iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048194

Ensembl Protein ID

ENSSTOP00000023043.1

UniProt Accession

I3NF96; I3NF96_ICTTR

Genbank Protein ID

ENSSTOP00000023043

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AGTP01071685

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000020045.1	ENSSTOT00000025930.1	ENSSTOP00000023043.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.20e-14	54.2	1419	1459

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1419 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1459
           8*********....*******************....99996.******8 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MLELPGTSSS STSQELPFCQ PKKKSTPLKY EVGDLIWAKF KRRPWWPCRI CSDPLINTHS 60
KMKVANRRPY REYYVEAFGD PSERAWVAGK AIVMFEGRHQ FEELPVLRKR GKQKEKGYRH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGGGAGGT GCTGCCGCAG CTGCGGGAAG GAGCGCGGCC CGGGCAGGCG GTGTCGGCGT 60
CGGCAGCAGC CATGTTTGTC AAGCTGTAGC AGCTGCTGCT ATCCTGATTT GGCTTCACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001795	Ailuropoda melanoleuca	89.28	0.00e+00	4171.00
IUUC-Apl-003953	Anas platyrhynchos	56.01	0.00e+00	2235.00
IUUC-Aca-005339	Anolis carolinensis	50.49	0.00e+00	1760.00
IUUC-Bta-012966	Bos taurus	89.28	0.00e+00	4224.00
IUUC-Bol-016001	Brassica oleracea	30.05	5.00e-17	83.60
IUUC-Bra-017864	Brassica rapa	29.51	7.00e-16	80.10
IUUC-Cja-018780	Callithrix jacchus	88.53	0.00e+00	3876.00
IUUC-Cfa-020975	Canis familiaris	88.99	0.00e+00	4159.00
IUUC-Cpo-021331	Cavia porcellus	89.33	0.00e+00	2770.00
IUUC-Csa-024226	Chlorocebus sabaeus	89.57	0.00e+00	4155.00
IUUC-Cho-024464	Choloepus hoffmanni	74.79	0.00e+00	1351.00
IUUC-Csv-026298	Ciona savignyi	38.54	4.00e-57	215.00
IUUC-Dre-028152	Danio rerio	62.18	0.00e+00	1254.00
IUUC-Dno-029230	Dasypus novemcinctus	84.91	0.00e+00	3919.00
IUUC-Dor-031016	Dipodomys ordii	83.20	0.00e+00	1343.00
IUUC-Dme-032193	Drosophila melanogaster	36.87	7.00e-123	435.00
IUUC-Eca-033591	Equus caballus	88.74	0.00e+00	4160.00
IUUC-Fca-035791	Felis catus	89.77	0.00e+00	4290.00
IUUC-Fal-037378	Ficedula albicollis	60.88	0.00e+00	2037.00
IUUC-Gmo-038919	Gadus morhua	71.20	0.00e+00	936.00
IUUC-Gga-040881	Gallus gallus	60.26	0.00e+00	2145.00
IUUC-Gac-041378	Gasterosteus aculeatus	78.03	0.00e+00	1072.00
IUUC-Hsa-046436	Homo sapiens	89.73	0.00e+00	4185.00
IUUC-Hvu-047760	Hordeum vulgare	40.98	1.00e-09	59.30
IUUC-Lch-049684	Latimeria chalumnae	50.48	0.00e+00	1610.00
IUUC-Lpe-051661	Leersia perrieri	28.72	6.00e-12	66.20
IUUC-Laf-054046	Loxodonta africana	88.57	0.00e+00	4075.00
IUUC-Mcc-055593	Macaca mulatta	89.40	0.00e+00	4152.00
IUUC-Mga-059756	Meleagris gallopavo	57.31	0.00e+00	2216.00
IUUC-Mmr-061182	Microcebus murinus	89.07	0.00e+00	4220.00
IUUC-Mdo-061984	Monodelphis domestica	67.76	0.00e+00	2999.00
IUUC-Mmu-063605	Mus musculus	82.80	0.00e+00	3905.00
IUUC-Mpu-066446	Mustela putorius furo	89.19	0.00e+00	4256.00
IUUC-Mlu-067261	Myotis lucifugus	87.47	0.00e+00	4090.00
IUUC-Nle-069818	Nomascus leucogenys	89.69	0.00e+00	4181.00
IUUC-Opr-070842	Ochotona princeps	84.35	0.00e+00	2374.00
IUUC-Ont-072448	Oreochromis niloticus	75.37	0.00e+00	1147.00
IUUC-Oan-073496	Ornithorhynchus anatinus	74.02	0.00e+00	1645.00
IUUC-Ocu-074918	Oryctolagus cuniculus	89.86	0.00e+00	4295.00
IUUC-Obr-076753	Oryza brachyantha	54.84	8.00e-08	53.10
IUUC-Ola-087518	Oryzias latipes	76.21	0.00e+00	1052.00
IUUC-Oga-088743	Otolemur garnettii	87.69	0.00e+00	4024.00
IUUC-Oar-090265	Ovis aries	88.86	0.00e+00	4198.00
IUUC-Ptr-090521	Pan troglodytes	89.94	0.00e+00	4204.00
IUUC-Psi-093245	Pelodiscus sinensis	59.00	0.00e+00	2046.00
IUUC-Pfo-096066	Poecilia formosa	76.77	0.00e+00	1206.00
IUUC-Pab-098644	Pongo abelii	89.52	0.00e+00	4160.00
IUUC-Pva-103094	Pteropus vampyrus	85.59	0.00e+00	2121.00
IUUC-Rno-105803	Rattus norvegicus	83.18	0.00e+00	3850.00
IUUC-Sha-107278	Sarcophilus harrisii	68.69	0.00e+00	3038.00
IUUC-Sar-113402	Sorex araneus	76.17	0.00e+00	2565.00
IUUC-Sbi-114400	Sorghum bicolor	36.54	3.00e-13	66.60
IUUC-Ssc-116193	Sus scrofa	88.33	0.00e+00	4049.00
IUUC-Tgu-116532	Taeniopygia guttata	90.15	0.00e+00	1254.00
IUUC-Tru-117988	Takifugu rubripes	77.71	0.00e+00	1204.00
IUUC-Tsy-118830	Tarsius syrichta	88.87	0.00e+00	3668.00
IUUC-Tca-121456	Theobroma cacao	30.33	1.00e-19	91.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence