iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059661

UUCD1 version

UUC-MeG-00107

Ensembl Protein ID

ENSMGAP00000001670.1

UniProt Accession

G1MTE4; G1MTE4_MELGA

Protein Name

E3 ubiquitin-protein ligase

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000002065.1	ENSMGAT00000002334.1	ENSMGAP00000001670.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-137	456.9	557	889

Active Site

Position(s)	Description	Evidence
858	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 557  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 644
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle+vdpe+y+sl ++ken   diee+gl++ fsv++eilge+k+++Lkp+G+ni Vt+eNkeeY++lv+e
   Q: 645  GFSLPFYKRILNKPVGLKDLESVDPEFYNSLIWVKEN---DIEECGLEMFFSVDKEILGEIKSHDLKPNGSNILVTEENKEEYIRLVAE 730
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d++++t y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 731  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHTIYRH-YTRTSRQILWFWQFVKEIDNEKRMRLLQFV 818
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+++e+lkekLl+Aieet+gF++
   Q: 819  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKNYEQLKEKLLFAIEETEGFGQ 889
           *********************************************************************96 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

TLFIQIQDPA HIMAGTGSKS GLPGGLYMKS QLQITVISAK LKEKNKWFGP SPYVEVSVDG 60
QSKKTEKCNN TNSPKWKQHL TVIVTPLSKL TFRVWSHQTL KSDVLLGSAA LDIHETLKSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTCTCTTTA TCCAGATTCA AGATCCAGCC CATATTATGG CTGGCACTGG ATCCAAGTCA 60
GGATTACCTG GTGGGCTGTA TATGAAATCA CAGCTTCAGA TCACTGGTAA GTTGTTGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	84.54	0.00e+00	1431.00
IUUC-Apl-003752	Anas platyrhynchos	95.73	0.00e+00	1612.00
IUUC-Aca-005338	Anolis carolinensis	86.92	0.00e+00	1488.00
IUUC-Ago-007742	Ashbya gossypii	49.05	3.00e-162	565.00
IUUC-Ang-009738	Aspergillus niger	47.49	5.00e-154	538.00
IUUC-Ame-010601	Astyanax mexicanus	86.63	0.00e+00	1113.00
IUUC-Bta-012782	Bos taurus	96.68	0.00e+00	1193.00
IUUC-Cja-018899	Callithrix jacchus	95.11	0.00e+00	1199.00
IUUC-Cfa-020648	Canis familiaris	83.45	0.00e+00	1397.00
IUUC-Cpo-022073	Cavia porcellus	82.52	0.00e+00	1456.00
IUUC-Csa-023252	Chlorocebus sabaeus	82.52	0.00e+00	1444.00
IUUC-Cho-024695	Choloepus hoffmanni	78.20	0.00e+00	1404.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.54	2.00e-155	543.00
IUUC-Cne-026849	Cryptococcus neoformans	46.36	1.00e-159	556.00
IUUC-Dre-028451	Danio rerio	72.45	0.00e+00	1287.00
IUUC-Dno-029884	Dasypus novemcinctus	82.20	0.00e+00	1449.00
IUUC-Dse-031241	Dothistroma septosporum	48.14	2.00e-155	542.00
IUUC-Eca-033793	Equus caballus	82.94	0.00e+00	1439.00
IUUC-Eeu-034716	Erinaceus europaeus	90.61	0.00e+00	874.00
IUUC-Fca-035605	Felis catus	82.91	0.00e+00	1453.00
IUUC-Fal-037126	Ficedula albicollis	94.65	0.00e+00	1590.00
IUUC-Fso-038393	Fusarium solani	47.04	5.00e-153	534.00
IUUC-Gmo-038596	Gadus morhua	80.79	0.00e+00	1003.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.60	4.00e-154	538.00
IUUC-Gga-040832	Gallus gallus	98.75	0.00e+00	1690.00
IUUC-Gac-041658	Gasterosteus aculeatus	85.86	0.00e+00	1118.00
IUUC-Ggo-044535	Gorilla gorilla	81.01	0.00e+00	1412.00
IUUC-Hsa-046564	Homo sapiens	78.96	0.00e+00	1430.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	94.44	0.00e+00	1197.00
IUUC-Kpa-049273	Komagataella pastoris	49.48	1.00e-163	569.00
IUUC-Lch-050454	Latimeria chalumnae	91.81	0.00e+00	1168.00
IUUC-Loc-052647	Lepisosteus oculatus	73.03	0.00e+00	1328.00
IUUC-Laf-054383	Loxodonta africana	82.86	0.00e+00	1456.00
IUUC-Mcc-055532	Macaca mulatta	82.29	0.00e+00	1442.00
IUUC-Mor-057097	Magnaporthe oryzae	47.70	2.00e-155	542.00
IUUC-Mpo-057442	Magnaporthe poae	51.55	2.00e-144	506.00
IUUC-Mla-058996	Melampsora laricipopulina	52.49	1.00e-148	520.00
IUUC-Mmr-061135	Microcebus murinus	83.88	0.00e+00	1456.00
IUUC-Mdo-062505	Monodelphis domestica	87.54	0.00e+00	1492.00
IUUC-Mmu-063375	Mus musculus	96.58	0.00e+00	1210.00
IUUC-Mpu-066203	Mustela putorius furo	85.01	0.00e+00	1436.00
IUUC-Mlu-067837	Myotis lucifugus	83.50	0.00e+00	1447.00
IUUC-Nle-069244	Nomascus leucogenys	83.31	0.00e+00	1437.00
IUUC-Opr-070585	Ochotona princeps	79.39	0.00e+00	1417.00
IUUC-Ont-071798	Oreochromis niloticus	89.73	0.00e+00	1135.00
IUUC-Ocu-074298	Oryctolagus cuniculus	96.58	0.00e+00	1211.00
IUUC-Ola-086526	Oryzias latipes	86.03	0.00e+00	1112.00
IUUC-Oga-088167	Otolemur garnettii	75.68	0.00e+00	1316.00
IUUC-Oar-090316	Ovis aries	73.61	0.00e+00	838.00
IUUC-Ptr-090819	Pan troglodytes	78.39	0.00e+00	1393.00
IUUC-Pan-092454	Papio anubis	82.03	0.00e+00	1442.00
IUUC-Psi-093319	Pelodiscus sinensis	88.43	0.00e+00	1481.00
IUUC-Pfo-097346	Poecilia formosa	85.67	0.00e+00	1101.00
IUUC-Pab-097580	Pongo abelii	74.08	0.00e+00	1278.00
IUUC-Pca-100923	Procavia capensis	68.67	0.00e+00	1182.00
IUUC-Pva-103209	Pteropus vampyrus	81.95	0.00e+00	1379.00
IUUC-Pgr-103620	Puccinia graminis	52.07	8.00e-147	513.00
IUUC-Rno-104924	Rattus norvegicus	96.40	0.00e+00	1209.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.48	2.00e-162	566.00
IUUC-Sha-107175	Sarcophilus harrisii	86.74	0.00e+00	1477.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	50.09	2.00e-159	555.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.89	7.00e-163	566.00
IUUC-Sar-113761	Sorex araneus	96.34	0.00e+00	1186.00
IUUC-Tgu-116632	Taeniopygia guttata	87.62	0.00e+00	1433.00
IUUC-Tru-118442	Takifugu rubripes	88.91	0.00e+00	1119.00
IUUC-Tsy-119198	Tarsius syrichta	75.94	0.00e+00	1315.00
IUUC-Tni-120168	Tetraodon nigroviridis	87.28	0.00e+00	1054.00
IUUC-Tme-126897	Tuber melanosporum	47.95	2.00e-144	505.00
IUUC-Tbe-127756	Tupaia belangeri	66.70	0.00e+00	1102.00
IUUC-Ttr-128504	Tursiops truncatus	74.76	0.00e+00	996.00
IUUC-Vda-129753	Verticillium dahliae	47.53	2.00e-154	539.00
IUUC-Vpa-130103	Vicugna pacos	81.62	0.00e+00	1007.00
IUUC-Xtr-132885	Xenopus tropicalis	91.79	0.00e+00	1187.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence