iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/CUE	CUE	25806814

Organism

Saccharomyces cerevisiae

Functional Description
(View)

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs, facilitating single-stranded DNA (ssDNA) production by the EXO1 and SGS1 machinery. Promotes gene silencing at heterochromatin by regulating the chromatin structure within or around silent loci. Also required for heterochromatin organization at centromeres.

Protein Sequence
(Fasta)

MSGSHSNDED DVVQVPETSS PTKVASSSPL KPTSPTVPDA SVASLRSRFT FKPSDPSEGA 60
HTSKPLPSGS PEVALVNLAR EFPDFSQTLV QAVFKSNSFN LQSARERLTR LRQQRQNWTW 120

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Nucleotide Sequence
(Fasta)

ATGAGTGGTT CGCATTCAAA TGATGAGGAT GACGTAGTGC AAGTGCCCGA GACGTCCTCT 60
CCCACCAAGG TAGCATCGTC GTCTCCCTTA AAGCCTACTT CGCCAACAGT TCCGGATGCA 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER

Pfam

PF00271--Helicase_C
PF00176--SNF2_N

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0000781--C:chromosome, telomeric region
GO:0031934--C:mating-type region heterochromatin
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0004386--F:helicase activity
GO:0042802--F:identical protein binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0006338--P:chromatin remodeling
GO:0000183--P:chromatin silencing at rDNA
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0016569--P:covalent chromatin modification
GO:0000729--P:DNA double-strand break processing
GO:0070869--P:heterochromatin assembly involved in chromatin silencing
GO:0070870--P:heterochromatin maintenance involved in chromatin silencing
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042766--P:nucleosome mobilization
GO:0016584--P:nucleosome positioning

KEGG

sce:YAL019W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000567	Aegilops tauschii	35.87	5.00e-96	343.00
IUUC-Aml-002063	Ailuropoda melanoleuca	44.84	2.00e-126	444.00
IUUC-Atr-003078	Amborella trichopoda	38.19	2.00e-96	344.00
IUUC-Apl-003860	Anas platyrhynchos	44.28	5.00e-128	450.00
IUUC-Aca-004485	Anolis carolinensis	44.84	3.00e-124	437.00
IUUC-Aly-006561	Arabidopsis lyrata	38.64	1.00e-95	342.00
IUUC-Ath-006832	Arabidopsis thaliana	38.28	5.00e-95	340.00
IUUC-Ago-007758	Ashbya gossypii	70.54	0.00e+00	837.00
IUUC-Acl-008226	Aspergillus clavatus	51.14	4.00e-170	590.00
IUUC-Afl-008556	Aspergillus flavus	51.36	1.00e-158	551.00
IUUC-Afu-008799	Aspergillus fumigatus	51.34	2.00e-168	584.00
IUUC-Ani-009127	Aspergillus nidulans	51.42	2.00e-160	558.00
IUUC-Ang-009676	Aspergillus niger	49.56	1.00e-163	568.00
IUUC-Aor-010184	Aspergillus oryzae	50.69	1.00e-160	558.00
IUUC-Ate-010559	Aspergillus terreus	51.58	1.00e-162	565.00
IUUC-Ame-011933	Astyanax mexicanus	45.40	2.00e-120	425.00
IUUC-Bgr-012028	Blumeria graminis	43.39	9.00e-80	288.00
IUUC-Bta-012963	Bos taurus	44.84	8.00e-126	442.00
IUUC-Bci-013670	Botrytis cinerea	44.91	1.00e-142	499.00
IUUC-Bdi-014286	Brachypodium distachyon	36.20	2.00e-95	341.00
IUUC-Bol-016519	Brassica oleracea	38.49	5.00e-95	340.00
IUUC-Bra-017239	Brassica rapa	38.49	5.00e-95	340.00
IUUC-Cel-018253	Caenorhabditis elegans	43.27	4.00e-116	410.00
IUUC-Cja-019465	Callithrix jacchus	44.84	4.00e-126	443.00
IUUC-Cfa-020637	Canis familiaris	45.03	2.00e-126	444.00
IUUC-Cpo-021822	Cavia porcellus	45.22	7.00e-126	442.00
IUUC-Csa-023315	Chlorocebus sabaeus	44.84	2.00e-125	441.00
IUUC-Cin-025444	Ciona intestinalis	42.41	5.00e-112	396.00
IUUC-Csv-025847	Ciona savignyi	33.45	7.00e-63	234.00
IUUC-Cgl-026383	Colletotrichum gloeosporioides	37.69	3.00e-106	377.00
IUUC-Cne-027090	Cryptococcus neoformans	41.64	2.00e-116	411.00
IUUC-Dre-028385	Danio rerio	44.24	3.00e-116	410.00
IUUC-Dno-028932	Dasypus novemcinctus	45.03	7.00e-127	446.00
IUUC-Dse-031394	Dothistroma septosporum	48.36	7.00e-131	459.00
IUUC-Dme-031640	Drosophila melanogaster	38.36	5.00e-100	357.00
IUUC-Eca-033276	Equus caballus	44.84	4.00e-127	447.00
IUUC-Fca-035936	Felis catus	44.09	6.00e-123	433.00
IUUC-Fal-037636	Ficedula albicollis	43.53	2.00e-125	441.00
IUUC-Fso-038229	Fusarium solani	39.18	1.00e-113	402.00
IUUC-Gmo-039654	Gadus morhua	42.72	7.00e-106	376.00
IUUC-Ggr-039922	Gaeumannomyces graminis	39.42	1.00e-106	379.00
IUUC-Gga-040646	Gallus gallus	44.84	8.00e-132	462.00
IUUC-Gac-042320	Gasterosteus aculeatus	44.15	3.00e-106	377.00
IUUC-Gma-042832	Glycine max	37.57	5.00e-93	333.00
IUUC-Ggo-044875	Gorilla gorilla	39.63	1.00e-100	359.00
IUUC-Hsa-046992	Homo sapiens	44.84	7.00e-126	442.00
IUUC-Hvu-047408	Hordeum vulgare	36.93	6.00e-98	350.00
IUUC-Itr-047881	Ictidomys tridecemlineatus	44.65	3.00e-124	436.00
IUUC-Kpa-049212	Komagataella pastoris	59.59	0.00e+00	697.00
IUUC-Lpe-050987	Leersia perrieri	36.27	1.00e-95	342.00
IUUC-Loc-052272	Lepisosteus oculatus	44.19	8.00e-121	426.00
IUUC-Lma-053118	Leptosphaeria maculans	46.81	2.00e-143	501.00
IUUC-Laf-053436	Loxodonta africana	44.44	8.00e-121	426.00
IUUC-Mcc-055209	Macaca mulatta	44.84	1.00e-125	441.00
IUUC-Meu-056292	Macropus eugenii	35.82	6.00e-24	105.00
IUUC-Mor-056994	Magnaporthe oryzae	40.67	2.00e-112	398.00
IUUC-Mpo-057305	Magnaporthe poae	39.42	1.00e-108	386.00
IUUC-Mtr-058432	Medicago truncatula	37.17	1.00e-94	338.00
IUUC-Mla-058972	Melampsora laricipopulina	48.15	2.00e-139	487.00
IUUC-Mga-059572	Meleagris gallopavo	44.55	5.00e-129	453.00
IUUC-Mvi-060209	Microbotryum violaceum	45.93	3.00e-149	521.00
IUUC-Mmr-061416	Microcebus murinus	43.34	1.00e-112	398.00
IUUC-Mdo-062869	Monodelphis domestica	44.28	6.00e-124	436.00
IUUC-Mmu-064272	Mus musculus	45.03	1.00e-118	419.00
IUUC-Mac-064963	Musa acuminata	37.61	3.00e-92	330.00
IUUC-Mpu-065755	Mustela putorius furo	45.03	1.00e-126	445.00
IUUC-Mlu-067604	Myotis lucifugus	44.47	9.00e-129	452.00
IUUC-Nfi-068310	Neosartorya fischeri	51.69	5.00e-169	586.00
IUUC-Ncr-068841	Neurospora crassa	37.91	1.00e-115	409.00
IUUC-Nle-069227	Nomascus leucogenys	44.84	7.00e-126	443.00
IUUC-Opr-071088	Ochotona princeps	41.09	8.00e-111	393.00
IUUC-Ont-072291	Oreochromis niloticus	44.75	2.00e-113	401.00
IUUC-Oan-073460	Ornithorhynchus anatinus	43.53	1.00e-124	438.00
IUUC-Ocu-074811	Oryctolagus cuniculus	44.84	7.00e-126	442.00
IUUC-Oba-075463	Oryza barthii	36.44	3.00e-95	340.00
IUUC-Obr-076342	Oryza brachyantha	36.03	3.00e-96	344.00
IUUC-Ogu-078837	Oryza glumaepatula	36.44	1.00e-95	342.00
IUUC-Oin-079623	Oryza indica	36.70	1.00e-95	342.00
IUUC-Ome-081105	Oryza meridionalis	36.19	3.00e-96	344.00
IUUC-Oni-082598	Oryza nivara	36.44	1.00e-95	342.00
IUUC-Opu-084040	Oryza punctata	36.82	2.00e-96	345.00
IUUC-Oru-084219	Oryza rufipogon	36.70	2.00e-95	341.00
IUUC-Osa-085461	Oryza sativa	36.44	6.00e-96	343.00
IUUC-Ola-087307	Oryzias latipes	44.64	5.00e-109	387.00
IUUC-Olu-087812	Ostreococcus lucimarinus	35.17	9.00e-88	315.00
IUUC-Oga-089064	Otolemur garnettii	44.84	2.00e-126	444.00
IUUC-Oar-090054	Ovis aries	44.84	7.00e-126	442.00
IUUC-Ptr-091228	Pan troglodytes	44.84	7.00e-126	442.00
IUUC-Pan-092769	Papio anubis	44.31	2.00e-113	401.00
IUUC-Psi-093202	Pelodiscus sinensis	43.71	2.00e-124	438.00
IUUC-Pma-094725	Petromyzon marinus	42.96	1.00e-126	445.00
IUUC-Pno-095130	Phaeosphaeria nodorum	45.83	1.00e-137	482.00
IUUC-Ppa-095559	Physcomitrella patens	38.88	9.00e-101	359.00
IUUC-Pfo-096546	Poecilia formosa	44.06	4.00e-117	414.00
IUUC-Pab-097698	Pongo abelii	45.03	5.00e-125	440.00
IUUC-Pop-099986	Populus trichocarpa	38.22	5.00e-95	340.00
IUUC-Ppe-101649	Prunus persica	37.57	8.00e-93	332.00
IUUC-Pva-102138	Pteropus vampyrus	44.47	2.00e-125	441.00
IUUC-Pgr-103272	Puccinia graminis	44.31	3.00e-127	447.00
IUUC-Ptt-103880	Puccinia triticina	43.78	3.00e-133	468.00
IUUC-Pte-104260	Pyrenophora teres	46.89	4.00e-140	490.00
IUUC-Pyt-104532	Pyrenophora triticirepentis	41.59	6.00e-110	390.00
IUUC-Rno-105903	Rattus norvegicus	44.84	2.00e-118	418.00
IUUC-Sha-106783	Sarcophilus harrisii	44.65	6.00e-123	433.00
IUUC-Sja-107887	Schizosaccharomyces japonicus	56.56	7.00e-174	602.00
IUUC-Spo-108154	Schizosaccharomyces pombe	53.74	1.00e-168	585.00
IUUC-Smo-108759	Selaginella moellendorffii	37.99	1.00e-98	351.00
IUUC-Sit-110023	Setaria italica	35.70	5.00e-96	343.00
IUUC-Sly-111423	Solanum lycopersicum	38.12	5.00e-96	343.00
IUUC-Sbi-114688	Sorghum bicolor	36.21	2.00e-95	341.00
IUUC-Sre-114983	Sporisorium reilianum	45.30	6.00e-129	453.00
IUUC-Ssc-116030	Sus scrofa	44.84	2.00e-126	444.00
IUUC-Tgu-117451	Taeniopygia guttata	44.57	1.00e-125	442.00
IUUC-Tru-118600	Takifugu rubripes	45.02	5.00e-106	377.00
IUUC-Tsy-119130	Tarsius syrichta	37.52	3.00e-93	334.00
IUUC-Tni-119758	Tetraodon nigroviridis	45.03	9.00e-109	385.00
IUUC-Tca-121797	Theobroma cacao	37.64	2.00e-95	341.00
IUUC-Tre-121883	Trichoderma reesei	38.37	4.00e-103	367.00
IUUC-Tvi-122333	Trichoderma virens	38.16	4.00e-113	400.00
IUUC-Tae-122848	Triticum aestivum	35.87	8.00e-96	342.00
IUUC-Tur-126594	Triticum urartu	35.87	2.00e-95	341.00
IUUC-Tme-127106	Tuber melanosporum	51.33	2.00e-163	568.00
IUUC-Tbe-127911	Tupaia belangeri	44.65	3.00e-114	404.00
IUUC-Ttr-128597	Tursiops truncatus	44.65	8.00e-126	442.00
IUUC-Uma-129321	Ustilago maydis	43.87	2.00e-129	454.00
IUUC-Vpa-130686	Vicugna pacos	39.88	2.00e-97	348.00
IUUC-Vvi-131046	Vitis vinifera	38.90	1.00e-94	338.00
IUUC-Xtr-132740	Xenopus tropicalis	44.67	2.00e-123	434.00
IUUC-Xma-134260	Xiphophorus maculatus	44.25	7.00e-117	412.00
IUUC-Yli-134634	Yarrowia lipolytica	58.09	0.00e+00	627.00
IUUC-Zma-135493	Zea mays	34.53	9.00e-96	343.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence