iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023770

Ensembl Protein ID

ENSCSAP00000011189.1

UniProt Accession

A0A0D9RRF0; A0A0D9RRF0_CHLSB

Genbank Protein ID

ENSCSAP00000011189

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01131838

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000015089.1	ENSCSAT00000013182.1	ENSCSAP00000011189.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.80e-115	383.6	247	868
ULD/UDP/UBQ/UBQ_Other	5.90e-18	64.5	88	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++ +v+pr+++++++++a++fsgy+
   Q: 247  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQ 335
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 336  QQDSQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 422
           ******************************8888..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 423  TLPLPLKKDRVMEvflvpadphcrptqyrvtvplmgavsdlcealsrlcgiaaenmvvadvynhrfhkifqmdeglnhimprddifvyq 511
           ********99999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 512  vcstsvdgsecvtlpvyfrerksrpsstssgsalygqplllsvpkhkltleslyqavcdrisryvkqplpddfgssplepgtcngsrns 600
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 601  cegedeeemehqeegkeqlsetegsgedelgndptkttqkkikgqpcpkrlftfslvnsygtadinslatdgkllklnsrstlaidwds 689
           ***************************************************************************************** PP
   S: 186  ................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfsee 242
                                            l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++
   Q: 690  etrslyydeqeseayekhvsmlqpqkkkkttvALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY 778
           ************************************************************************************99885 PP
   S: 243  qksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgst 329
              r k+++ vefp++ L++s+f+++p+     ++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+  +e+++++   + 
   Q: 779  --WRDKLDTVVEFPIRgLNMSEFVCNPSAR---PYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSNVSLASEDQIVT---KA 859
           ..567*********************8866...9**************************52666*******************...** PP
   S: 330  aYvlfYkrr 338
           aYvlfY+rr
   Q: 860  AYVLFYQRR 868
           *******96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 88   CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 166
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MYNVGEHNLF PGPIDNSGLF SDPESQTLKE HLIDELDYVL VPTEAWNKLL NWYGCVEGQQ 60
PIVRKVVEHG LFVKHCKVEV YLLELKLCEN SDPTNVLSCH FSKADTIATI EKEMRKLFNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCAATTTG GGAGGCTGAG GTGGGCAAAT TACCTGAGGT CAGGAGTTTG AGACCATCCT 60
GACCAACATG GAGAAACCCT GTCTCTACTA AAAATACGAA ATTAGCCGGG CGTGGTGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000058	Aegilops tauschii	40.94	9.00e-121	427.00
IUUC-Aml-001597	Ailuropoda melanoleuca	93.52	0.00e+00	1562.00
IUUC-Atr-002991	Amborella trichopoda	36.29	1.00e-138	487.00
IUUC-Apl-004068	Anas platyrhynchos	71.72	0.00e+00	1160.00
IUUC-Aca-004459	Anolis carolinensis	68.38	0.00e+00	1165.00
IUUC-Aly-006315	Arabidopsis lyrata	42.97	1.00e-129	457.00
IUUC-Ang-009562	Aspergillus niger	44.80	3.00e-55	211.00
IUUC-Ame-011064	Astyanax mexicanus	65.44	0.00e+00	875.00
IUUC-Bta-012929	Bos taurus	93.72	0.00e+00	1601.00
IUUC-Cja-018798	Callithrix jacchus	95.81	0.00e+00	1598.00
IUUC-Cfa-020599	Canis familiaris	94.94	0.00e+00	1599.00
IUUC-Cpo-022144	Cavia porcellus	89.88	0.00e+00	1575.00
IUUC-Cho-024595	Choloepus hoffmanni	84.56	0.00e+00	1085.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	43.75	1.00e-60	229.00
IUUC-Cne-026852	Cryptococcus neoformans	44.55	5.00e-72	266.00
IUUC-Dre-027869	Danio rerio	71.21	0.00e+00	813.00
IUUC-Dno-029316	Dasypus novemcinctus	91.75	0.00e+00	1603.00
IUUC-Ete-032970	Echinops telfairi	82.63	0.00e+00	1063.00
IUUC-Eca-034012	Equus caballus	94.39	0.00e+00	1577.00
IUUC-Eeu-035158	Erinaceus europaeus	77.13	0.00e+00	796.00
IUUC-Fca-035373	Felis catus	90.65	0.00e+00	1559.00
IUUC-Fal-037634	Ficedula albicollis	75.89	0.00e+00	1231.00
IUUC-Fox-037986	Fusarium oxysporum	44.32	6.00e-64	239.00
IUUC-Fso-038291	Fusarium solani	44.32	1.00e-63	239.00
IUUC-Gmo-038866	Gadus morhua	70.03	0.00e+00	780.00
IUUC-Ggr-039740	Gaeumannomyces graminis	44.32	1.00e-62	235.00
IUUC-Gga-040729	Gallus gallus	70.53	0.00e+00	1199.00
IUUC-Gac-042631	Gasterosteus aculeatus	67.62	0.00e+00	1178.00
IUUC-Ggo-045337	Gorilla gorilla	96.06	0.00e+00	1468.00
IUUC-Hsa-045669	Homo sapiens	98.24	0.00e+00	1664.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	94.28	0.00e+00	1607.00
IUUC-Lch-050533	Latimeria chalumnae	68.96	0.00e+00	1105.00
IUUC-Lpe-051424	Leersia perrieri	37.84	2.00e-145	509.00
IUUC-Laf-053803	Loxodonta africana	93.73	0.00e+00	1584.00
IUUC-Mcc-055556	Macaca mulatta	95.81	0.00e+00	1590.00
IUUC-Meu-056742	Macropus eugenii	75.78	0.00e+00	1276.00
IUUC-Mor-056985	Magnaporthe oryzae	43.22	5.00e-62	233.00
IUUC-Mpo-057486	Magnaporthe poae	45.05	1.00e-62	235.00
IUUC-Mtr-058138	Medicago truncatula	44.18	4.00e-139	489.00
IUUC-Mga-059300	Meleagris gallopavo	70.99	0.00e+00	1201.00
IUUC-Mdo-061848	Monodelphis domestica	83.90	0.00e+00	1446.00
IUUC-Mmu-063960	Mus musculus	90.53	0.00e+00	1548.00
IUUC-Mpu-066920	Mustela putorius furo	94.83	0.00e+00	1600.00
IUUC-Mlu-068088	Myotis lucifugus	92.63	0.00e+00	1586.00
IUUC-Ncr-068879	Neurospora crassa	32.87	4.00e-66	247.00
IUUC-Nle-070010	Nomascus leucogenys	98.02	0.00e+00	1661.00
IUUC-Opr-070740	Ochotona princeps	89.88	0.00e+00	1203.00
IUUC-Ont-072573	Oreochromis niloticus	65.44	0.00e+00	1187.00
IUUC-Oan-073363	Ornithorhynchus anatinus	78.01	0.00e+00	1364.00
IUUC-Ocu-074242	Oryctolagus cuniculus	88.85	0.00e+00	1474.00
IUUC-Oin-079300	Oryza indica	41.77	3.00e-129	456.00
IUUC-Osa-085641	Oryza sativa	41.77	3.00e-129	456.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.28	2.00e-123	436.00
IUUC-Oga-088562	Otolemur garnettii	85.98	0.00e+00	1405.00
IUUC-Oar-090439	Ovis aries	93.28	0.00e+00	1587.00
IUUC-Ptr-090801	Pan troglodytes	98.13	0.00e+00	1661.00
IUUC-Pan-092717	Papio anubis	96.88	0.00e+00	1595.00
IUUC-Psi-093942	Pelodiscus sinensis	73.82	0.00e+00	1250.00
IUUC-Pab-098522	Pongo abelii	97.28	0.00e+00	1297.00
IUUC-Pca-100161	Procavia capensis	82.62	0.00e+00	1370.00
IUUC-Rno-106081	Rattus norvegicus	89.54	0.00e+00	1551.00
IUUC-Sha-106937	Sarcophilus harrisii	84.81	0.00e+00	1454.00
IUUC-Sly-111746	Solanum lycopersicum	39.00	1.00e-149	523.00
IUUC-Stu-112671	Solanum tuberosum	38.54	4.00e-147	515.00
IUUC-Sar-113542	Sorex araneus	86.47	0.00e+00	1471.00
IUUC-Ssc-115637	Sus scrofa	94.38	0.00e+00	1582.00
IUUC-Tgu-117267	Taeniopygia guttata	72.27	0.00e+00	1218.00
IUUC-Tbe-127669	Tupaia belangeri	75.43	0.00e+00	893.00
IUUC-Ttr-128778	Tursiops truncatus	93.39	0.00e+00	1586.00
IUUC-Uma-129498	Ustilago maydis	49.04	5.00e-70	259.00
IUUC-Vda-129781	Verticillium dahliae	44.60	3.00e-65	244.00
IUUC-Vpa-130571	Vicugna pacos	96.00	0.00e+00	1081.00
IUUC-Vvi-131010	Vitis vinifera	38.24	1.00e-151	530.00
IUUC-Xtr-132305	Xenopus tropicalis	68.78	0.00e+00	1200.00
IUUC-Yli-134392	Yarrowia lipolytica	42.25	1.00e-61	231.00
IUUC-Zma-135699	Zea mays	36.97	6.00e-141	494.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence