iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105057

Ensembl Protein ID

ENSRNOP00000051977.3

UniProt Accession

Q3MHU2; F1LN52; Q3MHU2_RAT

Genbank Protein ID

AAI04677.1; EDL85147.1; EDL85148.1

Protein Name

Aurora kinase A; Serine/threonine kinase 6, isoform CRA_a

Genbank Nucleotide ID

AC131024; CH474062; CH474062

Gene Name

Aurka; Stk6; rCG_40899

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000004479.7	ENSRNOT00000055102.4	ENSRNOP00000051977.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	83.42	0.00e+00	667.00	IUUC-Hsa-046968

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDRCKENCVS RPVKSTVPFG PKRVLVTEQI PSQHPGSASS GQAQRVLCPS NSQRVPPQAQ 60
KPVAGQKPVL KQLPAASGPR PASRLSNPQK SEQPQPAASG NNSEKEQTSI QKTEDSKKRQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCAGGTGA CATGGACAGA TGTAAAGAAA ACTGTGTCTC TAGGCCTGTC AAGGTAAGTA 60
GAATTCCCTG CATTCACAAT TGCATTTTAA AAAGTTATTT ATTTTATGAA AATGAGTATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR030616--Aur
IPR030611--AURKA
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0043203--C:axon hillock
GO:0005829--C:cytosol
GO:0042585--C:germinal vesicle
GO:0072687--C:meiotic spindle
GO:0072686--C:mitotic spindle
GO:0048471--C:perinuclear region of cytoplasm
GO:0045120--C:pronucleus
GO:0005876--C:spindle microtubule
GO:0031616--C:spindle pole centrosome
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0009948--P:anterior/posterior axis specification
GO:0051642--P:centrosome localization
GO:0097421--P:liver regeneration
GO:0007100--P:mitotic centrosome separation
GO:0007052--P:mitotic spindle organization
GO:0043066--P:negative regulation of apoptotic process
GO:0032091--P:negative regulation of protein binding
GO:1990138--P:neuron projection extension
GO:1900195--P:positive regulation of oocyte maturation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071539--P:protein localization to centrosome
GO:0031647--P:regulation of protein stability
GO:0009611--P:response to wounding
GO:0007057--P:spindle assembly involved in female meiosis I

KEGG

rno:261730

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000930	Aegilops tauschii	63.23	6.00e-106	376.00
IUUC-Aml-001426	Ailuropoda melanoleuca	85.27	0.00e+00	662.00
IUUC-Atr-002453	Amborella trichopoda	65.05	2.00e-109	388.00
IUUC-Apl-003626	Anas platyrhynchos	67.73	9.00e-150	523.00
IUUC-Aca-004602	Anolis carolinensis	66.25	8.00e-144	503.00
IUUC-Aly-005878	Arabidopsis lyrata	64.08	2.00e-107	381.00
IUUC-Ath-007117	Arabidopsis thaliana	63.95	1.00e-107	382.00
IUUC-Acl-008199	Aspergillus clavatus	56.93	3.00e-86	311.00
IUUC-Afl-008419	Aspergillus flavus	53.90	2.00e-86	312.00
IUUC-Afu-008751	Aspergillus fumigatus	59.22	2.00e-85	309.00
IUUC-Ani-009181	Aspergillus nidulans	57.63	4.00e-89	321.00
IUUC-Ang-009787	Aspergillus niger	59.22	5.00e-86	311.00
IUUC-Aor-009980	Aspergillus oryzae	53.90	2.00e-86	312.00
IUUC-Ate-010286	Aspergillus terreus	50.96	3.00e-86	312.00
IUUC-Ame-010849	Astyanax mexicanus	71.81	5.00e-129	454.00
IUUC-Bgr-012110	Blumeria graminis	56.40	1.00e-86	313.00
IUUC-Bta-013474	Bos taurus	83.95	0.00e+00	663.00
IUUC-Bci-013756	Botrytis cinerea	58.16	9.00e-93	333.00
IUUC-Bdi-014257	Brachypodium distachyon	63.23	6.00e-107	380.00
IUUC-Bol-016310	Brassica oleracea	65.68	6.00e-105	373.00
IUUC-Bra-017438	Brassica rapa	63.54	2.00e-106	378.00
IUUC-Cel-018157	Caenorhabditis elegans	62.21	3.00e-99	354.00
IUUC-Cja-019282	Callithrix jacchus	83.58	0.00e+00	650.00
IUUC-Cfa-020162	Canis familiaris	82.47	0.00e+00	661.00
IUUC-Cpo-021764	Cavia porcellus	82.63	0.00e+00	639.00
IUUC-Cre-022827	Chlamydomonas reinhardtii	68.27	7.00e-111	393.00
IUUC-Csa-023694	Chlorocebus sabaeus	80.20	2.00e-179	621.00
IUUC-Cho-024350	Choloepus hoffmanni	90.70	3.00e-108	383.00
IUUC-Cin-025542	Ciona intestinalis	69.75	2.00e-117	415.00
IUUC-Csv-025873	Ciona savignyi	66.89	2.00e-119	421.00
IUUC-Cgl-026632	Colletotrichum gloeosporioides	50.48	3.00e-81	295.00
IUUC-Cne-026928	Cryptococcus neoformans	61.63	1.00e-95	343.00
IUUC-Cme-027336	Cyanidioschyzon merolae	63.19	4.00e-119	421.00
IUUC-Dre-028198	Danio rerio	62.83	1.00e-134	473.00
IUUC-Dno-029928	Dasypus novemcinctus	82.69	2.00e-177	615.00
IUUC-Dor-030238	Dipodomys ordii	78.80	8.00e-179	619.00
IUUC-Dse-031266	Dothistroma septosporum	53.41	2.00e-93	335.00
IUUC-Dme-032007	Drosophila melanogaster	61.83	5.00e-100	357.00
IUUC-Ete-032911	Echinops telfairi	63.78	1.00e-121	429.00
IUUC-Eca-033749	Equus caballus	83.37	0.00e+00	646.00
IUUC-Eeu-035170	Erinaceus europaeus	80.79	0.00e+00	637.00
IUUC-Fca-035498	Felis catus	83.63	0.00e+00	652.00
IUUC-Fal-037397	Ficedula albicollis	66.83	6.00e-147	513.00
IUUC-Fox-037747	Fusarium oxysporum	54.58	2.00e-90	326.00
IUUC-Fso-038429	Fusarium solani	50.76	7.00e-90	323.00
IUUC-Gmo-039378	Gadus morhua	59.85	2.00e-127	449.00
IUUC-Ggr-039939	Gaeumannomyces graminis	58.72	2.00e-94	338.00
IUUC-Gga-040187	Gallus gallus	67.72	3.00e-149	521.00
IUUC-Gac-042223	Gasterosteus aculeatus	59.28	3.00e-133	468.00
IUUC-Gma-042870	Glycine max	62.75	1.00e-101	362.00
IUUC-Ggo-045617	Gorilla gorilla	83.17	0.00e+00	665.00
IUUC-Hsa-046968	Homo sapiens	83.42	0.00e+00	667.00
IUUC-Hvu-047072	Hordeum vulgare	54.85	3.00e-81	294.00
IUUC-Itr-048233	Ictidomys tridecemlineatus	75.19	9.00e-166	576.00
IUUC-Kpa-049093	Komagataella pastoris	54.79	9.00e-75	273.00
IUUC-Lch-050346	Latimeria chalumnae	68.87	4.00e-148	517.00
IUUC-Lpe-051466	Leersia perrieri	65.85	5.00e-108	383.00
IUUC-Lma-053006	Leptosphaeria maculans	58.78	6.00e-88	317.00
IUUC-Laf-053422	Loxodonta africana	80.99	0.00e+00	649.00
IUUC-Mcc-055245	Macaca mulatta	80.25	4.00e-177	613.00
IUUC-Mor-056952	Magnaporthe oryzae	59.16	6.00e-90	324.00
IUUC-Mpo-057605	Magnaporthe poae	56.75	3.00e-94	338.00
IUUC-Mtr-057726	Medicago truncatula	66.79	5.00e-107	380.00
IUUC-Mla-059174	Melampsora laricipopulina	62.16	3.00e-97	348.00
IUUC-Mga-059562	Meleagris gallopavo	60.71	4.00e-116	410.00
IUUC-Mvi-060305	Microbotryum violaceum	58.42	2.00e-92	333.00
IUUC-Mmr-061588	Microcebus murinus	82.63	0.00e+00	662.00
IUUC-Mdo-061914	Monodelphis domestica	76.67	6.00e-168	583.00
IUUC-Mmu-063288	Mus musculus	93.70	0.00e+00	768.00
IUUC-Mac-064969	Musa acuminata	65.64	8.00e-109	386.00
IUUC-Mpu-066855	Mustela putorius furo	83.46	0.00e+00	649.00
IUUC-Mlu-068046	Myotis lucifugus	84.75	0.00e+00	657.00
IUUC-Nfi-068527	Neosartorya fischeri	59.61	1.00e-85	310.00
IUUC-Ncr-068678	Neurospora crassa	57.80	6.00e-92	331.00
IUUC-Nle-069848	Nomascus leucogenys	83.42	0.00e+00	667.00
IUUC-Opr-070589	Ochotona princeps	78.16	7.00e-173	599.00
IUUC-Ont-071733	Oreochromis niloticus	61.28	5.00e-126	444.00
IUUC-Oan-073399	Ornithorhynchus anatinus	83.23	5.00e-153	533.00
IUUC-Ocu-074063	Oryctolagus cuniculus	82.59	0.00e+00	660.00
IUUC-Oba-075264	Oryza barthii	64.26	2.00e-106	379.00
IUUC-Obr-076048	Oryza brachyantha	66.54	7.00e-106	376.00
IUUC-Ogl-077637	Oryza glaberrima	67.41	4.00e-106	377.00
IUUC-Ogu-078830	Oryza glumaepatula	64.26	1.00e-106	379.00
IUUC-Oin-079150	Oryza indica	64.26	7.00e-107	379.00
IUUC-Olo-080398	Oryza longistaminata	57.26	1.00e-81	296.00
IUUC-Ome-081544	Oryza meridionalis	54.91	2.00e-90	325.00
IUUC-Oni-082250	Oryza nivara	64.26	7.00e-107	379.00
IUUC-Opu-083638	Oryza punctata	64.26	4.00e-107	380.00
IUUC-Oru-084981	Oryza rufipogon	64.26	5.00e-107	380.00
IUUC-Osa-085961	Oryza sativa	64.26	5.00e-107	380.00
IUUC-Olu-087880	Ostreococcus lucimarinus	69.40	7.00e-113	400.00
IUUC-Oga-088891	Otolemur garnettii	83.90	0.00e+00	646.00
IUUC-Oar-090021	Ovis aries	81.98	0.00e+00	644.00
IUUC-Ptr-091458	Pan troglodytes	83.66	0.00e+00	668.00
IUUC-Pan-092546	Papio anubis	80.20	4.00e-179	620.00
IUUC-Psi-093280	Pelodiscus sinensis	74.86	2.00e-154	538.00
IUUC-Pma-094298	Petromyzon marinus	77.41	8.00e-122	429.00
IUUC-Pno-094847	Phaeosphaeria nodorum	60.00	1.00e-88	319.00
IUUC-Ppa-095855	Physcomitrella patens	62.80	4.00e-110	390.00
IUUC-Pfo-096428	Poecilia formosa	62.13	3.00e-130	458.00
IUUC-Pab-098696	Pongo abelii	83.21	0.00e+00	660.00
IUUC-Pop-099405	Populus trichocarpa	63.36	3.00e-108	384.00
IUUC-Pca-100740	Procavia capensis	77.72	8.00e-180	622.00
IUUC-Ppe-101854	Prunus persica	64.73	3.00e-109	387.00
IUUC-Pva-103212	Pteropus vampyrus	83.46	0.00e+00	640.00
IUUC-Pgr-103474	Puccinia graminis	62.88	2.00e-98	352.00
IUUC-Ptt-103933	Puccinia triticina	48.26	3.00e-61	228.00
IUUC-Pte-104089	Pyrenophora teres	58.87	8.00e-88	317.00
IUUC-Pyt-104555	Pyrenophora triticirepentis	58.87	7.00e-88	317.00
IUUC-Sha-107137	Sarcophilus harrisii	77.78	4.00e-170	590.00
IUUC-Sja-107767	Schizosaccharomyces japonicus	59.85	1.00e-97	349.00
IUUC-Spo-108078	Schizosaccharomyces pombe	55.52	4.00e-100	357.00
IUUC-Smo-109288	Selaginella moellendorffii	67.28	5.00e-109	387.00
IUUC-Sit-110246	Setaria italica	65.57	3.00e-105	374.00
IUUC-Sly-111379	Solanum lycopersicum	66.19	7.00e-109	386.00
IUUC-Stu-112777	Solanum tuberosum	61.79	9.00e-108	382.00
IUUC-Sbi-114325	Sorghum bicolor	65.20	3.00e-105	374.00
IUUC-Sre-115203	Sporisorium reilianum	58.49	1.00e-80	293.00
IUUC-Ssc-115361	Sus scrofa	83.62	0.00e+00	662.00
IUUC-Tgu-116967	Taeniopygia guttata	71.51	1.00e-145	508.00
IUUC-Tru-117570	Takifugu rubripes	63.59	3.00e-134	471.00
IUUC-Tsy-119280	Tarsius syrichta	92.09	1.00e-115	409.00
IUUC-Tni-120721	Tetraodon nigroviridis	62.79	9.00e-135	473.00
IUUC-Tca-121494	Theobroma cacao	64.26	2.00e-107	382.00
IUUC-Tre-121869	Trichoderma reesei	52.06	2.00e-92	332.00
IUUC-Tvi-122510	Trichoderma virens	58.45	5.00e-91	327.00
IUUC-Tae-123071	Triticum aestivum	63.23	6.00e-106	376.00
IUUC-Tur-126240	Triticum urartu	63.23	1.00e-105	375.00
IUUC-Tme-126921	Tuber melanosporum	59.64	2.00e-95	342.00
IUUC-Tbe-127872	Tupaia belangeri	77.61	1.00e-167	582.00
IUUC-Ttr-129134	Tursiops truncatus	82.95	0.00e+00	635.00
IUUC-Uma-129412	Ustilago maydis	47.52	2.00e-79	289.00
IUUC-Vda-130003	Verticillium dahliae	53.70	3.00e-92	332.00
IUUC-Vvi-131272	Vitis vinifera	64.38	2.00e-108	385.00
IUUC-Xtr-132019	Xenopus tropicalis	70.47	4.00e-149	520.00
IUUC-Xma-134203	Xiphophorus maculatus	62.37	8.00e-136	476.00
IUUC-Yli-134503	Yarrowia lipolytica	54.05	1.00e-85	309.00
IUUC-Zma-135232	Zea mays	65.57	1.00e-105	375.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence