00	799.00
IUUC-Lpe-051201	Leersia perrieri	44.75	6.00e-51	194.00
IUUC-Loc-052581	Lepisosteus oculatus	30.19	1.00e-15	75.90
IUUC-Opr-070842	Ochotona princeps	29.68	1.00e-12	69.70
IUUC-Oan-072724	Ornithorhynchus anatinus	31.06	3.00e-13	70.10
IUUC-Oba-075813	Oryza barthii	41.53	0.00e+00	658.00
IUUC-Obr-076122	Oryza brachyantha	45.61	1.00e-35	142.00
IUUC-Ogl-077641	Oryza glaberrima	48.64	8.00e-56	209.00
IUUC-Ogu-078898	Oryza glumaepatula	49.09	6.00e-56	210.00
IUUC-Oin-079557	Oryza indica	49.09	8.00e-56	209.00
IUUC-Olo-080581	Oryza longistaminata	35.59	7.00e-36	143.00
IUUC-Ome-081770	Oryza meridionalis	49.09	6.00e-56	210.00
IUUC-Oni-082657	Oryza nivara	49.09	6.00e-56	210.00
IUUC-Opu-083479	Oryza punctata	38.56	6.00e-40	157.00
IUUC-Oru-084464	Oryza rufipogon	49.09	9.00e-56	209.00
IUUC-Osa-085353	Oryza sativa	49.09	6.00e-56	210.00
IUUC-Oga-088702	Otolemur garnettii	30.57	2.00e-13	71.20
IUUC-Sly-111281	Solanum lycopersicum	45.32	4.00e-149	521.00
IUUC-Stu-112457	Solanum tuberosum	59.06	3.00e-51	194.00
IUUC-Sbi-114581	Sorghum bicolor	40.69	3.00e-35	141.00
IUUC-Tae-125914	Triticum aestivum	32.89	6.00e-30	123.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence