iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.30e-48	163.5	8	156

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk........... 87
           Rl+ e+k+l+ dppegi+a+p +e++++ewe+li Gpe+t++eggvF +++ fp+dYP++PPk+kf+  +fhPn+ ++G+vC+sil+           
   Q: 8    RLMAEYKQLTLDPPEGIVAGPISEDNFFEWEALIAGPEGTCFEGGVFPARLIFPTDYPLSPPKMKFTCDMFHPNIFADGRVCISILHapgddpmgyel 105
           99************************************************************************************9999999***** PP
   S: 88   eeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++e+Wsp++sve++lls++s+laepn es++n++aa +++++r e++ ++r
   Q: 106  SAERWSPVQSVEKILLSVVSMLAEPNDESGANVDAAIMWREQRDEFNAIAR 156
           ***********************************************9886 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MAGSALRRLM AEYKQLTLDP PEGIVAGPIS EDNFFEWEAL IAGPEGTCFE GGVFPARLIF 60
PTDYPLSPPK MKFTCDMFHP NIFADGRVCI SILHAPGDDP MGYELSAERW SPVQSVEKIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGAATCGA TTACTCTTGT TAAATTCACT CAGTACAGAT ATATTTTTAT AGAAAGCCAC 60
TCGATTCATT CGATATAAAT AAACACGGAA CACCGTTTGT GTTTATTATA TTACGACGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0050829--P:defense response to Gram-negative bacterium
GO:0045089--P:positive regulation of innate immune response
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG4443

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002172	Ailuropoda melanoleuca	78.34	5.00e-72	262.00
IUUC-Apl-003761	Anas platyrhynchos	79.01	2.00e-75	273.00
IUUC-Aca-005062	Anolis carolinensis	82.42	2.00e-79	286.00
IUUC-Ago-007853	Ashbya gossypii	62.42	1.00e-59	220.00
IUUC-Acl-008080	Aspergillus clavatus	65.66	2.00e-61	226.00
IUUC-Afl-008478	Aspergillus flavus	63.86	4.00e-60	223.00
IUUC-Afu-009051	Aspergillus fumigatus	65.66	1.00e-61	227.00
IUUC-Ani-009271	Aspergillus nidulans	66.21	5.00e-54	202.00
IUUC-Ang-009748	Aspergillus niger	65.66	2.00e-61	226.00
IUUC-Aor-010228	Aspergillus oryzae	64.46	3.00e-60	223.00
IUUC-Ate-010293	Aspergillus terreus	65.06	4.00e-61	226.00
IUUC-Ame-011698	Astyanax mexicanus	84.85	9.00e-84	301.00
IUUC-Bgr-012226	Blumeria graminis	60.98	3.00e-57	213.00
IUUC-Bta-013277	Bos taurus	80.49	7.00e-58	214.00
IUUC-Bci-013676	Botrytis cinerea	62.20	3.00e-58	216.00
IUUC-Cel-018676	Caenorhabditis elegans	79.04	9.00e-77	278.00
IUUC-Cja-019767	Callithrix jacchus	80.61	4.00e-79	285.00
IUUC-Cfa-020047	Canis familiaris	81.82	1.00e-79	287.00
IUUC-Cpo-021507	Cavia porcellus	82.42	2.00e-80	290.00
IUUC-Csa-023745	Chlorocebus sabaeus	77.36	1.00e-72	264.00
IUUC-Cho-024667	Choloepus hoffmanni	49.04	7.00e-40	155.00
IUUC-Cin-025310	Ciona intestinalis	78.79	9.00e-76	274.00
IUUC-Csv-025961	Ciona savignyi	76.51	8.00e-75	271.00
IUUC-Cgl-026553	Colletotrichum gloeosporioides	68.52	2.00e-64	236.00
IUUC-Cne-026903	Cryptococcus neoformans	58.79	3.00e-50	189.00
IUUC-Dre-027900	Danio rerio	84.85	1.00e-83	300.00
IUUC-Dno-029688	Dasypus novemcinctus	76.36	4.00e-73	266.00
IUUC-Dse-031253	Dothistroma septosporum	66.67	6.00e-65	238.00
IUUC-Ete-033010	Echinops telfairi	81.82	2.00e-78	283.00
IUUC-Eca-033294	Equus caballus	78.34	9.00e-73	264.00
IUUC-Eeu-034947	Erinaceus europaeus	62.99	5.00e-40	155.00
IUUC-Fca-036442	Felis catus	80.29	3.00e-64	235.00
IUUC-Fal-037188	Ficedula albicollis	81.05	1.00e-73	267.00
IUUC-Fox-037762	Fusarium oxysporum	67.27	6.00e-64	235.00
IUUC-Fso-038181	Fusarium solani	66.06	5.00e-63	232.00
IUUC-Gmo-038663	Gadus morhua	83.03	4.00e-81	292.00
IUUC-Ggr-039808	Gaeumannomyces graminis	65.64	6.00e-63	231.00
IUUC-Gga-040355	Gallus gallus	83.03	2.00e-81	293.00
IUUC-Gac-041847	Gasterosteus aculeatus	82.42	2.00e-81	293.00
IUUC-Ggo-045202	Gorilla gorilla	81.82	5.00e-80	288.00
IUUC-Hsa-046369	Homo sapiens	81.82	5.00e-80	288.00
IUUC-Itr-048349	Ictidomys tridecemlineatus	82.42	5.00e-80	288.00
IUUC-Kpa-049317	Komagataella pastoris	64.42	2.00e-60	223.00
IUUC-Lch-049596	Latimeria chalumnae	77.58	1.00e-73	267.00
IUUC-Loc-052346	Lepisosteus oculatus	84.55	3.00e-60	222.00
IUUC-Lma-053126	Leptosphaeria maculans	72.73	2.00e-55	206.00
IUUC-Laf-054560	Loxodonta africana	80.79	6.00e-72	261.00
IUUC-Mcc-055172	Macaca mulatta	81.82	5.00e-80	288.00
IUUC-Meu-056891	Macropus eugenii	78.34	2.00e-72	263.00
IUUC-Mor-057260	Magnaporthe oryzae	63.80	2.00e-61	227.00
IUUC-Mpo-057468	Magnaporthe poae	65.03	1.00e-62	230.00
IUUC-Mla-059084	Melampsora laricipopulina	57.23	4.00e-55	206.00
IUUC-Mga-059939	Meleagris gallopavo	76.22	4.00e-74	269.00
IUUC-Mvi-060514	Microbotryum violaceum	65.45	7.00e-60	221.00
IUUC-Mmr-061029	Microcebus murinus	76.79	1.00e-72	263.00
IUUC-Mdo-061820	Monodelphis domestica	81.82	2.00e-79	286.00
IUUC-Mmu-063123	Mus musculus	81.82	5.00e-80	288.00
IUUC-Mpu-065866	Mustela putorius furo	75.76	2.00e-72	263.00
IUUC-Mlu-067220	Myotis lucifugus	78.34	2.00e-72	263.00
IUUC-Nfi-068395	Neosartorya fischeri	65.66	1.00e-61	227.00
IUUC-Ncr-068623	Neurospora crassa	68.32	6.00e-63	231.00
IUUC-Nle-070007	Nomascus leucogenys	81.82	5.00e-80	288.00
IUUC-Opr-071095	Ochotona princeps	86.73	2.00e-55	206.00
IUUC-Ont-071736	Oreochromis niloticus	83.64	4.00e-83	299.00
IUUC-Oan-073475	Ornithorhynchus anatinus	77.71	9.00e-72	261.00
IUUC-Ocu-074820	Oryctolagus cuniculus	80.65	4.00e-73	265.00
IUUC-Ola-087571	Oryzias latipes	83.64	1.00e-82	297.00
IUUC-Oar-089706	Ovis aries	81.21	8.00e-80	288.00
IUUC-Ptr-090798	Pan troglodytes	81.82	5.00e-80	288.00
IUUC-Pan-091967	Papio anubis	81.82	5.00e-80	288.00
IUUC-Psi-093524	Pelodiscus sinensis	82.78	2.00e-73	266.00
IUUC-Pma-094602	Petromyzon marinus	83.45	7.00e-68	248.00
IUUC-Pno-094979	Phaeosphaeria nodorum	71.52	6.00e-69	251.00
IUUC-Pfo-097330	Poecilia formosa	83.64	4.00e-82	295.00
IUUC-Pab-098225	Pongo abelii	81.21	2.00e-79	286.00
IUUC-Pca-101040	Procavia capensis	79.74	7.00e-72	261.00
IUUC-Pva-102507	Pteropus vampyrus	68.15	8.00e-60	221.00
IUUC-Pgr-103674	Puccinia graminis	57.89	3.00e-53	200.00
IUUC-Ptt-103840	Puccinia triticina	56.14	7.00e-53	198.00
IUUC-Pte-104389	Pyrenophora teres	69.70	4.00e-68	249.00
IUUC-Pyt-104703	Pyrenophora triticirepentis	70.30	3.00e-68	249.00
IUUC-Rno-105228	Rattus norvegicus	81.82	5.00e-80	288.00
IUUC-Sce-106233	Saccharomyces cerevisiae	60.61	2.00e-56	209.00
IUUC-Sha-107274	Sarcophilus harrisii	75.90	5.00e-73	265.00
IUUC-Sja-107937	Schizosaccharomyces japonicus	72.05	4.00e-69	252.00
IUUC-Spo-108269	Schizosaccharomyces pombe	70.81	1.00e-67	247.00
IUUC-Ssl-108636	Sclerotinia sclerotiorum	62.80	2.00e-59	220.00
IUUC-Sre-114952	Sporisorium reilianum	64.24	5.00e-59	219.00
IUUC-Ssc-115365	Sus scrofa	76.97	1.00e-72	264.00
IUUC-Tgu-116816	Taeniopygia guttata	83.03	2.00e-81	293.00
IUUC-Tni-120278	Tetraodon nigroviridis	81.33	8.00e-80	288.00
IUUC-Tre-122131	Trichoderma reesei	66.87	3.00e-63	233.00
IUUC-Tvi-122669	Trichoderma virens	67.48	4.00e-64	236.00
IUUC-Tme-127052	Tuber melanosporum	66.87	1.00e-64	237.00
IUUC-Tbe-127792	Tupaia belangeri	81.82	5.00e-80	288.00
IUUC-Ttr-128619	Tursiops truncatus	82.50	6.00e-56	207.00
IUUC-Uma-129587	Ustilago maydis	64.24	3.00e-59	219.00
IUUC-Vda-129914	Verticillium dahliae	65.43	4.00e-62	229.00
IUUC-Xtr-132450	Xenopus tropicalis	84.24	1.00e-81	294.00
IUUC-Xma-133016	Xiphophorus maculatus	83.64	5.00e-82	295.00
IUUC-Yli-134379	Yarrowia lipolytica	68.94	1.00e-65	241.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence