iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000015415.6	ENSGALT00000024865.4	ENSGALP00000024819.4
ENSGALG00000015415.6	ENSGALT00000086898.1	ENSGALP00000060303.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-117	393.5	609	938

Active Site

Position(s)	Description	Evidence
909	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al +++l+++ 
   Q: 609  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSSEIVNPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALNHRQLVNIY 694
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG++i Vt+eNk eYv+lv+e+
   Q: 695  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTEL 780
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++ +++iqwFw+v+ee+++eer  +LqFvT
   Q: 781  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWLKNTEYTSGYERGDQVIQWFWDVVEELTQEERVLLLQFVT 869
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa ++     + f+i     + + lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 870  GSSRVPHGGFAHIMggsgLQNFTIAAvPYTANLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 938
           ******************888999995667799******************************986555 PP

Organism

Gallus gallus

Functional Description
(View)

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division.

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPDDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGCCCGG GCAGCCTCGG CCCCGGTGCC ACCGCCATGG GCTGAGGGGA ACGGTGTGAG 60
GGCTGTCAGC GGCTGTCGGG CGGGCTGCCC CGAGGATGGA GAGAGCCATG GAGCAGCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0032580--C:Golgi cisterna membrane
GO:0000139--C:Golgi membrane
GO:0017137--F:Rab GTPase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007049--P:cell cycle
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

KEGG

gga:421788

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	40.36	2.00e-82	302.00
IUUC-Aml-001490	Ailuropoda melanoleuca	90.90	0.00e+00	1768.00
IUUC-Atr-002582	Amborella trichopoda	42.95	4.00e-97	351.00
IUUC-Apl-003400	Anas platyrhynchos	99.53	0.00e+00	1331.00
IUUC-Aca-005375	Anolis carolinensis	89.60	0.00e+00	1769.00
IUUC-Aly-006157	Arabidopsis lyrata	44.55	1.00e-100	363.00
IUUC-Ame-011847	Astyanax mexicanus	84.98	0.00e+00	1669.00
IUUC-Bta-012831	Bos taurus	91.38	0.00e+00	1735.00
IUUC-Bdi-014884	Brachypodium distachyon	42.76	8.00e-97	350.00
IUUC-Bra-016726	Brassica rapa	44.77	2.00e-101	365.00
IUUC-Cja-019160	Callithrix jacchus	91.73	0.00e+00	1783.00
IUUC-Cfa-020346	Canis familiaris	91.30	0.00e+00	1779.00
IUUC-Cpo-021766	Cavia porcellus	90.76	0.00e+00	1775.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	42.89	2.00e-97	349.00
IUUC-Csa-023768	Chlorocebus sabaeus	91.40	0.00e+00	1781.00
IUUC-Cho-024688	Choloepus hoffmanni	85.49	0.00e+00	1113.00
IUUC-Cin-025417	Ciona intestinalis	51.50	2.00e-140	493.00
IUUC-Csv-025993	Ciona savignyi	45.21	7.00e-140	491.00
IUUC-Dre-027819	Danio rerio	82.46	0.00e+00	1632.00
IUUC-Dno-029027	Dasypus novemcinctus	91.34	0.00e+00	1783.00
IUUC-Dor-030327	Dipodomys ordii	84.17	0.00e+00	1555.00
IUUC-Ete-032966	Echinops telfairi	84.61	0.00e+00	1639.00
IUUC-Eca-034339	Equus caballus	91.40	0.00e+00	1780.00
IUUC-Eeu-034544	Erinaceus europaeus	78.23	4.00e-142	498.00
IUUC-Fca-035617	Felis catus	88.69	0.00e+00	1245.00
IUUC-Fal-036687	Ficedula albicollis	98.41	0.00e+00	1925.00
IUUC-Gmo-039508	Gadus morhua	87.93	0.00e+00	834.00
IUUC-Gac-041894	Gasterosteus aculeatus	82.34	0.00e+00	1588.00
IUUC-Gma-044216	Glycine max	43.86	3.00e-99	358.00
IUUC-Ggo-044465	Gorilla gorilla	88.04	0.00e+00	1707.00
IUUC-Hsa-045731	Homo sapiens	91.61	0.00e+00	1785.00
IUUC-Hvu-047697	Hordeum vulgare	42.53	5.00e-96	347.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	91.72	0.00e+00	1784.00
IUUC-Lch-050436	Latimeria chalumnae	87.12	0.00e+00	1701.00
IUUC-Lpe-051550	Leersia perrieri	42.99	4.00e-98	354.00
IUUC-Loc-052287	Lepisosteus oculatus	87.87	0.00e+00	1735.00
IUUC-Laf-053846	Loxodonta africana	91.83	0.00e+00	1794.00
IUUC-Mcc-055845	Macaca mulatta	91.51	0.00e+00	1784.00
IUUC-Meu-056060	Macropus eugenii	89.45	0.00e+00	691.00
IUUC-Mtr-057633	Medicago truncatula	42.34	1.00e-100	362.00
IUUC-Mga-059935	Meleagris gallopavo	95.71	0.00e+00	1853.00
IUUC-Mmr-060960	Microcebus murinus	91.72	0.00e+00	1788.00
IUUC-Mdo-061851	Monodelphis domestica	94.90	0.00e+00	1880.00
IUUC-Mmu-063657	Mus musculus	90.55	0.00e+00	1770.00
IUUC-Mac-065229	Musa acuminata	42.95	2.00e-97	352.00
IUUC-Mpu-066161	Mustela putorius furo	96.23	0.00e+00	809.00
IUUC-Mlu-067354	Myotis lucifugus	89.26	0.00e+00	1699.00
IUUC-Nle-069112	Nomascus leucogenys	91.51	0.00e+00	1781.00
IUUC-Opr-070686	Ochotona princeps	86.79	0.00e+00	794.00
IUUC-Ont-072398	Oreochromis niloticus	82.77	0.00e+00	1602.00
IUUC-Oan-073194	Ornithorhynchus anatinus	90.42	0.00e+00	1703.00
IUUC-Ocu-074397	Oryctolagus cuniculus	81.31	0.00e+00	1533.00
IUUC-Oba-075757	Oryza barthii	42.76	3.00e-97	351.00
IUUC-Obr-076553	Oryza brachyantha	43.21	7.00e-98	353.00
IUUC-Ogl-077520	Oryza glaberrima	42.76	4.00e-97	351.00
IUUC-Ogu-078278	Oryza glumaepatula	42.76	3.00e-97	351.00
IUUC-Oin-079767	Oryza indica	42.76	4.00e-97	351.00
IUUC-Olo-080380	Oryza longistaminata	42.60	1.00e-95	346.00
IUUC-Ome-081925	Oryza meridionalis	42.60	1.00e-95	346.00
IUUC-Oni-082619	Oryza nivara	42.76	4.00e-97	351.00
IUUC-Opu-083684	Oryza punctata	42.60	1.00e-95	346.00
IUUC-Oru-084501	Oryza rufipogon	42.76	3.00e-97	351.00
IUUC-Osa-086251	Oryza sativa	42.60	5.00e-97	348.00
IUUC-Ola-086777	Oryzias latipes	82.51	0.00e+00	1591.00
IUUC-Oga-088684	Otolemur garnettii	91.52	0.00e+00	1781.00
IUUC-Oar-089428	Ovis aries	90.85	0.00e+00	1747.00
IUUC-Ptr-090529	Pan troglodytes	91.51	0.00e+00	1783.00
IUUC-Pan-091702	Papio anubis	91.40	0.00e+00	1782.00
IUUC-Psi-093969	Pelodiscus sinensis	96.70	0.00e+00	1847.00
IUUC-Ppa-095834	Physcomitrella patens	43.18	8.00e-97	350.00
IUUC-Pfo-097364	Poecilia formosa	83.40	0.00e+00	1610.00
IUUC-Pab-098574	Pongo abelii	91.61	0.00e+00	1785.00
IUUC-Pop-099468	Populus trichocarpa	43.86	3.00e-99	358.00
IUUC-Pca-100525	Procavia capensis	85.47	2.00e-177	615.00
IUUC-Ppe-101641	Prunus persica	43.86	8.00e-100	360.00
IUUC-Pva-102365	Pteropus vampyrus	80.25	0.00e+00	1508.00
IUUC-Pgr-103465	Puccinia graminis	40.66	2.00e-100	362.00
IUUC-Ptt-103813	Puccinia triticina	38.12	7.00e-90	327.00
IUUC-Rno-105153	Rattus norvegicus	90.76	0.00e+00	1774.00
IUUC-Sha-107319	Sarcophilus harrisii	95.12	0.00e+00	1881.00
IUUC-Smo-109640	Selaginella moellendorffii	42.82	2.00e-97	352.00
IUUC-Sit-110598	Setaria italica	43.44	2.00e-97	352.00
IUUC-Sly-111706	Solanum lycopersicum	44.77	8.00e-102	366.00
IUUC-Stu-112894	Solanum tuberosum	33.90	4.00e-53	202.00
IUUC-Sar-113449	Sorex araneus	69.95	1.00e-158	553.00
IUUC-Sbi-114042	Sorghum bicolor	43.74	6.00e-98	353.00
IUUC-Ssc-115865	Sus scrofa	91.40	0.00e+00	1784.00
IUUC-Tgu-117225	Taeniopygia guttata	98.41	0.00e+00	1949.00
IUUC-Tru-118026	Takifugu rubripes	81.80	0.00e+00	1583.00
IUUC-Tsy-119407	Tarsius syrichta	79.19	0.00e+00	1483.00
IUUC-Tni-120234	Tetraodon nigroviridis	81.02	0.00e+00	1264.00
IUUC-Tca-121479	Theobroma cacao	43.64	3.00e-100	361.00
IUUC-Tur-126774	Triticum urartu	29.66	2.00e-46	180.00
IUUC-Tbe-127708	Tupaia belangeri	79.15	0.00e+00	816.00
IUUC-Ttr-128667	Tursiops truncatus	91.08	0.00e+00	1780.00
IUUC-Vpa-130200	Vicugna pacos	91.05	0.00e+00	1720.00
IUUC-Vvi-131078	Vitis vinifera	43.41	3.00e-99	358.00
IUUC-Xtr-132176	Xenopus tropicalis	90.57	0.00e+00	1791.00
IUUC-Xma-133936	Xiphophorus maculatus	82.46	0.00e+00	948.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence