iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
PHOSIDA
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	21304511
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	21304511

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.40e-58	190.1	411	446
E3 adaptor/Cullin RING/SCF/F-box	0.013	15.6	99	136
UBD/Beta-Prp	1.50e-66	224.6	327	489

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH++ v+c++f d +++vsG++Dg+ikvWDl    ++
   Q: 411  GHEELVRCIRF-DtKRIVSGAYDGKIKVWDLVAALDP 446
           8**********.559***************9876665 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 109  eilveilklldkeellraarvcrrwqelasqkalwktv 146
           +i  +il++ld+e+l + ++vc++w +++s+  lwk++
   Q: 99   HIAENILSYLDAESLKSSELVCKEWLRVISEGMLWKKL 136
           7899**********************99999****987 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncv 143
           r l gh a+v+ v+f+++  ++v++s Drtikvw+ s+++ v+tl+gh++ + +l++      +vsGs+d+ ir+wd+e g cl+ +l+gh+++v+c+
   Q: 327  RVLVGHRAAVNVVDFDEK--YIVSASGDRTIKVWSTSSCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNSIRLWDIECGACLR-VLEGHEELVRCI 419
           4569************99..8**************************************..************************.************ PP
   S: 144  vvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +++   + +vsG++D+++++Wdl         ++  +l tl + ht++v  l+fd+  +++vs s+d t+ +wd+
   Q: 420  RFDT--KRIVSGAYDGKIKVWDLvaaldpraaSNTLCLNTLVE-HTGRVFRLQFDE--FQIVSSSHDDTILIWDF 489
           ****..*************************99999*****98.************..99**************7 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MMKMETDKIM DETNSNAQAF TTTMLYDPVR KKDSSPTYQT ERELCFQYFT QWSESGQVDF 60
VEHLLSRMCH YQHGQINAYL KPMLQRDFIT LLPIKGLDHI AENILSYLDA ESLKSSELVC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGATAGTGC ACACTCATCT TTGGCTTTGT GGTTTCGCAG TCCGTATTTG GGCGAGATCT 60
GGTAAAAAAA AATAAAATTC TCCGTGTGAA AAGTGAGTGT CCAGTAGTTG GCGTCATCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0051219--F:phosphoprotein binding
GO:0007298--P:border follicle cell migration
GO:0007304--P:chorion-containing eggshell formation
GO:0007623--P:circadian rhythm
GO:0046843--P:dorsal appendage formation
GO:0090162--P:establishment of epithelial cell polarity
GO:0007293--P:germarium-derived egg chamber formation
GO:0030708--P:germarium-derived female germ-line cyst encapsulation
GO:0030727--P:germarium-derived female germ-line cyst formation
GO:0007611--P:learning or memory
GO:0045475--P:locomotor rhythm
GO:0043066--P:negative regulation of apoptotic process
GO:0008285--P:negative regulation of cell proliferation
GO:0060253--P:negative regulation of glial cell proliferation
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0045849--P:negative regulation of nurse cell apoptotic process
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0032007--P:negative regulation of TOR signaling
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0016322--P:neuron remodeling
GO:0008355--P:olfactory learning
GO:0007309--P:oocyte axis specification
GO:0030720--P:oocyte localization involved in germarium-derived egg chamber formation
GO:0030707--P:ovarian follicle cell development
GO:0030713--P:ovarian follicle cell stalk formation
GO:0045451--P:pole plasm oskar mRNA localization
GO:0016567--P:protein ubiquitination
GO:0006508--P:proteolysis
GO:0046599--P:regulation of centriole replication
GO:0060623--P:regulation of chromosome condensation
GO:2000114--P:regulation of establishment of cell polarity
GO:0007088--P:regulation of mitotic nuclear division
GO:0030162--P:regulation of proteolysis
GO:0008589--P:regulation of smoothened signaling pathway
GO:0030111--P:regulation of Wnt signaling pathway
GO:0008588--P:release of cytoplasmic sequestered NF-kappaB
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG3412

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001961	Ailuropoda melanoleuca	80.41	0.00e+00	819.00
IUUC-Apl-003437	Anas platyrhynchos	79.84	0.00e+00	811.00
IUUC-Aca-004410	Anolis carolinensis	79.59	0.00e+00	812.00
IUUC-Acl-008160	Aspergillus clavatus	36.59	3.00e-44	172.00
IUUC-Afu-009068	Aspergillus fumigatus	34.75	7.00e-43	168.00
IUUC-Ani-009324	Aspergillus nidulans	28.51	5.00e-47	181.00
IUUC-Ang-009766	Aspergillus niger	30.88	6.00e-51	194.00
IUUC-Aor-010185	Aspergillus oryzae	28.82	1.00e-47	183.00
IUUC-Ate-010546	Aspergillus terreus	36.59	6.00e-43	168.00
IUUC-Ame-011393	Astyanax mexicanus	79.37	0.00e+00	800.00
IUUC-Bgr-012194	Blumeria graminis	29.93	8.00e-50	191.00
IUUC-Bta-013453	Bos taurus	80.41	0.00e+00	820.00
IUUC-Bci-013685	Botrytis cinerea	30.57	3.00e-53	202.00
IUUC-Cel-018392	Caenorhabditis elegans	62.75	0.00e+00	641.00
IUUC-Cja-019121	Callithrix jacchus	80.66	0.00e+00	820.00
IUUC-Cfa-020553	Canis familiaris	80.41	0.00e+00	820.00
IUUC-Cpo-022151	Cavia porcellus	80.42	0.00e+00	804.00
IUUC-Csa-023688	Chlorocebus sabaeus	80.41	0.00e+00	820.00
IUUC-Cho-024658	Choloepus hoffmanni	74.02	7.00e-88	317.00
IUUC-Cin-025188	Ciona intestinalis	72.23	0.00e+00	752.00
IUUC-Csv-026020	Ciona savignyi	74.33	0.00e+00	730.00
IUUC-Cgl-026429	Colletotrichum gloeosporioides	30.70	3.00e-55	209.00
IUUC-Dre-028160	Danio rerio	79.16	0.00e+00	800.00
IUUC-Dno-029484	Dasypus novemcinctus	76.83	0.00e+00	800.00
IUUC-Dor-030498	Dipodomys ordii	80.42	0.00e+00	806.00
IUUC-Dse-031196	Dothistroma septosporum	32.14	4.00e-49	189.00
IUUC-Ete-032978	Echinops telfairi	66.53	0.00e+00	630.00
IUUC-Eca-033374	Equus caballus	80.00	0.00e+00	815.00
IUUC-Eeu-034760	Erinaceus europaeus	67.53	8.00e-135	473.00
IUUC-Fca-035427	Felis catus	80.41	0.00e+00	821.00
IUUC-Fal-037530	Ficedula albicollis	80.21	0.00e+00	818.00
IUUC-Fox-037978	Fusarium oxysporum	31.93	2.00e-57	216.00
IUUC-Fso-038077	Fusarium solani	31.78	1.00e-54	207.00
IUUC-Gmo-038590	Gadus morhua	78.11	0.00e+00	786.00
IUUC-Ggr-039974	Gaeumannomyces graminis	30.62	2.00e-53	202.00
IUUC-Gga-041087	Gallus gallus	80.21	0.00e+00	819.00
IUUC-Gac-041305	Gasterosteus aculeatus	76.80	0.00e+00	789.00
IUUC-Ggo-045369	Gorilla gorilla	80.41	0.00e+00	818.00
IUUC-Hsa-045962	Homo sapiens	80.41	0.00e+00	820.00
IUUC-Itr-047872	Ictidomys tridecemlineatus	80.91	0.00e+00	747.00
IUUC-Lch-050460	Latimeria chalumnae	80.42	0.00e+00	806.00
IUUC-Loc-052686	Lepisosteus oculatus	81.03	0.00e+00	823.00
IUUC-Lma-053289	Leptosphaeria maculans	34.22	1.00e-42	167.00
IUUC-Laf-054022	Loxodonta africana	80.62	0.00e+00	821.00
IUUC-Mcc-055782	Macaca mulatta	80.41	0.00e+00	818.00
IUUC-Meu-056078	Macropus eugenii	71.67	0.00e+00	684.00
IUUC-Mor-057283	Magnaporthe oryzae	31.30	7.00e-55	208.00
IUUC-Mpo-057540	Magnaporthe poae	31.04	4.00e-54	205.00
IUUC-Mla-058989	Melampsora laricipopulina	39.56	4.00e-58	217.00
IUUC-Mga-059388	Meleagris gallopavo	80.21	0.00e+00	819.00
IUUC-Mvi-060284	Microbotryum violaceum	43.65	3.00e-66	246.00
IUUC-Mmr-060969	Microcebus murinus	80.41	0.00e+00	820.00
IUUC-Mdo-063041	Monodelphis domestica	81.99	0.00e+00	814.00
IUUC-Mmu-064096	Mus musculus	77.98	0.00e+00	818.00
IUUC-Mpu-065716	Mustela putorius furo	80.84	0.00e+00	812.00
IUUC-Mlu-067621	Myotis lucifugus	80.29	0.00e+00	814.00
IUUC-Nfi-068261	Neosartorya fischeri	34.75	3.00e-43	169.00
IUUC-Ncr-068639	Neurospora crassa	35.38	3.00e-44	172.00
IUUC-Nle-069548	Nomascus leucogenys	80.41	0.00e+00	819.00
IUUC-Opr-071229	Ochotona princeps	81.05	0.00e+00	814.00
IUUC-Ont-071792	Oreochromis niloticus	78.32	0.00e+00	789.00
IUUC-Oan-072867	Ornithorhynchus anatinus	80.62	0.00e+00	821.00
IUUC-Ocu-074246	Oryctolagus cuniculus	80.41	0.00e+00	820.00
IUUC-Ola-086985	Oryzias latipes	78.32	0.00e+00	791.00
IUUC-Oga-088244	Otolemur garnettii	80.41	0.00e+00	818.00
IUUC-Oar-089199	Ovis aries	80.29	0.00e+00	813.00
IUUC-Ptr-091039	Pan troglodytes	80.63	0.00e+00	811.00
IUUC-Pan-092826	Papio anubis	80.41	0.00e+00	820.00
IUUC-Psi-093887	Pelodiscus sinensis	81.05	0.00e+00	813.00
IUUC-Pma-094315	Petromyzon marinus	74.90	0.00e+00	753.00
IUUC-Pfo-096783	Poecilia formosa	75.20	0.00e+00	795.00
IUUC-Pab-097680	Pongo abelii	80.00	0.00e+00	816.00
IUUC-Pca-100843	Procavia capensis	75.67	0.00e+00	735.00
IUUC-Pva-102547	Pteropus vampyrus	80.63	0.00e+00	805.00
IUUC-Pgr-103331	Puccinia graminis	35.22	4.00e-49	188.00
IUUC-Ptt-103853	Puccinia triticina	31.54	1.00e-60	226.00
IUUC-Pte-104392	Pyrenophora teres	38.79	8.00e-47	181.00
IUUC-Pyt-104678	Pyrenophora triticirepentis	38.43	4.00e-47	182.00
IUUC-Rno-105304	Rattus norvegicus	80.00	0.00e+00	816.00
IUUC-Sha-107454	Sarcophilus harrisii	81.99	0.00e+00	814.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.48	4.00e-74	271.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.07	3.00e-64	238.00
IUUC-Sar-113471	Sorex araneus	64.95	2.00e-174	605.00
IUUC-Sre-114916	Sporisorium reilianum	32.39	9.00e-43	168.00
IUUC-Ssc-115490	Sus scrofa	80.21	0.00e+00	817.00
IUUC-Tgu-117445	Taeniopygia guttata	80.00	0.00e+00	818.00
IUUC-Tru-117671	Takifugu rubripes	78.74	0.00e+00	792.00
IUUC-Tsy-118983	Tarsius syrichta	77.32	0.00e+00	783.00
IUUC-Tni-120359	Tetraodon nigroviridis	78.74	0.00e+00	792.00
IUUC-Tre-122207	Trichoderma reesei	35.34	9.00e-52	197.00
IUUC-Tvi-122344	Trichoderma virens	31.59	2.00e-51	196.00
IUUC-Tme-127141	Tuber melanosporum	33.41	2.00e-61	229.00
IUUC-Tbe-127418	Tupaia belangeri	76.21	0.00e+00	751.00
IUUC-Ttr-128946	Tursiops truncatus	80.21	0.00e+00	819.00
IUUC-Uma-129491	Ustilago maydis	34.24	1.00e-44	174.00
IUUC-Vda-129941	Verticillium dahliae	31.58	8.00e-55	207.00
IUUC-Vpa-130668	Vicugna pacos	80.84	0.00e+00	811.00
IUUC-Xtr-132861	Xenopus tropicalis	80.86	0.00e+00	818.00
IUUC-Xma-133187	Xiphophorus maculatus	84.93	1.00e-140	491.00
IUUC-Yli-134582	Yarrowia lipolytica	34.41	6.00e-54	204.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence