iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000006461.5	ENSGALT00000038686.3	ENSGALP00000037894.1
ENSGALG00000006461.5	ENSGALT00000069625.1	ENSGALP00000058146.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-106	356.9	747	1084

Active Site

Position(s)	Description	Evidence
1052	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +  + ++++flGr+lgkal++
   Q: 747  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD-SYARHYYFLGRMLGKALYE 832
           689**********99**9**************************************9**99999965.9****************** PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++++f+++llg+  ++++++l+++dpe+yk+l ++k++ e d+eelgl++t+   ++ lge+++ eLkpgG++ipVt +N
   Q: 833  NMLVELPFASFFLSKLLGTsaDVDIHHLASLDPEMYKNLLFLKSY-EGDVEELGLNFTVV--NNDLGEAQVIELKPGGKDIPVTSAN 916
           ******************9666889******************99.78999987777765..888********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i++++ afr+G+ +v++le+l++F+++e+++li+G    i+++dlk++t+y ggy +d+p+i++Fw+v+e+
   Q: 917  RIAYIHLVADYRLNKQIRQHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAqVPISLDDLKSFTNYSGGYAADHPVIKTFWRVVER 1003
           ****************************************************899******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f++ee++++L+FvT++sr Pl Gf+el p  f+i++ +sd drlP+++TC+n+LkLPe+  ++ +++kLlyAie ++gFels
   Q: 1004 FTDEEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGSDlDRLPTASTCMNLLKLPEFYDENLMRSKLLYAIECAAGFELS 1084
           ****************************88.*****99999**************************************985 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MFSFEGDFKT RPKVSLGGAS KKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFVRGYR 60
DRNHQYSTQR SEFDRCANLA QSGGTFSTAI GANLTLLVRQ LLFFYRQNED SKRLIWMCQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGCGCGC CTGGGAAGCT GCAGGCGGCG GCCATCTTCT GTCCACCGCC GGCTGCTCCC 60
CCAGTGCAAG TGAAGCAGCC CCGCCAGCCC CCTCCTCCTC TCCTTCCCTC CTCCTTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	88.72	0.00e+00	1848.00
IUUC-Atr-002669	Amborella trichopoda	35.36	6.00e-103	368.00
IUUC-Apl-003731	Anas platyrhynchos	97.79	0.00e+00	2052.00
IUUC-Aca-005248	Anolis carolinensis	93.63	0.00e+00	2018.00
IUUC-Aly-005768	Arabidopsis lyrata	34.88	3.00e-111	396.00
IUUC-Ath-006576	Arabidopsis thaliana	34.05	5.00e-112	399.00
IUUC-Ago-007748	Ashbya gossypii	41.19	9.00e-80	291.00
IUUC-Acl-008158	Aspergillus clavatus	38.17	3.00e-76	280.00
IUUC-Afl-008398	Aspergillus flavus	38.09	1.00e-78	288.00
IUUC-Afu-008937	Aspergillus fumigatus	38.64	2.00e-79	290.00
IUUC-Ani-009252	Aspergillus nidulans	37.95	3.00e-80	293.00
IUUC-Ang-009773	Aspergillus niger	33.91	9.00e-80	291.00
IUUC-Aor-009940	Aspergillus oryzae	38.09	1.00e-78	288.00
IUUC-Ate-010395	Aspergillus terreus	33.91	8.00e-80	292.00
IUUC-Ame-010769	Astyanax mexicanus	63.19	0.00e+00	1046.00
IUUC-Bgr-012269	Blumeria graminis	37.77	1.00e-75	276.00
IUUC-Bta-012841	Bos taurus	87.28	0.00e+00	1840.00
IUUC-Bci-013743	Botrytis cinerea	29.68	4.00e-86	313.00
IUUC-Bdi-014123	Brachypodium distachyon	47.55	3.00e-105	376.00
IUUC-Bol-015390	Brassica oleracea	46.60	3.00e-103	370.00
IUUC-Bra-016853	Brassica rapa	34.47	1.00e-109	391.00
IUUC-Cel-018638	Caenorhabditis elegans	39.61	2.00e-91	330.00
IUUC-Cja-019743	Callithrix jacchus	87.47	0.00e+00	1843.00
IUUC-Cfa-021031	Canis familiaris	90.07	0.00e+00	1900.00
IUUC-Cpo-022401	Cavia porcellus	89.21	0.00e+00	1873.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	44.25	9.00e-86	310.00
IUUC-Csa-024107	Chlorocebus sabaeus	90.31	0.00e+00	1909.00
IUUC-Cho-024750	Choloepus hoffmanni	80.62	0.00e+00	785.00
IUUC-Cin-025432	Ciona intestinalis	45.37	8.00e-99	353.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	33.86	2.00e-87	317.00
IUUC-Cne-026841	Cryptococcus neoformans	36.22	2.00e-95	343.00
IUUC-Cme-027265	Cyanidioschyzon merolae	47.34	3.00e-105	376.00
IUUC-Dre-028196	Danio rerio	79.15	0.00e+00	1630.00
IUUC-Dno-029024	Dasypus novemcinctus	90.77	0.00e+00	1921.00
IUUC-Dor-030483	Dipodomys ordii	88.77	0.00e+00	670.00
IUUC-Dse-031416	Dothistroma septosporum	31.54	7.00e-80	292.00
IUUC-Dme-031946	Drosophila melanogaster	37.34	0.00e+00	692.00
IUUC-Ete-032240	Echinops telfairi	81.25	1.00e-171	597.00
IUUC-Eca-033828	Equus caballus	90.68	0.00e+00	1889.00
IUUC-Eeu-034604	Erinaceus europaeus	83.85	2.00e-125	443.00
IUUC-Fca-035907	Felis catus	89.39	0.00e+00	1907.00
IUUC-Fal-037389	Ficedula albicollis	97.05	0.00e+00	2073.00
IUUC-Fox-037788	Fusarium oxysporum	36.53	5.00e-90	325.00
IUUC-Fso-038088	Fusarium solani	35.83	2.00e-88	321.00
IUUC-Gmo-039254	Gadus morhua	68.17	0.00e+00	1253.00
IUUC-Ggr-039941	Gaeumannomyces graminis	33.74	6.00e-83	302.00
IUUC-Gac-042054	Gasterosteus aculeatus	70.73	0.00e+00	1310.00
IUUC-Gma-042836	Glycine max	35.74	8.00e-103	368.00
IUUC-Ggo-045031	Gorilla gorilla	90.68	0.00e+00	1916.00
IUUC-Hsa-045880	Homo sapiens	90.59	0.00e+00	1914.00
IUUC-Hvu-047770	Hordeum vulgare	48.04	5.00e-106	378.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	79.91	0.00e+00	629.00
IUUC-Kpa-049307	Komagataella pastoris	36.99	2.00e-66	247.00
IUUC-Lch-050403	Latimeria chalumnae	84.56	0.00e+00	1708.00
IUUC-Lpe-051428	Leersia perrieri	46.15	1.00e-96	347.00
IUUC-Loc-052218	Lepisosteus oculatus	83.79	0.00e+00	1738.00
IUUC-Lma-053096	Leptosphaeria maculans	38.15	5.00e-81	296.00
IUUC-Laf-054162	Loxodonta africana	87.28	0.00e+00	1642.00
IUUC-Mcc-055127	Macaca mulatta	90.41	0.00e+00	1912.00
IUUC-Meu-056187	Macropus eugenii	83.48	2.00e-107	383.00
IUUC-Mor-057021	Magnaporthe oryzae	33.68	2.00e-79	290.00
IUUC-Mpo-057570	Magnaporthe poae	36.24	1.00e-76	281.00
IUUC-Mtr-058154	Medicago truncatula	35.28	1.00e-105	377.00
IUUC-Mla-059124	Melampsora laricipopulina	48.52	2.00e-103	369.00
IUUC-Mga-059581	Meleagris gallopavo	98.70	0.00e+00	2087.00
IUUC-Mvi-060445	Microbotryum violaceum	38.89	6.00e-107	382.00
IUUC-Mmr-061360	Microcebus murinus	86.77	0.00e+00	1763.00
IUUC-Mdo-062194	Monodelphis domestica	90.16	0.00e+00	1986.00
IUUC-Mmu-064189	Mus musculus	88.19	0.00e+00	1886.00
IUUC-Mac-065275	Musa acuminata	50.37	1.00e-111	397.00
IUUC-Mpu-066439	Mustela putorius furo	88.39	0.00e+00	1842.00
IUUC-Mlu-068228	Myotis lucifugus	86.06	0.00e+00	1836.00
IUUC-Nfi-068280	Neosartorya fischeri	39.28	5.00e-80	293.00
IUUC-Ncr-068869	Neurospora crassa	35.09	4.00e-83	303.00
IUUC-Nle-069687	Nomascus leucogenys	89.92	0.00e+00	1856.00
IUUC-Opr-070592	Ochotona princeps	94.50	5.00e-111	395.00
IUUC-Ont-071836	Oreochromis niloticus	79.98	0.00e+00	1674.00
IUUC-Oan-072800	Ornithorhynchus anatinus	94.65	0.00e+00	2019.00
IUUC-Ocu-074587	Oryctolagus cuniculus	90.87	0.00e+00	1921.00
IUUC-Oba-075006	Oryza barthii	49.14	3.00e-109	390.00
IUUC-Ogl-077003	Oryza glaberrima	49.14	3.00e-109	389.00
IUUC-Ogu-078947	Oryza glumaepatula	49.14	2.00e-109	390.00
IUUC-Olo-080475	Oryza longistaminata	49.14	2.00e-109	390.00
IUUC-Ome-081342	Oryza meridionalis	46.15	9.00e-97	348.00
IUUC-Oni-082385	Oryza nivara	49.14	3.00e-109	389.00
IUUC-Opu-083176	Oryza punctata	49.14	6.00e-109	388.00
IUUC-Oru-084554	Oryza rufipogon	46.15	1.00e-96	347.00
IUUC-Osa-085355	Oryza sativa	49.14	2.00e-109	390.00
IUUC-Ola-087209	Oryzias latipes	78.78	0.00e+00	1628.00
IUUC-Olu-087699	Ostreococcus lucimarinus	43.40	5.00e-90	324.00
IUUC-Oga-088776	Otolemur garnettii	85.24	0.00e+00	1731.00
IUUC-Oar-089441	Ovis aries	86.46	0.00e+00	1821.00
IUUC-Ptr-091273	Pan troglodytes	90.50	0.00e+00	1913.00
IUUC-Pan-091981	Papio anubis	90.31	0.00e+00	1910.00
IUUC-Psi-093203	Pelodiscus sinensis	94.82	0.00e+00	1765.00
IUUC-Pma-094738	Petromyzon marinus	65.63	0.00e+00	1350.00
IUUC-Pno-095132	Phaeosphaeria nodorum	34.67	2.00e-58	220.00
IUUC-Ppa-095682	Physcomitrella patens	35.67	2.00e-117	416.00
IUUC-Pfo-097511	Poecilia formosa	80.63	0.00e+00	1691.00
IUUC-Pab-098634	Pongo abelii	87.56	0.00e+00	1833.00
IUUC-Pop-098928	Populus trichocarpa	35.79	5.00e-101	362.00
IUUC-Pca-100987	Procavia capensis	83.88	0.00e+00	846.00
IUUC-Ppe-102040	Prunus persica	34.73	8.00e-98	351.00
IUUC-Pva-103034	Pteropus vampyrus	84.37	0.00e+00	1729.00
IUUC-Pgr-103513	Puccinia graminis	39.59	1.00e-107	384.00
IUUC-Ptt-103967	Puccinia triticina	41.73	1.00e-95	344.00
IUUC-Pte-104105	Pyrenophora teres	37.37	2.00e-79	290.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	37.15	3.00e-79	290.00
IUUC-Rno-105380	Rattus norvegicus	87.12	0.00e+00	1633.00
IUUC-Sce-106446	Saccharomyces cerevisiae	40.14	3.00e-69	256.00
IUUC-Sha-107108	Sarcophilus harrisii	86.56	0.00e+00	1825.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	44.64	9.00e-98	351.00
IUUC-Spo-108097	Schizosaccharomyces pombe	44.93	5.00e-97	348.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	28.64	3.00e-84	306.00
IUUC-Sit-110457	Setaria italica	49.02	1.00e-101	364.00
IUUC-Sly-111362	Solanum lycopersicum	35.98	1.00e-104	374.00
IUUC-Sar-113687	Sorex araneus	79.52	0.00e+00	892.00
IUUC-Sbi-113882	Sorghum bicolor	48.28	4.00e-99	356.00
IUUC-Sre-115038	Sporisorium reilianum	44.47	3.00e-98	353.00
IUUC-Ssc-116168	Sus scrofa	82.81	0.00e+00	754.00
IUUC-Tgu-116729	Taeniopygia guttata	96.59	0.00e+00	2056.00
IUUC-Tru-118068	Takifugu rubripes	78.78	0.00e+00	1641.00
IUUC-Tsy-118942	Tarsius syrichta	89.86	0.00e+00	697.00
IUUC-Tni-120732	Tetraodon nigroviridis	77.83	0.00e+00	1603.00
IUUC-Tca-121737	Theobroma cacao	35.90	2.00e-108	387.00
IUUC-Tre-121892	Trichoderma reesei	36.06	4.00e-87	316.00
IUUC-Tvi-122354	Trichoderma virens	35.50	3.00e-88	320.00
IUUC-Tme-127102	Tuber melanosporum	36.06	1.00e-93	338.00
IUUC-Tbe-127351	Tupaia belangeri	78.69	0.00e+00	1450.00
IUUC-Ttr-129061	Tursiops truncatus	86.25	0.00e+00	1800.00
IUUC-Uma-129343	Ustilago maydis	44.96	5.00e-100	359.00
IUUC-Vda-129748	Verticillium dahliae	38.38	2.00e-80	294.00
IUUC-Vvi-131234	Vitis vinifera	30.69	3.00e-111	396.00
IUUC-Xtr-132094	Xenopus tropicalis	88.86	0.00e+00	1870.00
IUUC-Xma-133923	Xiphophorus maculatus	80.81	0.00e+00	1692.00
IUUC-Yli-134496	Yarrowia lipolytica	40.04	2.00e-91	330.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence