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Tag Content
iUUCD ID IUUC-Mcc-054928
Ensembl Protein ID ENSMMUP00000054422.1
UniProt Accession I0FUW4; I0FUW4_MACMU
Genbank Protein ID AFH33895.1; AFI38240.1; AFJ71097.1
Protein Name Histone-lysine N-methyltransferase
Genbank Nucleotide ID JSUE03032764; JV048169; JV635757
Gene Name WHSC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000046942.1 ENSMMUT00000054754.1 ENSMMUP00000054422.1
ENSMMUG00000046942.1 ENSMMUT00000047699.2 ENSMMUP00000040724.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.30e-15 57.6 833 873
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 833  WCFVCSKGGS----LLCCESCPAAFHPDCLNIE----MPDGS-WFCNDCR 873
           8*********....*******************....9***8.******8 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MEFSIKQSPL SVQSVVKCIK MKQAPEILGS ANGKTPSCEV NRECSVFLSK AQLSSSLQEG 60
VMQKFNGHDA LPFIPADKLK DLTSRVFNGE PGAHDAKLRF ESQEMKGIGT PPNTTPIKNG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-054928|E3,PHD|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGGCCATTC TACCTTTTTA AGAAATTGTG CGGGCCAGAC AGAACACATT TGTGTGTGTT 60
TTGGTGTTAA AGAGTTGTCC AAAGCACATG AAACTGAACT GGGACTTTAA CGTTTTCAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-054928|E3,PHD|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2
Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization
KEGG mcc:100429321
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002181 Ailuropoda melanoleuca 92.56 0.00e+00 2439.00
IUUC-Apl-003677 Anas platyrhynchos 81.18 0.00e+00 2157.00
IUUC-Aca-004278 Anolis carolinensis 75.86 0.00e+00 1416.00
IUUC-Ame-011932 Astyanax mexicanus 70.43 0.00e+00 1028.00
IUUC-Bta-012522 Bos taurus 86.33 0.00e+00 2268.00
IUUC-Cja-018908 Callithrix jacchus 97.91 0.00e+00 2507.00
IUUC-Cfa-020894 Canis familiaris 91.69 0.00e+00 2472.00
IUUC-Cpo-021982 Cavia porcellus 89.99 0.00e+00 2393.00
IUUC-Csa-023807 Chlorocebus sabaeus 99.63 0.00e+00 2565.00
IUUC-Cho-024405 Choloepus hoffmanni 74.19 0.00e+00 738.00
IUUC-Csv-026298 Ciona savignyi 39.29 8.00e-58 217.00
IUUC-Dre-027492 Danio rerio 71.47 0.00e+00 1066.00
IUUC-Dno-030020 Dasypus novemcinctus 88.00 0.00e+00 2088.00
IUUC-Dor-031103 Dipodomys ordii 84.69 0.00e+00 2159.00
IUUC-Ete-032488 Echinops telfairi 82.20 0.00e+00 2148.00
IUUC-Eca-034066 Equus caballus 93.87 0.00e+00 2514.00
IUUC-Eeu-035199 Erinaceus europaeus 71.16 0.00e+00 759.00
IUUC-Fca-035434 Felis catus 87.56 0.00e+00 2000.00
IUUC-Fal-037113 Ficedula albicollis 79.17 0.00e+00 2164.00
IUUC-Gmo-039686 Gadus morhua 70.47 0.00e+00 1016.00
IUUC-Gga-040273 Gallus gallus 79.25 0.00e+00 2131.00
IUUC-Gac-042123 Gasterosteus aculeatus 50.90 0.00e+00 1253.00
IUUC-Ggo-044643 Gorilla gorilla 98.65 0.00e+00 2571.00
IUUC-Hsa-046380 Homo sapiens 98.80 0.00e+00 2541.00
IUUC-Itr-048658 Ictidomys tridecemlineatus 93.51 0.00e+00 1452.00
IUUC-Lch-050217 Latimeria chalumnae 67.16 0.00e+00 1755.00
IUUC-Lpe-051201 Leersia perrieri 28.48 1.00e-10 61.60
IUUC-Loc-052766 Lepisosteus oculatus 58.83 0.00e+00 1281.00
IUUC-Laf-053780 Loxodonta africana 90.44 0.00e+00 2449.00
IUUC-Meu-056184 Macropus eugenii 75.72 0.00e+00 794.00
IUUC-Mga-059576 Meleagris gallopavo 79.99 0.00e+00 2136.00
IUUC-Mmr-061045 Microcebus murinus 93.35 0.00e+00 2496.00
IUUC-Mdo-062576 Monodelphis domestica 83.57 0.00e+00 2229.00
IUUC-Mmu-063640 Mus musculus 90.89 0.00e+00 2378.00
IUUC-Mac-065303 Musa acuminata 29.22 3.00e-11 63.50
IUUC-Mpu-066512 Mustela putorius furo 92.79 0.00e+00 2436.00
IUUC-Mlu-067280 Myotis lucifugus 80.32 0.00e+00 1102.00
IUUC-Nle-069896 Nomascus leucogenys 98.82 0.00e+00 2444.00
IUUC-Ont-072197 Oreochromis niloticus 73.29 0.00e+00 1038.00
IUUC-Oan-072724 Ornithorhynchus anatinus 79.81 0.00e+00 1383.00
IUUC-Ocu-074758 Oryctolagus cuniculus 89.93 0.00e+00 2321.00
IUUC-Olo-080702 Oryza longistaminata 41.47 4.00e-45 176.00
IUUC-Opu-083371 Oryza punctata 41.88 1.00e-46 182.00
IUUC-Oga-088702 Otolemur garnettii 92.43 0.00e+00 2146.00
IUUC-Oar-089736 Ovis aries 81.28 0.00e+00 1997.00
IUUC-Ptr-091055 Pan troglodytes 98.80 0.00e+00 2539.00
IUUC-Pan-092752 Papio anubis 99.74 0.00e+00 1480.00
IUUC-Psi-093620 Pelodiscus sinensis 80.88 0.00e+00 2173.00
IUUC-Pfo-097464 Poecilia formosa 50.64 0.00e+00 1201.00
IUUC-Pab-098051 Pongo abelii 98.73 0.00e+00 2577.00
IUUC-Pop-099927 Populus trichocarpa 28.96 7.00e-12 66.20
IUUC-Pca-100273 Procavia capensis 89.84 0.00e+00 2379.00
IUUC-Pva-102473 Pteropus vampyrus 78.45 0.00e+00 1941.00
IUUC-Rno-105056 Rattus norvegicus 90.60 0.00e+00 2379.00
IUUC-Sha-107494 Sarcophilus harrisii 84.43 0.00e+00 2219.00
IUUC-Sar-113310 Sorex araneus 91.68 0.00e+00 1899.00
IUUC-Sbi-114581 Sorghum bicolor 35.19 6.00e-10 58.20
IUUC-Ssc-116344 Sus scrofa 86.13 0.00e+00 2274.00
IUUC-Tgu-116786 Taeniopygia guttata 80.78 0.00e+00 2162.00
IUUC-Tru-117638 Takifugu rubripes 50.75 0.00e+00 1236.00
IUUC-Tsy-118937 Tarsius syrichta 97.19 0.00e+00 1567.00
IUUC-Tni-120452 Tetraodon nigroviridis 53.66 0.00e+00 1173.00
IUUC-Tae-125237 Triticum aestivum 31.51 1.00e-07 50.10
IUUC-Tbe-127291 Tupaia belangeri 88.16 0.00e+00 1529.00
IUUC-Ttr-129017 Tursiops truncatus 84.07 0.00e+00 1794.00
IUUC-Xtr-132673 Xenopus tropicalis 67.62 0.00e+00 1791.00
Created Date 25-Jun-2017

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