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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-104909
UUCD1 version UUC-RaN-01076
Ensembl Protein ID ENSRNOP00000002879.5
UniProt Accession F1M625; G8ACC6; UBP46_RAT
Genbank Protein ID ADV57650.1; ENSRNOP00000002879
Protein Name Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46
Genbank Nucleotide ID GU455413; AABR07072397
Gene Name Usp46
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000002106.7 ENSRNOT00000002879.7 ENSRNOP00000002879.5
ENSRNOG00000002106.7 ENSRNOT00000083100.1 ENSRNOP00000072387.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
iRefIndexHINT
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.20e-98 329.9 35 364
Active Site
Position(s) Description Evidence
44 Nucleophile ECO:0000255|PROSITE-ProRule:PRU01035,
ECO:0000305|PubMed:22043315}
313 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU01035}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +Gl N+gNtCY+NSvLQ+L++++++re++l  +k +      +++k++ll++l++lf+++   k+k +++ p+++++ l+ke+  f++y
   Q: 35   FGLVNFGNTCYCNSVLQALYFCRPFRENVLA-YKAQ------QKKKENLLTCLADLFHSIAtqKKKVGVIPPKKFISRLRKENDLFDNY 116
           6******************************.3333......567899************976777779******************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +qqDa+Efl++ll+++ + l   ++++k+e+++ + ++ +++++ ++ k + ++++++Fqg+l+++++cl+c++vss++e+fldls++v
   Q: 117  MQQDAHEFLNYLLNTIADIL---QEEKKQEKQNGKLKNGNMNEPAENSKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDV 202
           ********************...34555555555556666677788888888************************************* PP
   S: 177  pgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           ++++     s+++cL++f+++e+l++e+kyyce+c++kqea+k++++kklP +L lhLkRf++ e+ ++ +k++ +v fpleL l  f+
   Q: 203  EQNT-----SITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRL--FN 284
           ****.....9**********************************************************************66555..77 PP
   S: 266  tspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           ts++  ++ ++ Y+L+avvvH G +++ GHY+++vk+ +g WllfdD+ V++++ + ++e+ g         +++Y+lfY++
   Q: 285  TSSDA-VNLDRMYDLVAVVVHCGsGPNRGHYITIVKS-HGFWLLFDDDIVEKIDAQAIEEFYGltsdisknsESGYILFYQS 364
           77554.4459***************************.888*******************999*****************97 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity).
 Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity).
Protein Sequence
(Fasta)
MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL QALYFCRPFR 60
ENVLAYKAQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK KFISRLRKEN DLFDNYMQQD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104909|DUB,USP|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGCGCGCC ACCATGGACA GTCCCGTTTT CCCCTGGTAA AGATGGCGGT GCGCGATCGC 60
TGCAACCTTT AGACTAATGA CTGTCCGAAA CATCGCCTCC ATCTGTAATA TGGTGAGTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104909|DUB,USP|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0085--Behavior
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008343--P:adult feeding behavior
GO:0001662--P:behavioral fear response
GO:0048149--P:behavioral response to ethanol
GO:0016579--P:protein deubiquitination
GO:0032228--P:regulation of synaptic transmission, GABAergic
GO:0060013--P:righting reflex
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG rno:289584
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000193 Aegilops tauschii 59.73 8.00e-126 443.00
IUUC-Aml-002353 Ailuropoda melanoleuca 98.08 0.00e+00 702.00
IUUC-Atr-002650 Amborella trichopoda 59.56 8.00e-126 443.00
IUUC-Apl-003380 Anas platyrhynchos 95.36 0.00e+00 688.00
IUUC-Aca-005031 Anolis carolinensis 96.99 0.00e+00 748.00
IUUC-Aly-005830 Arabidopsis lyrata 58.92 1.00e-123 436.00
IUUC-Ath-006663 Arabidopsis thaliana 59.07 1.00e-126 446.00
IUUC-Ago-007871 Ashbya gossypii 38.57 9.00e-49 188.00
IUUC-Ame-010862 Astyanax mexicanus 94.58 0.00e+00 723.00
IUUC-Bta-013023 Bos taurus 98.34 0.00e+00 699.00
IUUC-Bdi-014008 Brachypodium distachyon 60.82 8.00e-126 443.00
IUUC-Bol-015138 Brassica oleracea 58.60 5.00e-125 440.00
IUUC-Bra-017483 Brassica rapa 60.34 2.00e-126 445.00
IUUC-Cel-018379 Caenorhabditis elegans 62.41 5.00e-145 507.00
IUUC-Cja-018956 Callithrix jacchus 97.28 0.00e+00 697.00
IUUC-Cfa-021064 Canis familiaris 99.15 0.00e+00 688.00
IUUC-Cpo-022443 Cavia porcellus 98.88 0.00e+00 697.00
IUUC-Cre-022711 Chlamydomonas reinhardtii 53.93 3.00e-100 358.00
IUUC-Csa-023841 Chlorocebus sabaeus 99.73 0.00e+00 723.00
IUUC-Csv-025828 Ciona savignyi 54.00 1.00e-122 432.00
IUUC-Cne-026900 Cryptococcus neoformans 41.91 4.00e-60 226.00
IUUC-Dre-028230 Danio rerio 94.07 0.00e+00 722.00
IUUC-Dno-029209 Dasypus novemcinctus 97.26 0.00e+00 700.00
IUUC-Dme-032038 Drosophila melanogaster 80.68 2.00e-100 358.00
IUUC-Eca-033721 Equus caballus 99.44 0.00e+00 694.00
IUUC-Eeu-034916 Erinaceus europaeus 98.30 9.00e-162 562.00
IUUC-Fca-036299 Felis catus 97.27 0.00e+00 699.00
IUUC-Fox-037682 Fusarium oxysporum 42.63 1.00e-74 274.00
IUUC-Fso-038299 Fusarium solani 37.32 4.00e-75 276.00
IUUC-Gmo-038611 Gadus morhua 94.63 0.00e+00 693.00
IUUC-Ggr-039806 Gaeumannomyces graminis 42.86 1.00e-75 277.00
IUUC-Gga-041157 Gallus gallus 98.36 0.00e+00 711.00
IUUC-Gac-041764 Gasterosteus aculeatus 93.94 0.00e+00 706.00
IUUC-Gma-043828 Glycine max 60.66 6.00e-128 450.00
IUUC-Ggo-044659 Gorilla gorilla 97.55 0.00e+00 701.00
IUUC-Hsa-046156 Homo sapiens 99.73 0.00e+00 723.00
IUUC-Hvu-047692 Hordeum vulgare 58.86 8.00e-124 436.00
IUUC-Itr-048157 Ictidomys tridecemlineatus 99.73 0.00e+00 723.00
IUUC-Kpa-049250 Komagataella pastoris 44.83 1.00e-69 257.00
IUUC-Lch-049969 Latimeria chalumnae 96.45 0.00e+00 685.00
IUUC-Lpe-051368 Leersia perrieri 59.45 8.00e-123 433.00
IUUC-Loc-052479 Lepisosteus oculatus 91.26 0.00e+00 694.00
IUUC-Laf-054085 Loxodonta africana 99.73 0.00e+00 723.00
IUUC-Mcc-055566 Macaca mulatta 97.81 0.00e+00 700.00
IUUC-Mpo-057424 Magnaporthe poae 42.86 9.00e-76 278.00
IUUC-Mtr-057715 Medicago truncatula 60.33 4.00e-128 451.00
IUUC-Mla-059142 Melampsora laricipopulina 54.79 2.00e-96 347.00
IUUC-Mga-059575 Meleagris gallopavo 98.31 0.00e+00 685.00
IUUC-Mvi-060357 Microbotryum violaceum 53.96 1.00e-77 285.00
IUUC-Mdo-062579 Monodelphis domestica 99.45 0.00e+00 721.00
IUUC-Mmu-063611 Mus musculus 99.73 0.00e+00 723.00
IUUC-Mac-065323 Musa acuminata 60.11 3.00e-124 437.00
IUUC-Mpu-066038 Mustela putorius furo 99.72 0.00e+00 697.00
IUUC-Mlu-068183 Myotis lucifugus 97.80 0.00e+00 704.00
IUUC-Nle-069330 Nomascus leucogenys 99.73 0.00e+00 723.00
IUUC-Opr-070980 Ochotona princeps 100.00 0.00e+00 699.00
IUUC-Ont-072134 Oreochromis niloticus 94.85 0.00e+00 728.00
IUUC-Oan-073583 Ornithorhynchus anatinus 93.52 0.00e+00 685.00
IUUC-Ocu-074923 Oryctolagus cuniculus 99.44 0.00e+00 693.00
IUUC-Oba-075220 Oryza barthii 59.73 3.00e-123 434.00
IUUC-Obr-076208 Oryza brachyantha 57.65 6.00e-120 424.00
IUUC-Ogl-077216 Oryza glaberrima 59.73 3.00e-123 434.00
IUUC-Ogu-078836 Oryza glumaepatula 59.73 3.00e-123 434.00
IUUC-Oin-079522 Oryza indica 59.73 3.00e-123 434.00
IUUC-Olo-080882 Oryza longistaminata 59.73 3.00e-123 434.00
IUUC-Ome-081549 Oryza meridionalis 59.73 3.00e-123 434.00
IUUC-Oni-082982 Oryza nivara 59.73 3.00e-123 434.00
IUUC-Opu-083532 Oryza punctata 59.73 2.00e-123 435.00
IUUC-Oru-084568 Oryza rufipogon 59.73 3.00e-123 434.00
IUUC-Osa-085299 Oryza sativa 59.73 3.00e-123 434.00
IUUC-Ola-086546 Oryzias latipes 93.39 0.00e+00 703.00
IUUC-Olu-087809 Ostreococcus lucimarinus 48.44 1.00e-81 296.00
IUUC-Oga-088073 Otolemur garnettii 99.44 0.00e+00 694.00
IUUC-Oar-089248 Ovis aries 99.72 0.00e+00 697.00
IUUC-Ptr-090814 Pan troglodytes 99.73 0.00e+00 723.00
IUUC-Pan-091753 Papio anubis 99.73 0.00e+00 723.00
IUUC-Psi-094012 Pelodiscus sinensis 98.87 0.00e+00 687.00
IUUC-Pma-094388 Petromyzon marinus 89.54 0.00e+00 690.00
IUUC-Ppa-095415 Physcomitrella patens 59.03 7.00e-128 450.00
IUUC-Pfo-097369 Poecilia formosa 94.85 0.00e+00 727.00
IUUC-Pab-098594 Pongo abelii 99.72 0.00e+00 699.00
IUUC-Pop-099798 Populus trichocarpa 59.84 6.00e-127 447.00
IUUC-Pca-100913 Procavia capensis 83.94 3.00e-160 557.00
IUUC-Ppe-101474 Prunus persica 60.11 2.00e-127 449.00
IUUC-Pva-102892 Pteropus vampyrus 99.72 0.00e+00 697.00
IUUC-Sce-106367 Saccharomyces cerevisiae 37.97 4.00e-56 213.00
IUUC-Sha-107400 Sarcophilus harrisii 99.44 0.00e+00 696.00
IUUC-Smo-109064 Selaginella moellendorffii 60.33 5.00e-121 427.00
IUUC-Sit-110819 Setaria italica 59.73 8.00e-124 436.00
IUUC-Sly-111210 Solanum lycopersicum 59.73 9.00e-127 446.00
IUUC-Stu-112398 Solanum tuberosum 60.16 3.00e-127 447.00
IUUC-Sbi-114724 Sorghum bicolor 59.73 5.00e-124 437.00
IUUC-Ssc-115550 Sus scrofa 99.72 0.00e+00 697.00
IUUC-Tgu-116800 Taeniopygia guttata 98.36 0.00e+00 711.00
IUUC-Tru-118212 Takifugu rubripes 94.85 0.00e+00 729.00
IUUC-Tni-120071 Tetraodon nigroviridis 94.85 0.00e+00 729.00
IUUC-Tca-121329 Theobroma cacao 60.11 2.00e-127 448.00
IUUC-Tae-124807 Triticum aestivum 59.73 4.00e-126 444.00
IUUC-Tur-126563 Triticum urartu 59.73 3.00e-126 444.00
IUUC-Tme-126890 Tuber melanosporum 46.78 6.00e-91 328.00
IUUC-Vpa-130590 Vicugna pacos 94.65 0.00e+00 650.00
IUUC-Vvi-131371 Vitis vinifera 59.84 1.00e-126 446.00
IUUC-Xtr-132082 Xenopus tropicalis 90.44 0.00e+00 691.00
IUUC-Xma-133111 Xiphophorus maculatus 94.85 0.00e+00 727.00
Created Date 25-Jun-2017

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