iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003828

Ensembl Protein ID

ENSAPLP00000013218.1

UniProt Accession

U3J141; U3J141_ANAPL

Genbank Protein ID

ENSAPLP00000013218

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01043107

Gene Name

UBR2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000013268.1	ENSAPLT00000013967.1	ENSAPLP00000013218.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/N-recognin/N-domain	1.10e-39	134.2	226	301
E3 activity/RING/RING	1.30e-09	38.1	1108	1213
E3 activity/N-recognin/UBR-box	2.30e-31	107.8	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v++Gd+++c++ak++i++n++++++ pLkV+v
   Q: 226  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCDQAKSVIVRNTSRQTK-PLKVQV 301
           9*********************************************************************.****98 PP

E3 activity/RING/RING

   S: 1    CaiC......................................ledf........kdgplvlpCgHvfhadClqkw............ 29
           C++C                                      +           ++g+++++CgH++ha+C+q++            
   Q: 1108 CILCqeeqevkvdsramvlaafiqrstvlsknrnriipdpekY--DplfmhpdlSCGTHTGSCGHIMHAHCWQRYfdavqakeqrrq 1192
           8888333333333333333333333333333333333333332..02344444455899**************************** PP
   S: 30   .....pglknssskefrCPlC 45
                + +++++++ef+CPlC
   Q: 1193 qrlrvHTSYDVENGEFLCPLC 1213
           ********************* PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCgrvfkvge +y+Cr+C+vd+t+vlC+eCf  ++H++H+y++++s+gggfCdCGdteAw++g++C+k++
   Q: 97   HLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHREHRYRMTTSSGGGFCDCGDTEAWKEGPYCQKHE 167
           68******************************************************************996 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

TFRQLLPEFW GWESHLLEEQ EFSLARKWLQ GSELQKEVYR HLAYYVPKIY CRGPNPAPQR 60
EDMLAQHVLL GPMEWYLCGE DPAFGFPKLE QANKPSHLCG RVFKVGEPTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTTCAGGC AATTACTCCC AGAATTTTGG GGATGGGAAA GCCATTTACT TGAGGAACAA 60
GAATTTTCTC TGGCCAGGTA TTTGCCTGAG CTTGTAGTGC AGCTAATAGG CACCGTCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000785--C:chromatin
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0007141--P:male meiosis I
GO:0032007--P:negative regulation of TOR signaling
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	27.89	5.00e-22	100.00
IUUC-Aml-001876	Ailuropoda melanoleuca	78.64	0.00e+00	2563.00
IUUC-Atr-002501	Amborella trichopoda	29.72	3.00e-28	121.00
IUUC-Aca-005189	Anolis carolinensis	87.09	0.00e+00	3102.00
IUUC-Aly-005901	Arabidopsis lyrata	31.46	1.00e-25	112.00
IUUC-Ath-007148	Arabidopsis thaliana	30.05	2.00e-24	108.00
IUUC-Ago-007946	Ashbya gossypii	22.08	4.00e-31	130.00
IUUC-Afl-008479	Aspergillus flavus	23.51	7.00e-46	180.00
IUUC-Afu-008929	Aspergillus fumigatus	23.83	6.00e-53	203.00
IUUC-Ani-009334	Aspergillus nidulans	24.57	4.00e-50	194.00
IUUC-Ang-009550	Aspergillus niger	23.98	1.00e-47	185.00
IUUC-Aor-010124	Aspergillus oryzae	23.65	1.00e-45	179.00
IUUC-Ame-011917	Astyanax mexicanus	75.06	0.00e+00	2531.00
IUUC-Bta-012768	Bos taurus	85.75	0.00e+00	3025.00
IUUC-Bdi-014635	Brachypodium distachyon	25.73	3.00e-30	128.00
IUUC-Bol-015669	Brassica oleracea	30.39	7.00e-30	127.00
IUUC-Bra-017776	Brassica rapa	30.04	2.00e-29	125.00
IUUC-Cel-018476	Caenorhabditis elegans	30.35	3.00e-80	294.00
IUUC-Cja-019797	Callithrix jacchus	87.05	0.00e+00	2378.00
IUUC-Cfa-020950	Canis familiaris	87.56	0.00e+00	3075.00
IUUC-Cpo-022385	Cavia porcellus	86.19	0.00e+00	3045.00
IUUC-Csa-024082	Chlorocebus sabaeus	87.34	0.00e+00	3068.00
IUUC-Cho-025029	Choloepus hoffmanni	79.40	0.00e+00	2001.00
IUUC-Cin-025148	Ciona intestinalis	35.51	2.00e-138	486.00
IUUC-Cgl-026605	Colletotrichum gloeosporioides	23.84	1.00e-57	219.00
IUUC-Cne-026823	Cryptococcus neoformans	23.66	3.00e-42	167.00
IUUC-Dre-028343	Danio rerio	74.55	0.00e+00	2558.00
IUUC-Dno-030002	Dasypus novemcinctus	85.66	0.00e+00	1819.00
IUUC-Dor-030207	Dipodomys ordii	74.96	0.00e+00	1519.00
IUUC-Dse-031531	Dothistroma septosporum	25.10	5.00e-55	210.00
IUUC-Dme-031910	Drosophila melanogaster	34.15	0.00e+00	691.00
IUUC-Ete-033162	Echinops telfairi	81.17	0.00e+00	1318.00
IUUC-Eca-033454	Equus caballus	86.86	0.00e+00	3044.00
IUUC-Eeu-034783	Erinaceus europaeus	72.27	0.00e+00	1404.00
IUUC-Fca-036588	Felis catus	87.12	0.00e+00	3053.00
IUUC-Fal-036919	Ficedula albicollis	94.72	0.00e+00	3260.00
IUUC-Fso-038463	Fusarium solani	24.30	3.00e-45	178.00
IUUC-Gmo-039698	Gadus morhua	71.67	0.00e+00	1675.00
IUUC-Ggr-040070	Gaeumannomyces graminis	23.51	4.00e-46	181.00
IUUC-Gga-041123	Gallus gallus	97.12	0.00e+00	3388.00
IUUC-Gac-042622	Gasterosteus aculeatus	68.35	0.00e+00	2261.00
IUUC-Ggo-045583	Gorilla gorilla	85.82	0.00e+00	3036.00
IUUC-Hsa-046343	Homo sapiens	87.56	0.00e+00	3078.00
IUUC-Hvu-047626	Hordeum vulgare	28.98	6.00e-27	116.00
IUUC-Kpa-049088	Komagataella pastoris	22.93	4.00e-44	174.00
IUUC-Lch-049649	Latimeria chalumnae	76.87	0.00e+00	2650.00
IUUC-Lpe-051516	Leersia perrieri	25.00	2.00e-30	128.00
IUUC-Loc-052818	Lepisosteus oculatus	76.54	0.00e+00	2662.00
IUUC-Lma-053059	Leptosphaeria maculans	22.60	1.00e-47	186.00
IUUC-Laf-054142	Loxodonta africana	86.89	0.00e+00	3061.00
IUUC-Mcc-055677	Macaca mulatta	87.16	0.00e+00	3056.00
IUUC-Meu-056204	Macropus eugenii	67.46	0.00e+00	726.00
IUUC-Mor-057051	Magnaporthe oryzae	23.65	2.00e-43	171.00
IUUC-Mtr-058538	Medicago truncatula	30.04	2.00e-27	118.00
IUUC-Mla-058963	Melampsora laricipopulina	24.57	7.00e-53	203.00
IUUC-Mga-059698	Meleagris gallopavo	97.22	0.00e+00	3375.00
IUUC-Mvi-060535	Microbotryum violaceum	24.41	6.00e-49	190.00
IUUC-Mmr-060901	Microcebus murinus	84.65	0.00e+00	2976.00
IUUC-Mdo-062014	Monodelphis domestica	89.28	0.00e+00	3153.00
IUUC-Mmu-063699	Mus musculus	84.08	0.00e+00	2956.00
IUUC-Mpu-066153	Mustela putorius furo	87.51	0.00e+00	3073.00
IUUC-Mlu-068151	Myotis lucifugus	86.37	0.00e+00	3022.00
IUUC-Nfi-068403	Neosartorya fischeri	23.73	1.00e-52	202.00
IUUC-Ncr-068864	Neurospora crassa	23.15	9.00e-43	169.00
IUUC-Nle-069529	Nomascus leucogenys	87.39	0.00e+00	3071.00
IUUC-Opr-071107	Ochotona princeps	79.40	0.00e+00	1216.00
IUUC-Ont-072189	Oreochromis niloticus	67.06	0.00e+00	2202.00
IUUC-Oan-072893	Ornithorhynchus anatinus	88.18	0.00e+00	3099.00
IUUC-Ocu-074082	Oryctolagus cuniculus	85.50	0.00e+00	3010.00
IUUC-Obr-076117	Oryza brachyantha	24.01	7.00e-29	123.00
IUUC-Ogl-077571	Oryza glaberrima	25.68	1.00e-29	126.00
IUUC-Ome-081738	Oryza meridionalis	21.62	6.00e-14	73.90
IUUC-Osa-085336	Oryza sativa	25.41	3.00e-29	124.00
IUUC-Ola-087460	Oryzias latipes	65.94	0.00e+00	2186.00
IUUC-Olu-087832	Ostreococcus lucimarinus	28.33	1.10e-02	35.40
IUUC-Oga-088432	Otolemur garnettii	87.49	0.00e+00	3076.00
IUUC-Oar-090206	Ovis aries	84.96	0.00e+00	3014.00
IUUC-Ptr-091180	Pan troglodytes	86.14	0.00e+00	3037.00
IUUC-Pan-092375	Papio anubis	87.28	0.00e+00	3066.00
IUUC-Psi-093049	Pelodiscus sinensis	91.22	0.00e+00	3163.00
IUUC-Pno-094877	Phaeosphaeria nodorum	22.47	3.00e-42	167.00
IUUC-Pfo-096524	Poecilia formosa	64.85	0.00e+00	2103.00
IUUC-Pab-097989	Pongo abelii	85.74	0.00e+00	2989.00
IUUC-Pca-100207	Procavia capensis	74.58	0.00e+00	1157.00
IUUC-Ppe-101802	Prunus persica	28.14	3.00e-26	114.00
IUUC-Pgr-103372	Puccinia graminis	24.65	6.00e-50	193.00
IUUC-Ptt-103878	Puccinia triticina	24.30	4.00e-46	181.00
IUUC-Rno-105567	Rattus norvegicus	82.95	0.00e+00	2884.00
IUUC-Sce-106272	Saccharomyces cerevisiae	20.52	3.00e-26	114.00
IUUC-Sha-106980	Sarcophilus harrisii	89.95	0.00e+00	3063.00
IUUC-Sja-107980	Schizosaccharomyces japonicus	23.82	2.00e-48	188.00
IUUC-Spo-108183	Schizosaccharomyces pombe	25.05	5.00e-52	200.00
IUUC-Smo-108719	Selaginella moellendorffii	31.54	3.00e-29	125.00
IUUC-Sit-110716	Setaria italica	24.35	7.00e-31	130.00
IUUC-Sly-111286	Solanum lycopersicum	28.31	1.00e-26	116.00
IUUC-Sar-113332	Sorex araneus	80.31	0.00e+00	2043.00
IUUC-Sbi-114577	Sorghum bicolor	27.61	9.00e-30	126.00
IUUC-Ssc-115525	Sus scrofa	86.88	0.00e+00	2368.00
IUUC-Tgu-116943	Taeniopygia guttata	95.49	0.00e+00	3353.00
IUUC-Tru-117673	Takifugu rubripes	66.82	0.00e+00	2190.00
IUUC-Tsy-119032	Tarsius syrichta	87.49	0.00e+00	1739.00
IUUC-Tni-119987	Tetraodon nigroviridis	66.70	0.00e+00	2184.00
IUUC-Tca-121077	Theobroma cacao	32.70	3.00e-26	115.00
IUUC-Tre-122137	Trichoderma reesei	24.00	1.00e-59	225.00
IUUC-Tur-126562	Triticum urartu	28.21	1.00e-26	115.00
IUUC-Tme-127156	Tuber melanosporum	23.95	2.00e-50	195.00
IUUC-Tbe-128103	Tupaia belangeri	80.59	0.00e+00	1147.00
IUUC-Ttr-128253	Tursiops truncatus	81.35	0.00e+00	2820.00
IUUC-Uma-129344	Ustilago maydis	25.84	8.00e-51	196.00
IUUC-Vda-129778	Verticillium dahliae	24.09	1.00e-49	192.00
IUUC-Vpa-130540	Vicugna pacos	83.39	0.00e+00	2747.00
IUUC-Xtr-132690	Xenopus tropicalis	82.24	0.00e+00	2910.00
IUUC-Xma-133748	Xiphophorus maculatus	65.20	0.00e+00	2049.00
IUUC-Yli-134662	Yarrowia lipolytica	25.23	2.00e-32	135.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence