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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046592
UUCD1 version UUC-HoS-00663
Ensembl Protein ID ENSP00000381298.3
UniProt Accession Q17RB8; B4DM29; B4DU84; Q8TEA0; Q9BSV1; LONF1_HUMAN
Genbank Protein ID BAB85052.1; BAG59741.1; BAG62246.1; AAH04538.2; AAI17382.1; AAI17386.1
Protein Name LON peptidase N-terminal domain and RING finger protein 1; RING finger protein 191
Genbank Nucleotide ID AC123777; AK297266; AK300538; BC004538; BC117381; BC117385
Gene Name LONRF1; RNF191
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000154359.12 ENST00000398246.7 ENSP00000381298.3
ENSG00000154359.12 ENST00000526680.5 ENSP00000434090.1
ENSG00000154359.12 ENST00000524526.2 ENSP00000433327.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 5.40e-09 37.7 475 522
E3 activity/RING/RING 3.80e-09 38.6 479 517
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplte 52
           ++f C++ + l+ +Pv++p+G+++ ++++e++l++    cP+++++l+e
   Q: 475  SDFECSLCMRLFFEPVTTPCGHSFCKNCLERCLDHAPY-CPLCKESLKE 522
           68***********************************9.*******986 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+  f++ p+++pCgH f+++Cl++          + +CPlC+
   Q: 479  CSLCMRLFFE-PVTTPCGHSFCKNCLERC------LDHAPYCPLCK 517
           **********.9**************999......9*********6 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL LLRRGELLAL 60
GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR HGLGWSAAPV AGADGGAGGL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046592|E3,U-box;E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGAGTCCC AGTCATCTGC CGAAGGTGCG CTCCCAGGCC CCCTGCTTGG GCGCGCCCAC 60
CTGGAACATG GGCGTAGAGC TATGAAAATG CAGACCCGCA CAAGCGCGAG GCCACGCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046592|E3,U-box;E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51787--LON_N
PS50293--TPR_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02190--LON_substr_bdg
PF13445--zf-RING_UBOX
SMART

SM00464--LON
SM00184--RING
SM00028--TPR
Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
KEGG hsa:91694
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001989 Ailuropoda melanoleuca 91.92 0.00e+00 993.00
IUUC-Atr-002972 Amborella trichopoda 40.00 8.00e-43 168.00
IUUC-Apl-003309 Anas platyrhynchos 79.71 0.00e+00 650.00
IUUC-Aca-004288 Anolis carolinensis 64.30 0.00e+00 860.00
IUUC-Aly-005476 Arabidopsis lyrata 36.99 2.00e-40 160.00
IUUC-Ath-006654 Arabidopsis thaliana 37.40 6.00e-41 162.00
IUUC-Ang-009643 Aspergillus niger 29.81 3.00e-39 156.00
IUUC-Ame-010716 Astyanax mexicanus 51.03 0.00e+00 641.00
IUUC-Bta-012903 Bos taurus 87.50 0.00e+00 1066.00
IUUC-Bdi-014333 Brachypodium distachyon 41.71 3.00e-42 166.00
IUUC-Bol-016150 Brassica oleracea 34.62 6.00e-41 162.00
IUUC-Bra-016716 Brassica rapa 33.21 4.00e-38 152.00
IUUC-Cja-019312 Callithrix jacchus 98.29 0.00e+00 1240.00
IUUC-Cfa-020159 Canis familiaris 92.19 0.00e+00 1132.00
IUUC-Cpo-022528 Cavia porcellus 91.90 0.00e+00 968.00
IUUC-Csa-023361 Chlorocebus sabaeus 98.32 0.00e+00 1186.00
IUUC-Cho-024549 Choloepus hoffmanni 83.46 0.00e+00 840.00
IUUC-Cgl-026514 Colletotrichum gloeosporioides 31.38 3.00e-45 176.00
IUUC-Cme-027153 Cyanidioschyzon merolae 30.35 2.00e-29 123.00
IUUC-Dre-028195 Danio rerio 49.25 0.00e+00 641.00
IUUC-Dno-029284 Dasypus novemcinctus 91.17 0.00e+00 1001.00
IUUC-Dor-031123 Dipodomys ordii 80.75 0.00e+00 723.00
IUUC-Dme-031919 Drosophila melanogaster 36.95 4.00e-65 243.00
IUUC-Ete-032455 Echinops telfairi 91.32 0.00e+00 770.00
IUUC-Eca-033248 Equus caballus 95.49 0.00e+00 777.00
IUUC-Eeu-034441 Erinaceus europaeus 92.55 0.00e+00 806.00
IUUC-Fca-035551 Felis catus 92.29 0.00e+00 1018.00
IUUC-Fal-036731 Ficedula albicollis 75.95 0.00e+00 822.00
IUUC-Gmo-039315 Gadus morhua 44.70 3.00e-159 555.00
IUUC-Gga-040888 Gallus gallus 79.81 0.00e+00 684.00
IUUC-Gac-042121 Gasterosteus aculeatus 50.20 0.00e+00 632.00
IUUC-Ggo-044985 Gorilla gorilla 98.59 0.00e+00 1110.00
IUUC-Hvu-047145 Hordeum vulgare 40.65 1.00e-24 106.00
IUUC-Itr-048573 Ictidomys tridecemlineatus 93.69 0.00e+00 1073.00
IUUC-Lch-050404 Latimeria chalumnae 57.14 0.00e+00 742.00
IUUC-Laf-053431 Loxodonta africana 90.98 0.00e+00 995.00
IUUC-Mcc-055751 Macaca mulatta 96.92 0.00e+00 1073.00
IUUC-Mor-056963 Magnaporthe oryzae 41.71 4.00e-41 162.00
IUUC-Mla-058946 Melampsora laricipopulina 34.45 9.00e-46 177.00
IUUC-Mvi-060228 Microbotryum violaceum 33.98 1.00e-46 181.00
IUUC-Mmr-061283 Microcebus murinus 94.83 0.00e+00 1201.00
IUUC-Mmu-063169 Mus musculus 87.03 0.00e+00 1056.00
IUUC-Mac-065566 Musa acuminata 37.66 2.00e-43 170.00
IUUC-Mpu-066537 Mustela putorius furo 91.72 0.00e+00 1184.00
IUUC-Mlu-067497 Myotis lucifugus 91.92 0.00e+00 1012.00
IUUC-Nle-068971 Nomascus leucogenys 99.06 0.00e+00 1039.00
IUUC-Opr-070791 Ochotona princeps 92.87 0.00e+00 910.00
IUUC-Ont-071548 Oreochromis niloticus 49.10 0.00e+00 646.00
IUUC-Oan-072747 Ornithorhynchus anatinus 85.32 0.00e+00 718.00
IUUC-Ocu-074928 Oryctolagus cuniculus 95.99 0.00e+00 798.00
IUUC-Oba-075239 Oryza barthii 40.67 5.00e-42 165.00
IUUC-Obr-076158 Oryza brachyantha 40.62 3.00e-44 173.00
IUUC-Ogu-078154 Oryza glumaepatula 41.15 1.00e-42 167.00
IUUC-Oin-079067 Oryza indica 38.33 2.00e-42 167.00
IUUC-Olo-080663 Oryza longistaminata 40.67 7.00e-42 164.00
IUUC-Oni-082119 Oryza nivara 35.45 2.00e-42 167.00
IUUC-Opu-083266 Oryza punctata 42.11 5.00e-31 128.00
IUUC-Oru-085190 Oryza rufipogon 40.67 7.00e-42 165.00
IUUC-Ola-086977 Oryzias latipes 52.05 0.00e+00 657.00
IUUC-Oga-088719 Otolemur garnettii 88.50 0.00e+00 1194.00
IUUC-Oar-089577 Ovis aries 92.29 0.00e+00 1022.00
IUUC-Ptr-090711 Pan troglodytes 99.61 0.00e+00 1274.00
IUUC-Pan-092587 Papio anubis 98.19 0.00e+00 1227.00
IUUC-Psi-093128 Pelodiscus sinensis 74.22 0.00e+00 851.00
IUUC-Pfo-096474 Poecilia formosa 50.55 0.00e+00 648.00
IUUC-Pab-097800 Pongo abelii 98.02 0.00e+00 1208.00
IUUC-Ppe-101621 Prunus persica 38.29 8.00e-36 145.00
IUUC-Pte-104214 Pyrenophora teres 30.15 9.00e-39 155.00
IUUC-Pyt-104565 Pyrenophora triticirepentis 30.15 7.00e-39 155.00
IUUC-Rno-105718 Rattus norvegicus 85.42 0.00e+00 1013.00
IUUC-Sit-110495 Setaria italica 38.33 9.00e-42 165.00
IUUC-Sly-111396 Solanum lycopersicum 33.90 6.00e-42 165.00
IUUC-Sar-113220 Sorex araneus 89.90 0.00e+00 736.00
IUUC-Sbi-114779 Sorghum bicolor 37.50 9.00e-29 121.00
IUUC-Ssc-115733 Sus scrofa 89.91 0.00e+00 1165.00
IUUC-Tgu-117431 Taeniopygia guttata 70.29 0.00e+00 853.00
IUUC-Tru-118274 Takifugu rubripes 50.70 0.00e+00 629.00
IUUC-Tsy-119043 Tarsius syrichta 95.11 0.00e+00 1018.00
IUUC-Tni-120766 Tetraodon nigroviridis 49.78 3.00e-168 585.00
IUUC-Tca-121632 Theobroma cacao 31.42 1.00e-43 170.00
IUUC-Tae-125900 Triticum aestivum 34.38 6.00e-45 175.00
IUUC-Tur-126297 Triticum urartu 40.74 5.00e-32 132.00
IUUC-Tme-127112 Tuber melanosporum 37.35 9.00e-47 181.00
IUUC-Tbe-127284 Tupaia belangeri 91.35 0.00e+00 782.00
IUUC-Vda-129721 Verticillium dahliae 27.56 7.00e-36 145.00
IUUC-Vpa-130408 Vicugna pacos 84.59 0.00e+00 886.00
IUUC-Xtr-132417 Xenopus tropicalis 57.41 0.00e+00 730.00
IUUC-Xma-134099 Xiphophorus maculatus 49.86 0.00e+00 641.00
Created Date 25-Jun-2017

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