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Tag Content
iUUCD ID IUUC-Dre-028487
Ensembl Protein ID ENSDARP00000012048.8
UniProt Accession Q7ZU99; Q76KA4; TERA_DANRE
Genbank Protein ID BAC87740.1; AAS92631.1; CAM13143.1; AAH50488.1; AAH67384.1
Protein Name Transitional endoplasmic reticulum ATPase; Protein CDC48; Valosin-containing protein
Genbank Nucleotide ID AB093594; AY576993; CR318632; BC050488; BC067384
Gene Name vcp; cdc48; si:ch211-113n10.2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000020008.9 ENSDART00000023779.8 ENSDARP00000012048.8
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 96.77 0.00e+00 1437.00 IUUC-Hsa-046162
UBD/Other/Other 70.58 0.00e+00 1083.00 IUUC-Sce-106244
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Danio rerio
Functional Description
(View)

Functional Description


     Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (By similarity). Enhances cell cycle progression and inhibits apoptosis at low temperatures (PubMed:12914916). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (By similarity). Acts as a negative regulator of type I interferon production by promoting ubiquitination of ddx58/rig-i (By similarity).
 Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (By similarity). Enhances cell cycle progression and inhibits apoptosis at low temperatures (PubMed:12914916). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (By similarity). Acts as a negative regulator of type I interferon production by promoting ubiquitination of ddx58/rig-i (By similarity).
Protein Sequence
(Fasta)
MASGGESKND DLSTAILKQK NRPNRLIVDE SINEDNSVVS LSQAKMDELQ LFRGDTVLLK 60
GKKRRETVCI VLSDDTCSDE KVRMNRVVRN NLRVRLGDVI SIQPCPDVKY GKRIHVLPID 120
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Protein Fasta Sequence


>IUUC-Dre-028487|UBD,UBD/Other/Other|Danio rerio
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Nucleotide Sequence
(Fasta)
GTTGATGTTA GCAAGCTAAT CCAGTGCAGA GGTAAAGAAA AAAGCTAGTG TGAAGGTTGG 60
AATCGGTCAC TCAAGAGAGC TACTCATTTC CATCAACTAT TTATATCTTT TTGCGGGAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028487|UBD,UBD/Other/Other|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0072--Autophagy
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0446--Lipid-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR003593--AAA+_ATPase
IPR005938--AAA_ATPase_CDC48
IPR009010--Asp_de-COase-like_dom
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR004201--Cdc48_dom2
IPR029067--CDC48_domain_2-like
IPR003338--CDC4_N-term_subdom
IPR027417--P-loop_NTPase
IPR015415--Vps4_C
PROSITE

PS00674--AAA
Pfam

PF00004--AAA
PF02933--CDC48_2
PF02359--CDC48_N
PF09336--Vps4_C
SMART

SM00382--AAA
SM01072--CDC48_2
SM01073--CDC48_N
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0008289--F:lipid binding
GO:0097352--P:autophagosome maturation
GO:0006914--P:autophagy
GO:0007049--P:cell cycle
GO:0006974--P:cellular response to DNA damage stimulus
GO:0043009--P:chordate embryonic development
GO:0006302--P:double-strand break repair
GO:0036503--P:ERAD pathway
GO:0007626--P:locomotory behavior
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0016567--P:protein ubiquitination
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0019985--P:translesion synthesis
GO:0006810--P:transport
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG dre:327197
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000524 Aegilops tauschii 80.31 0.00e+00 1201.00
IUUC-Aml-001849 Ailuropoda melanoleuca 96.52 0.00e+00 1469.00
IUUC-Atr-002619 Amborella trichopoda 80.52 0.00e+00 1261.00
IUUC-Apl-004070 Anas platyrhynchos 96.65 0.00e+00 1462.00
IUUC-Aca-004847 Anolis carolinensis 95.42 0.00e+00 1467.00
IUUC-Aly-005406 Arabidopsis lyrata 79.56 0.00e+00 1227.00
IUUC-Ath-006796 Arabidopsis thaliana 79.55 0.00e+00 1238.00
IUUC-Ago-008001 Ashbya gossypii 71.12 0.00e+00 1051.00
IUUC-Acl-008066 Aspergillus clavatus 73.14 0.00e+00 1108.00
IUUC-Afl-008505 Aspergillus flavus 70.97 0.00e+00 1129.00
IUUC-Afu-008840 Aspergillus fumigatus 73.31 0.00e+00 1129.00
IUUC-Ani-009368 Aspergillus nidulans 71.02 0.00e+00 1138.00
IUUC-Ang-009724 Aspergillus niger 71.31 0.00e+00 1132.00
IUUC-Aor-010204 Aspergillus oryzae 70.97 0.00e+00 1129.00
IUUC-Ate-010370 Aspergillus terreus 71.46 0.00e+00 1133.00
IUUC-Ame-011388 Astyanax mexicanus 99.38 0.00e+00 1464.00
IUUC-Bgr-012223 Blumeria graminis 72.27 0.00e+00 1148.00
IUUC-Bta-013188 Bos taurus 96.65 0.00e+00 1477.00
IUUC-Bci-013831 Botrytis cinerea 72.75 0.00e+00 1134.00
IUUC-Bdi-014967 Brachypodium distachyon 80.45 0.00e+00 1248.00
IUUC-Bol-016113 Brassica oleracea 79.66 0.00e+00 1237.00
IUUC-Bra-017796 Brassica rapa 79.66 0.00e+00 1239.00
IUUC-Cel-018243 Caenorhabditis elegans 79.95 0.00e+00 1215.00
IUUC-Cja-019904 Callithrix jacchus 96.03 0.00e+00 1427.00
IUUC-Cfa-020304 Canis familiaris 96.65 0.00e+00 1475.00
IUUC-Cpo-021518 Cavia porcellus 97.00 0.00e+00 1463.00
IUUC-Cre-022719 Chlamydomonas reinhardtii 80.03 0.00e+00 1234.00
IUUC-Csa-023444 Chlorocebus sabaeus 96.77 0.00e+00 1474.00
IUUC-Cho-024482 Choloepus hoffmanni 95.62 0.00e+00 1435.00
IUUC-Cin-025517 Ciona intestinalis 86.72 0.00e+00 1290.00
IUUC-Csv-026060 Ciona savignyi 86.74 0.00e+00 1343.00
IUUC-Cgl-026690 Colletotrichum gloeosporioides 72.87 0.00e+00 1157.00
IUUC-Cne-026910 Cryptococcus neoformans 72.90 0.00e+00 1179.00
IUUC-Cme-027145 Cyanidioschyzon merolae 74.87 0.00e+00 1167.00
IUUC-Dno-029257 Dasypus novemcinctus 96.77 0.00e+00 1474.00
IUUC-Dor-030473 Dipodomys ordii 95.17 0.00e+00 1424.00
IUUC-Dse-031319 Dothistroma septosporum 70.78 0.00e+00 1102.00
IUUC-Dme-032203 Drosophila melanogaster 82.48 0.00e+00 1269.00
IUUC-Eca-033311 Equus caballus 96.27 0.00e+00 1454.00
IUUC-Eeu-035293 Erinaceus europaeus 97.24 0.00e+00 759.00
IUUC-Fca-036097 Felis catus 97.94 0.00e+00 1377.00
IUUC-Fal-037292 Ficedula albicollis 97.25 0.00e+00 1466.00
IUUC-Fox-037827 Fusarium oxysporum 73.59 0.00e+00 1162.00
IUUC-Fso-038226 Fusarium solani 73.32 0.00e+00 1168.00
IUUC-Gmo-039157 Gadus morhua 91.25 0.00e+00 1331.00
IUUC-Ggr-039951 Gaeumannomyces graminis 72.94 0.00e+00 1134.00
IUUC-Gga-041183 Gallus gallus 97.02 0.00e+00 1474.00
IUUC-Gac-042039 Gasterosteus aculeatus 97.77 0.00e+00 1454.00
IUUC-Gma-044090 Glycine max 77.28 0.00e+00 1258.00
IUUC-Ggo-045568 Gorilla gorilla 96.77 0.00e+00 1474.00
IUUC-Hsa-046162 Homo sapiens 96.77 0.00e+00 1474.00
IUUC-Hvu-047107 Hordeum vulgare 80.75 0.00e+00 999.00
IUUC-Itr-047885 Ictidomys tridecemlineatus 96.53 0.00e+00 1470.00
IUUC-Kpa-049220 Komagataella pastoris 70.61 0.00e+00 1111.00
IUUC-Lch-050657 Latimeria chalumnae 88.75 0.00e+00 1278.00
IUUC-Lpe-051083 Leersia perrieri 79.72 0.00e+00 1237.00
IUUC-Loc-052064 Lepisosteus oculatus 99.26 0.00e+00 1465.00
IUUC-Lma-053323 Leptosphaeria maculans 73.54 0.00e+00 1139.00
IUUC-Laf-054574 Loxodonta africana 97.00 0.00e+00 1465.00
IUUC-Mcc-055448 Macaca mulatta 96.77 0.00e+00 1474.00
IUUC-Meu-056316 Macropus eugenii 90.38 0.00e+00 1333.00
IUUC-Mor-057057 Magnaporthe oryzae 72.90 0.00e+00 1132.00
IUUC-Mpo-057406 Magnaporthe poae 73.45 0.00e+00 1130.00
IUUC-Mtr-057648 Medicago truncatula 79.30 0.00e+00 1255.00
IUUC-Mla-059156 Melampsora laricipopulina 76.12 0.00e+00 1210.00
IUUC-Mga-060004 Meleagris gallopavo 91.26 0.00e+00 1232.00
IUUC-Mvi-060488 Microbotryum violaceum 75.19 0.00e+00 1193.00
IUUC-Mmr-061027 Microcebus murinus 97.00 0.00e+00 1464.00
IUUC-Mdo-062159 Monodelphis domestica 97.02 0.00e+00 1472.00
IUUC-Mmu-063633 Mus musculus 96.77 0.00e+00 1474.00
IUUC-Mac-064919 Musa acuminata 78.96 0.00e+00 1244.00
IUUC-Mpu-066078 Mustela putorius furo 96.65 0.00e+00 1477.00
IUUC-Mlu-067757 Myotis lucifugus 96.65 0.00e+00 1474.00
IUUC-Nfi-068533 Neosartorya fischeri 73.31 0.00e+00 1122.00
IUUC-Ncr-068775 Neurospora crassa 73.49 0.00e+00 1102.00
IUUC-Nle-069424 Nomascus leucogenys 97.00 0.00e+00 1465.00
IUUC-Opr-071147 Ochotona princeps 96.37 0.00e+00 1427.00
IUUC-Ont-071351 Oreochromis niloticus 98.14 0.00e+00 1430.00
IUUC-Oan-073335 Ornithorhynchus anatinus 96.01 0.00e+00 1460.00
IUUC-Ocu-074072 Oryctolagus cuniculus 96.77 0.00e+00 1474.00
IUUC-Oba-075914 Oryza barthii 79.23 0.00e+00 1258.00
IUUC-Obr-076224 Oryza brachyantha 80.79 0.00e+00 1246.00
IUUC-Ogl-077282 Oryza glaberrima 79.51 0.00e+00 1259.00
IUUC-Ogu-078174 Oryza glumaepatula 79.23 0.00e+00 1258.00
IUUC-Oin-079103 Oryza indica 79.23 0.00e+00 1258.00
IUUC-Olo-080675 Oryza longistaminata 79.36 0.00e+00 1258.00
IUUC-Ome-081247 Oryza meridionalis 79.59 0.00e+00 1259.00
IUUC-Oni-082078 Oryza nivara 79.10 0.00e+00 1257.00
IUUC-Opu-083806 Oryza punctata 79.05 0.00e+00 1263.00
IUUC-Oru-084634 Oryza rufipogon 79.23 0.00e+00 1258.00
IUUC-Osa-085960 Oryza sativa 79.23 0.00e+00 1258.00
IUUC-Ola-086382 Oryzias latipes 97.40 0.00e+00 1422.00
IUUC-Olu-087839 Ostreococcus lucimarinus 78.63 0.00e+00 1220.00
IUUC-Oga-088037 Otolemur garnettii 96.53 0.00e+00 1464.00
IUUC-Oar-089684 Ovis aries 94.81 0.00e+00 1462.00
IUUC-Ptr-091378 Pan troglodytes 96.77 0.00e+00 1474.00
IUUC-Pan-092849 Papio anubis 96.77 0.00e+00 1474.00
IUUC-Psi-093725 Pelodiscus sinensis 96.06 0.00e+00 1385.00
IUUC-Pma-094537 Petromyzon marinus 89.19 0.00e+00 699.00
IUUC-Pno-094915 Phaeosphaeria nodorum 76.07 0.00e+00 1081.00
IUUC-Ppa-095632 Physcomitrella patens 79.58 0.00e+00 1207.00
IUUC-Pfo-097440 Poecilia formosa 98.01 0.00e+00 1428.00
IUUC-Pab-098469 Pongo abelii 96.77 0.00e+00 1474.00
IUUC-Pop-100047 Populus trichocarpa 80.52 0.00e+00 1263.00
IUUC-Pca-100399 Procavia capensis 92.31 0.00e+00 1379.00
IUUC-Ppe-101767 Prunus persica 78.65 0.00e+00 1257.00
IUUC-Pva-102426 Pteropus vampyrus 96.03 0.00e+00 1432.00
IUUC-Pgr-103599 Puccinia graminis 73.76 0.00e+00 1195.00
IUUC-Ptt-103740 Puccinia triticina 73.70 0.00e+00 1196.00
IUUC-Pte-104030 Pyrenophora teres 73.36 0.00e+00 1122.00
IUUC-Pyt-104541 Pyrenophora triticirepentis 73.45 0.00e+00 1122.00
IUUC-Rno-105144 Rattus norvegicus 96.90 0.00e+00 1471.00
IUUC-Sce-106244 Saccharomyces cerevisiae 69.97 0.00e+00 1056.00
IUUC-Sha-106589 Sarcophilus harrisii 97.25 0.00e+00 1464.00
IUUC-Sja-107673 Schizosaccharomyces japonicus 69.41 0.00e+00 1102.00
IUUC-Spo-108247 Schizosaccharomyces pombe 70.30 0.00e+00 1078.00
IUUC-Ssl-108642 Sclerotinia sclerotiorum 72.49 0.00e+00 1125.00
IUUC-Smo-108877 Selaginella moellendorffii 79.87 0.00e+00 1246.00
IUUC-Sit-110623 Setaria italica 79.49 0.00e+00 1255.00
IUUC-Sly-111151 Solanum lycopersicum 79.45 0.00e+00 1231.00
IUUC-Stu-111959 Solanum tuberosum 79.69 0.00e+00 1258.00
IUUC-Sar-113021 Sorex araneus 97.00 0.00e+00 1464.00
IUUC-Sbi-114457 Sorghum bicolor 80.41 0.00e+00 1258.00
IUUC-Sre-115052 Sporisorium reilianum 77.39 0.00e+00 1221.00
IUUC-Ssc-116293 Sus scrofa 96.41 0.00e+00 1471.00
IUUC-Tgu-116544 Taeniopygia guttata 94.01 0.00e+00 1382.00
IUUC-Tru-117991 Takifugu rubripes 97.20 0.00e+00 1014.00
IUUC-Tsy-119131 Tarsius syrichta 85.33 0.00e+00 1060.00
IUUC-Tni-120192 Tetraodon nigroviridis 96.53 0.00e+00 1419.00
IUUC-Tca-121502 Theobroma cacao 79.17 0.00e+00 1225.00
IUUC-Tre-122189 Trichoderma reesei 71.16 0.00e+00 1145.00
IUUC-Tvi-122310 Trichoderma virens 71.04 0.00e+00 1128.00
IUUC-Tae-124332 Triticum aestivum 80.31 0.00e+00 1220.00
IUUC-Tur-126733 Triticum urartu 80.05 0.00e+00 1201.00
IUUC-Tme-127147 Tuber melanosporum 73.11 0.00e+00 1110.00
IUUC-Tbe-127255 Tupaia belangeri 89.84 0.00e+00 1367.00
IUUC-Ttr-128876 Tursiops truncatus 96.37 0.00e+00 1447.00
IUUC-Uma-129448 Ustilago maydis 77.62 0.00e+00 1216.00
IUUC-Vda-129800 Verticillium dahliae 70.51 0.00e+00 1122.00
IUUC-Vpa-130573 Vicugna pacos 98.35 0.00e+00 825.00
IUUC-Vvi-131622 Vitis vinifera 81.05 0.00e+00 1267.00
IUUC-Xtr-132458 Xenopus tropicalis 96.61 0.00e+00 1389.00
IUUC-Xma-134045 Xiphophorus maculatus 98.14 0.00e+00 1428.00
IUUC-Yli-134382 Yarrowia lipolytica 72.02 0.00e+00 1144.00
IUUC-Zma-134817 Zea mays 80.15 0.00e+00 1264.00
Created Date 25-Jun-2017

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