iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063959

UUCD1 version

UUC-MuM-00059

Ensembl Protein ID

ENSMUSP00000031345.8

UniProt Accession

Q9CR50; Q920H0; ZN363_MOUSE

Genbank Protein ID

AAL75940.1; AAK96899.1; AAL09355.1; BAB31179.1; BAB31236.1; BAC37254.1; AAH57143.1

Protein Name

RING finger and CHY zinc finger domain-containing protein 1; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING-type E3 ubiquitin transferase RCHY1; Zinc finger protein 363

Genbank Nucleotide ID

AF071222; AF276959; AF305423; AK018364; AK018488; AK078397; BC057143

Gene Name

Rchy1; Arnip; Chimp; Zfp363; Znf363

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000029397.15	ENSMUST00000031345.14	ENSMUSP00000031345.8
ENSMUSG00000029397.15	ENSMUST00000169948.1	ENSMUSP00000131270.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	12200228

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.60e-07	30.9	145	186

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg...plvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iCled+ +     +vlpCgH+ h++C + +       +   rCPlC
   Q: 145  CPICLEDIHTSrvvAHVLPCGHLLHRTCYEEM------LKEGYRCPLC 186
           ********553334668***********8888......9********* PP

Organism

Mus musculus

Functional Description
(View)

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Monoubiquitinates the translesion DNA polymerase POLH (By similarity). Contributes to the regulation of the cell cycle progression.

Protein Sequence
(Fasta)

MAATAREDGV RNLAQGPRGC EHYDRACLLK APCCDKLYTC RLCHDTNEDH QLDRFKVKEV 60
QCINCEKLQH AQQTCEDCST LFGEYYCSIC HLFDKDKRQY HCESCGICRI GPKEDFFHCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCGCCAGA CGACGCAGCG GTCCCCTTCG CCCGCAATCA GGGCTGGCAG CGATGCCGGG 60
GCGGGGAAAA AGAGCCAACC TAAGACTTAC TACCATTAGC AGTGACGACA GCGACTAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004039--Rubredoxin-type_fold
IPR008913--Znf_CHY
IPR017921--Znf_CTCHY
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51266--ZF_CHY
PS51270--ZF_CTCHY
PS50089--ZF_RING_2

Pfam

PF05495--zf-CHY
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0002039--F:p53 binding
GO:0042803--F:protein homodimerization activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mmu:68098

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000576	Aegilops tauschii	45.96	8.00e-54	205.00
IUUC-Aml-002312	Ailuropoda melanoleuca	90.80	9.00e-143	498.00
IUUC-Atr-003010	Amborella trichopoda	44.94	4.00e-58	218.00
IUUC-Apl-003676	Anas platyrhynchos	81.70	5.00e-67	246.00
IUUC-Aly-005993	Arabidopsis lyrata	45.98	1.00e-64	239.00
IUUC-Ath-007665	Arabidopsis thaliana	44.44	7.00e-58	217.00
IUUC-Ago-007995	Ashbya gossypii	44.44	1.00e-52	201.00
IUUC-Acl-008144	Aspergillus clavatus	43.08	2.00e-56	213.00
IUUC-Afl-008618	Aspergillus flavus	44.07	2.00e-55	210.00
IUUC-Afu-008863	Aspergillus fumigatus	44.49	6.00e-57	215.00
IUUC-Ani-009131	Aspergillus nidulans	40.68	2.00e-48	186.00
IUUC-Ang-009555	Aspergillus niger	43.64	2.00e-56	213.00
IUUC-Aor-010177	Aspergillus oryzae	42.92	1.00e-50	192.00
IUUC-Ate-010343	Aspergillus terreus	40.68	3.00e-48	186.00
IUUC-Bgr-012193	Blumeria graminis	45.57	1.00e-56	214.00
IUUC-Bta-013191	Bos taurus	86.21	2.00e-131	461.00
IUUC-Bci-013852	Botrytis cinerea	44.92	1.00e-55	211.00
IUUC-Bdi-014852	Brachypodium distachyon	44.94	3.00e-59	221.00
IUUC-Bol-015118	Brassica oleracea	44.44	6.00e-64	237.00
IUUC-Bra-017289	Brassica rapa	45.75	5.00e-62	231.00
IUUC-Cja-019581	Callithrix jacchus	90.04	1.00e-141	495.00
IUUC-Cfa-021051	Canis familiaris	90.69	2.00e-133	468.00
IUUC-Cpo-022137	Cavia porcellus	92.81	4.00e-84	303.00
IUUC-Cre-022565	Chlamydomonas reinhardtii	42.74	1.00e-54	206.00
IUUC-Csa-024259	Chlorocebus sabaeus	90.42	9.00e-143	498.00
IUUC-Cho-024855	Choloepus hoffmanni	84.67	6.00e-127	446.00
IUUC-Cin-025667	Ciona intestinalis	51.68	3.00e-69	254.00
IUUC-Csv-025807	Ciona savignyi	51.93	5.00e-69	254.00
IUUC-Cgl-026589	Colletotrichum gloeosporioides	44.03	4.00e-54	206.00
IUUC-Cme-027329	Cyanidioschyzon merolae	43.88	1.00e-54	208.00
IUUC-Dre-028584	Danio rerio	70.25	5.00e-105	373.00
IUUC-Dor-030930	Dipodomys ordii	78.54	8.00e-99	352.00
IUUC-Dse-031251	Dothistroma septosporum	37.96	2.00e-51	197.00
IUUC-Dme-031649	Drosophila melanogaster	48.56	2.00e-60	226.00
IUUC-Ete-032847	Echinops telfairi	64.77	5.00e-98	350.00
IUUC-Eca-033470	Equus caballus	92.64	6.00e-128	449.00
IUUC-Eeu-034769	Erinaceus europaeus	69.74	7.00e-56	210.00
IUUC-Fca-035728	Felis catus	90.04	4.00e-140	489.00
IUUC-Fal-036768	Ficedula albicollis	78.72	9.00e-104	369.00
IUUC-Fox-037872	Fusarium oxysporum	45.39	1.00e-35	144.00
IUUC-Fso-038415	Fusarium solani	43.72	1.00e-59	224.00
IUUC-Gmo-038620	Gadus morhua	64.73	3.00e-97	347.00
IUUC-Ggr-040055	Gaeumannomyces graminis	41.95	8.00e-53	202.00
IUUC-Gga-040156	Gallus gallus	79.41	5.00e-113	400.00
IUUC-Gac-041535	Gasterosteus aculeatus	68.60	1.00e-94	338.00
IUUC-Gma-043631	Glycine max	46.94	6.00e-62	231.00
IUUC-Ggo-044951	Gorilla gorilla	90.42	1.00e-142	498.00
IUUC-Hsa-045737	Homo sapiens	90.42	9.00e-143	498.00
IUUC-Hvu-047256	Hordeum vulgare	43.63	1.00e-58	219.00
IUUC-Itr-048684	Ictidomys tridecemlineatus	91.57	2.00e-144	504.00
IUUC-Kpa-049272	Komagataella pastoris	42.26	2.00e-52	200.00
IUUC-Lch-050661	Latimeria chalumnae	67.65	1.00e-97	348.00
IUUC-Lpe-051493	Leersia perrieri	44.40	2.00e-59	222.00
IUUC-Loc-051936	Lepisosteus oculatus	68.40	2.00e-104	372.00
IUUC-Lma-053154	Leptosphaeria maculans	42.70	6.00e-21	95.10
IUUC-Laf-054226	Loxodonta africana	90.80	2.00e-138	484.00
IUUC-Mcc-055281	Macaca mulatta	90.42	9.00e-143	498.00
IUUC-Meu-056901	Macropus eugenii	79.65	2.00e-100	357.00
IUUC-Mor-057100	Magnaporthe oryzae	42.28	2.00e-56	214.00
IUUC-Mpo-057579	Magnaporthe poae	42.55	5.00e-54	206.00
IUUC-Mtr-058223	Medicago truncatula	45.75	3.00e-61	228.00
IUUC-Mla-059118	Melampsora laricipopulina	39.34	1.00e-03	40.00
IUUC-Mga-059512	Meleagris gallopavo	83.20	3.00e-60	223.00
IUUC-Mmr-060992	Microcebus murinus	89.96	3.00e-134	470.00
IUUC-Mdo-062157	Monodelphis domestica	84.68	5.00e-113	399.00
IUUC-Mac-065603	Musa acuminata	43.23	1.00e-60	226.00
IUUC-Mpu-065859	Mustela putorius furo	85.00	3.00e-56	209.00
IUUC-Mlu-067798	Myotis lucifugus	82.44	8.00e-125	439.00
IUUC-Nfi-068506	Neosartorya fischeri	44.07	5.00e-56	212.00
IUUC-Ncr-068859	Neurospora crassa	43.22	2.00e-54	207.00
IUUC-Nle-069585	Nomascus leucogenys	90.42	9.00e-143	498.00
IUUC-Opr-070267	Ochotona princeps	89.66	4.00e-139	486.00
IUUC-Ont-071374	Oreochromis niloticus	69.49	6.00e-97	346.00
IUUC-Oan-073381	Ornithorhynchus anatinus	81.90	1.00e-112	398.00
IUUC-Ocu-074867	Oryctolagus cuniculus	91.19	1.00e-143	501.00
IUUC-Oba-075296	Oryza barthii	45.12	5.00e-59	221.00
IUUC-Obr-076751	Oryza brachyantha	45.60	9.00e-59	220.00
IUUC-Ogl-077845	Oryza glaberrima	45.12	5.00e-59	221.00
IUUC-Ogu-078233	Oryza glumaepatula	44.26	2.00e-54	206.00
IUUC-Oin-079830	Oryza indica	43.80	7.00e-59	220.00
IUUC-Olo-080782	Oryza longistaminata	44.26	3.00e-57	216.00
IUUC-Ome-081602	Oryza meridionalis	45.12	4.00e-59	221.00
IUUC-Oni-082797	Oryza nivara	45.12	5.00e-59	221.00
IUUC-Opu-083572	Oryza punctata	45.12	1.00e-58	220.00
IUUC-Oru-085188	Oryza rufipogon	45.12	7.00e-59	221.00
IUUC-Osa-085573	Oryza sativa	45.12	6.00e-59	220.00
IUUC-Ola-087568	Oryzias latipes	68.07	4.00e-93	334.00
IUUC-Olu-087838	Ostreococcus lucimarinus	41.42	1.00e-50	193.00
IUUC-Oga-089082	Otolemur garnettii	85.82	1.00e-131	461.00
IUUC-Oar-089298	Ovis aries	84.67	3.00e-130	457.00
IUUC-Ptr-091569	Pan troglodytes	90.42	2.00e-142	498.00
IUUC-Pan-092256	Papio anubis	88.12	4.00e-138	483.00
IUUC-Psi-093159	Pelodiscus sinensis	81.43	1.00e-103	368.00
IUUC-Pma-094483	Petromyzon marinus	58.30	6.00e-78	283.00
IUUC-Pno-094998	Phaeosphaeria nodorum	40.68	3.00e-51	196.00
IUUC-Ppa-095916	Physcomitrella patens	44.11	8.00e-62	230.00
IUUC-Pfo-096583	Poecilia formosa	68.22	2.00e-100	358.00
IUUC-Pab-098741	Pongo abelii	90.42	9.00e-143	498.00
IUUC-Pop-099303	Populus trichocarpa	44.79	8.00e-62	230.00
IUUC-Pca-100669	Procavia capensis	85.19	5.00e-66	244.00
IUUC-Ppe-101606	Prunus persica	44.36	9.00e-60	223.00
IUUC-Pva-102213	Pteropus vampyrus	88.51	5.00e-138	483.00
IUUC-Pte-104080	Pyrenophora teres	39.83	3.00e-50	194.00
IUUC-Pyt-104774	Pyrenophora triticirepentis	39.83	1.00e-50	194.00
IUUC-Rno-105229	Rattus norvegicus	94.64	7.00e-147	512.00
IUUC-Sha-106745	Sarcophilus harrisii	83.55	3.00e-109	387.00
IUUC-Sja-107843	Schizosaccharomyces japonicus	43.51	1.00e-53	203.00
IUUC-Spo-108194	Schizosaccharomyces pombe	41.67	1.00e-51	197.00
IUUC-Ssl-108426	Sclerotinia sclerotiorum	36.64	7.00e-41	162.00
IUUC-Smo-108713	Selaginella moellendorffii	46.94	3.00e-59	221.00
IUUC-Sit-110031	Setaria italica	45.38	1.00e-60	226.00
IUUC-Sly-110906	Solanum lycopersicum	45.60	4.00e-61	228.00
IUUC-Stu-111990	Solanum tuberosum	45.25	2.00e-61	228.00
IUUC-Sar-113709	Sorex araneus	86.21	2.00e-134	471.00
IUUC-Sbi-114253	Sorghum bicolor	47.98	1.00e-63	236.00
IUUC-Ssc-116428	Sus scrofa	83.19	1.00e-112	398.00
IUUC-Tgu-116992	Taeniopygia guttata	78.19	2.00e-107	381.00
IUUC-Tru-118486	Takifugu rubripes	67.70	2.00e-83	301.00
IUUC-Tsy-118833	Tarsius syrichta	77.92	9.00e-102	362.00
IUUC-Tni-120395	Tetraodon nigroviridis	69.07	7.00e-91	326.00
IUUC-Tca-121091	Theobroma cacao	45.75	4.00e-56	211.00
IUUC-Tre-121938	Trichoderma reesei	44.35	6.00e-59	222.00
IUUC-Tvi-122465	Trichoderma virens	44.17	9.00e-60	224.00
IUUC-Tae-124038	Triticum aestivum	43.70	6.00e-59	220.00
IUUC-Tur-126465	Triticum urartu	42.48	2.00e-56	212.00
IUUC-Tme-127113	Tuber melanosporum	43.87	2.00e-58	220.00
IUUC-Tbe-127598	Tupaia belangeri	73.16	3.00e-88	317.00
IUUC-Ttr-128736	Tursiops truncatus	85.93	5.00e-65	240.00
IUUC-Vda-129684	Verticillium dahliae	44.49	7.00e-52	198.00
IUUC-Vpa-130311	Vicugna pacos	87.88	4.00e-121	426.00
IUUC-Vvi-131152	Vitis vinifera	44.83	5.00e-61	227.00
IUUC-Xtr-132909	Xenopus tropicalis	74.89	4.00e-105	373.00
IUUC-Xma-133441	Xiphophorus maculatus	68.64	8.00e-101	359.00
IUUC-Yli-134456	Yarrowia lipolytica	45.99	3.00e-58	219.00
IUUC-Zma-134792	Zea mays	46.46	4.00e-61	228.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence