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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106372
Ensembl Protein ID YBL007C
UniProt Accession P32790; D6VPZ3; SLA1_YEAST
Genbank Protein ID CAA80463.1; CAA84826.1; AAB23985.1; DAA07113.1
Protein Name Actin cytoskeleton-regulatory complex protein SLA1
Genbank Nucleotide ID Z22810; Z35768; S47695; BK006936
Gene Name SLA1; YBL007C; YBL0321
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YBL007C YBL007C YBL007C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/SH3 SH3 17244534
Classification
Family E-value Score Start End
UBD/SH3 5.40e-42 140.1 354 414
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           sk++ +v+yd++a+++deLt+k+Gd+v+++ +++++++W++++  ++gk+Gl+P++F+e ++
   Q: 354  SKKRGIVQYDFMAESQDELTIKSGDKVYIL-DDKKSKDWWMCQLVDSGKSGLVPAQFIEPVR 414
           78999*************************.****************************997 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
 Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
Protein Sequence
(Fasta)
MTVFLGIYRA VYAYEPQTPE ELAIQEDDLL YLLQKSDIDD WWTVKKRVIG SDSEEPVGLV 60
PSTYIEEAPV LKKVRAIYDY EQVQNADEEL TFHENDVFDV FDDKDADWLL VKSTVSNEFG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106372|UBD,SH3|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGACTGTGT TTCTGGGCAT CTATAGGGCC GTCTATGCCT ATGAGCCGCA GACACCAGAA 60
GAACTGGCCA TCCAAGAAGA CGATCTGTTG TACCTCTTAC AGAAGTCAGA CATTGACGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106372|UBD,SH3|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0967--Endosome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0832--Ubl conjugation
Interpro

IPR013761--SAM/pointed
IPR001452--SH3_domain
IPR007131--SHD1
IPR029922--Sla1
PROSITE

PS50002--SH3
Pfam

PF00018--SH3_1
PF14604--SH3_9
PF03983--SHD1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
Gene Ontology

GO:0030479--C:actin cortical patch
GO:0005938--C:cell cortex
GO:0010008--C:endosome membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0042802--F:identical protein binding
GO:0030674--F:protein binding, bridging
GO:0043130--F:ubiquitin binding
GO:0000147--P:actin cortical patch assembly
GO:0030041--P:actin filament polymerization
GO:0006897--P:endocytosis
KEGG sce:YBL007C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007979 Ashbya gossypii 44.07 8.00e-93 333.00
IUUC-Acl-008300 Aspergillus clavatus 37.92 6.00e-54 204.00
IUUC-Afl-008694 Aspergillus flavus 38.53 2.00e-39 156.00
IUUC-Afu-008881 Aspergillus fumigatus 35.74 5.00e-51 194.00
IUUC-Ani-009274 Aspergillus nidulans 36.10 6.00e-44 171.00
IUUC-Ang-009534 Aspergillus niger 33.19 3.00e-71 261.00
IUUC-Aor-010097 Aspergillus oryzae 33.12 3.00e-62 232.00
IUUC-Ate-010495 Aspergillus terreus 36.65 3.00e-41 162.00
IUUC-Bgr-012294 Blumeria graminis 44.44 1.00e-28 120.00
IUUC-Bci-013990 Botrytis cinerea 30.77 6.00e-31 127.00
IUUC-Bol-016323 Brassica oleracea 26.03 1.00e-02 31.20
IUUC-Cel-018144 Caenorhabditis elegans 36.84 8.00e-09 52.80
IUUC-Cgl-026697 Colletotrichum gloeosporioides 54.55 2.00e-21 96.30
IUUC-Cne-026842 Cryptococcus neoformans 30.13 9.00e-31 127.00
IUUC-Dse-031496 Dothistroma septosporum 35.24 1.00e-46 180.00
IUUC-Fso-038358 Fusarium solani 31.33 8.00e-38 150.00
IUUC-Ggr-040032 Gaeumannomyces graminis 42.35 3.00e-24 105.00
IUUC-Kpa-049118 Komagataella pastoris 36.52 4.00e-68 251.00
IUUC-Lma-053236 Leptosphaeria maculans 35.95 4.00e-44 171.00
IUUC-Mor-056954 Magnaporthe oryzae 38.87 1.00e-50 193.00
IUUC-Mpo-057576 Magnaporthe poae 43.02 9.00e-28 117.00
IUUC-Mla-059035 Melampsora laricipopulina 27.78 5.00e-18 85.10
IUUC-Mvi-060454 Microbotryum violaceum 42.06 2.00e-20 92.80
IUUC-Nfi-068406 Neosartorya fischeri 35.71 1.00e-50 192.00
IUUC-Ncr-068902 Neurospora crassa 37.95 4.00e-25 108.00
IUUC-Obr-076697 Oryza brachyantha 31.82 5.00e-03 31.60
IUUC-Pno-094774 Phaeosphaeria nodorum 57.81 1.00e-20 94.00
IUUC-Pgr-103396 Puccinia graminis 50.79 4.00e-20 92.00
IUUC-Ptt-103751 Puccinia triticina 52.38 7.00e-21 94.40
IUUC-Pte-104349 Pyrenophora teres 50.79 3.00e-27 115.00
IUUC-Pyt-104695 Pyrenophora triticirepentis 50.00 6.00e-27 114.00
IUUC-Sja-107962 Schizosaccharomyces japonicus 31.72 5.00e-44 171.00
IUUC-Spo-108375 Schizosaccharomyces pombe 30.10 1.00e-24 107.00
IUUC-Ssl-108553 Sclerotinia sclerotiorum 34.16 7.00e-24 104.00
IUUC-Sit-110611 Setaria italica 40.00 5.80e-02 29.60
IUUC-Stu-112077 Solanum tuberosum 31.48 1.60e-02 32.00
IUUC-Sre-115072 Sporisorium reilianum 38.68 2.00e-20 93.20
IUUC-Tre-121912 Trichoderma reesei 37.02 4.00e-34 138.00
IUUC-Tvi-122336 Trichoderma virens 34.38 9.00e-35 140.00
IUUC-Tme-127017 Tuber melanosporum 40.00 4.00e-31 127.00
IUUC-Tbe-128089 Tupaia belangeri 35.48 1.00e-07 47.80
IUUC-Uma-129502 Ustilago maydis 53.85 8.00e-20 90.90
IUUC-Vda-129879 Verticillium dahliae 39.41 2.00e-28 119.00
IUUC-Yli-134528 Yarrowia lipolytica 44.79 2.00e-39 155.00
IUUC-Zma-135724 Zea mays 32.50 9.00e-02 28.50
Created Date 25-Jun-2017

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