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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063809
UUCD1 version UUC-MuM-00935
Ensembl Protein ID ENSMUSP00000003513.3
UniProt Accession Q9D6T0; Q9D8J9; NOSIP_MOUSE
Genbank Protein ID BAB25373.1; BAB26637.1; AAH89029.1
Protein Name Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP
Genbank Nucleotide ID AK007962; AK010006; BC089029
Gene Name Nosip
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000003421.13 ENSMUST00000107829.8 ENSMUSP00000103460.2
ENSMUSG00000003421.13 ENSMUST00000003513.10 ENSMUSP00000003513.3
ENSMUSG00000003421.13 ENSMUST00000211465.1 ENSMUSP00000148148.1
ENSMUSG00000003421.13 ENSMUST00000210088.1 ENSMUSP00000148045.1
ENSMUSG00000003421.13 ENSMUST00000210520.1 ENSMUSP00000147796.1
ENSMUSG00000003421.13 ENSMUST00000209243.1 ENSMUSP00000147792.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 1.30e-13 51.9 40 79
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ ++++
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKR 79
           567789*****************************88876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (PubMed:25546391). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity).
 E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (PubMed:25546391). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity).
Protein Sequence
(Fasta)
MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKRE IARQVKAYEK QRGARREEQK ELQRAAAQDQ VRGFLEKEAA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063809|E3,U-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCCTGTCGG GCGGAAGTAG GAGGAGTAGA GTTTAAAAAC AGTACTCTTT TTCCGGTTCG 60
GGACGTAGTT GAAGCAACGA CAAGCCGGAT AACCGCTCTT GAGGTAAGCT GCAGGCGGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063809|E3,U-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF15906--zf-NOSIP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0007275--P:multicellular organism development
GO:0043086--P:negative regulation of catalytic activity
GO:0051001--P:negative regulation of nitric-oxide synthase activity
GO:0016567--P:protein ubiquitination
KEGG mmu:66394
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000769 Aegilops tauschii 48.15 4.00e-16 79.70
IUUC-Aml-002069 Ailuropoda melanoleuca 88.22 2.00e-159 555.00
IUUC-Atr-002661 Amborella trichopoda 31.85 1.00e-30 126.00
IUUC-Aca-004630 Anolis carolinensis 72.76 6.00e-131 459.00
IUUC-Aly-006316 Arabidopsis lyrata 30.26 2.00e-28 119.00
IUUC-Ath-007000 Arabidopsis thaliana 30.26 2.00e-28 119.00
IUUC-Acl-008175 Aspergillus clavatus 33.63 3.00e-06 46.60
IUUC-Afl-008440 Aspergillus flavus 33.90 3.00e-06 46.20
IUUC-Afu-009012 Aspergillus fumigatus 34.78 7.00e-07 48.50
IUUC-Ani-009153 Aspergillus nidulans 29.60 8.00e-03 35.00
IUUC-Ang-009556 Aspergillus niger 33.90 4.00e-06 45.80
IUUC-Aor-009892 Aspergillus oryzae 33.90 3.00e-06 46.20
IUUC-Ate-010473 Aspergillus terreus 30.43 1.00e-04 42.40
IUUC-Ame-011874 Astyanax mexicanus 63.64 2.00e-109 388.00
IUUC-Bgr-012090 Blumeria graminis 26.57 2.00e-05 43.50
IUUC-Bta-012956 Bos taurus 92.05 1.00e-163 568.00
IUUC-Bci-013897 Botrytis cinerea 41.25 1.00e-09 57.00
IUUC-Bdi-014968 Brachypodium distachyon 30.38 4.00e-33 135.00
IUUC-Bol-015578 Brassica oleracea 30.56 3.00e-33 135.00
IUUC-Bra-017234 Brassica rapa 30.56 3.00e-33 135.00
IUUC-Cel-018637 Caenorhabditis elegans 41.05 3.00e-58 218.00
IUUC-Cja-019632 Callithrix jacchus 90.37 3.00e-162 563.00
IUUC-Cfa-020192 Canis familiaris 91.03 1.00e-162 566.00
IUUC-Cpo-021939 Cavia porcellus 91.36 5.00e-155 540.00
IUUC-Cre-023005 Chlamydomonas reinhardtii 34.47 3.00e-41 162.00
IUUC-Csa-023802 Chlorocebus sabaeus 90.37 3.00e-161 560.00
IUUC-Cho-024637 Choloepus hoffmanni 73.73 2.00e-76 278.00
IUUC-Cin-025180 Ciona intestinalis 52.32 1.00e-85 309.00
IUUC-Csv-026206 Ciona savignyi 54.42 4.00e-44 170.00
IUUC-Cgl-026696 Colletotrichum gloeosporioides 24.72 4.00e-14 72.00
IUUC-Cne-026827 Cryptococcus neoformans 28.19 1.00e-07 50.80
IUUC-Dre-028092 Danio rerio 64.50 7.00e-116 410.00
IUUC-Dno-029501 Dasypus novemcinctus 85.10 1.00e-136 479.00
IUUC-Dor-030542 Dipodomys ordii 92.08 4.00e-164 570.00
IUUC-Dse-031188 Dothistroma septosporum 23.60 2.00e-14 73.60
IUUC-Dme-031734 Drosophila melanogaster 49.19 2.00e-79 289.00
IUUC-Eca-033577 Equus caballus 93.02 5.00e-166 576.00
IUUC-Fca-035761 Felis catus 92.36 2.00e-164 571.00
IUUC-Fox-037703 Fusarium oxysporum 26.38 4.00e-08 52.40
IUUC-Fso-038208 Fusarium solani 27.33 2.00e-14 73.20
IUUC-Gmo-038523 Gadus morhua 57.95 1.00e-59 222.00
IUUC-Ggr-040087 Gaeumannomyces graminis 39.74 2.00e-09 57.00
IUUC-Gac-042621 Gasterosteus aculeatus 59.43 3.00e-106 378.00
IUUC-Gma-042698 Glycine max 30.82 6.00e-32 130.00
IUUC-Ggo-045357 Gorilla gorilla 90.70 9.00e-162 562.00
IUUC-Hsa-046195 Homo sapiens 90.70 9.00e-162 562.00
IUUC-Hvu-047174 Hordeum vulgare 30.72 1.00e-33 136.00
IUUC-Itr-048487 Ictidomys tridecemlineatus 92.36 6.00e-161 559.00
IUUC-Lch-050569 Latimeria chalumnae 66.67 4.00e-112 397.00
IUUC-Lpe-050992 Leersia perrieri 34.31 7.00e-22 98.20
IUUC-Loc-052522 Lepisosteus oculatus 69.67 3.00e-115 407.00
IUUC-Lma-053254 Leptosphaeria maculans 37.97 4.00e-09 55.80
IUUC-Laf-053397 Loxodonta africana 91.42 1.00e-162 565.00
IUUC-Mcc-054681 Macaca mulatta 90.70 8.00e-162 563.00
IUUC-Meu-056723 Macropus eugenii 83.55 1.00e-148 518.00
IUUC-Mor-056961 Magnaporthe oryzae 36.36 9.00e-10 58.20
IUUC-Mpo-057359 Magnaporthe poae 26.40 2.00e-07 50.10
IUUC-Mtr-058063 Medicago truncatula 31.40 9.00e-33 134.00
IUUC-Mla-059004 Melampsora laricipopulina 29.39 1.00e-24 107.00
IUUC-Mvi-060460 Microbotryum violaceum 29.79 5.00e-25 108.00
IUUC-Mmr-060847 Microcebus murinus 92.03 2.00e-163 568.00
IUUC-Mdo-062480 Monodelphis domestica 84.54 5.00e-150 523.00
IUUC-Mac-064870 Musa acuminata 31.06 5.00e-33 134.00
IUUC-Mpu-066322 Mustela putorius furo 91.42 1.00e-162 565.00
IUUC-Mlu-067556 Myotis lucifugus 88.82 2.00e-153 534.00
IUUC-Nfi-068440 Neosartorya fischeri 34.78 8.00e-07 48.10
IUUC-Ncr-068898 Neurospora crassa 37.18 2.00e-07 50.10
IUUC-Nle-070049 Nomascus leucogenys 90.70 1.00e-161 562.00
IUUC-Opr-070972 Ochotona princeps 89.51 4.00e-154 536.00
IUUC-Ont-071682 Oreochromis niloticus 65.23 1.00e-114 405.00
IUUC-Oan-073296 Ornithorhynchus anatinus 98.31 1.00e-32 131.00
IUUC-Ocu-074218 Oryctolagus cuniculus 91.43 7.00e-134 469.00
IUUC-Oba-075284 Oryza barthii 31.51 5.00e-33 134.00
IUUC-Obr-076651 Oryza brachyantha 31.51 2.00e-35 142.00
IUUC-Ogl-077899 Oryza glaberrima 31.51 5.00e-33 134.00
IUUC-Ogu-078477 Oryza glumaepatula 31.85 2.00e-33 135.00
IUUC-Oin-080011 Oryza indica 31.51 5.00e-33 134.00
IUUC-Olo-080545 Oryza longistaminata 30.62 6.00e-26 112.00
IUUC-Ome-081543 Oryza meridionalis 31.51 5.00e-33 134.00
IUUC-Oni-082955 Oryza nivara 31.51 5.00e-33 134.00
IUUC-Opu-083565 Oryza punctata 31.51 3.00e-33 135.00
IUUC-Oru-084474 Oryza rufipogon 31.51 5.00e-33 134.00
IUUC-Osa-085913 Oryza sativa 31.51 5.00e-33 134.00
IUUC-Ola-086851 Oryzias latipes 64.78 1.00e-114 406.00
IUUC-Olu-087724 Ostreococcus lucimarinus 32.04 1.00e-11 63.90
IUUC-Oga-087970 Otolemur garnettii 90.40 4.00e-160 556.00
IUUC-Oar-089756 Ovis aries 88.45 6.00e-152 530.00
IUUC-Ptr-091485 Pan troglodytes 89.70 6.00e-158 549.00
IUUC-Pan-091832 Papio anubis 90.70 5.00e-162 563.00
IUUC-Pma-094551 Petromyzon marinus 62.87 6.00e-109 387.00
IUUC-Pno-094830 Phaeosphaeria nodorum 35.29 2.00e-09 56.20
IUUC-Ppa-095255 Physcomitrella patens 28.86 2.00e-30 125.00
IUUC-Pfo-096373 Poecilia formosa 64.50 6.00e-114 403.00
IUUC-Pab-098247 Pongo abelii 90.70 1.00e-161 561.00
IUUC-Pop-099186 Populus trichocarpa 30.48 4.00e-30 125.00
IUUC-Pca-100677 Procavia capensis 88.36 2.00e-134 471.00
IUUC-Ppe-101403 Prunus persica 30.38 8.00e-31 127.00
IUUC-Pva-103000 Pteropus vampyrus 91.69 4.00e-164 570.00
IUUC-Pgr-103663 Puccinia graminis 29.72 3.00e-29 122.00
IUUC-Ptt-103712 Puccinia triticina 38.46 1.00e-08 53.10
IUUC-Pte-104287 Pyrenophora teres 25.98 1.00e-16 80.90
IUUC-Pyt-104579 Pyrenophora triticirepentis 35.00 2.00e-08 53.50
IUUC-Rno-106069 Rattus norvegicus 98.67 2.00e-178 617.00
IUUC-Sha-106553 Sarcophilus harrisii 83.17 3.00e-149 520.00
IUUC-Smo-108874 Selaginella moellendorffii 32.24 7.00e-38 150.00
IUUC-Sit-110307 Setaria italica 31.51 3.00e-32 132.00
IUUC-Sly-111094 Solanum lycopersicum 31.76 5.00e-31 128.00
IUUC-Stu-112363 Solanum tuberosum 30.33 3.00e-31 128.00
IUUC-Sar-113480 Sorex araneus 91.36 9.00e-153 532.00
IUUC-Sbi-113939 Sorghum bicolor 31.51 8.00e-33 134.00
IUUC-Ssc-115644 Sus scrofa 93.02 4.00e-166 577.00
IUUC-Tru-118781 Takifugu rubripes 65.15 2.00e-120 425.00
IUUC-Tni-119672 Tetraodon nigroviridis 72.41 2.00e-33 132.00
IUUC-Tca-121795 Theobroma cacao 31.88 9.00e-35 140.00
IUUC-Tre-122037 Trichoderma reesei 35.06 6.00e-08 52.00
IUUC-Tvi-122524 Trichoderma virens 27.21 4.00e-18 85.50
IUUC-Tae-122828 Triticum aestivum 31.06 8.00e-34 137.00
IUUC-Tur-126387 Triticum urartu 30.23 9.00e-27 114.00
IUUC-Tme-127111 Tuber melanosporum 38.75 3.00e-09 55.80
IUUC-Ttr-128227 Tursiops truncatus 91.03 1.00e-161 561.00
IUUC-Vda-129924 Verticillium dahliae 26.37 2.00e-14 73.20
IUUC-Vpa-130802 Vicugna pacos 93.26 3.00e-43 168.00
IUUC-Vvi-131105 Vitis vinifera 31.51 4.00e-32 131.00
IUUC-Xtr-132830 Xenopus tropicalis 64.58 8.00e-120 423.00
IUUC-Xma-133618 Xiphophorus maculatus 64.14 5.00e-107 380.00
IUUC-Zma-135389 Zea mays 31.53 7.00e-32 130.00
Created Date 25-Jun-2017

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