iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	9615226

Classification

Family	E-value	Score	Start	End
DUB/USP	5.50e-121	402.3	140	667

Active Site

Position(s)	Description	Evidence
149	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
619	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp............................................................ 42
           +G++N+gNtCY+NSvLQcL+n+++lre++l+ +++k +e+++                                                            
   Q: 140  FGYENFGNTCYCNSVLQCLYNLSSLRENILQ-FPKKSRESDQprkkemrgkkprifteasfeksiagtnghlpnpkpqsvddgkptpvnsvnsntagpsekk 240
           6******************************.8888888888899999****************************************************** PP
   S: 43   ...................................................................................................... 42
                                                                                                                 
   Q: 241  skffksfsakhvqdnnkkegspailttgkpssrpqdapplivetpnepgapsrlsfenvtdrppdvprkiivgrvlnyenpsrgssnsnnldlkgesnssls 342
           ****************************************************************************************************** PP
   S: 43   ........................................kepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldq 102
                                                    ++k++l++sl+++fe+++  ++ +++vsp++++++lk+e++ f+++++qDa+Ef++fll++
   Q: 343  tpldkkdtrrsssssqispehrkksalirgpvlnidhslnGSDKATLYSSLRDIFECITenTYLTGVVSPSSFVDVLKRENVLFNTTMHQDAHEFFNFLLNE 444
           ***************************************999*****************99999************************************** PP
   S: 103  leeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegen 204
           l+e++          e+e++k+++sd++++++++k+k++isdlFqg+l++qikcl+cdn++sr+epfld++++v+g+eet   ++q++L+s++++e+l+g+n
   Q: 445  LSEYI----------ERENKKIAASDINSDSEPSKSKNFISDLFQGTLTNQIKCLTCDNITSRDEPFLDFPIEVQGDEET---DIQEILKSYHQREMLNGSN 533
           *****..........6689999********************************************************99...******************* PP
   S: 205  kyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgk 305
           k+yc++c+++qeae+ ++lk+lP++L+lhLkRf++se+q++++k+++++++pl+L++   c+s ++k+  ++kYeL ++vvH+G ++++GHYv+++k+ek++
   Q: 534  KFYCDECCGLQEAERLVGLKQLPDTLTLHLKRFKYSEKQNCNIKLFNNIHYPLTLNV---CSSINSKV--CQKYELAGIVVHMGgGPQHGHYVSLCKHEKFG 630
           ****************************************************66665...77766666..******************************** PP
   S: 306  WllfdDskVtevkeeevleetg.....staYvlfYkr 337
           WllfdD++V++vkee+vle+tg     +taYvlfYk 
   Q: 631  WLLFDDETVEAVKEETVLEFTGespnmATAYVLFYKA 667
           ***********************************97 PP

Organism

Saccharomyces cerevisiae

Protein Sequence
(Fasta)

MIRRWLTISK SGKKKKAVND TITEEVEKVD FKPVNHDIND ELCYSESSDN PSSSLFVSNL 60
DTKETFLNED NNLQISSGLD YSSETCNQGS NYSQDGIFYI SNAKAINAYG GIITQGPEAP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATCAGAA GATGGCTAAC TATAAGTAAG TCTGGGAAGA AGAAAAAGGC TGTTAATGAT 60
ACCATTACAG AAGAAGTAGA AAAGGTTGAC TTTAAGCCTG TAAACCACGA TATAAATGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0010995--P:free ubiquitin chain depolymerization
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YBL067C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000934	Aegilops tauschii	39.02	6.00e-59	219.00
IUUC-Atr-002650	Amborella trichopoda	39.00	5.00e-58	216.00
IUUC-Apl-003380	Anas platyrhynchos	37.29	4.00e-53	199.00
IUUC-Aly-005830	Arabidopsis lyrata	36.63	1.00e-56	211.00
IUUC-Ath-006663	Arabidopsis thaliana	38.73	1.00e-61	228.00
IUUC-Acl-008239	Aspergillus clavatus	41.81	4.00e-67	247.00
IUUC-Afl-008602	Aspergillus flavus	41.64	2.00e-67	248.00
IUUC-Afu-008816	Aspergillus fumigatus	41.64	2.00e-66	245.00
IUUC-Ani-009137	Aspergillus nidulans	40.54	4.00e-66	243.00
IUUC-Ang-009703	Aspergillus niger	39.76	7.00e-68	249.00
IUUC-Aor-009901	Aspergillus oryzae	41.06	2.00e-67	248.00
IUUC-Ate-010431	Aspergillus terreus	41.06	1.00e-65	242.00
IUUC-Ame-010862	Astyanax mexicanus	37.46	2.00e-55	207.00
IUUC-Bgr-012071	Blumeria graminis	39.24	3.00e-71	261.00
IUUC-Bta-013023	Bos taurus	37.63	3.00e-53	200.00
IUUC-Bci-013837	Botrytis cinerea	37.50	3.00e-67	248.00
IUUC-Bdi-014887	Brachypodium distachyon	38.69	1.00e-58	218.00
IUUC-Bol-015409	Brassica oleracea	38.61	3.00e-59	221.00
IUUC-Bra-016956	Brassica rapa	38.61	2.00e-59	220.00
IUUC-Cel-018379	Caenorhabditis elegans	33.80	2.00e-51	194.00
IUUC-Cja-018956	Callithrix jacchus	37.63	2.00e-53	200.00
IUUC-Cpo-022443	Cavia porcellus	37.29	5.00e-53	199.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	39.34	1.00e-50	191.00
IUUC-Cin-025659	Ciona intestinalis	30.22	4.00e-37	147.00
IUUC-Csv-025828	Ciona savignyi	35.89	3.00e-35	140.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	40.72	8.00e-72	263.00
IUUC-Cne-026900	Cryptococcus neoformans	37.22	3.00e-49	187.00
IUUC-Dre-028230	Danio rerio	36.69	5.00e-57	213.00
IUUC-Dse-031470	Dothistroma septosporum	40.62	2.00e-73	268.00
IUUC-Dme-032038	Drosophila melanogaster	37.91	2.00e-41	161.00
IUUC-Eca-033721	Equus caballus	37.29	2.00e-53	200.00
IUUC-Fca-036299	Felis catus	37.29	1.00e-52	198.00
IUUC-Fox-037682	Fusarium oxysporum	39.60	1.00e-69	255.00
IUUC-Fso-038299	Fusarium solani	39.83	3.00e-71	260.00
IUUC-Gmo-038611	Gadus morhua	37.37	4.00e-56	209.00
IUUC-Ggr-039806	Gaeumannomyces graminis	35.35	2.00e-68	251.00
IUUC-Gga-041157	Gallus gallus	37.29	5.00e-53	199.00
IUUC-Gac-041764	Gasterosteus aculeatus	37.72	2.00e-56	211.00
IUUC-Gma-042927	Glycine max	39.80	6.00e-59	219.00
IUUC-Hvu-047692	Hordeum vulgare	39.40	1.00e-58	218.00
IUUC-Kpa-049250	Komagataella pastoris	47.59	3.00e-82	297.00
IUUC-Lpe-051368	Leersia perrieri	37.91	3.00e-57	213.00
IUUC-Lma-053300	Leptosphaeria maculans	40.40	8.00e-70	256.00
IUUC-Mcc-055566	Macaca mulatta	37.29	3.00e-53	200.00
IUUC-Mor-057072	Magnaporthe oryzae	40.30	2.00e-70	258.00
IUUC-Mpo-057424	Magnaporthe poae	38.99	5.00e-67	247.00
IUUC-Mtr-057715	Medicago truncatula	39.22	4.00e-59	219.00
IUUC-Mla-059142	Melampsora laricipopulina	31.09	2.00e-73	269.00
IUUC-Mga-059575	Meleagris gallopavo	37.29	6.00e-53	199.00
IUUC-Mvi-060357	Microbotryum violaceum	39.85	9.00e-50	190.00
IUUC-Mac-065541	Musa acuminata	38.91	5.00e-58	216.00
IUUC-Mpu-066038	Mustela putorius furo	37.63	8.00e-54	202.00
IUUC-Nfi-068611	Neosartorya fischeri	41.64	3.00e-66	244.00
IUUC-Ncr-068699	Neurospora crassa	36.86	2.00e-69	254.00
IUUC-Opr-070980	Ochotona princeps	37.63	1.00e-53	201.00
IUUC-Oba-075620	Oryza barthii	38.69	2.00e-57	213.00
IUUC-Obr-076208	Oryza brachyantha	38.69	2.00e-57	213.00
IUUC-Ogl-077763	Oryza glaberrima	38.69	2.00e-57	213.00
IUUC-Ogu-078571	Oryza glumaepatula	38.69	2.00e-57	213.00
IUUC-Oin-080002	Oryza indica	39.74	4.00e-60	223.00
IUUC-Olo-080865	Oryza longistaminata	37.99	3.00e-55	206.00
IUUC-Ome-081549	Oryza meridionalis	38.24	6.00e-58	215.00
IUUC-Oni-082041	Oryza nivara	40.21	2.00e-55	207.00
IUUC-Opu-084002	Oryza punctata	38.69	3.00e-57	213.00
IUUC-Oru-084226	Oryza rufipogon	39.74	5.00e-60	222.00
IUUC-Osa-085453	Oryza sativa	39.74	5.00e-60	222.00
IUUC-Olu-087809	Ostreococcus lucimarinus	40.00	5.00e-44	169.00
IUUC-Oga-088073	Otolemur garnettii	37.29	2.00e-53	200.00
IUUC-Oar-089248	Ovis aries	37.29	4.00e-53	199.00
IUUC-Psi-094012	Pelodiscus sinensis	37.29	4.00e-53	199.00
IUUC-Pno-095044	Phaeosphaeria nodorum	40.79	2.00e-69	255.00
IUUC-Ppa-095696	Physcomitrella patens	40.20	5.00e-60	222.00
IUUC-Pfo-097369	Poecilia formosa	36.42	1.00e-55	208.00
IUUC-Pab-098594	Pongo abelii	37.29	3.00e-53	199.00
IUUC-Pop-099798	Populus trichocarpa	39.09	3.00e-60	223.00
IUUC-Ppe-101474	Prunus persica	39.74	2.00e-60	224.00
IUUC-Pgr-103306	Puccinia graminis	41.39	4.00e-67	248.00
IUUC-Pte-104356	Pyrenophora teres	40.77	7.00e-70	256.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	41.42	3.00e-70	257.00
IUUC-Rno-104909	Rattus norvegicus	37.63	1.00e-53	201.00
IUUC-Spo-108095	Schizosaccharomyces pombe	42.91	1.00e-64	238.00
IUUC-Smo-109064	Selaginella moellendorffii	39.16	4.00e-51	192.00
IUUC-Sit-109700	Setaria italica	39.34	1.00e-58	217.00
IUUC-Sly-111210	Solanum lycopersicum	40.26	3.00e-58	216.00
IUUC-Stu-112398	Solanum tuberosum	39.26	3.00e-57	213.00
IUUC-Sbi-114562	Sorghum bicolor	40.39	6.00e-61	225.00
IUUC-Sre-115197	Sporisorium reilianum	40.36	2.00e-59	222.00
IUUC-Tgu-116800	Taeniopygia guttata	37.29	5.00e-53	199.00
IUUC-Tca-121329	Theobroma cacao	39.80	2.00e-60	224.00
IUUC-Tre-122226	Trichoderma reesei	39.54	3.00e-71	261.00
IUUC-Tvi-122330	Trichoderma virens	39.54	1.00e-71	262.00
IUUC-Tae-125638	Triticum aestivum	39.02	5.00e-59	219.00
IUUC-Tur-126331	Triticum urartu	39.02	6.00e-59	219.00
IUUC-Tme-126890	Tuber melanosporum	42.77	6.00e-69	253.00
IUUC-Uma-129409	Ustilago maydis	39.93	6.00e-60	224.00
IUUC-Vda-129736	Verticillium dahliae	33.88	1.00e-54	206.00
IUUC-Vvi-131371	Vitis vinifera	40.13	6.00e-61	225.00
IUUC-Xma-133111	Xiphophorus maculatus	36.75	4.00e-56	209.00
IUUC-Yli-134632	Yarrowia lipolytica	45.26	2.00e-82	298.00
IUUC-Zma-135752	Zea mays	39.34	3.00e-58	216.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence