iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ate-010529

Ensembl Protein ID

CADATEAP00010237

UniProt Accession

Q0CCL1; RSP5_ASPTN

Genbank Protein ID

EAU30705.1

Protein Name

Probable E3 ubiquitin-protein ligase hulA; HECT ubiquitin ligase A; HECT-type E3 ubiquitin transferase hulA

Genbank Nucleotide ID

CH476606

Gene Name

ATEG_08573; hulA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADATEAG00010237	CADATEAT00010237	CADATEAP00010237

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-125	417.1	476	807

Active Site

Position(s)	Description	Evidence
776	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsk 94
           +sdlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld ++  
   Q: 476  ASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGV-NPEHLNYFKFIGRVVGLAIFHRRFLDSFFIG 567
           689*********************************************************9.89***************************** PP
   S: 95   sfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegik 187
           +fyk++l+kk+sl+d+e vd++l+++l++ ++n   die + ++ltf v++e++ge+++ +LkpgG++ipVtneNk+eYv+lv+e+++ ++++
   Q: 568  AFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLDN---DIEGI-IELTFAVDDEKFGERRTIDLKPGGRDIPVTNENKHEYVELVTEWKIVKRVE 656
           *******************************99...9***9.*************************************************** PP
   S: 188  eqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfa 280
           eq++af +Gfne+ip +l+++F+e+elelli G ++idv+d+kk+t y+g y+e++++iq+Fw++++ +++e+++++LqF+Tg+sr+P++Gf+
   Q: 657  EQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRG-YQEQDEVIQNFWKIVRTWDAEQKSRLLQFTTGTSRIPVNGFK 748
           ************************************************76.****************************************** PP
   S: 281  elk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +l+    pr+f+i+k+++++ lP+s+TCfn+L+LP+Y++ e+l++kL +A+eet gF++
   Q: 749  DLQgsdgPRRFTIEKSGDPAALPKSHTCFNRLDLPPYKTHETLEHKLSIAVEETLGFGQ 807
           *********************************************************86 PP

Organism

Aspergillus terreus

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.

Protein Sequence
(Fasta)

MGSNLPAQPN LRVTIIAADG LYKRDVFRFP DPFAVATVGG EQTHTTSVIK KTLNPYWNEM 60
FDLRVNEDSI LAIQIFDQKK FKKKDQGFLG VINVRIGDVI DLQMGGDEML TRDLKKSNDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTTCCA ATCTCCCCGC GTAAGTCTTT CTCGATCTCT CGTGGAGATC TAGTTTCATG 60
ACCTGTGAGC TTCTCGACTA ACAAGGAATC CATGTGCAGG CAACCCAACC TGAGGGTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	47.02	3.00e-159	553.00
IUUC-Apl-003893	Anas platyrhynchos	46.15	2.00e-156	544.00
IUUC-Aca-005338	Anolis carolinensis	47.55	4.00e-155	540.00
IUUC-Ago-007742	Ashbya gossypii	65.94	0.00e+00	1012.00
IUUC-Acl-008273	Aspergillus clavatus	93.94	0.00e+00	1443.00
IUUC-Afl-008713	Aspergillus flavus	95.67	0.00e+00	1467.00
IUUC-Afu-009103	Aspergillus fumigatus	90.95	0.00e+00	1426.00
IUUC-Ani-009259	Aspergillus nidulans	90.99	0.00e+00	1449.00
IUUC-Ang-009738	Aspergillus niger	93.67	0.00e+00	1472.00
IUUC-Aor-010053	Aspergillus oryzae	97.99	3.00e-178	615.00
IUUC-Ame-010810	Astyanax mexicanus	46.80	1.00e-153	535.00
IUUC-Bgr-012148	Blumeria graminis	71.75	0.00e+00	1113.00
IUUC-Bta-012679	Bos taurus	47.52	4.00e-159	553.00
IUUC-Bci-013785	Botrytis cinerea	75.12	0.00e+00	1183.00
IUUC-Cel-018299	Caenorhabditis elegans	45.96	9.00e-151	525.00
IUUC-Cja-018732	Callithrix jacchus	48.50	1.00e-159	555.00
IUUC-Cfa-021226	Canis familiaris	46.77	8.00e-161	559.00
IUUC-Cpo-021671	Cavia porcellus	46.49	1.00e-159	555.00
IUUC-Csa-023344	Chlorocebus sabaeus	46.94	3.00e-155	541.00
IUUC-Cho-024695	Choloepus hoffmanni	45.43	7.00e-158	549.00
IUUC-Cin-025212	Ciona intestinalis	49.28	3.00e-142	497.00
IUUC-Csv-026256	Ciona savignyi	46.11	1.00e-148	518.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	71.88	0.00e+00	1118.00
IUUC-Cne-026849	Cryptococcus neoformans	63.85	0.00e+00	1001.00
IUUC-Dre-027770	Danio rerio	52.67	4.00e-147	513.00
IUUC-Dno-029466	Dasypus novemcinctus	48.49	4.00e-159	553.00
IUUC-Dor-030138	Dipodomys ordii	45.79	1.00e-154	538.00
IUUC-Dse-031241	Dothistroma septosporum	75.03	0.00e+00	1205.00
IUUC-Dme-032041	Drosophila melanogaster	46.24	4.00e-144	503.00
IUUC-Ete-033145	Echinops telfairi	44.36	1.00e-146	512.00
IUUC-Eca-033445	Equus caballus	48.49	7.00e-159	552.00
IUUC-Eeu-035247	Erinaceus europaeus	46.71	3.00e-158	550.00
IUUC-Fca-036384	Felis catus	48.39	5.00e-158	550.00
IUUC-Fal-037604	Ficedula albicollis	44.69	8.00e-153	532.00
IUUC-Fox-037774	Fusarium oxysporum	73.57	0.00e+00	1132.00
IUUC-Fso-038393	Fusarium solani	72.50	0.00e+00	1109.00
IUUC-Gmo-039674	Gadus morhua	45.63	5.00e-153	533.00
IUUC-Ggr-040107	Gaeumannomyces graminis	71.96	0.00e+00	1152.00
IUUC-Gga-041276	Gallus gallus	46.45	1.00e-154	538.00
IUUC-Gac-042020	Gasterosteus aculeatus	46.98	6.00e-156	543.00
IUUC-Ggo-045332	Gorilla gorilla	46.88	3.00e-159	554.00
IUUC-Hsa-045968	Homo sapiens	48.50	6.00e-159	553.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	47.73	3.00e-156	543.00
IUUC-Kpa-049273	Komagataella pastoris	67.58	0.00e+00	1046.00
IUUC-Lch-050443	Latimeria chalumnae	48.49	1.00e-157	548.00
IUUC-Loc-052662	Lepisosteus oculatus	52.26	5.00e-142	496.00
IUUC-Lma-052980	Leptosphaeria maculans	73.01	0.00e+00	702.00
IUUC-Laf-053850	Loxodonta africana	47.02	4.00e-159	553.00
IUUC-Mcc-055821	Macaca mulatta	48.50	3.00e-159	554.00
IUUC-Meu-055953	Macropus eugenii	37.97	1.00e-115	409.00
IUUC-Mor-057097	Magnaporthe oryzae	74.11	0.00e+00	1175.00
IUUC-Mpo-057442	Magnaporthe poae	69.46	0.00e+00	1027.00
IUUC-Mla-058996	Melampsora laricipopulina	64.49	0.00e+00	985.00
IUUC-Mga-059362	Meleagris gallopavo	47.39	6.00e-153	533.00
IUUC-Mvi-060395	Microbotryum violaceum	79.00	0.00e+00	821.00
IUUC-Mmr-061061	Microcebus murinus	48.21	9.00e-161	559.00
IUUC-Mdo-062173	Monodelphis domestica	45.29	1.00e-156	545.00
IUUC-Mmu-064136	Mus musculus	48.49	5.00e-159	553.00
IUUC-Mpu-066765	Mustela putorius furo	48.49	8.00e-159	552.00
IUUC-Mlu-067565	Myotis lucifugus	48.49	1.00e-158	551.00
IUUC-Nfi-068427	Neosartorya fischeri	94.12	0.00e+00	1456.00
IUUC-Ncr-068918	Neurospora crassa	73.29	0.00e+00	1107.00
IUUC-Nle-069070	Nomascus leucogenys	47.43	2.00e-153	534.00
IUUC-Opr-071044	Ochotona princeps	46.71	3.00e-158	550.00
IUUC-Ont-071664	Oreochromis niloticus	47.04	5.00e-145	506.00
IUUC-Oan-073019	Ornithorhynchus anatinus	46.00	2.00e-149	521.00
IUUC-Ocu-074160	Oryctolagus cuniculus	46.81	5.00e-158	550.00
IUUC-Ola-087467	Oryzias latipes	47.25	4.00e-154	536.00
IUUC-Oga-088460	Otolemur garnettii	48.50	6.00e-159	552.00
IUUC-Oar-090198	Ovis aries	47.67	8.00e-159	552.00
IUUC-Ptr-090939	Pan troglodytes	48.50	6.00e-159	553.00
IUUC-Pan-092284	Papio anubis	48.50	3.00e-159	554.00
IUUC-Psi-093645	Pelodiscus sinensis	46.39	7.00e-159	552.00
IUUC-Pma-094364	Petromyzon marinus	52.05	1.00e-142	497.00
IUUC-Pno-095118	Phaeosphaeria nodorum	74.15	0.00e+00	1189.00
IUUC-Pfo-097145	Poecilia formosa	47.28	2.00e-150	524.00
IUUC-Pab-098088	Pongo abelii	48.50	4.00e-159	553.00
IUUC-Pca-100568	Procavia capensis	45.33	1.00e-136	479.00
IUUC-Pva-102354	Pteropus vampyrus	47.02	4.00e-159	553.00
IUUC-Pgr-103620	Puccinia graminis	78.17	0.00e+00	801.00
IUUC-Ptt-103806	Puccinia triticina	79.02	0.00e+00	690.00
IUUC-Pte-104016	Pyrenophora teres	75.85	0.00e+00	1202.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	75.85	0.00e+00	1202.00
IUUC-Rno-105318	Rattus norvegicus	48.49	3.00e-159	553.00
IUUC-Sce-106289	Saccharomyces cerevisiae	75.04	0.00e+00	926.00
IUUC-Sha-107482	Sarcophilus harrisii	45.94	3.00e-157	547.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	67.08	0.00e+00	1045.00
IUUC-Spo-108171	Schizosaccharomyces pombe	68.07	0.00e+00	1052.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	74.88	0.00e+00	1177.00
IUUC-Sar-113761	Sorex araneus	47.55	4.00e-155	540.00
IUUC-Sre-114929	Sporisorium reilianum	72.13	0.00e+00	876.00
IUUC-Ssc-115368	Sus scrofa	41.48	7.00e-148	516.00
IUUC-Tgu-117130	Taeniopygia guttata	46.15	2.00e-156	545.00
IUUC-Tru-118610	Takifugu rubripes	54.32	1.00e-153	535.00
IUUC-Tsy-119492	Tarsius syrichta	48.49	1.00e-157	548.00
IUUC-Tni-119993	Tetraodon nigroviridis	46.40	5.00e-149	520.00
IUUC-Tre-122203	Trichoderma reesei	73.65	0.00e+00	1110.00
IUUC-Tvi-122595	Trichoderma virens	71.33	0.00e+00	1130.00
IUUC-Tme-126897	Tuber melanosporum	71.80	0.00e+00	1089.00
IUUC-Tbe-127793	Tupaia belangeri	47.22	3.00e-131	461.00
IUUC-Ttr-128235	Tursiops truncatus	53.29	2.00e-148	518.00
IUUC-Uma-129332	Ustilago maydis	71.28	0.00e+00	842.00
IUUC-Vda-129753	Verticillium dahliae	69.06	0.00e+00	1071.00
IUUC-Vpa-130503	Vicugna pacos	45.83	2.00e-146	511.00
IUUC-Xtr-132859	Xenopus tropicalis	46.53	9.00e-159	552.00
IUUC-Xma-133797	Xiphophorus maculatus	46.41	1.00e-157	548.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence