iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000008688.7	ENSRNOT00000066043.2	ENSRNOP00000060364.1
ENSRNOG00000008688.7	ENSRNOT00000083132.1	ENSRNOP00000073155.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.60e-85	287.0	191	811

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenp.............kepkgellkslqklfeelwkskkkavsp 70
           +G++NlgNtC++N+v+Q L+++  l el++e      k       + +              ++ g+l+++l  +++++ + +k+  sp
   Q: 191  KGITNLGNTCFFNAVIQNLAQTYILFELMNEikedgtK------FKISlssapqleplvveLSSPGPLTSALFLFLHSMKEAEKGPLSP 273
           59*****************************5544442......3333444555777777788888*********************** PP
   S: 71   rellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksq 153
           + l+++l+++a++f+g++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ de      + + k+  + ++i+++F g+l+s+
   Q: 274  KVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEETKRIQASILKAFNNPTTKTADEetrkkvKAYGKEGVKMNFIDRIFIGELTST 362
           *************************************99888888888888877777773333335555555556************** PP
   S: 154  ikclecdnvssreepfldlslpvpgkeetkke......................................................... 185
           ++c+ec+n+s+ ++pf+d+slp+ +++ +k+                                                          
   Q: 363  VMCEECANISTMKDPFIDISLPIIEERVSKPVllgkmskcrslqetdqdhnkgtvtventhppraakkhsspkdktllshdrkhlrkwp 451
           ***************************98777********************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 452  seeertvgthpnsenseasplagilsneaslnesptegserdtslessvdadseasepevaykpsvllrssgdpgahgeqhphlplase 540
           ***************************************************************************************** PP
   S: 186  .............................................................................slqdcLesftke 197
                                                                                        s+q+cL +ft+ 
   Q: 541  lphtkethdcdeemaeamaelhlsgtvtgnrdfhrekqplnvpnnvcfsegkhtklhsaqnafqtlsqsyvttskecSVQSCLYQFTSM 629
           ***************************************************************************************** PP
   S: 198  eelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
           e l g+nk+ ce c++k++                   a+k+l ++ +P +LilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ 
   Q: 630  ELLMGNNKLLCEDCTEKKRkcqketssaerkaggvytnARKQLLISAVPAILILHLKRF--HQAGLSLRKVNRHVDFPLTLDLAPFCAA 716
           ***************88888999999999999999999*********************..9999************************ PP
   S: 268  peekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgs 328
           ++++ ++  k+ Y L+++v HsGs+++GHY+ayvk                             g+W++++D++V++v+e++ l+   +
   Q: 717  TCKNISVgeKVLYGLYGIVEHSGSMRGGHYTAYVKVrvpsrklsecitgrktapglkeadseLGGHWVHVSDTYVQVVPESRALS---A 802
           8887765669**************************999999999999999988887766544555*******************...* PP
   S: 329  taYvlfYkr 337
           +aY+lfY+r
   Q: 803  QAYLLFYER 811
           *******98 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MRVKDPSKDL PEKGKRSKRP LLPHDEDSSD DIAVGLTCQH ISYAVSVNHV KKAVAETLWS 60
VCSECLKERR LCDGQPVLPS DVWLCLKCGF QGCGKNSESQ HSLRHFKSSG AESHCVVISL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCTCTGCA CAGGCGCAGA AGCTCCTGCG TGTGGAAGCT GCGGCCCGGC GGGCGGGGTG 60
AGTTGGGGCC CAGGCTTTGG GGTCACTGCA ACCCCTGTGT CTTCGCTTAG GCGGTGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	69.10	0.00e+00	1052.00
IUUC-Apl-003512	Anas platyrhynchos	64.32	0.00e+00	1035.00
IUUC-Aca-004284	Anolis carolinensis	58.94	0.00e+00	949.00
IUUC-Ame-010735	Astyanax mexicanus	57.63	8.00e-85	307.00
IUUC-Bta-012880	Bos taurus	76.04	0.00e+00	1196.00
IUUC-Cja-019144	Callithrix jacchus	77.51	0.00e+00	1272.00
IUUC-Cfa-020971	Canis familiaris	81.24	0.00e+00	722.00
IUUC-Cpo-022497	Cavia porcellus	66.75	0.00e+00	1026.00
IUUC-Csa-023910	Chlorocebus sabaeus	76.55	0.00e+00	1155.00
IUUC-Cho-024358	Choloepus hoffmanni	59.83	1.00e-106	380.00
IUUC-Dre-028106	Danio rerio	60.58	8.00e-148	517.00
IUUC-Dno-029456	Dasypus novemcinctus	67.26	0.00e+00	661.00
IUUC-Dor-030438	Dipodomys ordii	63.13	0.00e+00	962.00
IUUC-Dme-031870	Drosophila melanogaster	46.71	4.00e-36	147.00
IUUC-Ete-032736	Echinops telfairi	62.30	0.00e+00	936.00
IUUC-Eca-034211	Equus caballus	76.56	0.00e+00	1261.00
IUUC-Eeu-034797	Erinaceus europaeus	77.78	2.00e-86	312.00
IUUC-Fca-035947	Felis catus	72.81	0.00e+00	1098.00
IUUC-Fal-037199	Ficedula albicollis	65.44	0.00e+00	894.00
IUUC-Gmo-039228	Gadus morhua	62.03	1.00e-141	496.00
IUUC-Gga-040823	Gallus gallus	58.27	5.00e-161	560.00
IUUC-Gac-042406	Gasterosteus aculeatus	62.25	1.00e-138	487.00
IUUC-Ggo-045402	Gorilla gorilla	77.36	0.00e+00	1236.00
IUUC-Hsa-046430	Homo sapiens	77.08	0.00e+00	1237.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	79.29	0.00e+00	737.00
IUUC-Lch-049547	Latimeria chalumnae	57.90	0.00e+00	881.00
IUUC-Loc-052842	Lepisosteus oculatus	57.66	0.00e+00	891.00
IUUC-Laf-053988	Loxodonta africana	76.95	0.00e+00	1248.00
IUUC-Mcc-055491	Macaca mulatta	73.11	0.00e+00	1169.00
IUUC-Meu-056256	Macropus eugenii	58.70	4.00e-169	588.00
IUUC-Mla-059026	Melampsora laricipopulina	30.73	2.00e-16	80.50
IUUC-Mga-059833	Meleagris gallopavo	55.42	2.00e-163	568.00
IUUC-Mmr-060952	Microcebus murinus	75.06	0.00e+00	1217.00
IUUC-Mdo-062642	Monodelphis domestica	67.39	0.00e+00	1045.00
IUUC-Mmu-063945	Mus musculus	93.23	0.00e+00	1519.00
IUUC-Mpu-065944	Mustela putorius furo	73.04	0.00e+00	1151.00
IUUC-Mlu-067049	Myotis lucifugus	75.61	0.00e+00	1177.00
IUUC-Nle-069828	Nomascus leucogenys	76.56	0.00e+00	1234.00
IUUC-Opr-070672	Ochotona princeps	68.65	7.00e-135	474.00
IUUC-Ont-072121	Oreochromis niloticus	59.51	1.00e-135	476.00
IUUC-Oan-073656	Ornithorhynchus anatinus	64.21	0.00e+00	1000.00
IUUC-Ocu-074323	Oryctolagus cuniculus	76.29	0.00e+00	1189.00
IUUC-Ola-087238	Oryzias latipes	52.34	0.00e+00	799.00
IUUC-Oga-088379	Otolemur garnettii	71.91	0.00e+00	1143.00
IUUC-Oar-089718	Ovis aries	75.85	0.00e+00	1193.00
IUUC-Ptr-091358	Pan troglodytes	77.21	0.00e+00	1237.00
IUUC-Pan-092023	Papio anubis	77.75	0.00e+00	1249.00
IUUC-Psi-093256	Pelodiscus sinensis	63.72	0.00e+00	965.00
IUUC-Pab-098539	Pongo abelii	77.02	0.00e+00	1236.00
IUUC-Pca-100610	Procavia capensis	63.37	0.00e+00	853.00
IUUC-Pva-102985	Pteropus vampyrus	85.95	0.00e+00	660.00
IUUC-Sha-107022	Sarcophilus harrisii	69.78	6.00e-178	617.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	28.21	6.00e-21	96.30
IUUC-Spo-108149	Schizosaccharomyces pombe	30.62	1.00e-19	92.40
IUUC-Sar-113637	Sorex araneus	67.60	0.00e+00	1007.00
IUUC-Ssc-115870	Sus scrofa	74.45	0.00e+00	1225.00
IUUC-Tgu-116907	Taeniopygia guttata	65.65	0.00e+00	1025.00
IUUC-Tru-117835	Takifugu rubripes	52.46	3.00e-108	386.00
IUUC-Tsy-118869	Tarsius syrichta	70.05	0.00e+00	1075.00
IUUC-Tni-119716	Tetraodon nigroviridis	64.14	7.00e-92	331.00
IUUC-Tbe-128041	Tupaia belangeri	60.39	0.00e+00	896.00
IUUC-Ttr-128901	Tursiops truncatus	74.08	0.00e+00	1200.00
IUUC-Vpa-130331	Vicugna pacos	77.37	0.00e+00	1123.00
IUUC-Xtr-131794	Xenopus tropicalis	51.09	0.00e+00	754.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence