iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.60e-44	152.1	256	584

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaee.fsgyeqqDaqEflafl 99
           +Gl+N+ +  Y+N++LQ+Ls++++lr+ +l++ + +  ++ p ++ + l + + +l+++lw     +++vsp+e+l+a+  ++++ f+  +q+Da +f+ fl
   Q: 256  VGLNNIKANDYCNAILQALSAVRPLRNWFLKESNYTSIKRPPGDKLTLLPQRFGELIRKLWnpRALRTHVSPHEMLQAVVVCSNKkFQFIKQNDAADFMLFL 357
           6******************************9999999999999999**************9999999********9998887666**************** PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk.................sqikclecdnvssreepfldlslpvpgkeetkk 184
           l +l+++l                         + + k++s+is++F+g+++                  +++++e +++ + e+pfl+l+l++p+      
   Q: 358  LTTLHSAL-------------------------NGTDKKPSIISKTFRGRMRqysrrvipaedtdeekyMKLRMPEYQEK-VIESPFLYLTLDLPSAPLYRD 433
           ********.........................34566777777777777777777777777777653345555554444.5688***********999999 PP
   S: 185  eslqdcLesftkeeele...genkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLia 282
            +lq+++ +      le   g+ + + ++ + + +  k+++l +lP++Li+  kRf  +++q++ ek+ + v+fp+  +d    ++++ ++++++++Y+L+a
   Q: 434  VQLQNIIPQVPLSTLLEkfdGKTEKEYPTYN-DNNIMKRFELLQLPDFLIITYKRF--QKNQWFVEKNPTIVNFPIAnVDFYDCLAKDARANHKYTTYDLVA 532
           9999999888777666600044444444443.4559********************..9999**************99************************ PP
   S: 283  vvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
            vvH+G+++ G Y   + +  +gkW+++ D +V+ +  + ++    ++ Y+ +++
   Q: 533  NVVHEGTFKDGNYRIQIVHeGSGKWFELEDLHVKDLLPQMIVL---AESYIQIWR 584
           *************98887725666************9999999...899998876 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MTNEEPKSPE KVERRRSTQE DSEKDKKRSR DDRKTEKRTH DRDRKRNRSR SRSRSRSPKR 60
SRRDKKEEKQ EQEEEDGEIR DTTPPAPEKP RQLTARELER QRIIEEELKS GKHDEHDDDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGACAAAC GAAGAGCCAA AATCTCCCGA AAAGGTGGAA CGCCGGCGGT CAACGCAGGA 60
AGATTCGGAA AAAGACAAGA AACGTTCGAG TTGGTGGATT TTAATCGATT TTTCTGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033809--USP39
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0000245--P:spliceosomal complex assembly

KEGG

cel:CELE_F09D1.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000483	Aegilops tauschii	45.79	7.00e-110	389.00
IUUC-Aml-001846	Ailuropoda melanoleuca	59.24	3.00e-178	617.00
IUUC-Atr-002758	Amborella trichopoda	45.65	9.00e-113	399.00
IUUC-Apl-003336	Anas platyrhynchos	54.19	3.00e-101	360.00
IUUC-Aca-004846	Anolis carolinensis	63.02	1.00e-173	600.00
IUUC-Aly-005683	Arabidopsis lyrata	45.70	9.00e-102	362.00
IUUC-Ath-007652	Arabidopsis thaliana	45.41	1.00e-102	365.00
IUUC-Ago-007802	Ashbya gossypii	31.22	9.00e-60	223.00
IUUC-Acl-008304	Aspergillus clavatus	39.53	4.00e-85	307.00
IUUC-Afl-008735	Aspergillus flavus	58.12	1.00e-38	152.00
IUUC-Afu-009100	Aspergillus fumigatus	36.89	1.00e-83	302.00
IUUC-Ani-009138	Aspergillus nidulans	39.01	9.00e-85	306.00
IUUC-Ang-009661	Aspergillus niger	40.31	3.00e-89	321.00
IUUC-Aor-010235	Aspergillus oryzae	41.13	2.00e-71	261.00
IUUC-Ate-010346	Aspergillus terreus	35.25	4.00e-65	241.00
IUUC-Ame-011688	Astyanax mexicanus	65.27	5.00e-179	619.00
IUUC-Bgr-011998	Blumeria graminis	42.72	5.00e-109	386.00
IUUC-Bta-013407	Bos taurus	62.39	6.00e-178	615.00
IUUC-Bci-013977	Botrytis cinerea	43.24	7.00e-110	389.00
IUUC-Bdi-014361	Brachypodium distachyon	46.19	1.00e-114	405.00
IUUC-Bol-016317	Brassica oleracea	45.20	3.00e-102	363.00
IUUC-Bra-017190	Brassica rapa	44.54	9.00e-103	365.00
IUUC-Cja-019134	Callithrix jacchus	59.56	2.00e-178	617.00
IUUC-Cfa-020098	Canis familiaris	59.24	3.00e-178	616.00
IUUC-Cpo-021595	Cavia porcellus	63.38	1.00e-177	614.00
IUUC-Cre-022886	Chlamydomonas reinhardtii	39.34	5.00e-24	101.00
IUUC-Csa-024121	Chlorocebus sabaeus	63.38	5.00e-178	615.00
IUUC-Cho-025057	Choloepus hoffmanni	57.64	2.00e-64	238.00
IUUC-Cin-025473	Ciona intestinalis	52.94	2.00e-50	190.00
IUUC-Csv-025815	Ciona savignyi	67.77	4.00e-103	367.00
IUUC-Cgl-026416	Colletotrichum gloeosporioides	41.05	9.00e-103	366.00
IUUC-Cne-026802	Cryptococcus neoformans	40.00	4.00e-89	320.00
IUUC-Dre-027870	Danio rerio	63.25	1.00e-177	614.00
IUUC-Dno-029655	Dasypus novemcinctus	63.60	8.00e-179	618.00
IUUC-Dor-030762	Dipodomys ordii	62.39	7.00e-178	615.00
IUUC-Dse-031441	Dothistroma septosporum	43.63	2.00e-101	361.00
IUUC-Dme-032101	Drosophila melanogaster	58.77	6.00e-158	549.00
IUUC-Ete-032841	Echinops telfairi	56.83	1.00e-169	588.00
IUUC-Eca-033463	Equus caballus	63.38	7.00e-178	615.00
IUUC-Eeu-034438	Erinaceus europaeus	51.82	8.00e-90	323.00
IUUC-Fca-035774	Felis catus	59.24	3.00e-178	616.00
IUUC-Fal-036988	Ficedula albicollis	61.97	3.00e-180	623.00
IUUC-Fox-037895	Fusarium oxysporum	44.14	1.00e-101	362.00
IUUC-Fso-038450	Fusarium solani	44.12	3.00e-101	361.00
IUUC-Gmo-038874	Gadus morhua	62.66	1.00e-174	604.00
IUUC-Ggr-040115	Gaeumannomyces graminis	42.49	3.00e-94	338.00
IUUC-Gac-041650	Gasterosteus aculeatus	63.34	5.00e-178	615.00
IUUC-Gma-043697	Glycine max	46.64	8.00e-113	399.00
IUUC-Ggo-044707	Gorilla gorilla	58.55	1.00e-159	555.00
IUUC-Hsa-046041	Homo sapiens	63.38	7.00e-178	615.00
IUUC-Hvu-047816	Hordeum vulgare	56.05	8.00e-80	290.00
IUUC-Itr-048945	Ictidomys tridecemlineatus	64.85	1.00e-128	451.00
IUUC-Lch-050419	Latimeria chalumnae	63.11	0.00e+00	629.00
IUUC-Lpe-051593	Leersia perrieri	47.69	4.00e-117	413.00
IUUC-Loc-052930	Lepisosteus oculatus	63.85	0.00e+00	630.00
IUUC-Lma-053256	Leptosphaeria maculans	42.95	5.00e-103	367.00
IUUC-Laf-053555	Loxodonta africana	63.38	8.00e-178	615.00
IUUC-Mcc-055630	Macaca mulatta	63.38	5.00e-178	615.00
IUUC-Meu-056579	Macropus eugenii	57.83	2.00e-101	362.00
IUUC-Mor-057078	Magnaporthe oryzae	43.15	2.00e-97	348.00
IUUC-Mpo-057607	Magnaporthe poae	36.07	1.00e-76	278.00
IUUC-Mtr-058644	Medicago truncatula	44.89	2.00e-110	391.00
IUUC-Mla-059120	Melampsora laricipopulina	39.22	3.00e-102	365.00
IUUC-Mvi-060429	Microbotryum violaceum	45.95	2.00e-70	258.00
IUUC-Mmr-061313	Microcebus murinus	63.38	4.00e-178	616.00
IUUC-Mdo-062801	Monodelphis domestica	58.16	2.00e-178	617.00
IUUC-Mmu-064424	Mus musculus	63.82	0.00e+00	627.00
IUUC-Mac-064694	Musa acuminata	46.97	3.00e-114	404.00
IUUC-Mpu-065980	Mustela putorius furo	60.66	1.00e-152	531.00
IUUC-Mlu-067007	Myotis lucifugus	62.31	7.00e-179	619.00
IUUC-Nfi-068274	Neosartorya fischeri	37.48	2.00e-83	301.00
IUUC-Ncr-068829	Neurospora crassa	44.23	4.00e-96	343.00
IUUC-Nle-069171	Nomascus leucogenys	62.39	3.00e-177	613.00
IUUC-Opr-070494	Ochotona princeps	55.34	2.00e-151	527.00
IUUC-Ont-072290	Oreochromis niloticus	63.68	0.00e+00	637.00
IUUC-Oan-073099	Ornithorhynchus anatinus	62.18	2.00e-177	613.00
IUUC-Ocu-074642	Oryctolagus cuniculus	62.39	8.00e-178	615.00
IUUC-Oba-075886	Oryza barthii	47.47	3.00e-116	410.00
IUUC-Obr-076220	Oryza brachyantha	47.17	1.00e-116	412.00
IUUC-Ogl-077682	Oryza glaberrima	47.47	2.00e-116	411.00
IUUC-Ogu-078492	Oryza glumaepatula	47.69	4.00e-117	413.00
IUUC-Oin-079956	Oryza indica	47.47	1.00e-116	411.00
IUUC-Olo-080239	Oryza longistaminata	41.53	2.00e-92	333.00
IUUC-Ome-081573	Oryza meridionalis	47.47	8.00e-117	412.00
IUUC-Oni-082975	Oryza nivara	47.47	1.00e-116	411.00
IUUC-Opu-083724	Oryza punctata	47.25	2.00e-116	411.00
IUUC-Oru-084566	Oryza rufipogon	47.47	2.00e-116	411.00
IUUC-Osa-086008	Oryza sativa	47.47	1.00e-116	412.00
IUUC-Ola-086967	Oryzias latipes	64.59	0.00e+00	625.00
IUUC-Olu-087614	Ostreococcus lucimarinus	41.89	7.00e-91	326.00
IUUC-Oga-088047	Otolemur garnettii	53.91	1.00e-109	388.00
IUUC-Oar-089393	Ovis aries	59.60	4.00e-178	616.00
IUUC-Ptr-090561	Pan troglodytes	63.38	6.00e-178	615.00
IUUC-Pan-091812	Papio anubis	63.38	4.00e-178	616.00
IUUC-Psi-093507	Pelodiscus sinensis	57.89	3.00e-93	333.00
IUUC-Pno-095104	Phaeosphaeria nodorum	41.89	4.00e-102	363.00
IUUC-Ppa-095995	Physcomitrella patens	47.71	7.00e-117	412.00
IUUC-Pfo-096754	Poecilia formosa	64.62	0.00e+00	632.00
IUUC-Pab-098053	Pongo abelii	63.38	6.00e-178	615.00
IUUC-Pop-099158	Populus trichocarpa	46.64	1.00e-109	389.00
IUUC-Pca-100407	Procavia capensis	56.14	7.00e-151	525.00
IUUC-Ppe-101699	Prunus persica	46.61	2.00e-112	398.00
IUUC-Pva-103159	Pteropus vampyrus	62.28	2.00e-168	584.00
IUUC-Pgr-103433	Puccinia graminis	43.12	3.00e-108	384.00
IUUC-Ptt-103701	Puccinia triticina	39.55	3.00e-93	334.00
IUUC-Pte-104281	Pyrenophora teres	41.55	4.00e-105	373.00
IUUC-Pyt-104714	Pyrenophora triticirepentis	41.63	2.00e-105	375.00
IUUC-Rno-105531	Rattus norvegicus	60.20	0.00e+00	629.00
IUUC-Sce-106368	Saccharomyces cerevisiae	28.54	2.00e-44	171.00
IUUC-Sha-107093	Sarcophilus harrisii	58.41	1.00e-177	615.00
IUUC-Sja-108004	Schizosaccharomyces japonicus	43.56	2.00e-109	388.00
IUUC-Spo-108018	Schizosaccharomyces pombe	40.82	1.00e-102	365.00
IUUC-Ssl-108460	Sclerotinia sclerotiorum	43.13	7.00e-98	349.00
IUUC-Smo-108892	Selaginella moellendorffii	47.06	2.00e-114	404.00
IUUC-Sit-110782	Setaria italica	48.59	1.00e-118	418.00
IUUC-Sly-111308	Solanum lycopersicum	45.81	1.00e-123	435.00
IUUC-Stu-112447	Solanum tuberosum	46.91	1.00e-123	435.00
IUUC-Sar-113352	Sorex araneus	61.17	3.00e-136	477.00
IUUC-Sbi-114806	Sorghum bicolor	48.91	8.00e-118	416.00
IUUC-Sre-115059	Sporisorium reilianum	38.60	3.00e-85	308.00
IUUC-Ssc-115677	Sus scrofa	58.75	3.00e-128	450.00
IUUC-Tru-118478	Takifugu rubripes	63.71	0.00e+00	631.00
IUUC-Tsy-119082	Tarsius syrichta	58.24	8.00e-128	448.00
IUUC-Tni-120419	Tetraodon nigroviridis	62.26	1.00e-175	608.00
IUUC-Tca-121294	Theobroma cacao	46.25	2.00e-120	424.00
IUUC-Tre-121962	Trichoderma reesei	45.69	9.00e-97	346.00
IUUC-Tvi-122280	Trichoderma virens	45.79	4.00e-105	374.00
IUUC-Tae-125873	Triticum aestivum	46.85	3.00e-115	407.00
IUUC-Tur-126551	Triticum urartu	46.85	5.00e-115	406.00
IUUC-Tme-126959	Tuber melanosporum	45.59	4.00e-111	394.00
IUUC-Tbe-127737	Tupaia belangeri	62.25	9.00e-171	592.00
IUUC-Ttr-129211	Tursiops truncatus	63.57	5.00e-108	383.00
IUUC-Uma-129591	Ustilago maydis	38.48	3.00e-92	331.00
IUUC-Vda-129674	Verticillium dahliae	42.24	6.00e-89	320.00
IUUC-Vpa-130793	Vicugna pacos	59.86	5.00e-158	549.00
IUUC-Xtr-132430	Xenopus tropicalis	61.33	1.00e-179	621.00
IUUC-Xma-133515	Xiphophorus maculatus	65.03	0.00e+00	626.00
IUUC-Yli-134488	Yarrowia lipolytica	36.42	1.00e-75	275.00
IUUC-Zma-134748	Zea mays	48.92	1.00e-117	415.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence