iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/Other	E3 adaptor/Cullin RING/Other	18704118

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-MMS22). RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition.

Protein Sequence
(Fasta)

MDVDEPNPIV ISDSEATDEE ISIIYEPEFN ENYLWAEENV QEASRSQKIV TERLSLDSTA 60
GESCTPSVVT DTQVTTGLRW SLRKRKAIQK MPYSLERIKH RQLLEGYDIS SFDSISNQLT 120

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Nucleotide Sequence
(Fasta)

ATGGATGTTG ATGAACCGAA TCCTATTGTG ATATCAGATT CTGAGGCCAC TGATGAGGAA 60
ATTAGTATCA TATACGAACC CGAATTCAAT GAAAATTATT TATGGGCAGA GGAAAACGTC 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR019021--Mms22
IPR013220--Mms22_budding_yeast

Pfam

PF09462--Mus7

Gene Ontology

GO:0035361--C:Cul8-RING ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006302--P:double-strand break repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0045144--P:meiotic sister chromatid segregation
GO:0000725--P:recombinational repair
GO:0031297--P:replication fork processing

KEGG

sce:YLR320W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002537	Amborella trichopoda	29.87	5.00e-03	33.10
IUUC-Aly-005555	Arabidopsis lyrata	19.74	4.10e-02	31.60
IUUC-Ath-006942	Arabidopsis thaliana	23.18	7.00e-03	33.50
IUUC-Ago-007724	Ashbya gossypii	29.84	2.00e-100	358.00
IUUC-Bta-013064	Bos taurus	29.31	2.10e-02	31.20
IUUC-Bci-013657	Botrytis cinerea	28.57	3.00e-02	31.60
IUUC-Bdi-014242	Brachypodium distachyon	31.46	9.00e-05	38.90
IUUC-Bol-016246	Brassica oleracea	26.72	1.20e-02	33.90
IUUC-Cel-018161	Caenorhabditis elegans	35.71	1.80e-02	32.00
IUUC-Cpo-022123	Cavia porcellus	34.09	5.00e-03	33.10
IUUC-Csv-025858	Ciona savignyi	27.08	7.00e-03	32.70
IUUC-Dre-028415	Danio rerio	31.25	3.00e-03	35.00
IUUC-Dno-028996	Dasypus novemcinctus	33.73	6.10e-02	32.70
IUUC-Dse-031454	Dothistroma septosporum	28.72	6.00e-03	33.10
IUUC-Eca-033935	Equus caballus	25.32	9.00e-03	32.30
IUUC-Fso-038106	Fusarium solani	29.63	2.00e-03	35.00
IUUC-Hvu-047857	Hordeum vulgare	27.27	1.80e-02	31.60
IUUC-Kpa-049153	Komagataella pastoris	22.66	3.00e-11	63.20
IUUC-Lch-050383	Latimeria chalumnae	25.44	7.00e-03	32.00
IUUC-Lpe-051260	Leersia perrieri	32.00	1.30e-01	30.40
IUUC-Mor-057151	Magnaporthe oryzae	31.08	1.10e-02	30.00
IUUC-Mpo-057606	Magnaporthe poae	36.73	1.50e-01	31.20
IUUC-Mtr-058252	Medicago truncatula	28.57	1.80e-02	33.10
IUUC-Mla-059076	Melampsora laricipopulina	41.46	9.30e-02	30.00
IUUC-Mac-065264	Musa acuminata	32.32	2.00e-02	32.70
IUUC-Mpu-065741	Mustela putorius furo	27.03	1.20e-02	34.70
IUUC-Ncr-068955	Neurospora crassa	22.81	4.00e-03	33.90
IUUC-Opr-071029	Ochotona princeps	27.54	7.70e-02	30.80
IUUC-Oba-075641	Oryza barthii	23.85	4.00e-03	33.50
IUUC-Obr-076425	Oryza brachyantha	32.00	8.80e-01	28.90
IUUC-Ogu-078794	Oryza glumaepatula	34.00	3.10e-02	32.30
IUUC-Oin-079725	Oryza indica	34.00	3.20e-02	32.30
IUUC-Olo-080842	Oryza longistaminata	34.00	8.60e-02	32.00
IUUC-Ome-081818	Oryza meridionalis	34.00	5.60e-02	32.00
IUUC-Opu-083361	Oryza punctata	34.00	3.10e-02	32.30
IUUC-Oru-084781	Oryza rufipogon	34.00	3.20e-02	32.30
IUUC-Osa-086293	Oryza sativa	34.00	3.20e-02	32.30
IUUC-Oga-088824	Otolemur garnettii	27.45	1.00e-02	32.70
IUUC-Psi-093042	Pelodiscus sinensis	25.64	1.00e+00	26.20
IUUC-Ppa-095921	Physcomitrella patens	35.29	3.00e-03	35.00
IUUC-Ppe-101512	Prunus persica	45.16	4.80e-02	30.80
IUUC-Pva-102837	Pteropus vampyrus	28.57	2.00e-03	36.20
IUUC-Pgr-103563	Puccinia graminis	35.21	1.80e-01	30.00
IUUC-Stu-112895	Solanum tuberosum	30.38	2.00e-03	33.10
IUUC-Tca-121322	Theobroma cacao	31.75	5.00e-03	31.20
IUUC-Tre-122219	Trichoderma reesei	40.43	9.00e-03	33.10
IUUC-Tvi-122577	Trichoderma virens	25.98	2.00e-03	36.60
IUUC-Tur-126537	Triticum urartu	27.27	1.50e-02	31.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence