iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069786

Ensembl Protein ID

ENSNLEP00000015863.1

UniProt Accession

G1RRJ9; G1RRJ9_NOMLE

Genbank Protein ID

ENSNLEP00000015863

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADFV01165116

Gene Name

FRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000013075.1	ENSNLET00000016673.1	ENSNLEP00000015863.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-10	40.9	45	107

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk.......elegkrGlfPenFvek 61
           +++ +l+dy+a + ++L++++Gd+++v+  ++  egW+ + +         ++ +G +P+n+v++
   Q: 45   HYFVALFDYQARTAEDLSFRAGDKLQVL--DTSHEGWWFARHlekrrdgSSQQLQGYIPSNYVAE 107
           6899************************..89999*****889999999889999*******975 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MSNICQRLWD YLEHYLPCLS TEADKSTVIE NPGAHCSPQS QRHGHYFVAL FDYQARTAED 60
LSFRAGDKLQ VLDTSHEGWW FARHLEKRRD GSSQQLQGYI PSNYVAEDRS LQAEPWFFGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGGTGAAA GCAAGGCGTG GGGGTTTTAC CAGGGGTTAG TAGCTTCCTC TTGCTAACTT 60
TTTATTGGGA CAAAAGGCAA GATGGCACCA TTCTGTTCTC AGATATTTGT CTAAATAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter

KEGG

nle:100593495

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	26.72	3.00e-24	107.00
IUUC-Apl-003394	Anas platyrhynchos	67.38	0.00e+00	723.00
IUUC-Aca-004553	Anolis carolinensis	67.86	0.00e+00	733.00
IUUC-Cel-018682	Caenorhabditis elegans	54.68	1.00e-151	529.00
IUUC-Cja-019885	Callithrix jacchus	97.43	0.00e+00	1037.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	30.21	2.00e-22	100.00
IUUC-Cin-025605	Ciona intestinalis	53.94	1.00e-152	532.00
IUUC-Dre-028274	Danio rerio	64.86	4.00e-180	624.00
IUUC-Dno-029689	Dasypus novemcinctus	87.23	0.00e+00	932.00
IUUC-Dme-031976	Drosophila melanogaster	61.65	2.00e-174	605.00
IUUC-Eeu-034770	Erinaceus europaeus	73.54	0.00e+00	662.00
IUUC-Fal-036892	Ficedula albicollis	65.52	0.00e+00	698.00
IUUC-Gga-041072	Gallus gallus	67.35	0.00e+00	709.00
IUUC-Gma-043806	Glycine max	27.82	3.00e-22	100.00
IUUC-Hvu-047855	Hordeum vulgare	27.10	3.00e-24	107.00
IUUC-Loc-052913	Lepisosteus oculatus	62.45	2.00e-180	625.00
IUUC-Mga-059456	Meleagris gallopavo	68.52	0.00e+00	712.00
IUUC-Mmr-061480	Microcebus murinus	87.70	0.00e+00	906.00
IUUC-Mlu-067167	Myotis lucifugus	81.19	0.00e+00	850.00
IUUC-Ont-072417	Oreochromis niloticus	62.15	0.00e+00	640.00
IUUC-Ogl-077331	Oryza glaberrima	30.54	2.00e-24	108.00
IUUC-Ogu-078962	Oryza glumaepatula	30.54	2.00e-24	108.00
IUUC-Oin-079172	Oryza indica	30.54	1.00e-24	108.00
IUUC-Olo-080286	Oryza longistaminata	30.54	1.00e-24	108.00
IUUC-Ome-081400	Oryza meridionalis	30.54	1.00e-24	108.00
IUUC-Oni-082734	Oryza nivara	30.54	3.00e-24	107.00
IUUC-Opu-083538	Oryza punctata	31.03	3.00e-24	107.00
IUUC-Oru-084741	Oryza rufipogon	30.54	1.00e-24	108.00
IUUC-Osa-085779	Oryza sativa	30.54	1.00e-24	108.00
IUUC-Ola-086419	Oryzias latipes	63.71	6.00e-179	620.00
IUUC-Pan-092732	Papio anubis	98.22	0.00e+00	1035.00
IUUC-Psi-093899	Pelodiscus sinensis	71.15	0.00e+00	761.00
IUUC-Pma-094230	Petromyzon marinus	61.61	3.00e-172	597.00
IUUC-Pfo-096035	Poecilia formosa	60.00	3.00e-172	597.00
IUUC-Pva-103122	Pteropus vampyrus	69.88	0.00e+00	700.00
IUUC-Rno-105269	Rattus norvegicus	89.11	0.00e+00	936.00
IUUC-Sit-110451	Setaria italica	27.66	1.00e-23	105.00
IUUC-Sly-111528	Solanum lycopersicum	28.03	2.00e-23	104.00
IUUC-Stu-112831	Solanum tuberosum	28.46	1.00e-22	102.00
IUUC-Tgu-116491	Taeniopygia guttata	71.46	0.00e+00	710.00
IUUC-Tru-117795	Takifugu rubripes	54.14	4.00e-164	571.00
IUUC-Tni-120512	Tetraodon nigroviridis	61.38	0.00e+00	633.00
IUUC-Tae-123192	Triticum aestivum	26.72	2.00e-24	107.00
IUUC-Tur-126022	Triticum urartu	26.72	1.00e-23	105.00
IUUC-Ttr-128817	Tursiops truncatus	90.12	0.00e+00	945.00
IUUC-Vpa-130389	Vicugna pacos	81.23	0.00e+00	834.00
IUUC-Xtr-132360	Xenopus tropicalis	59.25	0.00e+00	659.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence