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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045940
Ensembl Protein ID ENSP00000261308.4
UniProt Accession Q96BP3; B4DWR9; Q15002; Q7KZ89; PPWD1_HUMAN
Genbank Protein ID BAG63131.1; AAH15385.1; BAA07555.1
Protein Name Peptidylprolyl isomerase domain and WD repeat-containing protein 1; Spliceosome-associated cyclophilin
Genbank Nucleotide ID AK301654; AC008560; D38552
Gene Name PPWD1; KIAA0073
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000113593.11 ENST00000261308.9 ENSP00000261308.4
ENSG00000113593.11 ENST00000503435.5 ENSP00000427642.1
ENSG00000113593.11 ENST00000515447.5 ENSP00000424519.1
ENSG00000113593.11 ENST00000510930.5 ENSP00000423486.1
ENSG00000113593.11 ENST00000511908.5 ENSP00000425390.1
ENSG00000113593.11 ENST00000502703.5 ENSP00000427054.1
ENSG00000113593.11 ENST00000514172.1 ENSP00000421595.1
ENSG00000113593.11 ENST00000535264.5 ENSP00000442371.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.70e-09 37.6 89 117
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWD 29
           H d +t +    +++++++s+Dg +k W 
   Q: 89   HRDVITHVVCtKTDFIITASHDGHVKFWK 117
           788888875543389*************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Identified in the spliceosome C complex.
 Identified in the spliceosome C complex.
Protein Sequence
(Fasta)
MAAESGSDFQ QRRRRRRDPE EPEKTELSER ELAVAVAVSQ ENDEENEERW VGPLPVEATL 60
AKKRKVLEFE RVYLDNLPSA SMYERSYMHR DVITHVVCTK TDFIITASHD GHVKFWKKIE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045940|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACAGAAGAC TGCGCCGCTG CTTTGGGATT GGTAGCTGAG TTTTGTGTCG CGCCTTTTCT 60
GACGATGCGA ACAACATGGC GGCGGAAAGT GGTAGCGATT TTCAGCAGAG ACGTAGAAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045940|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0413--Isomerase
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0697--Rotamase
KW-0747--Spliceosome
KW-0853--WD repeat
Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR002130--Cyclophilin-type_PPIase_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50072--CSA_PPIASE_2
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00160--Pro_isomerase
PF00400--WD40
PRINTS

PR00153--CSAPPISMRASE
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006457--P:protein folding
KEGG hsa:23398
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000971 Aegilops tauschii 52.19 1.00e-176 612.00
IUUC-Aml-001897 Ailuropoda melanoleuca 97.83 0.00e+00 1293.00
IUUC-Apl-003599 Anas platyrhynchos 93.69 0.00e+00 1160.00
IUUC-Aca-004814 Anolis carolinensis 94.14 0.00e+00 1202.00
IUUC-Aly-005546 Arabidopsis lyrata 53.98 0.00e+00 655.00
IUUC-Acl-008086 Aspergillus clavatus 48.34 4.00e-161 561.00
IUUC-Afu-008839 Aspergillus fumigatus 48.58 9.00e-160 557.00
IUUC-Ani-009162 Aspergillus nidulans 50.08 3.00e-160 558.00
IUUC-Ang-009524 Aspergillus niger 50.00 7.00e-168 584.00
IUUC-Ate-010284 Aspergillus terreus 49.09 4.00e-164 571.00
IUUC-Ame-011100 Astyanax mexicanus 85.05 0.00e+00 989.00
IUUC-Bgr-012307 Blumeria graminis 42.44 4.00e-87 314.00
IUUC-Bta-012821 Bos taurus 97.37 0.00e+00 1281.00
IUUC-Bci-013978 Botrytis cinerea 48.76 3.00e-165 575.00
IUUC-Bdi-014828 Brachypodium distachyon 52.16 0.00e+00 648.00
IUUC-Cja-018769 Callithrix jacchus 98.45 0.00e+00 1296.00
IUUC-Cfa-020555 Canis familiaris 97.21 0.00e+00 1249.00
IUUC-Cpo-022169 Cavia porcellus 96.75 0.00e+00 1285.00
IUUC-Cre-022808 Chlamydomonas reinhardtii 48.93 3.00e-138 485.00
IUUC-Csa-023086 Chlorocebus sabaeus 99.07 0.00e+00 1298.00
IUUC-Cin-025611 Ciona intestinalis 62.13 0.00e+00 783.00
IUUC-Csv-026237 Ciona savignyi 56.96 0.00e+00 725.00
IUUC-Cgl-026661 Colletotrichum gloeosporioides 49.25 2.00e-168 585.00
IUUC-Dre-028591 Danio rerio 85.29 0.00e+00 1118.00
IUUC-Dno-029074 Dasypus novemcinctus 95.22 0.00e+00 1242.00
IUUC-Dor-030544 Dipodomys ordii 88.60 0.00e+00 1122.00
IUUC-Dse-031430 Dothistroma septosporum 48.76 2.00e-162 566.00
IUUC-Dme-031943 Drosophila melanogaster 60.10 0.00e+00 763.00
IUUC-Eca-034176 Equus caballus 97.83 0.00e+00 1267.00
IUUC-Fca-036583 Felis catus 97.37 0.00e+00 1288.00
IUUC-Fal-037662 Ficedula albicollis 95.04 0.00e+00 1147.00
IUUC-Fox-037831 Fusarium oxysporum 46.53 3.00e-152 532.00
IUUC-Fso-038360 Fusarium solani 47.10 1.00e-151 530.00
IUUC-Gmo-039705 Gadus morhua 83.36 0.00e+00 1064.00
IUUC-Ggr-040077 Gaeumannomyces graminis 48.18 2.00e-160 559.00
IUUC-Gga-040138 Gallus gallus 93.98 0.00e+00 1200.00
IUUC-Gac-042647 Gasterosteus aculeatus 83.61 0.00e+00 1080.00
IUUC-Ggo-045218 Gorilla gorilla 99.69 0.00e+00 1337.00
IUUC-Hvu-047090 Hordeum vulgare 52.20 0.00e+00 630.00
IUUC-Itr-048024 Ictidomys tridecemlineatus 98.61 0.00e+00 1322.00
IUUC-Lch-049614 Latimeria chalumnae 87.94 0.00e+00 1138.00
IUUC-Lpe-051688 Leersia perrieri 52.97 0.00e+00 654.00
IUUC-Loc-051834 Lepisosteus oculatus 87.29 0.00e+00 1119.00
IUUC-Lma-052989 Leptosphaeria maculans 47.95 3.00e-153 535.00
IUUC-Laf-054056 Loxodonta africana 97.52 0.00e+00 1306.00
IUUC-Mcc-055891 Macaca mulatta 99.38 0.00e+00 1304.00
IUUC-Meu-056503 Macropus eugenii 89.58 0.00e+00 1140.00
IUUC-Mor-057121 Magnaporthe oryzae 48.10 2.00e-160 559.00
IUUC-Mpo-057304 Magnaporthe poae 48.02 1.00e-162 566.00
IUUC-Mmr-061049 Microcebus murinus 97.52 0.00e+00 1266.00
IUUC-Mdo-062399 Monodelphis domestica 96.27 0.00e+00 1240.00
IUUC-Mmu-063093 Mus musculus 97.21 0.00e+00 1305.00
IUUC-Mpu-066077 Mustela putorius furo 97.83 0.00e+00 1296.00
IUUC-Mlu-066977 Myotis lucifugus 97.06 0.00e+00 1282.00
IUUC-Nfi-068247 Neosartorya fischeri 48.75 1.00e-160 560.00
IUUC-Ncr-068924 Neurospora crassa 48.28 4.00e-159 555.00
IUUC-Nle-069866 Nomascus leucogenys 99.38 0.00e+00 1301.00
IUUC-Opr-071094 Ochotona princeps 90.87 0.00e+00 1175.00
IUUC-Ont-071762 Oreochromis niloticus 85.79 0.00e+00 1108.00
IUUC-Oan-073117 Ornithorhynchus anatinus 81.12 0.00e+00 986.00
IUUC-Ocu-074295 Oryctolagus cuniculus 96.90 0.00e+00 1299.00
IUUC-Obr-076638 Oryza brachyantha 52.03 0.00e+00 640.00
IUUC-Ogl-077801 Oryza glaberrima 52.81 0.00e+00 640.00
IUUC-Oin-079614 Oryza indica 46.02 1.00e-105 377.00
IUUC-Opu-083158 Oryza punctata 51.87 0.00e+00 644.00
IUUC-Ola-087124 Oryzias latipes 84.49 0.00e+00 1105.00
IUUC-Olu-087758 Ostreococcus lucimarinus 50.25 4.00e-167 581.00
IUUC-Oga-088254 Otolemur garnettii 96.90 0.00e+00 1300.00
IUUC-Oar-089414 Ovis aries 97.68 0.00e+00 1287.00
IUUC-Ptr-091471 Pan troglodytes 99.54 0.00e+00 1335.00
IUUC-Pan-091762 Papio anubis 99.23 0.00e+00 1300.00
IUUC-Psi-093822 Pelodiscus sinensis 94.17 0.00e+00 1196.00
IUUC-Pma-094613 Petromyzon marinus 74.78 2.00e-157 548.00
IUUC-Ppa-095551 Physcomitrella patens 50.74 0.00e+00 630.00
IUUC-Pfo-096544 Poecilia formosa 86.45 0.00e+00 1110.00
IUUC-Pab-098657 Pongo abelii 99.07 0.00e+00 1329.00
IUUC-Pca-100456 Procavia capensis 96.45 0.00e+00 1290.00
IUUC-Pte-104062 Pyrenophora teres 47.28 2.00e-154 539.00
IUUC-Rno-106026 Rattus norvegicus 96.59 0.00e+00 1276.00
IUUC-Sha-106972 Sarcophilus harrisii 97.70 0.00e+00 1173.00
IUUC-Sja-107835 Schizosaccharomyces japonicus 40.67 1.00e-123 437.00
IUUC-Spo-108123 Schizosaccharomyces pombe 40.80 7.00e-120 424.00
IUUC-Smo-109088 Selaginella moellendorffii 53.52 0.00e+00 654.00
IUUC-Sit-110058 Setaria italica 50.80 0.00e+00 649.00
IUUC-Sbi-114363 Sorghum bicolor 50.89 0.00e+00 647.00
IUUC-Ssc-115357 Sus scrofa 97.68 0.00e+00 1299.00
IUUC-Tgu-116509 Taeniopygia guttata 93.98 0.00e+00 1201.00
IUUC-Tru-117813 Takifugu rubripes 83.36 0.00e+00 1078.00
IUUC-Tre-122148 Trichoderma reesei 48.26 1.00e-157 550.00
IUUC-Tvi-122519 Trichoderma virens 47.93 5.00e-157 548.00
IUUC-Tae-124690 Triticum aestivum 51.86 0.00e+00 637.00
IUUC-Tur-126759 Triticum urartu 52.03 0.00e+00 642.00
IUUC-Tme-127094 Tuber melanosporum 46.45 1.00e-151 530.00
IUUC-Tbe-128038 Tupaia belangeri 96.44 0.00e+00 1286.00
IUUC-Ttr-128520 Tursiops truncatus 86.69 0.00e+00 1117.00
IUUC-Vda-129717 Verticillium dahliae 48.26 6.00e-160 557.00
IUUC-Vpa-130129 Vicugna pacos 97.37 0.00e+00 1294.00
IUUC-Xtr-131757 Xenopus tropicalis 87.62 0.00e+00 1143.00
IUUC-Xma-133563 Xiphophorus maculatus 86.39 0.00e+00 1102.00
IUUC-Zma-135633 Zea mays 49.05 0.00e+00 628.00
Created Date 25-Jun-2017

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