iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
TargetScan	SomamiR	miRcode	RAID2
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/OTU	OTU	19615732
UBD/Alpha-Helix/UIM	UIM	23827681

Classification

Family	E-value	Score	Start	End
DUB/OTU	3.50e-32	113.3	310	437

Active Site

Position(s)	Description	Evidence
317	N/A	{ECO:0000250}
320	Nucleophile	ECO:0000250}
431		{ECO:0000250}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfdddslsdalveaLreltseylqkesdffsefieekedekefcqklvepeakgeeihifaLaqiLsrpi 93
           ++ ++ +DGnCL+rAvs++   v++d+s    l+++Lre+t +y++++ d+fs++ie+  d+ ef+  ++++ a+++  ++ a+ q+L+++i
   Q: 310  YRFHIIPDGNCLYRAVSKT---VYGDQS----LHRELREQTVHYIADHLDHFSPLIEG--DVGEFIIAAAQDGAWAGYPELLAMGQMLNVNI 392
           78899**************...******....**************************..9******************************* PP
   S: 94   ivvdvdsleskvggillpllfpeeklkkpivLlY.rsgHYdaLva 137
           ++++  +les++ ++++++l pe++l+++i+L++ ++gHYda+++
   Q: 393  HLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWlSNGHYDAVFD 437
           ******************************************986 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.

Protein Sequence
(Fasta)

MQLYSSVCTH YPAGAPGPTA AAPAPPAAAT PFKVSLQPPG AAGAAPEPET GECQPAAAAE 60
HREAAAVPAA KMPAFSSCFE VVSGAAAPAS AAAGPPGASC KPPLPPHYTS TAQITVRALG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGCTCT ACAGCAGCGT CTGCACCCAC TACCCCGCCG GGGCCCCGGG TCCCACGGCC 60
GCCGCCCCCG CGCCACCCGC CGCCGCTACC CCCTTCAAGG TCTCGCTGCA GCCCCCGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0070536--P:protein K63-linked deubiquitination

KEGG

hsa:220213

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003381	Anas platyrhynchos	87.28	1.00e-90	325.00
IUUC-Aca-004882	Anolis carolinensis	69.90	7.00e-79	287.00
IUUC-Ame-011068	Astyanax mexicanus	77.08	5.00e-91	328.00
IUUC-Bta-013311	Bos taurus	84.30	6.00e-145	507.00
IUUC-Cel-018389	Caenorhabditis elegans	38.75	8.00e-10	59.70
IUUC-Cja-019570	Callithrix jacchus	89.11	3.00e-170	591.00
IUUC-Cfa-021137	Canis familiaris	96.55	8.00e-119	419.00
IUUC-Csa-024211	Chlorocebus sabaeus	95.63	0.00e+00	650.00
IUUC-Dre-028539	Danio rerio	60.58	1.00e-93	337.00
IUUC-Fal-037563	Ficedula albicollis	87.11	1.00e-101	362.00
IUUC-Gmo-039313	Gadus morhua	67.01	2.00e-77	281.00
IUUC-Gga-040877	Gallus gallus	86.60	5.00e-101	360.00
IUUC-Gac-042036	Gasterosteus aculeatus	72.02	1.00e-85	308.00
IUUC-Ggo-045008	Gorilla gorilla	98.96	0.00e+00	634.00
IUUC-Lch-049775	Latimeria chalumnae	78.43	1.00e-97	350.00
IUUC-Loc-052017	Lepisosteus oculatus	79.08	7.00e-95	340.00
IUUC-Laf-053375	Loxodonta africana	73.26	1.00e-151	529.00
IUUC-Mcc-055248	Macaca mulatta	95.23	0.00e+00	663.00
IUUC-Mla-058976	Melampsora laricipopulina	38.89	3.00e-09	55.10
IUUC-Mga-059968	Meleagris gallopavo	87.65	4.00e-84	303.00
IUUC-Mmr-061376	Microcebus murinus	77.59	1.00e-71	263.00
IUUC-Mdo-062375	Monodelphis domestica	72.56	5.00e-121	427.00
IUUC-Mmu-063193	Mus musculus	72.24	1.00e-142	499.00
IUUC-Oan-073325	Ornithorhynchus anatinus	84.18	3.00e-100	357.00
IUUC-Oga-087994	Otolemur garnettii	90.34	3.00e-172	597.00
IUUC-Oar-089449	Ovis aries	91.02	2.00e-125	441.00
IUUC-Ptr-090831	Pan troglodytes	99.38	5.00e-179	620.00
IUUC-Pan-091895	Papio anubis	95.84	0.00e+00	659.00
IUUC-Psi-093538	Pelodiscus sinensis	84.00	2.00e-100	357.00
IUUC-Pfo-097114	Poecilia formosa	76.29	8.00e-92	330.00
IUUC-Pab-098228	Pongo abelii	100.00	4.00e-104	369.00
IUUC-Rno-105089	Rattus norvegicus	71.84	2.00e-133	469.00
IUUC-Tgu-117161	Taeniopygia guttata	86.73	2.00e-102	364.00
IUUC-Tru-117642	Takifugu rubripes	73.33	1.00e-87	315.00
IUUC-Tsy-119310	Tarsius syrichta	95.93	3.00e-126	445.00
IUUC-Tni-120672	Tetraodon nigroviridis	70.24	2.00e-84	305.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence