iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048632

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01028764

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000004965.2	ENSSTOT00000004960.2	ENSSTOP00000004448.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.60e-08	34.3	16	55
E3 activity/RING/U-box	3.50e-10	39.8	12	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl+++ d p+   CgH f+++C+ ++      + +   CP+Cr
   Q: 16   CAICLDPMVD-PVNIECGHSFCQECISQV-----GKDGGSVCPVCR 55
           **********.888************999.....7899999****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliq 66
           ee  C+I l++M dPv +++G+++ +++I +  ++gg+ cPv+rq++  + l Pn  l ++++
   Q: 12   EEVTCAICLDPMVDPVNIECGHSFCQECISQVGKDGGSVCPVCRQHFMLRHLRPNRQLANMVE 74
           6889***************************99***********************9998876 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MASAIPLEMM WEEVTCAICL DPMVDPVNIE CGHSFCQECI SQVGKDGGSV CPVCRQHFML 60
RHLRPNRQLA NMVENLRRIG QDAKKETQGA RCAVHGEKLH LFCEKDGQAL CWVCAQSKKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCTCAG CAATACCCCT GGAAATGATG TGGGAAGAGG TCACATGCGC TATCTGCCTC 60
GATCCCATGG TGGATCCTGT GAACATCGAA TGTGGCCACA GCTTCTGCCA AGAATGCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR003613--Ubox_domain
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	73.83	0.00e+00	701.00
IUUC-Aca-004891	Anolis carolinensis	43.28	3.00e-88	318.00
IUUC-Bta-013083	Bos taurus	70.72	0.00e+00	636.00
IUUC-Cja-019002	Callithrix jacchus	77.99	0.00e+00	730.00
IUUC-Cfa-020415	Canis familiaris	71.28	0.00e+00	679.00
IUUC-Cpo-021948	Cavia porcellus	70.51	0.00e+00	653.00
IUUC-Csa-023135	Chlorocebus sabaeus	78.83	0.00e+00	666.00
IUUC-Cho-024493	Choloepus hoffmanni	63.16	3.00e-90	324.00
IUUC-Dno-030061	Dasypus novemcinctus	68.53	0.00e+00	630.00
IUUC-Dor-030451	Dipodomys ordii	74.30	6.00e-91	327.00
IUUC-Ete-033168	Echinops telfairi	67.08	3.00e-163	567.00
IUUC-Eca-033578	Equus caballus	77.78	0.00e+00	695.00
IUUC-Eeu-034749	Erinaceus europaeus	53.49	7.00e-119	420.00
IUUC-Fca-035468	Felis catus	71.14	0.00e+00	654.00
IUUC-Ggo-045190	Gorilla gorilla	77.78	0.00e+00	691.00
IUUC-Hsa-046583	Homo sapiens	78.20	0.00e+00	695.00
IUUC-Laf-053455	Loxodonta africana	73.71	0.00e+00	655.00
IUUC-Mcc-054609	Macaca mulatta	79.04	0.00e+00	666.00
IUUC-Mor-057034	Magnaporthe oryzae	33.73	5.00e-08	52.40
IUUC-Mmr-061369	Microcebus murinus	74.05	4.00e-175	607.00
IUUC-Mmu-063166	Mus musculus	70.84	0.00e+00	636.00
IUUC-Mpu-066889	Mustela putorius furo	72.77	0.00e+00	691.00
IUUC-Mlu-067647	Myotis lucifugus	74.57	5.00e-179	620.00
IUUC-Nle-069567	Nomascus leucogenys	77.78	0.00e+00	691.00
IUUC-Opr-071178	Ochotona princeps	64.10	8.00e-157	546.00
IUUC-Oar-090413	Ovis aries	75.16	0.00e+00	652.00
IUUC-Ptr-091187	Pan troglodytes	78.20	0.00e+00	695.00
IUUC-Pan-092231	Papio anubis	79.79	0.00e+00	661.00
IUUC-Pab-098079	Pongo abelii	75.49	8.00e-146	509.00
IUUC-Pca-100639	Procavia capensis	73.13	3.00e-147	514.00
IUUC-Pva-102476	Pteropus vampyrus	73.58	0.00e+00	664.00
IUUC-Rno-105054	Rattus norvegicus	71.09	1.00e-164	572.00
IUUC-Sar-113204	Sorex araneus	71.94	1.00e-171	595.00
IUUC-Ssc-116291	Sus scrofa	74.89	0.00e+00	672.00
IUUC-Tsy-118803	Tarsius syrichta	74.85	4.00e-125	441.00
IUUC-Tbe-127337	Tupaia belangeri	60.24	7.00e-92	330.00
IUUC-Ttr-128914	Tursiops truncatus	72.98	5.00e-172	597.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence