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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063458
Ensembl Protein ID ENSMUSP00000047308.7
UniProt Accession Q9WTU0; Q6A023; Q80WA8; PHF2_MOUSE
Genbank Protein ID AAD21792.1; AAH51633.1; BAD32273.1
Protein Name Lysine-specific demethylase PHF2; GRC5; PHD finger protein 2
Genbank Nucleotide ID AF043726; AC109249; AK172995
Gene Name Phf2; Kiaa0662
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000038025.7 ENSMUST00000035540.7 ENSMUSP00000047308.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
iRefIndexMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 8.70e-10 39.8 6 55
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C vC+ +++ ++ ++eC+ C++wfH  C++ + eee p+ + + Cp+C++
   Q: 6    VYC-VCRLPYDVTRFMIECDACKDWFHGSCVGVE-EEEAPDIDIYHCPNCEK 55
           69*.******************************.*******99******86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).
 Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).
Protein Sequence
(Fasta)
MATVPVYCVC RLPYDVTRFM IECDACKDWF HGSCVGVEEE EAPDIDIYHC PNCEKTHGKS 60
TLKKKRTWHK HGPGPTPDVK PVQNGSQLFI KELRSRTFPS AEDVVSRVPG SQLTVGYMEE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063458|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
CCGTCCGCTC CGGCCGCGGC GCCCGCGCCC GCCGCCCCCG CCGCCCTCGC CGCGCGGCCC 60
CCGGCCCGGC CCGGCCCGAC CCGGGCAGCG CAGCGGCGGG GCGAGCGGCG GCGCGGCAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063458|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0995--Kinetochore
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF00628--PHD
SMART

SM00558--JmjC
SM00249--PHD
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0000776--C:kinetochore
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0005506--F:iron ion binding
GO:0035064--F:methylated histone binding
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0033169--P:histone H3-K9 demethylation
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0006482--P:protein demethylation
GO:0006351--P:transcription, DNA-templated
KEGG mmu:18676
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002986 Amborella trichopoda 37.18 7.00e-12 63.90
IUUC-Aca-005043 Anolis carolinensis 90.44 0.00e+00 898.00
IUUC-Aly-005443 Arabidopsis lyrata 35.82 2.00e-11 62.40
IUUC-Ath-007631 Arabidopsis thaliana 46.00 3.00e-11 62.00
IUUC-Bdi-014153 Brachypodium distachyon 43.64 1.00e-12 66.20
IUUC-Bol-015887 Brassica oleracea 48.00 4.00e-12 64.70
IUUC-Dre-028285 Danio rerio 79.30 0.00e+00 764.00
IUUC-Fal-037017 Ficedula albicollis 89.13 0.00e+00 926.00
IUUC-Gga-040290 Gallus gallus 88.91 0.00e+00 924.00
IUUC-Gma-042998 Glycine max 36.76 1.00e-11 62.80
IUUC-Hsa-046760 Homo sapiens 92.43 0.00e+00 1607.00
IUUC-Hvu-047723 Hordeum vulgare 32.84 4.00e-10 58.20
IUUC-Lpe-051400 Leersia perrieri 45.45 2.00e-12 65.90
IUUC-Loc-051927 Lepisosteus oculatus 83.48 0.00e+00 845.00
IUUC-Mtr-057710 Medicago truncatula 38.46 2.00e-11 62.80
IUUC-Mmr-061132 Microcebus murinus 91.41 0.00e+00 1620.00
IUUC-Mac-065355 Musa acuminata 45.10 1.00e-11 63.20
IUUC-Ont-071935 Oreochromis niloticus 76.84 0.00e+00 740.00
IUUC-Oba-075188 Oryza barthii 45.45 5.00e-12 64.30
IUUC-Obr-076844 Oryza brachyantha 45.45 5.00e-12 64.30
IUUC-Ogl-077260 Oryza glaberrima 45.45 5.00e-12 64.30
IUUC-Ogu-078663 Oryza glumaepatula 45.45 2.00e-12 65.90
IUUC-Oin-079894 Oryza indica 45.45 2.00e-12 65.90
IUUC-Olo-080411 Oryza longistaminata 45.45 2.00e-12 65.50
IUUC-Ome-081623 Oryza meridionalis 45.45 3.00e-12 65.50
IUUC-Oni-082587 Oryza nivara 45.45 2.00e-12 65.90
IUUC-Opu-083591 Oryza punctata 43.64 4.00e-12 64.70
IUUC-Oru-084597 Oryza rufipogon 45.45 2.00e-12 65.90
IUUC-Osa-086057 Oryza sativa 45.45 2.00e-12 65.90
IUUC-Ola-087236 Oryzias latipes 77.83 0.00e+00 766.00
IUUC-Ptr-091328 Pan troglodytes 85.45 0.00e+00 1112.00
IUUC-Pfo-096227 Poecilia formosa 76.42 0.00e+00 763.00
IUUC-Pop-098853 Populus trichocarpa 44.00 2.00e-11 62.80
IUUC-Ppe-101818 Prunus persica 37.66 6.00e-12 64.30
IUUC-Spo-108120 Schizosaccharomyces pombe 35.91 3.00e-50 193.00
IUUC-Sit-110411 Setaria italica 47.46 6.00e-14 70.50
IUUC-Sly-110932 Solanum lycopersicum 35.06 5.00e-12 64.30
IUUC-Stu-112357 Solanum tuberosum 40.68 2.00e-11 62.40
IUUC-Sbi-114098 Sorghum bicolor 49.09 2.00e-13 69.30
IUUC-Tgu-117091 Taeniopygia guttata 89.13 0.00e+00 922.00
IUUC-Tru-118118 Takifugu rubripes 59.86 0.00e+00 1224.00
IUUC-Tni-120632 Tetraodon nigroviridis 78.95 0.00e+00 798.00
IUUC-Tca-121518 Theobroma cacao 48.00 5.00e-12 64.30
IUUC-Tae-125802 Triticum aestivum 43.64 1.00e-12 67.00
IUUC-Tur-126461 Triticum urartu 43.64 1.00e-12 66.20
IUUC-Ttr-128194 Tursiops truncatus 92.19 0.00e+00 1625.00
IUUC-Vvi-131614 Vitis vinifera 48.00 6.00e-12 64.30
IUUC-Xma-134037 Xiphophorus maculatus 76.42 0.00e+00 764.00
Created Date 25-Jun-2017

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