iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/Josephin	50.87	2.00e-41	166.00	IUUC-Hsa-046522

Active Site

Position(s)	Description	Evidence
49	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU00331}
152	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00331}

Organism

Drosophila melanogaster

Functional Description
(View)

May act as a deubiquitinating enzyme.

Protein Sequence
(Fasta)

MESPSARTLG NSLGDDSGNG NENGNGSGNG NTTMMPHGIY HERQTRHLCG LHALNNLFQG 60
PDMFSKSELD DYCTTLTPRN WLNPHRSWIG WGNYDVNVIM YALQQRNCEA VWFDRRRDPH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAAGCCAC TTCATCTAGT GACCATTTGG AGCTGCCCGT CCGTTTGGAG CTATTTCACC 60
TACTGGCTAC TGTCACCACC TCACACTGAA CCGCTCCGAA ATGGAATCGC CCAGTGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR006155--Josephin

PROSITE

PS50957--JOSEPHIN

Pfam

PF02099--Josephin

SMART

SM01246--Josephin

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination

KEGG

dme:Dmel_CG3781

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000785	Aegilops tauschii	34.83	1.00e-25	108.00
IUUC-Aml-001650	Ailuropoda melanoleuca	49.68	5.00e-33	132.00
IUUC-Atr-002584	Amborella trichopoda	38.46	1.00e-23	102.00
IUUC-Apl-003240	Anas platyrhynchos	47.40	6.00e-39	152.00
IUUC-Aca-004262	Anolis carolinensis	47.13	1.00e-38	151.00
IUUC-Aly-005621	Arabidopsis lyrata	35.80	2.00e-23	102.00
IUUC-Ath-007306	Arabidopsis thaliana	37.28	5.00e-24	104.00
IUUC-Ame-010835	Astyanax mexicanus	50.60	1.00e-45	174.00
IUUC-Bta-012918	Bos taurus	52.63	6.00e-34	136.00
IUUC-Bdi-014128	Brachypodium distachyon	37.08	2.00e-28	117.00
IUUC-Bol-015647	Brassica oleracea	35.43	2.00e-24	104.00
IUUC-Bra-017811	Brassica rapa	35.06	5.00e-24	102.00
IUUC-Cel-018568	Caenorhabditis elegans	34.73	4.00e-32	129.00
IUUC-Cja-019837	Callithrix jacchus	52.63	4.00e-33	133.00
IUUC-Cfa-021001	Canis familiaris	53.29	2.00e-33	134.00
IUUC-Cpo-021340	Cavia porcellus	51.32	2.00e-31	127.00
IUUC-Csa-023069	Chlorocebus sabaeus	53.29	2.00e-33	134.00
IUUC-Cho-025019	Choloepus hoffmanni	45.86	3.00e-38	150.00
IUUC-Cin-025666	Ciona intestinalis	50.70	8.00e-40	155.00
IUUC-Csv-026011	Ciona savignyi	47.95	2.00e-40	157.00
IUUC-Cme-027180	Cyanidioschyzon merolae	26.98	9.00e-04	36.20
IUUC-Dre-028459	Danio rerio	49.44	2.00e-45	174.00
IUUC-Dno-029569	Dasypus novemcinctus	50.33	1.00e-33	135.00
IUUC-Dor-030570	Dipodomys ordii	51.57	6.00e-33	132.00
IUUC-Ete-032777	Echinops telfairi	46.39	1.00e-38	151.00
IUUC-Eca-034395	Equus caballus	45.86	6.00e-38	149.00
IUUC-Eeu-035075	Erinaceus europaeus	29.94	5.00e-17	79.70
IUUC-Fca-036089	Felis catus	52.63	1.00e-32	132.00
IUUC-Fal-037330	Ficedula albicollis	47.40	7.00e-39	152.00
IUUC-Gmo-038493	Gadus morhua	49.44	3.00e-44	170.00
IUUC-Gga-040456	Gallus gallus	47.40	1.00e-38	152.00
IUUC-Gac-041579	Gasterosteus aculeatus	49.71	2.00e-46	177.00
IUUC-Gma-043620	Glycine max	35.00	7.00e-27	112.00
IUUC-Ggo-045508	Gorilla gorilla	50.32	9.00e-34	135.00
IUUC-Hsa-046522	Homo sapiens	50.32	1.00e-33	135.00
IUUC-Hvu-047184	Hordeum vulgare	34.83	7.00e-26	109.00
IUUC-Itr-048074	Ictidomys tridecemlineatus	52.63	4.00e-33	133.00
IUUC-Lch-050506	Latimeria chalumnae	47.34	7.00e-42	162.00
IUUC-Lpe-051421	Leersia perrieri	35.96	1.00e-26	112.00
IUUC-Loc-051775	Lepisosteus oculatus	50.00	2.00e-37	148.00
IUUC-Laf-054283	Loxodonta africana	45.28	1.00e-36	145.00
IUUC-Mcc-054840	Macaca mulatta	53.29	2.00e-33	134.00
IUUC-Meu-056539	Macropus eugenii	47.70	9.00e-37	145.00
IUUC-Mtr-058745	Medicago truncatula	32.04	5.00e-26	109.00
IUUC-Mla-059013	Melampsora laricipopulina	27.22	5.00e-03	34.70
IUUC-Mga-059703	Meleagris gallopavo	47.40	9.00e-39	152.00
IUUC-Mmr-061038	Microcebus murinus	26.67	5.00e-07	47.80
IUUC-Mdo-062114	Monodelphis domestica	47.13	6.00e-39	152.00
IUUC-Mmu-063463	Mus musculus	50.32	8.00e-34	135.00
IUUC-Mac-065631	Musa acuminata	39.02	8.00e-25	107.00
IUUC-Mpu-066337	Mustela putorius furo	50.00	2.00e-32	131.00
IUUC-Mlu-067564	Myotis lucifugus	46.75	6.00e-38	149.00
IUUC-Nle-069739	Nomascus leucogenys	51.97	1.00e-32	131.00
IUUC-Opr-070945	Ochotona princeps	38.22	4.00e-27	113.00
IUUC-Ont-072050	Oreochromis niloticus	51.25	6.00e-45	172.00
IUUC-Oan-073122	Ornithorhynchus anatinus	47.01	2.00e-26	110.00
IUUC-Ocu-074128	Oryctolagus cuniculus	48.31	2.00e-24	103.00
IUUC-Oba-075401	Oryza barthii	35.39	1.00e-27	114.00
IUUC-Obr-076916	Oryza brachyantha	35.96	4.00e-27	113.00
IUUC-Ogl-077194	Oryza glaberrima	35.39	1.00e-27	114.00
IUUC-Ogu-078532	Oryza glumaepatula	35.39	1.00e-27	114.00
IUUC-Oin-079562	Oryza indica	36.25	4.00e-25	106.00
IUUC-Olo-080503	Oryza longistaminata	35.39	2.00e-27	114.00
IUUC-Ome-081997	Oryza meridionalis	35.96	1.00e-27	115.00
IUUC-Oni-082854	Oryza nivara	34.48	2.00e-25	108.00
IUUC-Opu-083984	Oryza punctata	34.27	1.00e-26	112.00
IUUC-Oru-084655	Oryza rufipogon	35.03	3.00e-26	110.00
IUUC-Osa-085854	Oryza sativa	35.39	1.00e-27	114.00
IUUC-Ola-086805	Oryzias latipes	49.71	4.00e-45	172.00
IUUC-Oga-088741	Otolemur garnettii	51.32	6.00e-28	116.00
IUUC-Oar-089548	Ovis aries	52.63	6.00e-34	135.00
IUUC-Ptr-090936	Pan troglodytes	45.86	7.00e-38	149.00
IUUC-Pan-092144	Papio anubis	53.29	2.00e-33	134.00
IUUC-Psi-093448	Pelodiscus sinensis	46.54	3.00e-39	153.00
IUUC-Pma-094374	Petromyzon marinus	23.50	2.00e-03	35.80
IUUC-Ppa-095444	Physcomitrella patens	36.32	1.00e-25	108.00
IUUC-Pfo-097459	Poecilia formosa	49.44	9.00e-46	175.00
IUUC-Pab-097628	Pongo abelii	45.86	7.00e-38	149.00
IUUC-Pop-099793	Populus trichocarpa	31.50	2.00e-19	88.20
IUUC-Pca-100200	Procavia capensis	47.10	1.00e-34	138.00
IUUC-Ppe-102087	Prunus persica	35.56	9.00e-27	112.00
IUUC-Pva-102585	Pteropus vampyrus	52.26	3.00e-33	133.00
IUUC-Rno-105654	Rattus norvegicus	50.66	5.00e-33	133.00
IUUC-Sha-107606	Sarcophilus harrisii	47.13	5.00e-39	152.00
IUUC-Smo-109138	Selaginella moellendorffii	41.23	7.00e-17	79.00
IUUC-Sit-110826	Setaria italica	37.64	2.00e-28	117.00
IUUC-Sly-111452	Solanum lycopersicum	37.29	2.00e-26	110.00
IUUC-Stu-112215	Solanum tuberosum	36.67	4.00e-26	110.00
IUUC-Sar-113534	Sorex araneus	26.06	4.00e-04	38.10
IUUC-Sbi-114786	Sorghum bicolor	38.20	2.00e-28	117.00
IUUC-Ssc-115298	Sus scrofa	52.63	1.00e-33	134.00
IUUC-Tgu-117374	Taeniopygia guttata	45.96	2.00e-39	154.00
IUUC-Tru-118437	Takifugu rubripes	49.13	3.00e-46	176.00
IUUC-Tsy-119298	Tarsius syrichta	45.86	1.00e-38	151.00
IUUC-Tni-120715	Tetraodon nigroviridis	52.90	4.00e-45	173.00
IUUC-Tca-121220	Theobroma cacao	35.87	7.00e-28	117.00
IUUC-Tae-123012	Triticum aestivum	34.83	1.00e-25	108.00
IUUC-Tur-126618	Triticum urartu	31.37	3.00e-17	80.50
IUUC-Tbe-127896	Tupaia belangeri	45.86	6.00e-38	149.00
IUUC-Ttr-128523	Tursiops truncatus	45.86	9.00e-38	149.00
IUUC-Uma-129359	Ustilago maydis	25.79	1.20e-01	30.80
IUUC-Vpa-130184	Vicugna pacos	43.35	5.00e-38	149.00
IUUC-Vvi-131246	Vitis vinifera	35.14	2.00e-25	107.00
IUUC-Xtr-132462	Xenopus tropicalis	51.63	1.00e-42	164.00
IUUC-Xma-134148	Xiphophorus maculatus	49.44	1.00e-45	174.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence