iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-58	192.3	486	519
UBD/Beta-Prp	1.70e-68	231.4	400	564

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgv 34
           gH++ v+c++f d +++vsG++Dg+ikvWDl    
   Q: 486  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLMAAL 519
           8**********.44****************97665 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +
   Q: 400  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-V 483
           445579*************9..8**************************************..************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           l+gh+++v+c++++   + +vsG++D+++++Wdl         +   +lrtl + h ++v  l+fd+  +++vs s+d t+ +wd+
   Q: 484  LEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLmaaldprapAGTLCLRTLVE-HSGRVFRLQFDE--FQIVSSSHDDTILIWDF 564
           **************9..*************************877889****98.************..99**************7 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MPRSLWLGCS SLADSMPSLR CLYNPGTGAL TAFQNSSERE DCNNGEPPRK IIPEKNSLRQ 60
TYNSCARLCI NQETVCLTST AMKTENCVAK TKLANGTSSM IVPKQRKLSA SYEKEKELCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTATGCCC AGGTCTCTGT GGCTGGGCTG CTCCAGCCTG GCGGACAGCA TGCCCTCGCT 60
GCGATGCCTG TATAACCCAG GGACTGGCGC ACTCACAGCT TTCCAGGTAC TTTCTCTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0071407--P:cellular response to organic cyclic compound
GO:0033598--P:mammary gland epithelial cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001961	Ailuropoda melanoleuca	98.81	0.00e+00	1212.00
IUUC-Apl-003437	Anas platyrhynchos	97.60	0.00e+00	1013.00
IUUC-Aca-004410	Anolis carolinensis	95.40	0.00e+00	1174.00
IUUC-Acl-008355	Aspergillus clavatus	29.76	3.00e-50	193.00
IUUC-Afl-008580	Aspergillus flavus	27.92	4.00e-44	172.00
IUUC-Afu-008790	Aspergillus fumigatus	29.79	2.00e-38	154.00
IUUC-Aor-009916	Aspergillus oryzae	28.88	3.00e-47	183.00
IUUC-Ate-010492	Aspergillus terreus	29.53	2.00e-49	190.00
IUUC-Bgr-012194	Blumeria graminis	32.30	7.00e-54	205.00
IUUC-Bta-013453	Bos taurus	98.56	0.00e+00	1144.00
IUUC-Bci-013685	Botrytis cinerea	31.29	2.00e-54	207.00
IUUC-Cja-019121	Callithrix jacchus	93.87	0.00e+00	1140.00
IUUC-Cfa-020553	Canis familiaris	98.64	0.00e+00	1211.00
IUUC-Cpo-022126	Cavia porcellus	96.59	0.00e+00	1149.00
IUUC-Csa-023688	Chlorocebus sabaeus	98.47	0.00e+00	1211.00
IUUC-Csv-026020	Ciona savignyi	76.14	0.00e+00	786.00
IUUC-Cgl-026429	Colletotrichum gloeosporioides	33.26	2.00e-60	226.00
IUUC-Dno-029484	Dasypus novemcinctus	92.56	0.00e+00	1154.00
IUUC-Dor-031010	Dipodomys ordii	92.46	0.00e+00	1063.00
IUUC-Dse-031287	Dothistroma septosporum	28.91	4.00e-52	199.00
IUUC-Dme-031885	Drosophila melanogaster	80.00	0.00e+00	815.00
IUUC-Ete-032978	Echinops telfairi	85.14	0.00e+00	1005.00
IUUC-Eca-033374	Equus caballus	98.13	0.00e+00	1205.00
IUUC-Eeu-034760	Erinaceus europaeus	77.00	0.00e+00	901.00
IUUC-Fca-035427	Felis catus	94.21	0.00e+00	1143.00
IUUC-Fal-037530	Ficedula albicollis	97.61	0.00e+00	1195.00
IUUC-Fox-037978	Fusarium oxysporum	33.77	8.00e-63	235.00
IUUC-Fso-038077	Fusarium solani	32.97	1.00e-57	218.00
IUUC-Ggr-039974	Gaeumannomyces graminis	32.30	5.00e-56	213.00
IUUC-Gga-041087	Gallus gallus	97.61	0.00e+00	1196.00
IUUC-Ggo-045369	Gorilla gorilla	98.01	0.00e+00	1135.00
IUUC-Hsa-045962	Homo sapiens	98.47	0.00e+00	1211.00
IUUC-Itr-047872	Ictidomys tridecemlineatus	98.90	0.00e+00	934.00
IUUC-Lch-050285	Latimeria chalumnae	88.98	0.00e+00	932.00
IUUC-Loc-052686	Lepisosteus oculatus	92.33	0.00e+00	1136.00
IUUC-Lma-053289	Leptosphaeria maculans	38.08	3.00e-47	183.00
IUUC-Laf-054022	Loxodonta africana	98.13	0.00e+00	1205.00
IUUC-Mcc-055782	Macaca mulatta	98.47	0.00e+00	1208.00
IUUC-Meu-056078	Macropus eugenii	83.84	0.00e+00	891.00
IUUC-Mor-057283	Magnaporthe oryzae	33.26	1.00e-58	221.00
IUUC-Mpo-057540	Magnaporthe poae	32.52	2.00e-56	214.00
IUUC-Mla-058989	Melampsora laricipopulina	40.57	1.00e-60	226.00
IUUC-Mga-059388	Meleagris gallopavo	97.61	0.00e+00	1197.00
IUUC-Mmr-060969	Microcebus murinus	98.64	0.00e+00	1211.00
IUUC-Mdo-063041	Monodelphis domestica	97.96	0.00e+00	1175.00
IUUC-Mmu-064096	Mus musculus	99.49	0.00e+00	1221.00
IUUC-Mpu-066875	Mustela putorius furo	98.69	0.00e+00	1103.00
IUUC-Mlu-067621	Myotis lucifugus	98.01	0.00e+00	1025.00
IUUC-Nfi-068263	Neosartorya fischeri	29.50	1.00e-49	191.00
IUUC-Ncr-068639	Neurospora crassa	34.54	1.00e-44	175.00
IUUC-Nle-069548	Nomascus leucogenys	98.30	0.00e+00	1208.00
IUUC-Opr-071194	Ochotona princeps	92.84	0.00e+00	1122.00
IUUC-Oan-072867	Ornithorhynchus anatinus	94.38	0.00e+00	1181.00
IUUC-Ocu-074246	Oryctolagus cuniculus	98.64	0.00e+00	1211.00
IUUC-Oga-088244	Otolemur garnettii	98.59	0.00e+00	1027.00
IUUC-Oar-089199	Ovis aries	98.43	0.00e+00	1039.00
IUUC-Pan-092826	Papio anubis	98.47	0.00e+00	1211.00
IUUC-Psi-093485	Pelodiscus sinensis	95.06	0.00e+00	1160.00
IUUC-Pma-094315	Petromyzon marinus	79.71	0.00e+00	884.00
IUUC-Pab-097680	Pongo abelii	97.96	0.00e+00	1204.00
IUUC-Pca-100843	Procavia capensis	91.48	0.00e+00	1088.00
IUUC-Pva-102793	Pteropus vampyrus	88.25	0.00e+00	1048.00
IUUC-Pgr-103331	Puccinia graminis	37.69	3.00e-52	199.00
IUUC-Ptt-103853	Puccinia triticina	32.52	3.00e-61	229.00
IUUC-Pte-104392	Pyrenophora teres	37.01	6.00e-47	182.00
IUUC-Pyt-104678	Pyrenophora triticirepentis	37.37	4.00e-47	183.00
IUUC-Sha-107454	Sarcophilus harrisii	93.34	0.00e+00	1159.00
IUUC-Sar-113471	Sorex araneus	77.68	0.00e+00	889.00
IUUC-Sre-114916	Sporisorium reilianum	34.08	1.00e-45	178.00
IUUC-Ssc-115490	Sus scrofa	98.81	0.00e+00	1045.00
IUUC-Tgu-117445	Taeniopygia guttata	97.44	0.00e+00	1196.00
IUUC-Tsy-118983	Tarsius syrichta	94.55	0.00e+00	1152.00
IUUC-Tre-122207	Trichoderma reesei	33.63	2.00e-55	210.00
IUUC-Tvi-122344	Trichoderma virens	33.63	1.00e-55	211.00
IUUC-Tme-127141	Tuber melanosporum	34.32	3.00e-64	239.00
IUUC-Tbe-128146	Tupaia belangeri	88.59	0.00e+00	1026.00
IUUC-Ttr-128946	Tursiops truncatus	98.47	0.00e+00	1211.00
IUUC-Uma-129491	Ustilago maydis	33.97	8.00e-47	182.00
IUUC-Vda-129941	Verticillium dahliae	32.59	3.00e-57	216.00
IUUC-Vpa-130709	Vicugna pacos	96.59	0.00e+00	1177.00
IUUC-Xtr-132861	Xenopus tropicalis	93.70	0.00e+00	1156.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence