iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089199

Ensembl Protein ID

ENSOARP00000017683.1

UniProt Accession

W5Q4P3; W5Q4P3_SHEEP

Genbank Protein ID

ENSOARP00000017683

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01063667

Gene Name

BTRC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000016467.1	ENSOART00000017933.1	ENSOARP00000017683.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-59	195.7	407	442
UBD/Beta-Prp	3.40e-69	233.5	321	485

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH++ v+c++f d +++vsG++Dg+ikvWDl    ++
   Q: 407  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLVAALDP 442
           8**********.44****************9876665 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +
   Q: 321  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-V 404
           445569*************9..8**************************************..************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           l+gh+++v+c++++   + +vsG++D+++++Wdl         +   +lrtl + h ++v  l+fd+  +++vs s+d t+ +wd+
   Q: 405  LEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLvaaldprapAGTLCLRTLVE-HSGRVFRLQFDE--FQIVSSSHDDTILIWDF 485
           **************9..*************************877889****98.************..99**************7 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MKTENCVVKT KLANGTSSMI VPKQRKLSAS YEKEKELCVK YFEQWSESDQ VEFVEHLISQ 60
MCHYQHGHIN SYLKPMLQRD FITALPAKAR GLDHIAENIL SYLDARSLCA AELVCKEWYR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACCCGG CCGAGGCGGT GCTGCAGGAA AAAGCGCTCA AGTTTATGGT GAGGAGAAGG 60
TGCAGGCCGG GGAACTGTGC AGGCGGTGCG TTGGCGGCGT CTCTGAGGCT CGGGCCTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0071407--P:cellular response to organic cyclic compound
GO:0033598--P:mammary gland epithelial cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061136--P:regulation of proteasomal protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001961	Ailuropoda melanoleuca	99.41	0.00e+00	1049.00
IUUC-Apl-003437	Anas platyrhynchos	98.20	0.00e+00	1021.00
IUUC-Aca-004410	Anolis carolinensis	96.26	0.00e+00	1016.00
IUUC-Acl-008355	Aspergillus clavatus	29.57	2.00e-50	193.00
IUUC-Afl-008580	Aspergillus flavus	27.14	1.00e-43	171.00
IUUC-Afu-008790	Aspergillus fumigatus	30.15	2.00e-48	187.00
IUUC-Ani-009324	Aspergillus nidulans	29.61	3.00e-48	186.00
IUUC-Aor-010185	Aspergillus oryzae	29.28	1.00e-50	194.00
IUUC-Ate-010492	Aspergillus terreus	30.18	9.00e-50	191.00
IUUC-Bgr-012194	Blumeria graminis	32.16	1.00e-53	204.00
IUUC-Bta-013453	Bos taurus	99.41	0.00e+00	1050.00
IUUC-Bci-013685	Botrytis cinerea	31.22	4.00e-54	206.00
IUUC-Cja-019121	Callithrix jacchus	98.82	0.00e+00	1046.00
IUUC-Cfa-020553	Canis familiaris	99.21	0.00e+00	1048.00
IUUC-Cpo-022126	Cavia porcellus	97.24	0.00e+00	993.00
IUUC-Csa-023688	Chlorocebus sabaeus	99.02	0.00e+00	1047.00
IUUC-Cgl-026429	Colletotrichum gloeosporioides	33.41	1.00e-60	227.00
IUUC-Dno-029484	Dasypus novemcinctus	92.40	0.00e+00	992.00
IUUC-Dor-031010	Dipodomys ordii	97.23	0.00e+00	944.00
IUUC-Dme-031885	Drosophila melanogaster	80.29	0.00e+00	813.00
IUUC-Ete-032978	Echinops telfairi	83.82	0.00e+00	845.00
IUUC-Eca-033374	Equus caballus	98.62	0.00e+00	1041.00
IUUC-Eeu-034760	Erinaceus europaeus	82.07	9.00e-171	593.00
IUUC-Fca-035427	Felis catus	99.21	0.00e+00	1048.00
IUUC-Fal-037530	Ficedula albicollis	98.03	0.00e+00	1034.00
IUUC-Fox-037978	Fusarium oxysporum	33.41	5.00e-62	232.00
IUUC-Fso-038077	Fusarium solani	32.17	7.00e-57	215.00
IUUC-Ggr-039974	Gaeumannomyces graminis	32.16	2.00e-55	210.00
IUUC-Gga-041087	Gallus gallus	98.03	0.00e+00	1035.00
IUUC-Ggo-045369	Gorilla gorilla	98.82	0.00e+00	1044.00
IUUC-Hsa-045962	Homo sapiens	99.02	0.00e+00	1047.00
IUUC-Itr-047872	Ictidomys tridecemlineatus	98.90	0.00e+00	933.00
IUUC-Lch-050285	Latimeria chalumnae	89.60	0.00e+00	934.00
IUUC-Loc-052686	Lepisosteus oculatus	96.46	0.00e+00	1019.00
IUUC-Lma-053289	Leptosphaeria maculans	38.43	2.00e-47	184.00
IUUC-Laf-054022	Loxodonta africana	98.82	0.00e+00	1043.00
IUUC-Mcc-055782	Macaca mulatta	99.02	0.00e+00	1046.00
IUUC-Meu-056078	Macropus eugenii	88.77	0.00e+00	851.00
IUUC-Mor-057283	Magnaporthe oryzae	33.11	4.00e-58	219.00
IUUC-Mpo-057540	Magnaporthe poae	32.16	6.00e-56	213.00
IUUC-Mla-058989	Melampsora laricipopulina	40.88	6.00e-61	227.00
IUUC-Mga-059388	Meleagris gallopavo	98.03	0.00e+00	1035.00
IUUC-Mmr-060969	Microcebus murinus	99.21	0.00e+00	1048.00
IUUC-Mdo-063041	Monodelphis domestica	98.43	0.00e+00	1010.00
IUUC-Mmu-064096	Mus musculus	98.23	0.00e+00	1039.00
IUUC-Mpu-066875	Mustela putorius furo	98.90	0.00e+00	937.00
IUUC-Mlu-067621	Myotis lucifugus	99.20	0.00e+00	1042.00
IUUC-Nfi-068263	Neosartorya fischeri	29.37	9.00e-50	191.00
IUUC-Ncr-068639	Neurospora crassa	34.82	7.00e-45	176.00
IUUC-Nle-069548	Nomascus leucogenys	99.02	0.00e+00	1046.00
IUUC-Opr-071194	Ochotona princeps	92.13	0.00e+00	954.00
IUUC-Oan-072867	Ornithorhynchus anatinus	94.87	0.00e+00	1025.00
IUUC-Ocu-074246	Oryctolagus cuniculus	99.21	0.00e+00	1048.00
IUUC-Oga-088244	Otolemur garnettii	99.20	0.00e+00	1031.00
IUUC-Pan-092826	Papio anubis	99.02	0.00e+00	1047.00
IUUC-Psi-093485	Pelodiscus sinensis	95.28	0.00e+00	998.00
IUUC-Pma-094315	Petromyzon marinus	85.32	0.00e+00	870.00
IUUC-Pab-097680	Pongo abelii	98.43	0.00e+00	1040.00
IUUC-Pca-100843	Procavia capensis	90.75	0.00e+00	921.00
IUUC-Pva-102793	Pteropus vampyrus	91.18	0.00e+00	919.00
IUUC-Pgr-103331	Puccinia graminis	37.91	5.00e-52	198.00
IUUC-Pte-104392	Pyrenophora teres	37.37	3.00e-47	183.00
IUUC-Pyt-104678	Pyrenophora triticirepentis	37.72	2.00e-47	184.00
IUUC-Rno-105304	Rattus norvegicus	98.43	0.00e+00	1039.00
IUUC-Sha-107454	Sarcophilus harrisii	98.43	0.00e+00	1009.00
IUUC-Sar-113471	Sorex araneus	79.56	0.00e+00	770.00
IUUC-Sre-114916	Sporisorium reilianum	33.71	3.00e-45	177.00
IUUC-Ssc-115490	Sus scrofa	99.02	0.00e+00	1046.00
IUUC-Tgu-117445	Taeniopygia guttata	97.83	0.00e+00	1034.00
IUUC-Tsy-118983	Tarsius syrichta	94.29	0.00e+00	985.00
IUUC-Tre-122207	Trichoderma reesei	33.48	1.00e-55	211.00
IUUC-Tvi-122344	Trichoderma virens	33.85	2.00e-55	210.00
IUUC-Tme-127141	Tuber melanosporum	35.70	3.00e-64	239.00
IUUC-Tbe-128146	Tupaia belangeri	87.40	0.00e+00	856.00
IUUC-Ttr-128946	Tursiops truncatus	99.02	0.00e+00	1047.00
IUUC-Uma-129491	Ustilago maydis	33.97	2.00e-46	181.00
IUUC-Vda-129941	Verticillium dahliae	32.09	8.00e-57	215.00
IUUC-Vpa-130709	Vicugna pacos	96.85	0.00e+00	1014.00
IUUC-Xtr-132861	Xenopus tropicalis	96.65	0.00e+00	1020.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence