iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069453

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01179576

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000011935.2	ENSNLET00000015296.2	ENSNLEP00000014570.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.10e-101	337.7	725	1048

Active Site

Position(s)	Description	Evidence
1017	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 725  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 806
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e++p++ +s+++++++ e+diee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++
   Q: 807  HFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEET-FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 892
           ***************************************9**998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 893  VDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQF 979
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y++ke+l++kL+ Ai++++gF+l
   Q: 980  LLFLTGSDRIPILGMKSLK---LVIQStGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
           *******************...7777758889**************************************86 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKKVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCTACCTC GCGTGGCCAC CTCCCCCTCT GCCTTCTCCT ACCCAGTCTG TTCCCCAACT 60
CTCCCCACCC CTCGTGCTCT CCGCCCCACT TGCCTCCCGT TCTTCCCCGC CCGCTCCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

nle:100604395

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	97.54	0.00e+00	1988.00
IUUC-Apl-003295	Anas platyrhynchos	87.81	0.00e+00	1856.00
IUUC-Aca-004336	Anolis carolinensis	86.69	0.00e+00	1826.00
IUUC-Ame-010768	Astyanax mexicanus	73.62	0.00e+00	1577.00
IUUC-Bta-013279	Bos taurus	97.07	0.00e+00	1982.00
IUUC-Bdi-014791	Brachypodium distachyon	37.29	5.00e-52	198.00
IUUC-Cja-019023	Callithrix jacchus	98.01	0.00e+00	1999.00
IUUC-Cfa-021074	Canis familiaris	97.73	0.00e+00	1995.00
IUUC-Cpo-021461	Cavia porcellus	95.37	0.00e+00	1937.00
IUUC-Csa-024261	Chlorocebus sabaeus	98.49	0.00e+00	2010.00
IUUC-Cho-024513	Choloepus hoffmanni	78.41	0.00e+00	870.00
IUUC-Cin-025232	Ciona intestinalis	43.14	0.00e+00	821.00
IUUC-Dre-028829	Danio rerio	75.29	0.00e+00	1569.00
IUUC-Dno-029445	Dasypus novemcinctus	94.37	0.00e+00	1603.00
IUUC-Dor-030158	Dipodomys ordii	95.82	0.00e+00	861.00
IUUC-Dme-032103	Drosophila melanogaster	45.22	0.00e+00	895.00
IUUC-Ete-033072	Echinops telfairi	87.23	0.00e+00	1727.00
IUUC-Eca-033317	Equus caballus	95.27	0.00e+00	1941.00
IUUC-Fca-035682	Felis catus	98.67	0.00e+00	2006.00
IUUC-Fal-036969	Ficedula albicollis	86.38	0.00e+00	1826.00
IUUC-Gmo-038671	Gadus morhua	74.32	0.00e+00	1576.00
IUUC-Gga-041174	Gallus gallus	87.42	0.00e+00	1855.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.77	0.00e+00	1509.00
IUUC-Ggo-044589	Gorilla gorilla	98.49	0.00e+00	2039.00
IUUC-Hsa-046772	Homo sapiens	98.49	0.00e+00	2036.00
IUUC-Lch-050147	Latimeria chalumnae	81.17	0.00e+00	1439.00
IUUC-Loc-052684	Lepisosteus oculatus	80.49	0.00e+00	1696.00
IUUC-Laf-053844	Loxodonta africana	96.88	0.00e+00	1973.00
IUUC-Mcc-055531	Macaca mulatta	96.21	0.00e+00	1995.00
IUUC-Mga-060151	Meleagris gallopavo	86.66	0.00e+00	1538.00
IUUC-Mmr-060954	Microcebus murinus	97.73	0.00e+00	1993.00
IUUC-Mdo-062246	Monodelphis domestica	93.12	0.00e+00	1785.00
IUUC-Mmu-063369	Mus musculus	97.24	0.00e+00	1999.00
IUUC-Mpu-065936	Mustela putorius furo	96.74	0.00e+00	1825.00
IUUC-Mlu-067326	Myotis lucifugus	96.97	0.00e+00	1950.00
IUUC-Ont-071720	Oreochromis niloticus	75.38	0.00e+00	1580.00
IUUC-Oan-073464	Ornithorhynchus anatinus	91.96	0.00e+00	1768.00
IUUC-Ocu-074207	Oryctolagus cuniculus	95.36	0.00e+00	1831.00
IUUC-Oba-075262	Oryza barthii	34.63	5.00e-47	181.00
IUUC-Ogl-077586	Oryza glaberrima	34.63	6.00e-47	181.00
IUUC-Ogu-078796	Oryza glumaepatula	34.63	6.00e-47	181.00
IUUC-Oin-079298	Oryza indica	34.63	5.00e-47	181.00
IUUC-Olo-080768	Oryza longistaminata	37.86	4.00e-53	202.00
IUUC-Ome-081908	Oryza meridionalis	33.94	2.00e-47	183.00
IUUC-Oni-082049	Oryza nivara	34.63	6.00e-47	181.00
IUUC-Opu-083608	Oryza punctata	34.83	1.00e-47	183.00
IUUC-Oru-084712	Oryza rufipogon	34.63	6.00e-47	181.00
IUUC-Osa-086078	Oryza sativa	34.63	6.00e-47	181.00
IUUC-Ola-086762	Oryzias latipes	74.60	0.00e+00	1535.00
IUUC-Oga-088435	Otolemur garnettii	98.01	0.00e+00	1998.00
IUUC-Oar-089233	Ovis aries	97.07	0.00e+00	1982.00
IUUC-Ptr-091368	Pan troglodytes	98.68	0.00e+00	2041.00
IUUC-Pan-092300	Papio anubis	98.49	0.00e+00	2010.00
IUUC-Psi-093406	Pelodiscus sinensis	89.03	0.00e+00	1870.00
IUUC-Pma-094113	Petromyzon marinus	71.17	0.00e+00	1123.00
IUUC-Ppa-095354	Physcomitrella patens	32.59	1.00e-147	517.00
IUUC-Pfo-097021	Poecilia formosa	73.98	0.00e+00	1586.00
IUUC-Pab-098327	Pongo abelii	98.86	0.00e+00	2042.00
IUUC-Pca-101075	Procavia capensis	96.27	0.00e+00	816.00
IUUC-Pva-102909	Pteropus vampyrus	86.09	0.00e+00	1679.00
IUUC-Rno-105457	Rattus norvegicus	96.69	0.00e+00	1991.00
IUUC-Sha-106632	Sarcophilus harrisii	94.47	0.00e+00	1962.00
IUUC-Sit-110415	Setaria italica	36.60	8.00e-53	201.00
IUUC-Sar-113679	Sorex araneus	89.19	0.00e+00	1155.00
IUUC-Tgu-116849	Taeniopygia guttata	82.59	0.00e+00	1719.00
IUUC-Tru-118206	Takifugu rubripes	73.03	0.00e+00	1476.00
IUUC-Tsy-119521	Tarsius syrichta	83.07	0.00e+00	1592.00
IUUC-Tni-120233	Tetraodon nigroviridis	72.53	0.00e+00	1462.00
IUUC-Tbe-127941	Tupaia belangeri	81.96	0.00e+00	1382.00
IUUC-Ttr-128926	Tursiops truncatus	96.65	0.00e+00	1159.00
IUUC-Vpa-130448	Vicugna pacos	96.50	0.00e+00	1970.00
IUUC-Xtr-132719	Xenopus tropicalis	71.24	0.00e+00	1394.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence