iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/MINDY	MINDY	27292798
UBD/Alpha-Helix/MIU	MIU	27292798

Classification

Family	E-value	Score	Start	End
DUB/MINDY	4.10e-47	157.8	35	154

Active Site

Position(s)	Description	Evidence
28	Nucleophile	{ECO:0000250\|UniProtKB:Q8N5J2}
216	Proton acceptor	{ECO:0000250\|UniProtKB:Q8N5J2}

Domain Profile

DUB/MINDY

   S: 1    nilllswk........vklvpkkevitleelievlgdilldvkdkekseiselnyeqnvddalsllpklaeGldvnvrftGvrsfeytkecsvfdlldidly 94 
           nil+ls++        ++lv+k+++i+l+elievl+di+l+v+dk++++isel         lsllp+l+eGl++n++f+G  sfe+tke+s+f+l+++d++
   Q: 35   NILILSPDhtrfsnelIRLVNKGSQISLKELIEVLADIALQVTDKPSTDISEL---------LSLLPRLHEGLNINPEFNG--SFENTKEMSIFRLFNVDVV 125
           9****************************************************.........*******************..******************* PP
   S: 95   hGWlvdsqideav.kavgklsyeqlveril 123
           hGW+++s+i+e++ ++++++sye+ ++ril
   Q: 126  HGWVINSFINENIdEKLSHYSYES-AQRIL 154
           ************************.***97 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has endodeubiquitinase activity.

Protein Sequence
(Fasta)

MDLSFTTKSV KINGQNHRIL LQNENGPCAL LALANILILS PDHTRFSNEL IRLVNKGSQI 60
SLKELIEVLA DIALQVTDKP STDISELLSL LPRLHEGLNI NPEFNGSFEN TKEMSIFRLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATTTAA GTTTCACGAC TAAAAGTGTC AAAATTAATG GTCAAAACCA TCGAATATTA 60
CTGCAAAACG AAAACGGACC TTGTGCCTTG TTAGCACTTG CAAATATTCT AATACTTTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR007518--MINDY
IPR033979--MINDY_domain

Pfam

PF04424--MINDY_DUB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016807--F:cysteine-type carboxypeptidase activity
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity

KEGG

sce:YPL191C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-136378	Aegilops tauschii	43.21	2.00e-15	75.50
IUUC-Aml-136381	Ailuropoda melanoleuca	30.11	4.00e-27	114.00
IUUC-Atr-136384	Amborella trichopoda	30.24	4.00e-18	84.70
IUUC-Apl-136388	Anas platyrhynchos	30.11	4.00e-27	113.00
IUUC-Aca-136392	Anolis carolinensis	31.07	1.00e-26	112.00
IUUC-Aly-136395	Arabidopsis lyrata	48.15	8.00e-18	82.80
IUUC-Ath-136398	Arabidopsis thaliana	38.28	3.00e-17	81.30
IUUC-Ago-136399	Ashbya gossypii	41.51	2.00e-63	234.00
IUUC-Acl-136400	Aspergillus clavatus	32.35	2.00e-34	139.00
IUUC-Afl-136401	Aspergillus flavus	48.15	4.00e-15	75.10
IUUC-Afu-136402	Aspergillus fumigatus	38.08	7.00e-34	137.00
IUUC-Ani-136403	Aspergillus nidulans	37.16	9.00e-34	136.00
IUUC-Ang-136404	Aspergillus niger	36.78	4.00e-30	124.00
IUUC-Aor-136405	Aspergillus oryzae	34.17	3.00e-32	131.00
IUUC-Ate-136406	Aspergillus terreus	35.14	2.00e-30	125.00
IUUC-Ame-136409	Astyanax mexicanus	27.51	3.00e-22	97.80
IUUC-Bgr-136410	Blumeria graminis	32.41	9.00e-23	100.00
IUUC-Bta-136414	Bos taurus	32.04	5.00e-30	124.00
IUUC-Bci-136415	Botrytis cinerea	32.78	8.00e-28	117.00
IUUC-Bdi-136418	Brachypodium distachyon	28.46	9.00e-17	80.50
IUUC-Bol-136420	Brassica oleracea	46.15	2.00e-17	82.00
IUUC-Bra-136422	Brassica rapa	46.15	2.00e-17	81.60
IUUC-Cel-136423	Caenorhabditis elegans	28.35	1.00e-18	85.50
IUUC-Cja-136427	Callithrix jacchus	32.04	2.00e-30	124.00
IUUC-Cfa-136430	Canis familiaris	31.74	6.00e-30	123.00
IUUC-Cpo-136434	Cavia porcellus	30.45	1.00e-28	118.00
IUUC-Cre-136437	Chlamydomonas reinhardtii	45.68	2.00e-13	68.90
IUUC-Csa-136441	Chlorocebus sabaeus	31.74	4.00e-30	124.00
IUUC-Cho-136442	Choloepus hoffmanni	43.04	3.00e-13	67.80
IUUC-Cin-136446	Ciona intestinalis	30.38	4.00e-03	30.80
IUUC-Csv-136449	Ciona savignyi	28.96	4.00e-26	109.00
IUUC-Cgl-136450	Colletotrichum gloeosporioides	31.99	2.00e-30	125.00
IUUC-Cme-136451	Cyanidioschyzon merolae	44.59	1.00e-15	75.50
IUUC-Dre-136454	Danio rerio	30.54	6.00e-31	127.00
IUUC-Dno-136459	Dasypus novemcinctus	30.72	1.00e-30	125.00
IUUC-Dor-136463	Dipodomys ordii	28.81	3.00e-16	78.20
IUUC-Dse-136464	Dothistroma septosporum	34.04	3.00e-29	122.00
IUUC-Ete-136469	Echinops telfairi	31.41	4.00e-28	117.00
IUUC-Eca-136473	Equus caballus	31.74	8.00e-30	122.00
IUUC-Eeu-136475	Erinaceus europaeus	32.42	1.00e-21	95.10
IUUC-Fca-136479	Felis catus	31.74	8.00e-30	123.00
IUUC-Fal-136483	Ficedula albicollis	31.97	3.00e-26	110.00
IUUC-Fox-136484	Fusarium oxysporum	31.88	3.00e-33	134.00
IUUC-Fso-136485	Fusarium solani	31.68	8.00e-33	133.00
IUUC-Gmo-136489	Gadus morhua	30.65	8.00e-30	122.00
IUUC-Ggr-136490	Gaeumannomyces graminis	31.37	2.00e-28	119.00
IUUC-Gga-136493	Gallus gallus	32.04	1.00e-28	118.00
IUUC-Gac-136497	Gasterosteus aculeatus	29.88	1.00e-29	121.00
IUUC-Gma-136500	Glycine max	42.39	4.00e-16	78.20
IUUC-Ggo-136505	Gorilla gorilla	31.72	3.00e-27	114.00
IUUC-Hsa-136507	Homo sapiens	31.74	4.00e-30	124.00
IUUC-Hvu-136509	Hordeum vulgare	28.57	2.00e-09	55.10
IUUC-Itr-136512	Ictidomys tridecemlineatus	29.37	3.00e-26	110.00
IUUC-Kpa-136513	Komagataella pastoris	32.98	1.00e-30	125.00
IUUC-Lch-136516	Latimeria chalumnae	30.80	2.00e-29	120.00
IUUC-Lpe-136520	Leersia perrieri	27.52	2.00e-18	86.30
IUUC-Loc-136524	Lepisosteus oculatus	30.18	9.00e-30	122.00
IUUC-Lma-136525	Leptosphaeria maculans	36.10	7.00e-33	134.00
IUUC-Laf-136528	Loxodonta africana	32.12	6.00e-28	115.00
IUUC-Mcc-136533	Macaca mulatta	29.37	8.00e-26	109.00
IUUC-Meu-136536	Macropus eugenii	28.80	8.00e-28	116.00
IUUC-Mor-136537	Magnaporthe oryzae	30.14	3.00e-29	122.00
IUUC-Mpo-136538	Magnaporthe poae	32.32	3.00e-29	121.00
IUUC-Mtr-136539	Medicago truncatula	46.25	3.00e-16	78.20
IUUC-Mla-136542	Melampsora laricipopulina	30.87	9.00e-10	55.50
IUUC-Mga-136545	Meleagris gallopavo	31.76	1.00e-28	118.00
IUUC-Mvi-136546	Microbotryum violaceum	30.43	4.00e-20	91.30
IUUC-Mmr-136549	Microcebus murinus	31.74	5.00e-30	124.00
IUUC-Mdo-136553	Monodelphis domestica	30.77	3.00e-30	124.00
IUUC-Mmu-136558	Mus musculus	31.74	4.00e-30	124.00
IUUC-Mac-136560	Musa acuminata	47.06	2.00e-14	72.00
IUUC-Mpu-136564	Mustela putorius furo	29.74	1.00e-27	115.00
IUUC-Mlu-136568	Myotis lucifugus	31.12	4.00e-28	117.00
IUUC-Nfi-136569	Neosartorya fischeri	37.69	2.00e-33	135.00
IUUC-Ncr-136571	Neurospora crassa	32.91	1.00e-32	133.00
IUUC-Nle-136575	Nomascus leucogenys	31.74	5.00e-30	124.00
IUUC-Opr-136578	Ochotona princeps	30.00	1.00e-26	112.00
IUUC-Ont-136581	Oreochromis niloticus	28.73	4.00e-25	107.00
IUUC-Oan-136584	Ornithorhynchus anatinus	29.00	2.00e-12	63.20
IUUC-Ocu-136588	Oryctolagus cuniculus	32.63	6.00e-29	120.00
IUUC-Oba-136590	Oryza barthii	44.44	5.00e-16	77.80
IUUC-Obr-136591	Oryza brachyantha	43.21	7.00e-15	73.90
IUUC-Ogl-136594	Oryza glaberrima	44.44	4.00e-16	77.80
IUUC-Ogu-136596	Oryza glumaepatula	44.44	5.00e-16	77.40
IUUC-Oin-136598	Oryza indica	44.44	5.00e-16	77.80
IUUC-Olo-136600	Oryza longistaminata	44.44	6.00e-16	77.40
IUUC-Ome-136601	Oryza meridionalis	44.44	5.00e-16	77.80
IUUC-Oni-136603	Oryza nivara	44.44	4.00e-16	77.80
IUUC-Opu-136605	Oryza punctata	44.44	5.00e-16	77.80
IUUC-Oru-136607	Oryza rufipogon	44.44	5.00e-16	77.80
IUUC-Osa-136609	Oryza sativa	44.44	5.00e-16	77.80
IUUC-Ola-136611	Oryzias latipes	30.18	4.00e-28	117.00
IUUC-Olu-136613	Ostreococcus lucimarinus	40.62	3.00e-16	77.80
IUUC-Oga-136616	Otolemur garnettii	32.34	5.00e-29	120.00
IUUC-Oar-136622	Ovis aries	32.04	3.00e-30	124.00
IUUC-Ptr-136626	Pan troglodytes	31.74	4.00e-30	124.00
IUUC-Pan-136629	Papio anubis	31.74	6.00e-30	123.00
IUUC-Psi-136633	Pelodiscus sinensis	31.02	1.00e-30	125.00
IUUC-Pma-136636	Petromyzon marinus	31.66	3.00e-33	134.00
IUUC-Pno-136637	Phaeosphaeria nodorum	34.55	4.00e-35	141.00
IUUC-Ppa-136640	Physcomitrella patens	42.68	1.00e-13	69.70
IUUC-Pfo-136644	Poecilia formosa	29.88	1.00e-28	119.00
IUUC-Pab-136647	Pongo abelii	31.74	4.00e-30	124.00
IUUC-Pop-136651	Populus trichocarpa	45.78	3.00e-17	81.30
IUUC-Pca-136655	Procavia capensis	30.60	4.00e-26	109.00
IUUC-Ppe-136657	Prunus persica	45.00	7.00e-16	77.00
IUUC-Pva-136661	Pteropus vampyrus	28.17	1.00e-27	115.00
IUUC-Pgr-136662	Puccinia graminis	22.36	2.00e-09	55.50
IUUC-Pte-136663	Pyrenophora teres	35.64	4.00e-32	131.00
IUUC-Pyt-136664	Pyrenophora triticirepentis	34.44	2.00e-32	132.00
IUUC-Rno-136667	Rattus norvegicus	31.33	6.00e-31	127.00
IUUC-Sha-136673	Sarcophilus harrisii	28.85	9.00e-28	115.00
IUUC-Sja-136675	Schizosaccharomyces japonicus	25.00	5.00e-15	73.20
IUUC-Spo-136676	Schizosaccharomyces pombe	28.67	8.00e-12	62.40
IUUC-Ssl-136677	Sclerotinia sclerotiorum	33.11	4.00e-29	121.00
IUUC-Smo-136679	Selaginella moellendorffii	42.34	1.00e-19	89.40
IUUC-Sit-136681	Setaria italica	43.90	7.00e-16	77.00
IUUC-Sly-136682	Solanum lycopersicum	36.21	7.00e-16	77.00
IUUC-Stu-136684	Solanum tuberosum	43.75	1.00e-15	76.30
IUUC-Sar-136687	Sorex araneus	30.30	3.00e-17	81.30
IUUC-Sbi-136689	Sorghum bicolor	44.44	7.00e-16	77.00
IUUC-Sre-136690	Sporisorium reilianum	23.91	6.00e-17	81.30
IUUC-Ssc-136693	Sus scrofa	30.11	2.00e-27	114.00
IUUC-Tgu-136696	Taeniopygia guttata	32.44	2.00e-29	121.00
IUUC-Tru-136700	Takifugu rubripes	30.06	4.00e-28	117.00
IUUC-Tsy-136704	Tarsius syrichta	31.12	8.00e-30	123.00
IUUC-Tni-136709	Tetraodon nigroviridis	30.84	4.00e-27	113.00
IUUC-Tca-136710	Theobroma cacao	42.39	1.00e-16	79.30
IUUC-Tre-136712	Trichoderma reesei	34.87	5.00e-37	146.00
IUUC-Tvi-136713	Trichoderma virens	32.07	4.00e-35	141.00
IUUC-Tae-136715	Triticum aestivum	44.44	4.00e-16	77.80
IUUC-Tur-136717	Triticum urartu	39.08	1.00e-12	66.20
IUUC-Tme-136718	Tuber melanosporum	35.90	5.00e-27	114.00
IUUC-Tbe-136721	Tupaia belangeri	31.90	2.00e-27	114.00
IUUC-Ttr-136725	Tursiops truncatus	29.74	6.00e-27	113.00
IUUC-Uma-136726	Ustilago maydis	26.25	6.00e-15	74.30
IUUC-Vda-136728	Verticillium dahliae	32.41	4.00e-33	134.00
IUUC-Vpa-136731	Vicugna pacos	32.04	1.00e-29	122.00
IUUC-Vvi-136733	Vitis vinifera	45.00	1.00e-15	76.30
IUUC-Xtr-136737	Xenopus tropicalis	29.15	2.00e-29	120.00
IUUC-Xma-136741	Xiphophorus maculatus	30.24	8.00e-28	116.00
IUUC-Yli-136742	Yarrowia lipolytica	32.68	8.00e-37	146.00
IUUC-Zma-136745	Zea mays	45.12	5.00e-17	79.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence