iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-37	127.1	141	179
UBD/Beta-Prp	9.70e-59	199.9	14	252

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt +v+ l+f +d + +vsG+ D+++kvWDl+ g+ll+
   Q: 141  GHTRGVNVLRFtPDgRWIVSGGEDNVVKVWDLTAGKLLH 179
           8***********9999*******************9987 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkf.spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp 104
           +h++ ++c+k+  +++++l+tg++d+++ +w + +++++ sl+gh++++ +v+f+ ++ + + g+  +tik+wdl+  k v+tl+gh ++ +s++f+p
   Q: 14   AHSAAVNCLKIgRKSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDLEEAKVVRTLTGHRSNCVSVNFHP 111
           789999*****99************************************************************************************* PP
   S: 105  sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldg 202
            g++++sGs d  +++wd++++ c++ t +gh++ vn++++ pdg+ +vsG+ D++v++Wdl  gkll+++++ h+++++sl+f++  + l++gs d+
   Q: 112  FGEFFASGSLDTNLKIWDIRKKGCIH-TYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWDLTAGKLLHEFKS-HEGKIQSLDFHPHEFLLATGSADK 207
           **************************.*********************************************9.************************ PP
   S: 203  tvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiri 248
           tvk+wdl+t e + +    t+ v+++ f p+++ +++g   +s++i
   Q: 208  TVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCGL-QESLKI 252
           **********************************99996.445555 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.

Protein Sequence
(Fasta)

MNTKRAYKLQ EFVAHSAAVN CLKIGRKSSR VLVTGGEDHK VNLWAIGKPN AILSLYGHSS 60
GIDSVTFDAS EGLVAAGAAS GTIKLWDLEE AKVVRTLTGH RSNCVSVNFH PFGEFFASGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAGAGGTA AGTAAAATAA TAAAGCAGCT CCCTTTCTCT CTCTGCTTCC TTGTGTGTGT 60
CTGTGTGTCA TTCACATCTC CCTCCTCTCT TCTTCACCAT TAGAGGAGAG AAAACACACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0051013--P:microtubule severing

KEGG

ath:AT5G08390

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006226	Arabidopsis lyrata	96.55	0.00e+00	1591.00
IUUC-Bdi-014652	Brachypodium distachyon	47.58	0.00e+00	737.00
IUUC-Bol-015242	Brassica oleracea	84.88	0.00e+00	1362.00
IUUC-Bra-017390	Brassica rapa	84.41	0.00e+00	1374.00
IUUC-Cin-025156	Ciona intestinalis	45.79	2.00e-84	306.00
IUUC-Csv-025962	Ciona savignyi	47.77	2.00e-83	301.00
IUUC-Dme-032188	Drosophila melanogaster	37.75	2.00e-56	213.00
IUUC-Gma-044134	Glycine max	56.97	0.00e+00	883.00
IUUC-Lpe-051554	Leersia perrieri	50.21	0.00e+00	777.00
IUUC-Oba-075448	Oryza barthii	49.66	0.00e+00	766.00
IUUC-Ogu-078428	Oryza glumaepatula	44.96	2.00e-167	582.00
IUUC-Oni-082640	Oryza nivara	49.66	0.00e+00	766.00
IUUC-Opu-083748	Oryza punctata	50.61	0.00e+00	775.00
IUUC-Oru-084609	Oryza rufipogon	49.66	0.00e+00	766.00
IUUC-Osa-086267	Oryza sativa	73.48	3.00e-147	515.00
IUUC-Pop-099149	Populus trichocarpa	61.28	0.00e+00	986.00
IUUC-Ppe-101237	Prunus persica	60.81	0.00e+00	966.00
IUUC-Tru-117865	Takifugu rubripes	45.85	1.00e-93	337.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence